{"title":"血清MVIH、HNF1A-AS1和NEAT1长链非编码rna水平：结直肠癌的潜在生物标志物","authors":"Mohsen Mohamadnejad, Mohammad-Reza Firoozi, Shahriar Hashemzadeh, Venus Zafari, Habib Zarredar, Rojin Farzaneh, Negar Pedram, Touraj Asvadi Kermani","doi":"10.31557/APJCP.2025.26.6.1953","DOIUrl":null,"url":null,"abstract":"<p><p>Long noncoding RNAs (lncRNAs) are a significant class of non-coding RNAs that play critical roles in cancer development, progression, and metastasis. This study aimed to investigate the expression of MVIH, HNF1A-AS1, and NEAT1 in the blood samples of patients with colorectal cancer (CRC), both before and three months after surgery, in comparison to a healthy control group. The objective was to assess the potential of these genes as biomarkers for CRC. A total of 75 blood samples were collected from patients diagnosed with colorectal carcinomas (before surgery and at the three-month post-surgery mark), while an additional 75 samples were obtained from a healthy control group. The relative expression levels of the target genes in the serum were measured using quantitative real-time PCR. Our findings demonstrated that the levels of MVIH, HNF1A-AS1, and NEAT1 in the serum were significantly upregulated in CRC subjects compared to the healthy controls. Receiver operating characteristic (ROC) curve analysis revealed that the serum levels of all three genes could effectively distinguish CRC cases from controls with notable accuracy. Furthermore, the serum levels of MVIH, HNF1A-AS1, and HNF1A-AS1 were significantly downregulated three months after surgery. However, no significant correlations were observed between the serum levels of the studied genes and the clinical features of the patients. Collectively, our results suggest that the serum levels of MVIH, HNF1A-AS1, and HNF1A-AS1 have the potential to serve as valuable biomarkers for the diagnosis and prognosis of CRC.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 6","pages":"1953-1958"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Serum Level of MVIH, HNF1A-AS1, and NEAT1 Long Noncoding RNAs: Potential Biomarkers for Colorectal Cancer.\",\"authors\":\"Mohsen Mohamadnejad, Mohammad-Reza Firoozi, Shahriar Hashemzadeh, Venus Zafari, Habib Zarredar, Rojin Farzaneh, Negar Pedram, Touraj Asvadi Kermani\",\"doi\":\"10.31557/APJCP.2025.26.6.1953\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Long noncoding RNAs (lncRNAs) are a significant class of non-coding RNAs that play critical roles in cancer development, progression, and metastasis. This study aimed to investigate the expression of MVIH, HNF1A-AS1, and NEAT1 in the blood samples of patients with colorectal cancer (CRC), both before and three months after surgery, in comparison to a healthy control group. The objective was to assess the potential of these genes as biomarkers for CRC. A total of 75 blood samples were collected from patients diagnosed with colorectal carcinomas (before surgery and at the three-month post-surgery mark), while an additional 75 samples were obtained from a healthy control group. The relative expression levels of the target genes in the serum were measured using quantitative real-time PCR. Our findings demonstrated that the levels of MVIH, HNF1A-AS1, and NEAT1 in the serum were significantly upregulated in CRC subjects compared to the healthy controls. Receiver operating characteristic (ROC) curve analysis revealed that the serum levels of all three genes could effectively distinguish CRC cases from controls with notable accuracy. Furthermore, the serum levels of MVIH, HNF1A-AS1, and HNF1A-AS1 were significantly downregulated three months after surgery. However, no significant correlations were observed between the serum levels of the studied genes and the clinical features of the patients. Collectively, our results suggest that the serum levels of MVIH, HNF1A-AS1, and HNF1A-AS1 have the potential to serve as valuable biomarkers for the diagnosis and prognosis of CRC.</p>\",\"PeriodicalId\":55451,\"journal\":{\"name\":\"Asian Pacific Journal of Cancer Prevention\",\"volume\":\"26 6\",\"pages\":\"1953-1958\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Pacific Journal of Cancer Prevention\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31557/APJCP.2025.26.6.1953\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Pacific Journal of Cancer Prevention","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31557/APJCP.2025.26.6.1953","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Serum Level of MVIH, HNF1A-AS1, and NEAT1 Long Noncoding RNAs: Potential Biomarkers for Colorectal Cancer.
Long noncoding RNAs (lncRNAs) are a significant class of non-coding RNAs that play critical roles in cancer development, progression, and metastasis. This study aimed to investigate the expression of MVIH, HNF1A-AS1, and NEAT1 in the blood samples of patients with colorectal cancer (CRC), both before and three months after surgery, in comparison to a healthy control group. The objective was to assess the potential of these genes as biomarkers for CRC. A total of 75 blood samples were collected from patients diagnosed with colorectal carcinomas (before surgery and at the three-month post-surgery mark), while an additional 75 samples were obtained from a healthy control group. The relative expression levels of the target genes in the serum were measured using quantitative real-time PCR. Our findings demonstrated that the levels of MVIH, HNF1A-AS1, and NEAT1 in the serum were significantly upregulated in CRC subjects compared to the healthy controls. Receiver operating characteristic (ROC) curve analysis revealed that the serum levels of all three genes could effectively distinguish CRC cases from controls with notable accuracy. Furthermore, the serum levels of MVIH, HNF1A-AS1, and HNF1A-AS1 were significantly downregulated three months after surgery. However, no significant correlations were observed between the serum levels of the studied genes and the clinical features of the patients. Collectively, our results suggest that the serum levels of MVIH, HNF1A-AS1, and HNF1A-AS1 have the potential to serve as valuable biomarkers for the diagnosis and prognosis of CRC.
期刊介绍：
Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation.
The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally.
The APJCP publishes original research results under the following categories:
-Epidemiology, detection and screening.
-Cellular research and bio-markers.
-Identification of bio-targets and agents with novel mechanisms of action.
-Optimal clinical use of existing anti-cancer agents, including combination therapies.
-Radiation and surgery.
-Palliative care.
-Patient adherence, quality of life, satisfaction.
-Health economic evaluations.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
