Oral Contraceptives Use and Colorectal Cancer Risk Among Moroccan Women: A Case-Control Study.

Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2025-06-01 DOI:10.31557/APJCP.2025.26.6.2225

Hamza Elbaylek, Soumia Ammor

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引用次数: 0

Abstract

Objective: Colorectal cancer (CRC) encompasses both non-modifiable and modifiable risk factors. While diet remains the main factor influencing CRC risk, hormonal and reproductive factors have also demonstrated a potential impact on CRC risk. This study aims to explore the relationship between oral contraceptives (OC) use and Colorectal cancer risk among Moroccan women.

Methods: We conducted a case-control study included 300 participants, divided into 150 cases and 150 controls matched by age (± 3 years). Through a face-to-face interview with trained investigators, we collected data on oral contraceptives use among participants. we performed conditional logistic regression to estimate Odds Ratio (OR) and 95% confidence interval (95% CI), to elaborate a basic model and adjusted model for confounding factors to assess the relationship between OC use and CRC risk.

Results: An inverse correlation was observed between OC use and CRC risk with OR²:0.57 (0.36-0.92), using OC at younger ages (≤24 years) for a longer period (>8 years) was also associated with a decreased risk of CRC, with OR²: 0.52 (0.31-0.89) and OR²: 0.43 (0.26-0.79), respectively. this association was consistent across all tumor location in the adjusted model, with OR²: 0.54 (0.27-0.98) for colon cancer, OR²: 0.47 (0.21-0.96) for rectal cancer, and OR²: 0.35 (0.12-0.9) for colorectal cancer. Furthermore, combined oral contraceptives use significantly reduced CRC risk, with OR²: 0.42 (0.21-0.75), whereas no significant reduction was observed with progestin-only pills with OR²: 0.64 (0.32-1.17).

Conclusion: These findings underscore the potential role of reproductive and hormone factors, such as oral contraceptive use, in reducing colorectal cancer risk, particularly for combined oral contraceptives initiated in a younger age, also the importance of incorporating reproductive and hormone factors in future research in Morocco, providing a broader understanding of colorectal cancer prevention strategies.

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摩洛哥妇女口服避孕药的使用与结直肠癌风险：一项病例对照研究

目的：结直肠癌（CRC）包括不可改变和可改变的危险因素。虽然饮食仍然是影响结直肠癌风险的主要因素，但激素和生殖因素也显示出对结直肠癌风险的潜在影响。本研究旨在探讨摩洛哥妇女口服避孕药（OC）使用与结直肠癌风险之间的关系。方法：采用病例-对照研究，纳入300人，按年龄（±3岁）分为150例病例和150例对照。通过与训练有素的调查人员的面对面访谈，我们收集了参与者使用口服避孕药的数据。我们使用条件logistic回归来估计比值比（OR）和95%置信区间（95% CI），为混杂因素制定基本模型和调整模型，以评估口服避孕药使用与CRC风险之间的关系。结果：使用OC与CRC风险呈负相关，OR2:0.57(0.36-0.92)，较年轻（≤24岁）使用OC的时间较长（bb0 - 8年）也与CRC风险降低相关，OR2: 0.52（0.31-0.89）和OR2: 0.43（0.26-0.79）。在调整后的模型中，这种关联在所有肿瘤部位都是一致的，结肠癌的OR2: 0.54(0.27-0.98)，直肠癌的OR2: 0.47(0.21-0.96)，结直肠癌的OR2: 0.35（0.12-0.9）。此外，联合口服避孕药可显著降低结直肠癌风险，OR2: 0.42(0.21-0.75)，而单用孕激素避孕药无显著降低，OR2: 0.64（0.32-1.17）。结论：这些发现强调了生殖和激素因素，如口服避孕药的使用，在降低结直肠癌风险方面的潜在作用，特别是在年轻时开始联合口服避孕药，以及在摩洛哥未来的研究中纳入生殖和激素因素的重要性，为结直肠癌预防策略提供了更广泛的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.