Association of rs2294008 (PSCA) Gene polymorphism in Urothelial Bladder Cancer of South Indian Population.

Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2025-04-01 DOI:10.31557/APJCP.2025.26.4.1441

Saziya R Bidi, Shridhar C Ghagane, Shadab Rangrez, Rajendra Nerli

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引用次数: 0

Abstract

Background: Urothelial Bladder cancer (UBC) is a significant health problem worldwide. Prostate stem cell antigen (PSCA) gene has been reported earlier in Genome Wide Association Study (GWAS) for the risk of UBC. It is highly expressed in urothelial bladder tumours and considered to be involved in the cell proliferation inhibition and/or cell-death induction activity. The study aims to investigate PSCA gene as a possible marker for the diagnosis and prognosis of urothelial bladder cancer.

Patients and methods: We genotyped PSCA rs2294008C/T gene by Real Time Taqman® probes to evaluate the risk of UBC in histologically confirmed bladder tumour patients 107 and healthy controls 105 (age and gender matched) in a hospital-based setting from South Indian population. Statistical analysis was carried out using (SPSS ver 22.0 Armonk NY, USA).

Results: The heterozygous CT genotype showed increased significance risk to UBC with PSCA rs2294008 C/T having 2.77 folds risk (p<0.0001). The variant allele T was also significantly associated with UBC risk (p<0.0001; OR=3.349) for PSCA rs2294008C/T. A significant UBC risk was noted when risk was evaluated with tumor-grade-stage level for PSCA rs2294008C/T with heterozygous CT genotype for high grade tumours (p<0.001; OR=1.984). The smoking factor was significantly modulated with the risk of UBC in patients with heterozygous CT genotype (p<0.0001) for PSCA rs2294008C/T gene polymorphism. Urothelial Bladder cancer patients receiving BCG treatment showed no significant association with genotype of PSCA.

Conclusions: The present study has unveiled a complex intervention of PSCA rs2294008C/T conferring a higher risk of UBC risk among smokers in South Indian population, providing evidence that it may contribute to bladder carcinogenesis regardless of ethnicity. These findings suggest that the PSCA rs2294008C/T polymorphism of PSCA gene could be served as a biomarker for genetic susceptibility to bladder cancer in Indian populations.

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rs2294008 （PSCA）基因多态性与南印度人群尿路上皮性膀胱癌的关系

背景：尿路上皮性膀胱癌（UBC）是一个全球性的重大健康问题。前列腺干细胞抗原（PSCA）基因早前在全基因组关联研究（GWAS）中被报道与UBC的风险有关。它在尿路上皮膀胱肿瘤中高度表达，并被认为参与细胞增殖抑制和/或细胞死亡诱导活性。本研究旨在探讨PSCA基因作为尿路上皮性膀胱癌诊断和预后的可能标志。患者和方法：我们通过Real Time Taqman®探针对PSCA rs2294008C/T基因进行分型，以评估组织学证实的膀胱肿瘤患者107例和健康对照105例（年龄和性别匹配）中UBC的风险。采用SPSS 22.0版本进行统计分析（Armonk NY， USA）。结果：杂合子CT基因型显示UBC风险增加，PSCA rs2294008C/T风险为2.77倍(结论：本研究揭示了PSCA rs2294008C/T的复杂干预，赋予南印度人群吸烟者更高的UBC风险，提供证据表明它可能与膀胱癌的发生无关种族。这些发现提示PSCA基因rs2294008C/T多态性可作为印度人群膀胱癌遗传易感性的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.