Asian Pacific Journal of Cancer Prevention最新文献

{"title":"Ultrasound-Guided Fine-Needle Aspiration Biopsy Of Thyroid Nodules Smaller Than 10 mm in the Maximum Diameter: The Efficacy and Its Correlation with TIRADS Classification.","authors":"Hau Van Vy Nguyen, Bang Van Nguyen, Xuan Thi Nguyen, Linh Nguyen Tuyen Pham, Thoi Thi Ngoc Nguyen, Trang Thanh Vo, Tam Thi Le, Binh Trong Le, Thuy Hai Nguyen, Chi Van Le","doi":"10.31557/APJCP.2025.26.5.1563","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1563","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective study evaluated the effectiveness of ultrasound-guided fine-needle aspiration cytology (US-FNAc) for diagnosing thyroid nodules less than 10mm and explored the correlation between the TIRADS classification and US-FNAc reports.</p><p><strong>Methods: </strong>This analysis of 344 patients with 407 thyroid nodules less than 10mm was conducted from June 2022 to July 2023 at the Centre of Endocrinology and Diabetes, Danang Family hospital, Danang, Vietnam. US-FNAc was performed on all nodules, and cytology was reported according to The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of US-FNAc were calculated. Correlation between cytology and TIRADS classification was assessed using Spearman's correlation.</p><p><strong>Results: </strong>Adequate specimens were obtained in 81% of thyroid nodules after the first FNAc. Cytological diagnoses included 36.6% benign, 12.8% suspicious for malignancy, 1.2% malignant, and 19.7% indeterminate. Among surgically resected thyroid nodules, 78.6% were malignant. US-FNAc demonstrated moderate sensitivity (80%) and high PPV (92.3%) but lower specificity (75%) and NPV (50%) for malignancy in nodules less than 10mm in max diameter. A significant positive correlation (r = 0.24, p < 0.001) was observed between TIRADS classification and TBSRTC.</p><p><strong>Conclusion: </strong>US-FNAc offers moderate sensitivity and high PPV for diagnosing malignancy in smaller than 10 mm thyroid nodules, but specificity and NPV are lower. A positive correlation exists between TIRADS classification and cytological outcomes.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1563-1569"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mismatch Repair Proteins Immunostaining in Lip Squamous Cell Carcinoma: A Role in Lip Carcinogenesis?","authors":"Yamyle Velasquez Barragán, Anna Clara Aragao Matos Carlos, Gabriella Alves Juliao Costa, Osias Vieira Oliveira Filho, Thâmara Manoela Marinho Bezerra, Sergio Ferreira Juaçaba, Thinali Sousa Dantas, Ana Paula Negreiros Nunes Alves, Paulo Goberlânio De Barros Silva","doi":"10.31557/APJCP.2025.26.5.1553","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1553","url":null,"abstract":"<p><strong>Objective: </strong>Lip squamous cell carcinoma (LSCC) is associated with malignant transformation of actinic cheilitis (AC). Since solar radiation alters the functions of mismatch repair (MMR) complex, we evaluated for their possible role in lip carcinogenesis.</p><p><strong>Materials and methods: </strong>Samples of normal lip epithelia (NLE) (n=15), AC (n=30), and LSCC (n=45) were subjected to immunohistochemistry for MutSα (MSH2/MSH6) and MutLα (MLH1/PMS2) to assess the percentage (brown nuclei over all the keratinocytes in NLE and AC or all tumoral cells in LSCC) of nuclear positive cells and MSH2/MSH6 (MutSα-imbalance) and MLH1/PMS2 (MutLα-imbalance) ratios. Clinical-prognostic variables of the primary tumor and histopathological gradation (LSCC and AC) were evaluated. Mann-Whitney, Kruskal-Wallis/Dunn, and Spearman correlation tests were used (p<0.05, SPSS 20.0).</p><p><strong>Results: </strong>LSCC and AC showed significant increases in MSH2 (p<0.001), MSH6 (p<0.001), MLH1 (p=0.040) percentage of immunostained cells, and MutSα-imbalance (p<0.001). MutSα-imbalance in AC was higher than MutLα-imbalance (p=0.028). In LSCC, T3/T4 tumors showed higher MutSα-imbalance (p=0.028) and MutLα-imbalance (p=0.014). In LSCC with nodal metastasis, the MutLα-imbalance was significantly higher than the MutSα-imbalance (p=0.046). AC with high-risk dysplasia (p=0.024) and LSCC with vascular invasion (p=0.035) showed lower immunostaining for MSH6. Direct correlations between MMR-proteins increased in LSCC.</p><p><strong>Conclusions: </strong>Increased MMR expression in lip cancer and the imbalance between MutSa and MutLα is associated with the progression and prognosis of LSCC.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1553-1562"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of Circulating HPV DNA as a Biomarker for Cervical pre-cancer and cancer: A Pilot Study.","authors":"Apoorva Gangwar, Shivanjali Raghuvanshi, Shalini Bhalla, Preeti Agarwal, Ajay Kumar Singh, Nisha Singh, Madhu Kumar, Sudhir Singh, Nitu Nigam, Esha Jafa, Harshi Srivastava","doi":"10.31557/APJCP.2025.26.5.1681","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1681","url":null,"abstract":"<p><strong>Background: </strong>Tumor cells release fragments of their DNA into the bloodstream, called cell-free tumor DNA (ctDNA) or liquid biopsy. In this study, we investigate whether human papillomavirus cell-free tumor DNA (ctHPV DNA) can be detected in patients with cervical cancer or premalignant lesions before and after treatment. We are also investigating whether ctHPV DNA levels correlate with patient or tumor characteristics and outcomes.</p><p><strong>Methods: </strong>A total of 67 cases were included, including 42 with locally advanced cervical cancer (LACC) and 11 with early-stage cervical cancer (ESCC), as well as 14 with premalignant lesions. Pre- and post-treatment plasma samples were tested for ctHPV DNA levels using digital droplet PCR.</p><p><strong>Results: </strong>The pretreatment ctHPV DNA was detected in 21.42%(n=09/42) cases with LACC and post treatment ctHPV DNA was detected in 16.66% (07/42) LACC cases. While circulating ctHPV DNA was not detected in ESCC and premalignant lesion cases. Higher levels of ctHPV DNA were correlated to the higher FIGO2018 stage.</p><p><strong>Conclusion: </strong>ctHPV DNA is a promising biomarker in locally advanced cervical cancer and should be further investigated for clinical use. In ESCC patients, the detection rate of ctHPV DNA is not sufficient for clinical benefit even using ddPCR, the most sensitive technologies available.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1681-1687"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of DIBH Coaching on Dosimetric Parameters of Heart and Lung Doses in Patients Undergoing Adjuvant Breast Radiotherapy.","authors":"Laraib Khan, Maham Khan, Fabiha Shakeel, Tooba Ali, Mariam Hina, Aahan Arif, Firza Rahim Sarfaraz, Maria Tariq, Asim Hafiz, Bilal Mazhar Qureshi, Ahmed Nadeem Abbasi, Nasir Ali","doi":"10.31557/APJCP.2025.26.5.1809","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1809","url":null,"abstract":"<p><strong>Introduction: </strong>Radiation exposure to the heart in women with left-sided breast cancer can lead to cardiac disease and increased mortality. Several techniques, including deep inspiration breath hold (DIBH), have been used to reduce cardiac exposure during radiotherapy. DIBH coaching prior to radiation planning can further reduce cardiac doses. This study aims to compare heart and lung dosimetric parameters between coached and non-coached patients using the DIBH technique for left-sided breast cancer treatment.</p><p><strong>Methods: </strong>All patients with left-sided breast cancer who received adjuvant radiotherapy (RT) using the DIBH were included. The first cohort, designated as the non-coached group, received verbal guidance on the breath hold technique but did not undergo formal coaching. The second cohort involved a comprehensive coaching protocol, which began in January 2022. This protocol, led by a physician, included demonstrations and instructions for performing the DIBH technique in the clinic and encouraged patients to practice at home before and during RT to optimize cardiac protection.</p><p><strong>Results: </strong>A total of 40 patients met the inclusion criteria for the study, with a mean age of 45.7 ± 8.38 years. Most patients had IDC and Stage II disease, and radiation was primarily delivered using 3DCRT with 4256 cGy in 16 fractions regimes. In terms of cardiac dose exposure, coached patients had slightly lower mean and maximum point cardiac doses, but these differences were not statistically significant. Coached patients also had a significantly lower mean V17 for left lung volume exposure compared to non-coached patients (18.3 vs. 21.6, p < 0.05).</p><p><strong>Conclusion: </strong>DIBH coaching and home practice prior to RT planning can further reduce cardiac and lung doses, offering a cost-effective intervention, particularly in resource-limited settings, though further controlled studies with larger sample sizes and longer follow-up are needed to assess its clinical impact.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1809-1813"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness and Adverse Events of Eribulin Monotherapy in Indonesian Metastatic Breast Cancer (MBC) Patients.","authors":"Putu Anda Tusta Adiputra, Kristina Maria Siswiandari, Dhian Hangesti, Nur Qodir, Walta Gautama, Dedy Hermansyah","doi":"10.31557/APJCP.2025.26.5.1773","DOIUrl":"10.31557/APJCP.2025.26.5.1773","url":null,"abstract":"<p><strong>Objective: </strong>Metastatic breast cancer (MBC) remains a major cause of cancer-related mortality, with limited treatment options in advanced stages. Eribulin is now recommended for MBC and covered by the Indonesian National Health Insurance Policy as monotherapy for 6 cycles. However, data on its effectiveness and safety in Indonesian patients remain scarce. This study aimed to evaluate the disease control rate, overall survival (OS), and adverse events of eribulin monotherapy after 6 treatment cycles in Indonesian MBC patients.</p><p><strong>Methods: </strong>This multi-center bidirectional longitudinal study was conducted in Indonesia (November 2023 - December 2024). Patients with stage IV MBC receiving eribulin were included. Demographic data, tumor response, OS, and adverse events were extracted from medical records. Kaplan-Meier analysis and the log-rank test were used to assess OS, while Cox regression evaluated potential prognostic factors. Adverse events were analyzed using descriptive statistics.</p><p><strong>Result: </strong>A total of 53 patients were included, with 54.7% aged >50 years and 56.6% classified as luminal subtype. The majority (51.0%) received eribulin as a third-line or later treatment, and 56.6% had lung metastases. Disease control was achieved in 43.4% of patients after 6 cycles. The median OS was 10 months (95% CI: 6.81 - 13.18 months). Eribulin was well tolerated, with nausea (32.1%) being the most common adverse event.</p><p><strong>Conclusion: </strong>This study suggests that eribulin monotherapy is associated with disease control and survival benefits in Indonesian MBC patients while maintaining a manageable safety profile. However, further prospective studies are needed to confirm its long-term efficacy, impact beyond 6 cycles, and comparative effectiveness relative to other chemotherapy regimens.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1773-1780"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Lenvatinib versus Atezolizumab Plus Bevacizumab in the Treatment of Unresectable Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.","authors":"Ni Putu Sri Indrani Remitha, Ni Putu Rista Pradnya Dewi, I Komang Wira Ananta Kusuma, I Gede Aswin Parisya Sasmana, I Gede Putu Supadmanaba, Dwijo Anargha Sindhughosa, I Ketut Mariadi","doi":"10.31557/APJCP.2025.26.5.1529","DOIUrl":"10.31557/APJCP.2025.26.5.1529","url":null,"abstract":"<p><strong>Introduction: </strong>Hepatocellular carcinoma (HCC), the leading form of primary liver cancer, is strongly associated with liver cirrhosis and major risk factors such as hepatitis B and C, alcohol consumption, obesity, and non-alcoholic fatty liver disease. Despite treatment advancements, survival rates for unresectable HCC remain low. Lenvatinib and the combination of atezolizumab and bevacizumab (ATE/BEV) show promise, but further studies are needed to compare their clinical outcomes. This study aims to assess the efficacy and safety of LEN and ATE/BEV in unresectable HCC patients.</p><p><strong>Methods: </strong>This research was conducted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) strategy. Literature searches were conducted through PubMed, ScienceDirect, Google Scholar, Cochrane Library, SpringerLink, and Ebsco to gather studies on comparing LEN versus ATE/BEV for managing unresectable HCC. The quality assessment was assessed using the Newcastle-Ottawa Scale (NOS). Overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR) and treatment-related adverse events (AEs) were evaluated using Review Manager 5.4 and RStudio 2024.04.1.</p><p><strong>Results: </strong>Twelve retrospective studies were included, comprising 6,620 samples. There was no difference in the OS (HR=0.72; 95%CI: 0.44-1.18, p=0.20), PFS (HR=0.90; 95%CI: 0.75-1.07; p=0.23), ORR (OR=1.16; 95%CI:0.86-1.56; p=0.34) and DCR (OR=1.14; 95%CI:0.97-1.34; p=0.12) between groups. Moreover, in viral and non-viral patients group, LEN showed similar OS and PFS compared with ATE/BEV. In terms of safety, LEN exhibited higher incidences of decreased appetite (OR=2.95; 95%CI:1.12-7.79; p=0.03), diarrhea (OR=2.61; 95%CI:2.06-3.32; p<0.00001), fatigue (OR=1.48; 95%CI:1.27-1.73; P<0.00001), hand-foot syndrome (OR=7.73; 95%CI:4.84-12.33; P<0.00001), and showed lower incidences of increased aspartate aminotransferase (OR=0.44; 95%CI:0.28-0.69; p=0.0004) compared to ATE/BEV. Moreover, LEN showed similar AEs in grade ≥ 3 AEs (OR=1.15; 95%CI:0.29-4.55; p=0.84), hypertension (OR=1.39; 95%CI:0.84-2.28; p=0.20), proteinuria (OR=1.10; 95%CI:0.75-1.60; p=0.63) compared to ATE/BEV.</p><p><strong>Conclusion: </strong>LEN was found to be non-inferior to ATE/BEV in terms of OS, PFS, ORR, DCR. However, LEN may be associated with a higher incidence of AEs.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1529-1542"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors Associated with Breast Cancer among Women in Iraq: A Case-Control Study.","authors":"Farah Mohammed Hassan","doi":"10.31557/APJCP.2025.26.5.1701","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1701","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is the most common malignant among females in Al-Najf, Iraq, the aim of the study was to identify risk factors associated with breast cancer.</p><p><strong>Methods: </strong>A hospital-based case-control study was conducted by enrolled 100 women with breast cancer and 200 non-malignant women selected randomly by using purposive sampling methods in the National Hospital for Cancer Therapy in AL-Najaf Province. Data was collected by questionnaire form through direct interview, which consisted of four parts (sociodemographic variables, clinical variables, reproductive variables, behavior and lifestyle variables). Questionnaire form was reviewed by a panel of experts from different specialists for checking validity, while reliability was checked by Cronbach's alpha, and the result was (0.8). Risk factors were estimated descriptively using percentages and odd ratios with their correlated 95% confidence interval (CI). The predictors of the occurrence of breast cancer were determined using logistic regression to estimate unadjusted association and adjusted association.</p><p><strong>Result: </strong>Breast cancer risk was found to be increased in women with age after 40 years and elderly especially ≥60 years (OR: 10.18, 95% CI: 4.1388,25.048), illiterate women (OR: 2.24, 95% CI: 1.06, 4.73), living in low economic status (OR: 2.87, 95% CI: 1.31,6.27), smoking (2.634, 95% CI: 1.021,6.792), women who bottle-feed their children (OR: 2.16, 95% CI: 1.01,4.61), eating backed and processed food (P: <0.001), overweight and obese women (OR: 1.875, 95% CI: 0.208, 16.88) and (OR: 4.062, 95%CI: 0.463, 35.64), previous abortion (OR: 1.08, 95% CI: 0.64,1.83), women who didn't perform routine self-examination (P: 0.05), women who didn't have information about it (P: 0.041), women who didn't visit health facilities for breast examination (P: <0.001).</p><p><strong>Conclusion: </strong>The majority of participants had at least one risk factor for Breast cancer and had low knowledge; consequently, emphasize the role of breast cancer early detection program in healthcare facilities, regular training of doctors and healthcare professionals who work in the program with respects of updates. Elevating women's awareness regarding Breast cancer risk factors, lifestyle modification, importance of early detection, self-examination, and regular visits to healthcare facilities for routine breast examinations through educational campaigns, sharing health messages by using social media and healthcare professionals, also by sharing educational materials like posters. Community campaigns for detecting women at high risk for Breast cancer to give them special attention according to their risk profile. Further high-quality research in genetic concern, environmental factors, and our daily diet.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1701-1708"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Cognitive-Behavioral Counseling on Sexual Function in Women with Breast Cancer: An Interventional Study.","authors":"Mohadeseh Latifi, Mahtab Attarha, Mehran Shayganfard, Mohammad Reza Sharbafchi","doi":"10.31557/APJCP.2025.26.5.1745","DOIUrl":"10.31557/APJCP.2025.26.5.1745","url":null,"abstract":"<p><strong>Objective: </strong>Breast cancer is the most common malignancy in women worldwide. This can expose all aspect of their life including sexual function. The aim of this research was to investigate the effect of cognitive-behavioral counseling on sexual function in women with breast cancer.</p><p><strong>Methods: </strong>This study was an interventional per-test, post-test design with control group. One hundred women with breast cancer referring to Maxa center in Esfahan at the time of data collection were conventionally selected in 2020. They were randomly divided into intervention and control groups (n=50), using permuted blocks. The intervention group receiving cognitive-behavioral counseling in 10 one-hour, sessions twice a week. Data were collected through a demographic questionnaire, the Female Sexual Function Index (FSFI) questionnaire, filled out by patients before and one month after intervention. Data analyzed using independent t-test, paired t-test, and chi-square. Significance level was considered P <0.05.</p><p><strong>Results: </strong>The results showed that cognitive-behavioral counseling group therapy improved total sexual functioning and its subscales. Four weeks after the counseling, there was a significant difference in mean scores of total sexual functions between the two groups (P = 0.001).  In the intervention group the mean scores for lubrication and dyspareunia did not show a significant difference in post-test results (P = 0.129, P = 0.89, respectively).</p><p><strong>Conclusion: </strong>Cognitive - behavioral group therapy can be improved total sexual functioning and its subscales in the intervention group one month after the intervention. So, this method can be used besides with medical treatment as a complementary therapy in oncology wards.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1745-1751"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Habitual Tub Bathing and Risk of Breast Cancer: The Japan Public Health Center-Based Prospective Study.","authors":"Naoya Teraoka, Isao Muraki, Hiroyasu Iso, Ryo Kawasaki, Manami Inoue, Shoichiro Tsugane, Norie Sawada, - For The Japan Public Health Center-Based Prospective Jphc Study Groupa","doi":"10.31557/APJCP.2025.26.5.1615","DOIUrl":"https://doi.org/10.31557/APJCP.2025.26.5.1615","url":null,"abstract":"<p><strong>Background: </strong>Several studies reported that hot tub bathing, a unique Japanese culture, may benefit breast cancer risk factors. It is, however, uncertain whether moderate heat exposure through hot tub bathing could potentially reduce the risk of breast cancer. In this study, we aimed to investigate this association through a long-term prospective cohort study conducted in Japan.</p><p><strong>Methods: </strong>A total of 15,927 Japanese women aged 40-59 years with no history of breast cancer were followed up from 1990 to 2015. The frequency of tub bathing was categorized as 0-2 days/week, 3-4 days/week, and almost every day. The hazard ratios (HRs) and 95% confidence intervals (CIs) for the incident breast cancer were estimated using Cox proportional hazards models after adjusting for potential risk factors for breast cancer, including overweight.</p><p><strong>Results: </strong>During 367,950 person-years of the follow-up period, 370 breast cancer cases were identified. After adjusting for known confounders for breast cancer risk, the multivariable HR (95% CI) of incident breast cancer was 1.23 (0.93-1.62) for 3-4 days/week and 0.72 (0.40-1.31) for ≤2 days/week (trend p=0.90), compared to almost every day of tub bathing (p for trend = 0.90). No association was also seen for pre-menopausal or post-menopausal women and subjective lukewarm, warm, or hot bath temperatures.</p><p><strong>Conclusion: </strong>We found no reduced risk of breast cancer for women associated with frequent tub bathing. Further research is needed to obtain objective information on the frequency, duration, and water temperature of tub bathing.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1615-1621"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Predictive Model of Suboptimal Primary Debulking Surgery among Women with Ovarian Cancer Using Pre-Operative Computerized Tomography, Tumor Markers and Comparison with the Intraoperative Findings: An Experience in Tertiary Care Hospital of Pakistan.","authors":"Ayesha Saba, Muhammad Saqib Qamar Ishaqi, Muhammad Shadab Khan, Anita Manzoor, Shajeea Arshad Ali","doi":"10.31557/APJCP.2025.26.5.1671","DOIUrl":"10.31557/APJCP.2025.26.5.1671","url":null,"abstract":"<p><strong>Objective: </strong>Ovarian cancer is reported to be one of the most morbid gynecological cancers, often diagnosed at advanced stages. Primary debulking surgery (PDS) along with chemotherapy is the treatment of choice; however, there is a high probability of suboptimal excision. Thus, each patient should be evaluated for the appropriate treatment modality and PDS should be deferred as the risk of surgical complications and delay in chemotherapy consequently impacts survival. It is imperative to formulate a predictive model to select patients for optimal debulking surgery.</p><p><strong>Methods: </strong>A prospective observational study was conducted on women with ovarian cancer who underwent PDS at Indus Hospital and Health Network (IHHN), Pakistan from March 1st, 2020 till June 30th, 2024. Data was analyzed using SPSS 20.0. Chi-Square test was used to find the association between the predictors of optimal and sub-optimal debulking surgery using pre-operative computed tomography (CT) scan findings, and serum tumor markers. The sensitivity and specificity of serum cancer antigen 125 (CA-125) levels were measured.</p><p><strong>Results: </strong>A total of 65 women with ovarian tumors were recruited in the study. Around 90.7% of patients had optimal PDS while 9.2% of patients underwent suboptimal PDS. Using pre-operative predictive scoring criteria, 48 (73.8%) patients scored 0-5 and all had optimal PDS while 11 (16.9%) patients scored 6-8, out of which 9 had suboptimal PDS (P value 0.00). A predictive score of 9 or more was reported in 6 (9.2%) patients, out of which 4 had suboptimal PDS.</p><p><strong>Conclusion: </strong>This study proposed a predictive model using pre-operative CT scan criteria and tumor marker serum CA-125 level which will help in scoring the patients with epithelial ovarian cancer. Subsequent treatment options should be decided either in the form of upfront debulking surgery or neoadjuvant chemotherapy. Further prospective studies are required to formulate a better applicable predictive model in all types of ovarian cancer including germ-cell ovarian tumors and sex cord-stromal tumors.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 5","pages":"1671-1679"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}