Asian Pacific Journal of Cancer Prevention最新文献

{"title":"Influence of Exosomes on Tumorigenic Behavior in Triple-Negative Breast Cancer Cells through STAT3 Inhibition in Autophagy.","authors":"Shymaa Abdullah Mohamed, Mohamed Ahmed Abdel-Mohsen, Fatma El-Zahraa A Omar, Toka Mohamed Ibrahim Badawy, Mohamed Salama, Yasser Moustafa El Kerm, Amr Mohamed Hussien","doi":"10.31557/APJCP.2026.27.8.2909","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.8.2909","url":null,"abstract":"<p><strong>Objectives: </strong>The prime aim of this research was to evaluate the effect of exosomes on the tumorigenic behavior of TNBC via the autophagic process.</p><p><strong>Materials and methods: </strong>TNBC cell lines, MDA-MB-231 and HCC1806 cells, and non-TNBC cell line, MCF-7 cells, were utilized in this study. Cells were maintained in the presence of isolated exosomes, after characterization, before and after the downregulation of the STAT3 signaling pathway. The cell cycle and apoptosis were analyzed using flow cytometry. Moreover, to evaluate overall autophagic flux, LC3B levels were measured by ELISA, and the expression of autophagy-related genes, Beclin-1, ATG16L, ATG5, and RAB24, was analyzed using qRT-PCR.</p><p><strong>Results: </strong>The results of this study may suggest that TNBC-derived exosomes play a central role in the tumorigenic behavior of breast cancer by manipulating the autophagic machinery.</p><p><strong>Conclusion: </strong>Accordingly, it may be concluded that the potentiation of the aggressive behavior of TNBC cells by exosomes could be autophagy-dependent, while that in NTNBC cells is autophagy-independent.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 8","pages":"2909-2921"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intersecting Burdens: HIV Prevalence and Cervical Cancer Progression Among Women in the Eastern Cape, South Africa: A Retrospective Descriptive Study.","authors":"Muamabangu Jean Paul Milambo, Nwabisa Giyosi, Zukisa Jafta, Nondumiso Ngxola, Charles Businge, Dominic Abavar","doi":"10.31557/APJCP.2026.27.8.2795","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.8.2795","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer remains a leading cause of cancer-related mortality in low- and middle-income countries, especially in sub-Saharan Africa, where the HIV epidemic further amplifies the disease burden. HIV-positive women are at greater risk for persistent HPV infection and accelerated cervical cancer progression.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted using secondary data from 606 women diagnosed with cervical cancer in the Eastern Cape, South Africa. Key variables included age, HIV status, antiretroviral therapy (ARV) usage, cancer stage, and referral modality. Descriptive statistics and multivariable regression analyses (STATA v16) were used to assess relationships between clinical and demographic variables.</p><p><strong>Results: </strong>HIV prevalence among cervical cancer patients was 60.23%. Most patients (68.48%) presented with stage III cancer, indicating delayed diagnosis. HIV-positive women were significantly older than their HIV-negative counterparts by 9.2 years on average (β = 9.20, p < 0.001). Age was positively associated with later cancer stages (β = 1.91, p = 0.019). ARV uptake was high (60.89%) and strongly predicted by HIV status (β = 0.96, p < 0.001).</p><p><strong>Conclusion: </strong>The findings emphasize a critical overlap between HIV and cervical cancer, particularly among older women. Despite robust ARV coverage, the high rate of late-stage presentation points to gaps in early detection and the integration of HIV and cancer services. Strengthening cervical cancer screening, especially for HIV-positive women, is essential to improving outcomes.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 8","pages":"2795-2801"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Diagnosis of Cervical Cancer Using Archer Fish Hunting Optimizer-Optimized Xception Network with AI Interpretability via Grad-CAM.","authors":"Sabura Banu Urundai Meeran","doi":"10.31557/APJCP.2026.27.8.2783","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.8.2783","url":null,"abstract":"<p><strong>Objective: </strong>The primary objective of this study is to enhance the performance of cervical cancer classification by optimizing the Xception deep learning model using the Archer Fish Hunting Optimizer (AHO). The study aims to evaluate the effectiveness of the AHO-optimized Xception model in classifying cervical cytology images and to compare it against traditional CNN architectures. It also integrates Grad-CAM visualization to ensure model interpretability and to support explainable AI in clinical decision-making.</p><p><strong>Methods: </strong>A cervical cytology image dataset comprising four diagnostic classes High Squamous Intraepithelial Lesion (HSIL), Low Squamous Intraepithelial Lesion (LSIL), Negative for Intraepithelial Malignancy (NILM), and Squamous Cell Carcinoma (SCC) was used for model development. Preprocessing steps included image normalization and augmentation to improve generalization. Several deep learning models AlexNet, MobileNet V2, ResNet-50, Inception V3, and the standard Xception were trained and benchmarked. The AHO algorithm was applied to optimize the hyperparameters of the Xception model. Model performance was evaluated using metrics such as accuracy, precision, and AUC-ROC. Grad-CAM visualization was utilized to highlight image regions influencing classification decisions.</p><p><strong>Result: </strong>The AHO-optimized Xception model demonstrated superior classification performance, achieving 98.96% accuracy, 98.57% precision, and an AUC-ROC of 99.97%. It outperformed all baseline models in classification effectiveness. The Grad-CAM-based visualization provided valuable insights into the model's focus areas, supporting interpretability and confidence in its predictions.</p><p><strong>Conclusion: </strong>The study establishes the efficacy of using the Archer Fish Hunting Optimizer for hyperparameter tuning in deep learning-based cervical cancer diagnosis. The AHO-optimized Xception model offers improved classification performance and robust explainability, making it a valuable tool for AI-assisted cervical cancer screening. Future research may explore hybrid metaheuristic strategies and their real-time deployment in clinical environments.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 8","pages":"2783-2793"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinoblastoma Incidence in Saudi Arabia: A 20-Year Analysis.","authors":"Shahabuddin T Shaikh, Amen Bawazir, Melissa Bouhouf, Ahmed Hazza Alzahrani, Rana Abdulrahman Alnahdi, Yousef Hazza Alzahrani, Wasif Ali Khan, Ismail Ahmed Khoja, Hoda Jradi","doi":"10.31557/APJCP.2026.27.8.2853","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.8.2853","url":null,"abstract":"<p><strong>Background: </strong>Retinoblastoma (Rb) represents the most frequent primary intraocular cancer in the pediatric population; yet comprehensive national data are limited in Saudi Arabia due to incomplete cancer registry coverage and underreporting. The present study systematically investigates the incidence, distribution, and trends of retinoblastoma across Saudi Arabia over two decades, utilizing robust data from the Saudi National Cancer Registry (SCR), a nationwide surveillance system overseen by the Ministry of Health.</p><p><strong>Methods: </strong>This retrospective population-based analysis included all children diagnosed with Rb in Saudi Arabia between January 1, 2000, and December 31, 2019. The study examined incidence rates and temporal patterns by age, regional location, and tumor histology.</p><p><strong>Results: </strong>Out of 542 documented cases (258 females, 284 males), the age-standardized incidence rate (ASIR) for children aged 0-4 years demonstrated an initial increase, peaking at 1.26 per 100,000 in 2003, followed by a gradual decline to 0.93 per 100,000 by 2019. Higher incidence rates were detected in major urban centers, especially Riyadh and Makkah, likely reflecting demographic density, enhanced diagnostic practices, and more accessible specialized care. Most tumors were either undifferentiated (Grade IV) or not otherwise specified (NOS, 63%), while diffuse retinoblastoma was rare (2%). Diagnosis was predominantly confirmed by histopathological evaluation (88.3%).</p><p><strong>Conclusion: </strong>This study offers the most comprehensive picture to date of retinoblastoma incidence and patterns in Saudi Arabia. The observed rising incidence, together with regional disparities, emphasizes the need for more refined cancer surveillance, equitable resource allocation, and accelerated early detection strategies, particularly in underserved areas. These findings provide essential baseline metrics to inform national cancer control policies and optimize equitable resource distribution.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 8","pages":"2853-2860"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium Levels in Early and Advanced Stages of Epithelial Ovarian Cancer.","authors":"Lubena Lubena, Kartiwa Hadi Nuryanto, Endy Cahyono, Nani Cahyani, Laila Nuranna, Hariyono Winarto, Tricia Dewi Anggraeni, Teuku Mirza Iskandar, Ediwibowo Ambari, Very Great Eka Putra, Muhammad Yurizar Yudhistira","doi":"10.31557/APJCP.2026.27.8.2755","DOIUrl":"10.31557/APJCP.2026.27.8.2755","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore selenium levels in patients with epithelial ovarian cancer and evaluate the role of this micronutrient in disease development.</p><p><strong>Methods: </strong>This analytical observational study employed a cross-sectional design and was conducted at the Cipto Mangunkusumo National Referral Hospital from March to August 2024. The study included patients with suspected ovarian malignancy undergoing oophorectomy, including conservative surgical staging, unilateral surgical staging, or debulking surgery. The primary outcome was the correlation between serum selenium levels and the staging of ovarian cancer. ANOVA or the Kruskal-Wallis test was used to examine relationships between variables. Receiver operating characteristic (ROC) curve analysis was also performed to determine the optimal cutoff value for serum selenium levels.</p><p><strong>Result: </strong>A total of sixty patients with ovarian cancer were studied, with 40% at stage I, 8.3% at stage II, 41.7% at stage III, and 10% at stage IV. Serum selenium levels varied significantly by tumor stage (p < 0.05), showing a negative correlation with tumor severity (Spearman's r = -0.27). Lower selenium levels were linked to higher cancer stages, with stage II exhibiting the highest levels and stage IV the lowest. ROC curve analysis demonstrated an area under the curve (AUC) of 0.648 (95% CI 0.503-0.794; p < 0.05), with a sensitivity of 65.5% and specificity of 61.3% at a cutoff value of selenium > 91.50 μg/L. Although patients with selenium levels ≤91.50 μg/L showed a higher proportion of advanced-stage disease, the difference was not statistically significant (OR 2.59, 95% CI 0.91-7.34; p = 0.073).</p><p><strong>Conclusion: </strong>Lower serum selenium levels were associated with more advanced stages of epithelial ovarian cancer, suggesting a potential relationship between selenium status and disease progression.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 8","pages":"2755-2759"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian Randomization Using a Japanese GWAS Identifies an HLA-Linked Causal Effect of Chronic Hepatitis B on Cholangiocarcinoma Risk.","authors":"Khaled Elgeshy, Katsuya Nagaoka, Hajime Yamazaki, Munenori Honda, Maiko Nagaoka, Takahiro Mizuta, Toshinori Toyota, Daiki Maeda, Sotaro Kurano, Kentaro Tanaka, Satoshi Narahara, Hiroki Inada, Takayuki Tokunaga, Etsuko Iio, Takehisa Watanabe, Hiroko Setoyama, Haruki Uojima, Yasuhito Tanaka","doi":"10.31557/APJCP.2026.27.8.2923","DOIUrl":"10.31557/APJCP.2026.27.8.2923","url":null,"abstract":"<p><strong>Background: </strong>Cholangiocarcinoma (CCA) is a highly malignant cancer that develops in the bile ducts. Its incidence is particularly high in East Asian populations, but the underlying genetic factors remain unclear. To investigate potential risk factors for CCA, we conducted a Mendelian randomization study to infer causality.</p><p><strong>Methods: </strong>Using large-scale genome-wide association study data from the BioBank Japan resource, we systematically investigated the causal effects of genetic predisposition to seven conditions, chronic hepatitis B (CHB), chronic hepatitis C, autoimmune hepatitis, type 1 diabetes, type 2 diabetes, chronic gastritis, and chronic pancreatitis, on CCA risk.</p><p><strong>Results: </strong>Our analysis reveals a significant association between genetic susceptibility to CHB with a 24% higher likelihood of developing CCA than non-susceptible individuals (Inverse-Variance Weighted Odds Ratio = 1.24, 95% Confidence Interval: 1.08-1.42; p = 0.002). This genetic association is significantly driven by instrumental variables enriched in the immune-regulatory HLA class II region (6p21), suggesting a plausible biological mechanism. For the primary outcome (CCA), statistical significance was assessed across seven exposures at a Bonferroni-corrected threshold (two-sided p<0.0071). Notably, the CHB-CCA association remains significant after correction. This primary finding is strongly supported by comprehensive sensitivity analyses that showed no evidence of confounding by horizontal pleiotropy or heterogeneity. Conversely, no significant causal effects on CCA were identified for the other six conditions.</p><p><strong>Conclusions: </strong>Our MR analysis supports a causal role of HBV infection in CCA development, highlighting the importance of targeted HBV screening and surveillance.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 8","pages":"2923-2930"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations of Inflammatory Mediators (TNF-α and HMGB1) and Circulating microRNA-22 Expression in Pre- and Post-Menopausal Women with Early-Stage Epithelial Ovarian Cancer.","authors":"Nawal Khinteel Jabbar, Rasha A H Alathary, Widad Abed Jawad, Mohammed Naser Al-Delfi","doi":"10.31557/APJCP.2026.27.8.3115","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.8.3115","url":null,"abstract":"<p><strong>Background: </strong>Ovarian cancer is an important cause of cancer-related mortality among women, disease severity increases due to hormonal changes, which modify the ovarian environment and may contribute to the development of ovarian cancer (OC). Inflammatory mediators play a central role in the enhancement of OC progression. Several microRNA play central role in OC; microRNA-22 (miR-22) is a biomarker associated with hormonal status regarding menopause and the development of ovarian cancer. Evaluating these biomarkers and assess the interaction among them, may contribute to a deeper understanding of the disease mechanism and can improve diagnostic accuracy.</p><p><strong>Objective: </strong>Assess CA125, TNF-α, HMGB1, and miR-22 levels in pre- and post-menopausal epithelial ovarian cancer (EOC) patients as well as the correlation of these factors and their impact on EOC progression in pre- and post- menopausal patients.</p><p><strong>Methods: </strong>120 women enrolled in this study were divided into four groups (n=30 for each group): two control groups (healthy premenopausal and postmenopausal) and two patient groups (premenopausal and postmenopausal with EOC). Serum levels of CA125, TNF-α, HMGB, and miR-22 expression were measured. Statistical analysis was performed to compare groups and to assess correlations within patient groups at (p< 0.05) using SPSS Statistics analysis version 26.</p><p><strong>Results: </strong>All biomarkers showed statistically significant differences among groups at p < 0.05. levels of CA125, HMGB1, and TNF-α were significantly increased in EOC groups Especially in the postmenopausal group. Expression of serum miR-22 was significantly decreased in EOC patient groups compared to control groups. Regarding correlation analyses, there were positive associations between TNF-α and HMGB1 in patient groups. Conversely, the expression of miRN-22 was inversely correlated with HMGB1.</p><p><strong>Conclusions: </strong>The relative expression level of miR-22 significantly decreases depending on menopausal and inflammatory status, suggesting that miR-22 plays as tumor suppressor role and is negatively affected by inflammation.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 8","pages":"3115-3121"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Content Quality of YouTube Videos on Human Papillomavirus Vaccine: A Systematic Analysis.","authors":"Soumya Swaroop Sahoo, Prince Kumar, Raju Kumar, Abhilash Ludhiadch, Shubham Mishra, Pragyan Paramita Parija","doi":"10.31557/APJCP.2026.27.8.3029","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.8.3029","url":null,"abstract":"<p><strong>Background: </strong>The growing dependence on digital platforms for health-related information has positioned YouTube as a key provider of vaccine-related content in India. Nonetheless, the quality, reliability, and completeness of the information accessible on this platform are still questionable. This study sought to assess the content, quality, and reliability of YouTube videos pertaining to HPV vaccination within the Indian context.</p><p><strong>Methods: </strong>Search terms \"Cervical Cancer Vaccination\" and \"HPV Vaccine\" were used to cross-sectionally analyze YouTube videos. Screening the first 200 videos yielded 81 suitable English or Hindi videos. Data on video attributes and engagement was captured. Audio-Visual Quality (AVQ), Global Quality Score (GQS), modified Quality Criteria for Consumer Health Information (mDISCERN), and Video Information and Quality Index assessed quality and dependability. The new Content Score for Cervical Cancer Vaccination (CSCCV) was developed based on national and international guidelines to assess content completeness.</p><p><strong>Results: </strong>A total of 81 videos were analyzed and median duration of the videos 169 seconds, Health-related channels accounted for 51(63.0%) of uploads, and doctors or medical experts serving as speakers in 46(56.8%) of cases. Although none of the videos depicted HPV vaccination unfavourably, engagement metrics did not align with the level of information presented. Videos involving medical professionals exhibited markedly higher mDISCERN scores (p = 0.001), signifying enhanced reliability. The overall content completeness was moderate, exhibiting notable deficiencies in guideline-based information.</p><p><strong>Conclusion: </strong>YouTube videos regarding HPV vaccination in India are predominantly favourable, although they exhibit variability in dependability and comprehensiveness. Enhancing expert-driven, guideline-compliant, and multilingual digital resources is crucial for promoting HPV vaccine adoption and advancing cervical cancer prevention initiatives in India.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 8","pages":"3029-3036"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Cervical Cancer Screening Uptake Among Women of Reproductive Age in Indonesia: A Nationwide Cross-Sectional Study Based on the 2023 Indonesian Health Survey.","authors":"Suci Muchtariza, Yeffi Masnarivan, Radian Ilmaskal","doi":"10.31557/APJCP.2026.27.8.3013","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.8.3013","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer is a major public health issue in Indonesia due to limited screening reach. Identifying the factors influencing screening uptake is critical for enhancing screening uptake strategies.</p><p><strong>Methods: </strong>This cross-sectional study utilised data from the 2023 Indonesian Health Survey (IHS) to explore the predictors of cervical cancer screening uptake among women aged 15-49 years. Bivariate and multivariate logistic regression analyses were performed to assess associations.</p><p><strong>Results: </strong>This study included 163,433 women, with only 8.7% (n = 14,184) reporting participation in cervical cancer screening. Age, education, occupation, health insurance ownership, information exposure, and parity were significantly associated with cervical cancer screening. Among these, exposure to cervical cancer information showed the strongest effect, with informed women having more than twice the odds of screening (OR = 2.252, 95% CI: 1.992-2.545).</p><p><strong>Conclusions: </strong>Cervical cancer screening uptake is low in Indonesia and is predicted by age, education, health insurance coverage, and exposure to cervical cancer information. Targeted interventions to improve these factors are essential for enhancing screening uptake and reducing the burden of cervical cancer. Future research should explore longitudinal studies to establish causal relationships between the identified factors and cervical cancer screening uptake.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 8","pages":"3013-3020"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of VEGF and Ki-67 Expression with Histopathological Features and WHO Grade in Meningioma: A Cross-sectional Study.","authors":"Djoko Widodo, Upik Anderiani Miskad, M Wildan Hakim, Hendra Fajar Pajan, Husni Harmansyah, Hanif Fakhruddin, Ahmad Yasin, Muhammad Faruk","doi":"10.31557/APJCP.2026.27.8.2861","DOIUrl":"https://doi.org/10.31557/APJCP.2026.27.8.2861","url":null,"abstract":"<p><strong>Background: </strong>Meningiomas, the most common primary central nervous system tumors, exhibit variable clinical behavior. While World Health Organization (WHO) grading is standard, complementary biomarkers are needed to refine prognostication. Vascular Endothelial Growth Factor (VEGF) and Ki-67 are potential indicators of angiogenesis and proliferation that may enhance diagnostic precision. This study aimed to evaluate the correlation between VEGF and Ki-67 expression with the histopathological features and WHO 2021 grade of meningiomas.</p><p><strong>Methods: </strong>In this cross-sectional study, 73 formalin-fixed, paraffin-embedded meningioma specimens were analyzed. Tumors were graded per WHO 2021 criteria. VEGF expression (H-score) and Ki-67 labeling index (LI) were assessed via immunohistochemistry and correlated with histopathological features, including mitotic activity and brain invasion. Statistical analysis utilized chi-square, Kruskal-Wallis, and Spearman tests (p<0.05).</p><p><strong>Results: </strong>Most tumors were WHO Grade I (83.6%). Higher VEGF expression was significantly associated with mitotic activity, brain invasion, and hypercellularity, and was increased in high-grade (WHO II-III) meningiomas. Ki-67 labeling index showed a significant positive correlation with WHO grade and other aggressive histopathological features.</p><p><strong>Conclusion: </strong>Both VEGF and Ki-67 are associated with aggressive histopathology in meningiomas. Ki-67 expression strongly correlates with overall WHO grade, whereas VEGF is more indicative of specific invasive traits. Their combined evaluation provides a valuable molecular adjunct to conventional histology, potentially refining risk stratification, particularly in borderline cases. However, interpretation of these findings is limited by the single-center, cross-sectional design and the relatively small number of high-grade and invasive cases.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"27 8","pages":"2861-2870"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}