Ultrasound-Guided Fine-Needle Aspiration Biopsy Of Thyroid Nodules Smaller Than 10 mm in the Maximum Diameter: The Efficacy and Its Correlation with TIRADS Classification.

Q2 Medicine
Hau Van Vy Nguyen, Bang Van Nguyen, Xuan Thi Nguyen, Linh Nguyen Tuyen Pham, Thoi Thi Ngoc Nguyen, Trang Thanh Vo, Tam Thi Le, Binh Trong Le, Thuy Hai Nguyen, Chi Van Le
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Abstract

Objective: This retrospective study evaluated the effectiveness of ultrasound-guided fine-needle aspiration cytology (US-FNAc) for diagnosing thyroid nodules less than 10mm and explored the correlation between the TIRADS classification and US-FNAc reports.

Methods: This analysis of 344 patients with 407 thyroid nodules less than 10mm was conducted from June 2022 to July 2023 at the Centre of Endocrinology and Diabetes, Danang Family hospital, Danang, Vietnam. US-FNAc was performed on all nodules, and cytology was reported according to The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of US-FNAc were calculated. Correlation between cytology and TIRADS classification was assessed using Spearman's correlation.

Results: Adequate specimens were obtained in 81% of thyroid nodules after the first FNAc. Cytological diagnoses included 36.6% benign, 12.8% suspicious for malignancy, 1.2% malignant, and 19.7% indeterminate. Among surgically resected thyroid nodules, 78.6% were malignant. US-FNAc demonstrated moderate sensitivity (80%) and high PPV (92.3%) but lower specificity (75%) and NPV (50%) for malignancy in nodules less than 10mm in max diameter. A significant positive correlation (r = 0.24, p < 0.001) was observed between TIRADS classification and TBSRTC.

Conclusion: US-FNAc offers moderate sensitivity and high PPV for diagnosing malignancy in smaller than 10 mm thyroid nodules, but specificity and NPV are lower. A positive correlation exists between TIRADS classification and cytological outcomes.

超声引导下最大直径小于10mm甲状腺结节细针穿刺活检的疗效及其与TIRADS分级的相关性
目的:本回顾性研究评估超声引导下细针穿刺细胞学检查(US-FNAc)诊断小于10mm甲状腺结节的有效性,并探讨TIRADS分级与US-FNAc报告的相关性。方法:对2022年6月至2023年7月在越南岘港家庭医院内分泌与糖尿病中心就诊的344例407例小于10mm甲状腺结节患者进行分析。所有结节均行US-FNAc检查,并按照The Bethesda甲状腺细胞病理学报告系统(TBSRTC)报告细胞学。计算US-FNAc的敏感性、特异性、阳性预测值(PPV)和阴性预测值(NPV)。采用Spearman相关法评估细胞学与TIRADS分类的相关性。结果:81%的甲状腺结节在第一次FNAc后获得了足够的标本。细胞学诊断为良性36.6%,可疑恶性12.8%,恶性1.2%,不确定19.7%。手术切除的甲状腺结节中,78.6%为恶性结节。US-FNAc在最大直径小于10mm的结节中表现出中度敏感性(80%)和高PPV(92.3%),但较低的特异性(75%)和NPV(50%)。TIRADS分类与TBSRTC呈显著正相关(r = 0.24, p < 0.001)。结论:US-FNAc对小于10 mm的甲状腺结节诊断具有中等敏感性和高PPV,但特异性和NPV较低。TIRADS分类与细胞学结果呈正相关。
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来源期刊
CiteScore
2.80
自引率
0.00%
发文量
779
审稿时长
3 months
期刊介绍: Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.
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