Cancer Chemo-Preventive Potential of Calligonum polygonoides Stem Extract Against DMBA Induced Skin Carcinogenesis.

Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2025-05-01 DOI:10.31557/APJCP.2025.26.5.1831

Gyan Prakash Meghwal, Mahendra Kumar Jeengar, Shivani Jangeer, Kamlesh Kumar Sharma, Dev Dutt Patel, Priyadarshi Meena

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引用次数: 0

Abstract

Background: Cancer remains a global health challenge, and natural plant-based compounds show potential in prevention. Calligonum polygonoides Linn., a drought- and frost-resistant shrub native to the Thar desert, has adaptive resilience and ethnomedicinal applications. This study explores C. polygonoides stem extract (CPSE) against DMBA-induced two stage skin carcinogenesis in male Swiss albino mice.

Methods: Skin carcinogenesis was induced in male Swiss albino mice using a single topical application of carcinogen DMBA (100 µg/animal), followed by the application of promotor croton oil (1% solution) thrice weekly as a tumour promoter, starting two weeks after DMBA initiation. CPSE was orally administered at a dose of 600 mg/kg body weight/day (100 µL per animal). Tumour incidence, yield, and burden were assessed, along with biochemical markers of oxidative stress in skin and liver tissues, including reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), lipid peroxidation (LPO), total protein, and vitamin C levels.

Results: Mice treated with CPSE demonstrated a significant reduction in tumour incidence, yield, and burden compared to the carcinogen-treated control group. Additionally, CPSE administration significantly modulated oxidative stress and biochemical parameters in both skin and liver tissues. The CPSE-treated group exhibited decreased LPO levels and elevated antioxidant enzyme activities (GSH, SOD, and CAT), along with elevated total protein content and vitamin C levels, indicating enhanced systemic antioxidant defences.

Conclusion: The findings of this study reveal the significant cancer chemo-preventive potential of C. polygonoides stem extract. Its ability to reduce tumour progression and modulate oxidative stress underscores its promise as a natural agent for cancer prevention. These results highlight C. polygonoides as a potential source for the development of cost-effective and sustainable cancer prevention strategies.

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蓼茎提取物对DMBA诱导的皮肤癌的化学预防作用。

背景：癌症仍然是一个全球性的健康挑战，天然植物化合物显示出预防癌症的潜力。蓼形蓼；它是一种原产于塔尔沙漠的抗旱和抗冻灌木，具有适应能力和民族医学应用。本研究探讨蓼茎提取物（CPSE）对dmba诱导的雄性瑞士白化小鼠两期皮肤癌的抑制作用。方法：采用单次局部应用致癌物DMBA（100µg/只）诱导雄性瑞士白化小鼠皮肤癌变，然后在DMBA启动后两周开始，每周三次应用启动子巴豆油（1%溶液）作为肿瘤启动子。CPSE以600 mg/kg体重/天（每只动物100µL）的剂量口服。评估肿瘤发生率、产量和负担，以及皮肤和肝脏组织氧化应激的生化标志物，包括还原性谷胱甘肽（GSH）、过氧化氢酶（CAT）、超氧化物歧化酶（SOD）、脂质过氧化（LPO）、总蛋白和维生素C水平。结果：与经致癌物处理的对照组相比，经CPSE处理的小鼠肿瘤发病率、产量和负担显著降低。此外，CPSE可显著调节皮肤和肝脏组织的氧化应激和生化参数。cpse处理组显示LPO水平降低，抗氧化酶活性（GSH、SOD和CAT）升高，总蛋白含量和维生素C水平升高，表明系统抗氧化防御能力增强。结论：本研究结果揭示了蓼茎提取物具有显著的抗癌化学作用。它减少肿瘤进展和调节氧化应激的能力强调了它作为预防癌症的天然药物的前景。这些结果突出表明，蓼形蓼是开发具有成本效益和可持续的癌症预防策略的潜在来源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.