Association of Selective VDR Gene Polymorphisms with Diffuse Large B-Cell Lymphoma (DLBCL) in a South Indian Population.

Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2025-05-01 DOI:10.31557/APJCP.2025.26.5.1761

Annuja Anandaradje, Shravan Venkatraman, Luxitaa Goenka, Prasanth Ganesn, Shyam Kumar Tripathi, Jayanthi Mathaiyan, Sandhiya Selvarajan

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引用次数: 0

Abstract

Background: The prevalence of Diffuse Large B-Cell Lymphoma (DLBCL) in India ranges from 34% to 60%. The prognosis for DLBCL can vary widely depending on various factors, including vitamin D deficiency. Research suggests that low vitamin D levels may be linked to poor overall survival (OS) and progression-free survival (PFS) in DLBCL patients. Additionally, polymorphisms in the vitamin D receptor (VDR) gene, specifically the BsmI and TaqI alleles, have been significantly associated with disease prognosis. However, the association of VDR polymorphisms and vitamin D deficiency with DLBCL is yet to be explored. Therefore, this study aims to evaluate the association of VDR gene polymorphisms (BsmI, TaqI, FokI, ApaI) in DLBCL patients.

Methods: In this cross-sectional study, 50 treatment-naive DLBCL patients from southern part of India were included. 100 samples of unrelated apparently healthy controls were used as comparator. Demographic characteristics of DLBCL patients were recorded and SNPs in VDR (real time polymerase chain reaction) were assessed. All analyses were performed using SPSS (V26). P<0.05 was considered statistically significant.

Results: The frequencies of mutant genotypes [TT- BsmI, AG- TaqI and AG- FokI] were significantly associated with a reduced risk of DLBCL, decreasing the risk DLBCL by 71% (OR=0.29, 95% CI= 0.105 to 0.807), 72% (OR=0.28, 95% CI= 0.133 to 0.608) and 70% (OR=0.3, 95% CI= 0.07 to 1.225). Additionally, comparison with other Indian studies and ethnic groups revealed significant distinctions in VDR genotypes. Further, the haplotype analysis of SNPs in the VDR gene revealed significant association of C-A-G-T haplotype (rs731236-rs7975232-rs1544410-rs2228570) with the disease phenotype.

Conclusion: The study shows significant association of BsmI, TaqI, and FokI VDR SNPs with DLBCL.

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选择性VDR基因多态性与南印度人群弥漫性大b细胞淋巴瘤（DLBCL）的关系

背景：弥漫性大b细胞淋巴瘤（DLBCL）在印度的患病率为34%至60%。DLBCL的预后取决于多种因素，包括维生素D缺乏。研究表明，低维生素D水平可能与DLBCL患者的总生存期（OS）和无进展生存期（PFS）较差有关。此外，维生素D受体（VDR）基因的多态性，特别是BsmI和TaqI等位基因，与疾病预后显著相关。然而，VDR多态性和维生素D缺乏与DLBCL的关系尚待探讨。因此，本研究旨在评估VDR基因多态性（BsmI、TaqI、FokI、ApaI）在DLBCL患者中的相关性。方法：在这项横断面研究中，包括来自印度南部的50例初次治疗的DLBCL患者。100例不相关的表面健康对照作为比较。记录DLBCL患者的人口统计学特征，并评估VDR（实时聚合酶链反应）的snp。所有分析均采用SPSS （V26）软件进行。结果：突变基因型[TT- BsmI、AG- TaqI和AG- FokI]的频率与DLBCL风险降低显著相关，分别使DLBCL风险降低71% （OR=0.29, 95% CI= 0.105 ~ 0.807）、72% （OR=0.28, 95% CI= 0.133 ~ 0.608）和70% （OR=0.3, 95% CI= 0.07 ~ 1.225）。此外，与其他印度研究和种族群体的比较显示了VDR基因型的显著差异。此外，对VDR基因snp的单倍型分析显示，C-A-G-T单倍型（rs731236-rs7975232-rs1544410-rs2228570）与疾病表型显著相关。结论：BsmI、TaqI、FokI VDR snp与DLBCL有显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.