Clinical and Experimental Ophthalmology最新文献

{"title":"Overcoming Bell's Phenomenon During Neonatal Eye Examination: A Comparison of Two Paediatric Eye Specula","authors":"Cindy Yue-Ying Liu, Keith Ong, Shuan Dai","doi":"10.1111/ceo.70018","DOIUrl":"10.1111/ceo.70018","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"54 2","pages":"290-291"},"PeriodicalIF":5.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cessation of Anti-VEGF Treatment Therapy in Age-Related Macular Degeneration: A Narrative Review","authors":"Eiman Usmani,&nbsp;Bobak Bahrami,&nbsp;Andreas Ebneter,&nbsp;Weng Onn Chan","doi":"10.1111/ceo.70034","DOIUrl":"10.1111/ceo.70034","url":null,"abstract":"<div>\u0000 \u0000 <p>Intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy has revolutionised the treatment of neovascular age-related macular degeneration (nAMD), significantly improving visual outcomes and enhancing the quality of life for affected patients. However, the decision to discontinue anti-VEGF therapy in nAMD management remains complex and lacks consensus, with various criteria being applied. This narrative review examines the available evidence on the cessation of anti-VEGF treatment in nAMD in detail.</p>\u0000 </div>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"54 2","pages":"275-283"},"PeriodicalIF":5.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Burden of Treatment for Sporadic Unilateral Retinoblastoma in Australia","authors":"Olivia Rolfe,&nbsp;James Elder,&nbsp;John McKenzie,&nbsp;Anu Mathew,&nbsp;Michael Sullivan,&nbsp;Martin Campbell,&nbsp;Elhamy Bekhit,&nbsp;John Vrazas,&nbsp;Sandra Staffieri,&nbsp;Roderick O'Day","doi":"10.1111/ceo.70031","DOIUrl":"10.1111/ceo.70031","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The objective of this study was to compare the burden of treatment of different primary treatment modalities for unilateral sporadic retinoblastoma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixty individuals with unilateral sporadic retinoblastoma were treated at the Royal Children's Hospital Melbourne, Australia, between January 2000 and December 2022. All International Classification of Retinoblastoma (ICRB) staging groups were included for analysis. The total number of anaesthetics and the total number of other hospital visits were calculated. The data was stratified by primary treatment modality and time from diagnosis (less than 12 months vs. beyond 12 months). The minimum follow-up period was 12 months from diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Average age at presentation was 24.85 ± 16.47 months. Forty children (66.7%) presented with ICRB Group E disease, 15 (25%) with Group D, 4 (6.7%) with Group C and 1 (1.6%) with Group B Disease. Forty-six (76.7%) children underwent primary enucleation, 9 (15%) underwent primary intravenous chemotherapy (IVC) and 5 (8.3%) were treated with intra-arterial chemotherapy (IAC). In the first 12 months following diagnosis, all measures of treatment burden were higher in children who underwent chemotherapy (intravenous or intra-arterial) compared to enucleation, except the number of ophthalmology outpatient appointments. Beyond 12 months of diagnosis, all measures of treatment burden were higher in children who underwent chemotherapy compared to enucleation alone, except the total number of anaesthetics and the number of day admissions. There were no deaths.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Globe-conserving therapies, such as primary IVC and IAC, are associated with a significantly higher burden of treatment compared to primary enucleation in the management of unilateral sporadic retinoblastoma.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"54 2","pages":"241-249"},"PeriodicalIF":5.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145566333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing Shunt Launch: A Novel Technique for Extraocular Flushing of the PreserFlo MicroShunt","authors":"Assaf Kratz,&nbsp;Boris Knyazer,&nbsp;Ahed Imtirat","doi":"10.1111/ceo.70020","DOIUrl":"10.1111/ceo.70020","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"54 2","pages":"284-286"},"PeriodicalIF":5.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145395152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Limitations in Prognostic Modelling for Refractory Vogt-Koyanagi-Harada Disease","authors":"DuJiang Yang,&nbsp;Jiexiang Yang,&nbsp;GuoYou Wang","doi":"10.1111/ceo.70017","DOIUrl":"10.1111/ceo.70017","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"54 2","pages":"300-301"},"PeriodicalIF":5.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myopia Progression Management: Current Trends and Future Directions","authors":"Susan Zhang,&nbsp;Ann L. Webber,&nbsp;Shuan Dai","doi":"10.1111/ceo.70024","DOIUrl":"10.1111/ceo.70024","url":null,"abstract":"<div>\u0000 \u0000 <p>The prevalence of myopia has increased significantly in recent decades. Myopia has become one of the most common vision impairments globally, driven by genetic and environmental factors, including increased near work and reduced time outdoors. Reducing myopia progression is critical to mitigating its associated long-term risks. A substantial body of research has demonstrated the efficacy of various methods in slowing myopia progression, However, there is no clear consensus on myopia management as publications frequently present conflicting evidence. This narrative review aims to provide evidence-informed clinical guidance by summarising current strategies for managing myopia progression in the context of a rapidly evolving evidence base. It highlights practical, evidence-based approaches, including pharmacological treatments, optical interventions, lifestyle and environmental modifications, and emerging therapies and discusses the role of public health campaigns and policy initiatives.</p>\u0000 </div>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"54 2","pages":"250-259"},"PeriodicalIF":5.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Microsurgical Skills Course Improves Cataract Surgery Proficiency in First Year Australia and New Zealand Ophthalmology Trainees","authors":"Vivien Nguyen,&nbsp;Santosh Khanal,&nbsp;Graham Wilson,&nbsp;Constantinos Petsoglou,&nbsp;Yves Kerdraon","doi":"10.1111/ceo.70035","DOIUrl":"10.1111/ceo.70035","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The University of Sydney ‘Microsurgical Skills Course’ (MSC) was made mandatory to the Royal Australian and New Zealand College of Ophthalmologists (RANZCO) Vocational Training Program in 2023. This study evaluates the MSC impact on first-year ophthalmology trainees' cataract surgical performance compared to those who did not complete the MSC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study analysed de-identified RANZCO surgical logbook data and EyeSi survey responses from first-year trainees across Australia and New Zealand. The intervention cohort (2023–2024 first-year trainees) completed the MSC, while the control cohort (2022 first-year trainees) did not. Data included demographics, prior surgical experience, number of cataract surgeries, surgical role, senior surgeon takeovers and intraoperative complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 112 trainees (intervention = 77; control = 35), 11 613 cataract surgeries were recorded during the first 12 months of training. By 3 months, trainees in the intervention cohort performed more cataract surgeries (36.2 ± 22.6 vs. 26.0 ± 17.4, <i>p</i> = 0.017), assumed more senior roles in surgery (<i>p</i> &lt; 0.001), required fewer senior surgeon takeovers (<i>p</i> &lt; 0.001) and had a lower rate of posterior capsule tear (PCT) (1.3% vs. 2.9%, <i>p</i> &lt; 0.001) compared to the control cohort. By 12 months, cataract surgery numbers and PCT rates (1.4% vs. 1.8%; <i>p</i> = 0.186) were similar; however, the intervention cohort still held a higher rate of leading surgical roles (<i>p</i> &lt; 0.001) and less senior surgeon takeover (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The MSC accelerates early surgical proficiency while improving patient safety. This resource will serve as a foundation for assessing surgical outcomes beyond cataract surgery and extending past the first 12 months of training.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"54 2","pages":"194-201"},"PeriodicalIF":5.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.70035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Four-Point Sutured Scleral-Fixated Intraocular Lens Implantation Using Gore-Tex Suture in Paediatric Eyes","authors":"Li Yen Chan,&nbsp;Ye Li,&nbsp;Shuan Dai","doi":"10.1111/ceo.70038","DOIUrl":"10.1111/ceo.70038","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Intraocular lens implantation in children with insufficient zonular support can be challenging. Scleral-fixated intraocular lens (SFIOL) implantation can be useful in these cases. We aim to report the visual and refractive outcomes of four-point sutured SFIOL in children.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective review of children who underwent primary or secondary four-point SFIOL using Akreos AO60 or Luxgood intraocular lens with polytetrafluoroethylene monofilament (PTFE, Gore-Tex) at Queensland Children's Hospital, Brisbane, Australia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty-three eyes of 31 children were included for review. The mean age of SFIOL implantation was 7.86 ± 3.71 years. The median follow-up time was 24 months (IQR 35, range 1–77). The majority of children had subluxed crystalline lenses secondary to Marfan syndrome (44 eyes, 83.02%). Best corrected visual acuity (BCVA) was maintained or improved from the preoperative BCVA in 92.6% of eyes. Median postoperative BCVA improved to logMAR 0.2 (IQR 0.16) at 1-year follow-up (<i>p</i> &lt; 0.01). Compared to target refraction, the postoperative refraction was more myopic, but this was not statistically significant. In 33 eyes that had more than 1 year of follow-up, residual refractive error was within 1.00D for 21 eyes, within 2.00D for 7 eyes, within 3.00D for 3 eyes and greater than 3.00D for 2 eyes. Retinal detachment occurred in three eyes (5.66%). Asymptomatic IOL tilt/decentration was noted in one eye (1.88%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Four-point SFIOL implantation using Gore-Tex suture offered excellent visual and refractive outcomes. Postoperative complications were rare and there were no new cases of amblyopia during the follow-up period.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"54 2","pages":"202-208"},"PeriodicalIF":5.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saving the Eye, Counting the Cost: Rethinking Treatment Burden in Unilateral Retinoblastoma","authors":"Jesse L. Berry,&nbsp;Paula J. Belson,&nbsp;Jeffrey I. Gold,&nbsp;Rima Jubran,&nbsp;Rachana Shah","doi":"10.1111/ceo.70090","DOIUrl":"10.1111/ceo.70090","url":null,"abstract":"&lt;p&gt;The management of retinoblastoma has changed profoundly over recent decades. In high-income countries, survival now exceeds 95%, shifting therapeutic priorities from life preservation alone towards globe salvage and vision preservation [&lt;span&gt;1, 2&lt;/span&gt;]. Advances such as intravenous chemotherapy (IVC), intra-arterial chemotherapy (IAC), intravitreal chemotherapy and focal consolidation have enabled many children to retain an eye that would previously have been enucleated. Yet as treatment options expand, an essential dimension of care warrants closer attention: the cumulative burden of treatment experienced by children and their families.&lt;/p&gt;&lt;p&gt;In this issue of &lt;i&gt;Clinical and Experimental Ophthalmology&lt;/i&gt;, Rolfe and colleagues present a detailed evaluation of treatment burden in children with sporadic unilateral retinoblastoma treated in Australia [&lt;span&gt;3&lt;/span&gt;]. By quantifying examinations under anaesthesia (EUAs), total anaesthetics, hospital admissions, outpatient visits and total healthcare encounters, the authors move beyond traditional oncologic and ocular endpoints to capture the lived experience of contemporary retinoblastoma care and the cost to save an eye. Their findings are compelling. Children treated with globe-conserving therapies—whether IVC or IAC—experienced a substantially higher treatment burden than those undergoing primary enucleation, particularly within the first 12 months following diagnosis, with increased healthcare utilisation persisting beyond the first year.&lt;/p&gt;&lt;p&gt;This work builds on prior studies using EUAs as a surrogate measure of disease burden. Fabian and colleagues demonstrated that children undergoing eye-salvaging therapy require approximately two to three times more EUAs than those treated with primary enucleation, even in unilateral disease [&lt;span&gt;4, 5&lt;/span&gt;]. Rolfe et al. extend this concept by capturing a broader range of encounters, including oncology visits and admissions related to chemotherapy and its complications. Their data demonstrate a three- to four-fold increase in total hospital visits in the first year for children receiving globe-conserving therapy, with no significant difference between IVC and IAC during that period.&lt;/p&gt;&lt;p&gt;These findings are particularly relevant in sporadic unilateral retinoblastoma, where cure rates are excellent regardless of primary treatment modality and therapeutic decisions are often guided by the preference of caregivers—who may not understand the full impact of the care needs especially early after diagnosis when these initial decisions are made. Globe salvage offers the potential for retained vision and avoids the lifelong cosmetic implications of eye loss. However, as this study clearly shows, it also entails a prolonged and intensive treatment course characterised by repeated anaesthetic administrations for EUAs, IAC, MRI, chemotherapy exposure and hospitalizations for both planned therapy and treatment-related complications.&lt;/p&gt;&lt;p&gt;For children, this ","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"54 2","pages":"183-185"},"PeriodicalIF":5.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.70090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macular Atrophy in the Better-Seeing Eye of Australian Patients Treated for Neovascular Age-Related Macular Degeneration","authors":"Yohei Hashimoto,&nbsp;Ian Reddie,&nbsp;Zanne Louw,&nbsp;Mark Gillies","doi":"10.1111/ceo.70032","DOIUrl":"10.1111/ceo.70032","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"54 2","pages":"295-297"},"PeriodicalIF":5.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.70032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145515025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}