Current Pharmaceutical Therapies for Meibomian Gland Dysfunction: From Basic Research to Clinical Practice.

IF 4.9 2区 医学 Q1 OPHTHALMOLOGY
Sai Luo, Yuli Guo, Zuguo Liu
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引用次数: 0

Abstract

Meibomian gland dysfunction (MGD) is a group of chronic abnormalities of meibomian glands (MGs), which is recognised as the leading cause of evaporative dry eye. MGD is characterised by obstruction of the terminal ducts and/or alterations in the glandular secretion, which culminates in alterations in tear film stability, inflammation and ocular irritation. Lately, several physical therapies have been developed clinically, including warming compress and massage, eyelid hygiene, as well as advanced approaches such as intraductal probing, thermal pulsation and intense pulsed light therapy. Recently, there is increasing awareness regarding the pharmaceutical therapies for MGD, which have shown potential. Here, we summarise current pharmaceutical therapies for MGD from four aspects including ameliorating microenvironment, inhibiting keratinisation, regulating secretory function and therapies targeting stem cells based on basic and clinical research, discuss their applications and limitations, and provide perspectives for future studies in the field.

睑板腺功能障碍的药物治疗现状:从基础研究到临床实践。
睑板腺功能障碍(MGD)是一组睑板腺(mg)的慢性异常,被认为是蒸发性干眼的主要原因。MGD的特征是末梢导管阻塞和/或腺体分泌改变,最终导致泪膜稳定性改变、炎症和眼部刺激。最近,临床上发展了几种物理疗法,包括热敷和按摩,眼睑卫生,以及先进的方法,如导管内探查,热脉冲和强脉冲光疗法。最近,人们越来越关注MGD的药物治疗,这已经显示出潜力。本文基于基础研究和临床研究,从改善微环境、抑制角化、调节分泌功能和靶向干细胞治疗四个方面对目前MGD的药物治疗进行了综述,并对其应用和局限性进行了讨论,并对未来的研究进行了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.60
自引率
12.50%
发文量
150
审稿时长
4-8 weeks
期刊介绍: Clinical & Experimental Ophthalmology is the official journal of The Royal Australian and New Zealand College of Ophthalmologists. The journal publishes peer-reviewed original research and reviews dealing with all aspects of clinical practice and research which are international in scope and application. CEO recognises the importance of collaborative research and welcomes papers that have a direct influence on ophthalmic practice but are not unique to ophthalmology.
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