Clinical and Experimental Ophthalmology最新文献

{"title":"Adalimumab Monotherapy or Combination Therapy With Methotrexate in Paediatric Uveitis: Data From the AIDA Network Uveitis Registry.","authors":"Carla Gaggiano, Alejandra de-la-Torre, Silvana Guerriero, Stefania Costi, Gaafar Ragab, Maria Pia Paroli, Emanuela Del Giudice, Luciana Breda, Saverio La Bella, Marco Cattalini, Maria Cristina Maggio, Alex Fonollosa, Ester Carreño, Maria Tarsia, Rosanna Dammacco, Soad Hashad, Antonio Vitale, Lampros Fotis, Stefano Gentileschi, Francesca Minoia, Germán Mejía-Salgado, Halah Etayari, Paola Saboya-Galindo, María Andrea Bernal-Valencia, Adele Civino, Maria Sole Chimenti, Valeria Caggiano, Maria Francesca Gicchino, Jurgen Sota, Angela Mauro, Giuseppe Lopalco, Kalpana Babu Murthy, Mohamed Tharwat Hegazy, Vishali Gupta, Francesco La Torre, Rana Hussein Amin, Bruno Frediani, Gian Marco Tosi, Luca Cantarini, Claudia Fabiani","doi":"10.1111/ceo.14534","DOIUrl":"https://doi.org/10.1111/ceo.14534","url":null,"abstract":"<p><strong>Background: </strong>The study objective was to compare the effectiveness of adalimumab (ADA) in monotherapy and in combination with methotrexate (MTX) for paediatric noninfectious uveitis (NIU).</p><p><strong>Methods: </strong>Registry-based observational study. Children receiving ADA for active uveitis were divided into the ADA monotherapy group (group 1) and the ADA plus MTX combination group (group 2).</p><p><strong>Results: </strong>Eighty four children were enrolled (146 eyes): 22 in group 1 (26.2%) and 62 in group 2 (73.8%). ADA effectiveness was complete in 48 children (57.1%), partial in 23 (27.4%) and absent in 4 (5.3%), without any differences across the groups (p = 0.89). Fewer relapses per 100 PY occurred after ADA treatment both in group 1 (280.0 vs. 23.0, p = 0.005) and in group 2 (297.9 vs. 86.0, p < 0.001). The final BCVA was similar between groups 1 and 2 [median 1.0 (IQR 0.3) and 1.0 (IQR 0.3), respectively, p = 0.55]. A statistically significant steroid-sparing effect was observed in the entire cohort and in group 2 at the 6-month (p = 0.01 and p = 0.01), 12-month (p = 0.02 and p = 0.02), and last follow-up (p = 0.045 and p = 0.045). The estimated ADA retention rate was 97.1% at 12 months, 87.7% at 24 months, and 82.6% at 36 months, without a statistically significant difference among the groups (p = 0.77).</p><p><strong>Conclusions: </strong>ADA monotherapy could be equally effective as its combination with MTX in both preventing uveitis relapses and preserving visual acuity in paediatric NIU, with comparable retention rates over 36 months of treatment. The steroid-sparing effect of ADA monotherapy warrants further extensive evaluation to define its optimal placement in the therapeutic strategy for paediatric NIU.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal Trends in HLA-B27-Associated Uveitis: A Commentary on Recent Findings-Response.","authors":"Priya D Samalia, James Brodie, Joanne L Sims, Rachael L Niederer","doi":"10.1111/ceo.14531","DOIUrl":"https://doi.org/10.1111/ceo.14531","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phototransduction in the Genomic Era: Mechanisms, Genetics and Therapeutic Advances","authors":"John R. Grigg,&nbsp;Robyn V. Jamieson","doi":"10.1111/ceo.14517","DOIUrl":"https://doi.org/10.1111/ceo.14517","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 3","pages":"229-231"},"PeriodicalIF":4.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Communicating Hope and Fact to Families With Leber Hereditary Optic Neuropathy","authors":"Clare L. Fraser,&nbsp;Kate Ahmad","doi":"10.1111/ceo.14513","DOIUrl":"https://doi.org/10.1111/ceo.14513","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 3","pages":"227-228"},"PeriodicalIF":4.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuing Professional Development","authors":"","doi":"10.1111/ceo.14523","DOIUrl":"https://doi.org/10.1111/ceo.14523","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 3","pages":"331-333"},"PeriodicalIF":4.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Retinopathy During Pregnancy: Implications of Intensive Control Prior to Pregnancy with Incretin Mimetic Therapy in Type 2 Diabetes Mellitus-Response.","authors":"Felicia Widyaputri, Alison J Nankervis, Alexis Shub, Lyndell L Lim","doi":"10.1111/ceo.14532","DOIUrl":"https://doi.org/10.1111/ceo.14532","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal Trends in HLA-B27-Associated Uveitis: A Commentary on Recent Findings.","authors":"Li-Fen Chen, Lien-Chung Wei","doi":"10.1111/ceo.14530","DOIUrl":"https://doi.org/10.1111/ceo.14530","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Eyes Undergoing Silicone Oil Removal Following Complex Rhegmatogenous Retinal Detachment Repair.","authors":"Emma C Stenz, Ankoor R Shah, Tien P Wong, James C Major, Matthew S Benz, David M Brown, William A Pearce, Effie Z Rahman, Kenneth C Fan, Charles C Wykoff, Sagar B Patel","doi":"10.1111/ceo.14518","DOIUrl":"https://doi.org/10.1111/ceo.14518","url":null,"abstract":"<p><strong>Background: </strong>Describe outcomes following silicone oil removal (SOR) in eyes undergoing complex rhegmatogenous retinal detachment (RRD) repair with silicone oil (SO) tamponade.</p><p><strong>Methods: </strong>Retrospective analysis of eyes undergoing SOR after SO placement (SOP) for RRD repair between January 2016 and December 2021. Proliferative diabetic retinopathy and postoperative follow-up periods of < 3 months were exclusionary. ANOVA testing and standard error analyses investigated statistical significance (p < 0.05).</p><p><strong>Results: </strong>Eighty nine eyes of 88 patients underwent SOR following ³1 RRD repair with SOP. 13.5% of eyes underwent additional RRD repair(s) (12 of 89 eyes). The re-detachment (re-RD) rate following SOR was 15.7% (14 of 89 eyes). Eyes without further RRD repairs after SOR received 360° laser retinopexy prior to SOR more frequently than eyes undergoing additional RRD repair(s) after SOR (87.0% vs. 33.3%) (p = 0.03). Final visual acuity (VA) among eyes without additional RRD repairs following SOR improved by 3 lines of EDTRS letters (20/400 to 20/225) (p = 0.04). The overall rate of persistent hypotony was 6.7% (6 of 89 eyes).</p><p><strong>Conclusion: </strong>Laser retinopexy was associated with fewer repairs for re-RD following SOR. Postoperative re-RD and hypotony occurred in 15.7% and 6.7% of eyes, respectively. Final VA improved in eyes that underwent SOR without subsequent RRD repairs.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Retinopathy During Pregnancy: Implications of Intensive Control Prior to Pregnancy With Incretin Mimetic Therapy in Type 2 Diabetes Mellitus.","authors":"Maria S Varughese, Sarita Jacob","doi":"10.1111/ceo.14529","DOIUrl":"https://doi.org/10.1111/ceo.14529","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Resolution Microperimetry for Detecting Glaucomatous Damage: A Prospective Evaluation of Performance.","authors":"Marc G Sarossy, Sandy Rezk, Dongzhe Li, Xavier Hadoux, Maxime Jannaud, Michael A Coote, Ghee Soon Ang, Peter van Wijngaarden, Keith R Martin, Zhichao Wu","doi":"10.1111/ceo.14528","DOIUrl":"https://doi.org/10.1111/ceo.14528","url":null,"abstract":"<p><strong>Background: </strong>To compare the performance of high-resolution microperimetry testing against standard automated perimetry (SAP) for detecting glaucomatous damage seen on optical coherence tomography (OCT) scans.</p><p><strong>Methods: </strong>250 eyes from 200 individuals underwent high-resolution microperimetry testing of a hemifield using a stimulus pattern optimised to sample typical arcuate patterns of visual field loss in glaucoma. SAP was performed using a 24-2 stimulus pattern. The presence of glaucomatous damage in each hemifield was subsequently independently assessed by two graders based on a circumpapillary OCT circle scan, 6×6 mm optic disc-centred OCT volume scan, and 15×15 mm widefield OCT volume scan.</p><p><strong>Results: </strong>The hemifield-based mean total deviation (MTD) and pointwise sensitivity standard deviation (PSD) for high-resolution microperimetry and SAP were both independently associated with the presence of glaucomatous damage in multivariable logistic regression analyses (p ≤ 0.046). Prediction models developed using these two parameters showed significantly higher performance with high-resolution microperimetry compared to SAP (partial area under the receiver operating characteristic curve [pAUC] = 0.86 and 0.75 respectively; p = 0.007). The performance of microperimetry decreased with decreasing resolution when the MTD and PSD values were derived from every second, third, and sixth test locations (pAUC = 0.85 [p = 0.16], 0.85 [p = 0.044] and 0.84 [p < 0.001] respectively), but they were all significantly better than SAP (p ≤ 0.028 for all).</p><p><strong>Conclusions: </strong>High-resolution microperimetry enabled improved performance for detecting glaucomatous damage compared to SAP, highlighting the potential value of fundus-tracking and higher-resolution sampling for the detection of glaucomatous visual field loss.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}