Clinical and Experimental Ophthalmology最新文献

Optimising the Evaluation of Optic Neuritis YouTube Videos: A Call for Multimedia-Specific Tools and Audience-Oriented Approaches-Response. 视神经炎YouTube视频的优化评估：对多媒体专用工具和面向受众的方法的呼吁-回应。

IF 4.9 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-05-24 DOI: 10.1111/ceo.14555

Bedia Kesimal, Sıdıka Gerçeker Demircan, Sücattin İlker Kocamış

引用次数: 0

Real-World 10-Year Outcomes of Anti-VEGF Therapy for Neovascular Age-Related Macular Degeneration: A Meta-Analysis. 抗vegf治疗新生血管性年龄相关性黄斑变性的真实世界10年结果：荟萃分析

IF 4.9 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-05-24 DOI: 10.1111/ceo.14559

Kimberly Spooner, Geoffrey Broadhead, Samantha Fraser-Bell, Thomas Hong, James G Wong, Andrew A Chang

{"title":"Real-World 10-Year Outcomes of Anti-VEGF Therapy for Neovascular Age-Related Macular Degeneration: A Meta-Analysis.","authors":"Kimberly Spooner, Geoffrey Broadhead, Samantha Fraser-Bell, Thomas Hong, James G Wong, Andrew A Chang","doi":"10.1111/ceo.14559","DOIUrl":"https://doi.org/10.1111/ceo.14559","url":null,"abstract":"Background: This study examines the long-term effectiveness of anti-VEGF therapy in managing neovascular age-related macular degeneration (nAMD). Despite the well-established short-term improvements of anti-VEGF therapy, there is limited data on its continued efficacy over extended periods. This meta-analysis synthesises real-world data to evaluate anti-VEGF therapy's long-term outcomes systematically.Methods: We conducted a comprehensive literature review across PubMed, EMBASE and Cochrane databases, focusing on studies that reported outcomes of anti-VEGF treatment for nAMD over a decade. The analysis included pooling baseline patient characteristics, study designs, sample sizes and changes in visual acuity (VA) over 10 years.Results: Our search produced 12 observational studies encompassing 7509 eyes, with 1274 completing 10-years of follow-up. The most substantial improvement in VA was observed in the first year following the initiation of anti-VEGF therapy. On average, there was a decline of 8.11 letters in VA after 10 years from baseline (95% CI -10.83 to -5.39, p < 0.01). In some cases, VA reverted to baseline levels after 10 years; in others, it declined significantly below baseline. Meta-regression showed that mean VA change was greater in those with a lower baseline VA and those treated with a higher number of injections over 10-years(p < 0.01).Conclusion: Our findings suggest that the mean visual acuity of eyes treated for nAMD deteriorates progressively over the long-term from two years after starting treatment. Regular injections appear crucial for preserving maximum vision. While our analysis did not identify an increased incidence of serious ocular adverse events, the long-term impact of anti-VEGF therapy on geographic atrophy remains unclear and warrants further investigation.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normative Values on Stromal Curvature, Power and Corneal-Stromal Curvature Ratios From a Hybrid AS-OCT. 混合AS-OCT对基质曲率、功率和角膜-基质曲率比值的规范值。

IF 4.9 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-05-22 DOI: 10.1111/ceo.14556

Jascha A Wendelstein, Arianna Grendele, Achim Langenbucher, Alice Galzignato, Catarina Praefke Coutinho, Seth Pantanelli, Kamran M Riaz, Giacomo Savini

{"title":"Normative Values on Stromal Curvature, Power and Corneal-Stromal Curvature Ratios From a Hybrid AS-OCT.","authors":"Jascha A Wendelstein, Arianna Grendele, Achim Langenbucher, Alice Galzignato, Catarina Praefke Coutinho, Seth Pantanelli, Kamran M Riaz, Giacomo Savini","doi":"10.1111/ceo.14556","DOIUrl":"https://doi.org/10.1111/ceo.14556","url":null,"abstract":"Background: To establish normative values for stromal curvature and its relationships to anterior and posterior curvature.Methods: Retrospective observational study. Data were obtained from 75 eyes of cataract surgery patients using a high-resolution anterior segment optical coherence tomograph (AS-OCT; MS-39, CSO). Data analysis included anterior, stromal, and posterior curvature across multiple zones (1.0-5.0 mm), and derived curvature ratios.Results: The anterior-to-stromal curvature ratio (ASR) remained stable (1.016-1.007), while the stromal-to-posterior (SPR) and anterior-to-posterior (APR) ratios exhibited trends of slight change (SPR: 1.149-1.167; APR: 1.167-1.175). The refractive power analysis revealed incremental effects across one, two, and three refractive surface models, emphasising the importance of integrating posterior and stromal curvature data into optical assessments.Conclusion: This study provides the first normative values for stromal curvature and its ratios with anterior and posterior curvature. These findings may have implications for corneal- and lens-based surgeries and diagnostics.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuing Professional Development. 持续专业发展。

IF 4.9 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-05-20 DOI: 10.1111/ceo.14541

引用次数: 0

Real World Data to Improve Outcomes in Retinal Vein Occlusion. 真实世界数据改善视网膜静脉闭塞的结果。

IF 4.9 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-05-20 DOI: 10.1111/ceo.14547

Rachael C Heath Jeffery, Ian L McAllister, Fred K Chen

引用次数: 0

Cytomegalovirus Anterior Uveitis and Endotheliitis: Searching for the Therapeutic Holy Grail. 巨细胞病毒前葡萄膜炎和内皮炎：寻找治疗的圣杯。

IF 4.9 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-05-20 DOI: 10.1111/ceo.14546

Luke K Chehade, Ming Lee Lin

引用次数: 0

Evidence on the Use of Topical Ciclosporin for Ocular Surface Disease: A Systematic Review and Meta-Analysis-Response. 使用局部环孢素治疗眼表疾病的证据：一项系统综述和荟萃分析反应。

IF 4.9 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-05-20 DOI: 10.1111/ceo.14558

Ngozi C Chidi-Egboka, Leo Fan, Maria Qureshi, Chameen Samarawickrama, Fiona Stapleton, Tanya Trinh, Maria Markoulli, Elsie Chan, Jern Yee Chen, Jason Holland, Stephanie L Watson

引用次数: 0

Microbiology and Management of Neonatal Conjunctivitis Presenting to an Urban Australian Paediatric Hospital: An Eight-Year Retrospective Review. 澳大利亚一家城市儿科医院新生儿结膜炎的微生物学和管理：一项8年回顾性研究。

IF 4.9 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-05-19 DOI: 10.1111/ceo.14557

Zixin Hong, Maryza Graham, Andrew J Daley, Robyn Troutbeck

引用次数: 0

Evaluating the Quality and Reliability of YouTube Videos on Optic Neuritis: A Commentary on Advancing Assessments. 评估视神经炎YouTube视频的质量和可靠性：对先进评估的评论。

IF 4.9 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-05-12 DOI: 10.1111/ceo.14551

Youran Cai, Qing Zhou

引用次数: 0

Outcomes of Stent Removal in Eyes With the Paul Glaucoma Implant With Intraluminal 6-0 Polypropylene. 腔内6-0聚丙烯保罗青光眼支架移除的疗效。

IF 4.9 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-05-09 DOI: 10.1111/ceo.14549

Nicole Shu-Wen Chan, Seah Wei Hing, Naoki Okada, Li Hengtong, Maria Cecilia Aquino, Victor Koh Teck Chang, Katherine Wanxian Lun, Dawn Ka Ann Lim, Paul Tec Kuan Chew, Marcus Chun Jin Tan

{"title":"Outcomes of Stent Removal in Eyes With the Paul Glaucoma Implant With Intraluminal 6-0 Polypropylene.","authors":"Nicole Shu-Wen Chan, Seah Wei Hing, Naoki Okada, Li Hengtong, Maria Cecilia Aquino, Victor Koh Teck Chang, Katherine Wanxian Lun, Dawn Ka Ann Lim, Paul Tec Kuan Chew, Marcus Chun Jin Tan","doi":"10.1111/ceo.14549","DOIUrl":"https://doi.org/10.1111/ceo.14549","url":null,"abstract":"Background: To evaluate the 12-month outcomes of stent removal in eyes with the Paul Glaucoma Implant (PGI) and intraluminal 6-0 polypropylene in an Asian population.Methods: Retrospective review of patients ≥ 18 years of age with glaucoma in a tertiary institution, who underwent the PGI stented with intraluminal 6-0 polypropylene (October 2018 to January 2023), with a minimum follow-up duration of 12 months. The main outcome measures were intraocular pressure (IOP) and number of glaucoma medications.Results: We included 103 eyes of 97 patients, who were mostly Chinese (73.8%). The stent was removed in 43 eyes (41.7%), at a median of 12.3 (interquartile range: 4.1-18.4) postoperative weeks. The mean IOP reduction immediately following stent removal was -6.4 ± 5.0 mmHg, and there was a strong linear correlation with the IOP before stent removal (Pearson correlation -0.554; p < 0.001). No eyes developed hypotony after stent removal.Conclusions: Less than half of the eyes with PGI stented with intraluminal 6-0 polypropylene required stent removal. The IOP reduction achieved after stent removal correlated with the IOP before stent removal, and there were no complications of hypotony.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0