{"title":"Optimising the Evaluation of Optic Neuritis YouTube Videos: A Call for Multimedia-Specific Tools and Audience-Oriented Approaches-Response.","authors":"Bedia Kesimal, Sıdıka Gerçeker Demircan, Sücattin İlker Kocamış","doi":"10.1111/ceo.14555","DOIUrl":"https://doi.org/10.1111/ceo.14555","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kimberly Spooner, Geoffrey Broadhead, Samantha Fraser-Bell, Thomas Hong, James G Wong, Andrew A Chang
{"title":"Real-World 10-Year Outcomes of Anti-VEGF Therapy for Neovascular Age-Related Macular Degeneration: A Meta-Analysis.","authors":"Kimberly Spooner, Geoffrey Broadhead, Samantha Fraser-Bell, Thomas Hong, James G Wong, Andrew A Chang","doi":"10.1111/ceo.14559","DOIUrl":"https://doi.org/10.1111/ceo.14559","url":null,"abstract":"<p><strong>Background: </strong>This study examines the long-term effectiveness of anti-VEGF therapy in managing neovascular age-related macular degeneration (nAMD). Despite the well-established short-term improvements of anti-VEGF therapy, there is limited data on its continued efficacy over extended periods. This meta-analysis synthesises real-world data to evaluate anti-VEGF therapy's long-term outcomes systematically.</p><p><strong>Methods: </strong>We conducted a comprehensive literature review across PubMed, EMBASE and Cochrane databases, focusing on studies that reported outcomes of anti-VEGF treatment for nAMD over a decade. The analysis included pooling baseline patient characteristics, study designs, sample sizes and changes in visual acuity (VA) over 10 years.</p><p><strong>Results: </strong>Our search produced 12 observational studies encompassing 7509 eyes, with 1274 completing 10-years of follow-up. The most substantial improvement in VA was observed in the first year following the initiation of anti-VEGF therapy. On average, there was a decline of 8.11 letters in VA after 10 years from baseline (95% CI -10.83 to -5.39, p < 0.01). In some cases, VA reverted to baseline levels after 10 years; in others, it declined significantly below baseline. Meta-regression showed that mean VA change was greater in those with a lower baseline VA and those treated with a higher number of injections over 10-years(p < 0.01).</p><p><strong>Conclusion: </strong>Our findings suggest that the mean visual acuity of eyes treated for nAMD deteriorates progressively over the long-term from two years after starting treatment. Regular injections appear crucial for preserving maximum vision. While our analysis did not identify an increased incidence of serious ocular adverse events, the long-term impact of anti-VEGF therapy on geographic atrophy remains unclear and warrants further investigation.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jascha A Wendelstein, Arianna Grendele, Achim Langenbucher, Alice Galzignato, Catarina Praefke Coutinho, Seth Pantanelli, Kamran M Riaz, Giacomo Savini
{"title":"Normative Values on Stromal Curvature, Power and Corneal-Stromal Curvature Ratios From a Hybrid AS-OCT.","authors":"Jascha A Wendelstein, Arianna Grendele, Achim Langenbucher, Alice Galzignato, Catarina Praefke Coutinho, Seth Pantanelli, Kamran M Riaz, Giacomo Savini","doi":"10.1111/ceo.14556","DOIUrl":"https://doi.org/10.1111/ceo.14556","url":null,"abstract":"<p><strong>Background: </strong>To establish normative values for stromal curvature and its relationships to anterior and posterior curvature.</p><p><strong>Methods: </strong>Retrospective observational study. Data were obtained from 75 eyes of cataract surgery patients using a high-resolution anterior segment optical coherence tomograph (AS-OCT; MS-39, CSO). Data analysis included anterior, stromal, and posterior curvature across multiple zones (1.0-5.0 mm), and derived curvature ratios.</p><p><strong>Results: </strong>The anterior-to-stromal curvature ratio (ASR) remained stable (1.016-1.007), while the stromal-to-posterior (SPR) and anterior-to-posterior (APR) ratios exhibited trends of slight change (SPR: 1.149-1.167; APR: 1.167-1.175). The refractive power analysis revealed incremental effects across one, two, and three refractive surface models, emphasising the importance of integrating posterior and stromal curvature data into optical assessments.</p><p><strong>Conclusion: </strong>This study provides the first normative values for stromal curvature and its ratios with anterior and posterior curvature. These findings may have implications for corneal- and lens-based surgeries and diagnostics.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Continuing Professional Development.","authors":"","doi":"10.1111/ceo.14541","DOIUrl":"https://doi.org/10.1111/ceo.14541","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachael C Heath Jeffery, Ian L McAllister, Fred K Chen
{"title":"Real World Data to Improve Outcomes in Retinal Vein Occlusion.","authors":"Rachael C Heath Jeffery, Ian L McAllister, Fred K Chen","doi":"10.1111/ceo.14547","DOIUrl":"https://doi.org/10.1111/ceo.14547","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cytomegalovirus Anterior Uveitis and Endotheliitis: Searching for the Therapeutic Holy Grail.","authors":"Luke K Chehade, Ming Lee Lin","doi":"10.1111/ceo.14546","DOIUrl":"https://doi.org/10.1111/ceo.14546","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ngozi C Chidi-Egboka, Leo Fan, Maria Qureshi, Chameen Samarawickrama, Fiona Stapleton, Tanya Trinh, Maria Markoulli, Elsie Chan, Jern Yee Chen, Jason Holland, Stephanie L Watson
{"title":"Evidence on the Use of Topical Ciclosporin for Ocular Surface Disease: A Systematic Review and Meta-Analysis-Response.","authors":"Ngozi C Chidi-Egboka, Leo Fan, Maria Qureshi, Chameen Samarawickrama, Fiona Stapleton, Tanya Trinh, Maria Markoulli, Elsie Chan, Jern Yee Chen, Jason Holland, Stephanie L Watson","doi":"10.1111/ceo.14558","DOIUrl":"https://doi.org/10.1111/ceo.14558","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zixin Hong, Maryza Graham, Andrew J Daley, Robyn Troutbeck
{"title":"Microbiology and Management of Neonatal Conjunctivitis Presenting to an Urban Australian Paediatric Hospital: An Eight-Year Retrospective Review.","authors":"Zixin Hong, Maryza Graham, Andrew J Daley, Robyn Troutbeck","doi":"10.1111/ceo.14557","DOIUrl":"https://doi.org/10.1111/ceo.14557","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluating the Quality and Reliability of YouTube Videos on Optic Neuritis: A Commentary on Advancing Assessments.","authors":"Youran Cai, Qing Zhou","doi":"10.1111/ceo.14551","DOIUrl":"https://doi.org/10.1111/ceo.14551","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicole Shu-Wen Chan, Seah Wei Hing, Naoki Okada, Li Hengtong, Maria Cecilia Aquino, Victor Koh Teck Chang, Katherine Wanxian Lun, Dawn Ka Ann Lim, Paul Tec Kuan Chew, Marcus Chun Jin Tan
{"title":"Outcomes of Stent Removal in Eyes With the Paul Glaucoma Implant With Intraluminal 6-0 Polypropylene.","authors":"Nicole Shu-Wen Chan, Seah Wei Hing, Naoki Okada, Li Hengtong, Maria Cecilia Aquino, Victor Koh Teck Chang, Katherine Wanxian Lun, Dawn Ka Ann Lim, Paul Tec Kuan Chew, Marcus Chun Jin Tan","doi":"10.1111/ceo.14549","DOIUrl":"https://doi.org/10.1111/ceo.14549","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the 12-month outcomes of stent removal in eyes with the Paul Glaucoma Implant (PGI) and intraluminal 6-0 polypropylene in an Asian population.</p><p><strong>Methods: </strong>Retrospective review of patients ≥ 18 years of age with glaucoma in a tertiary institution, who underwent the PGI stented with intraluminal 6-0 polypropylene (October 2018 to January 2023), with a minimum follow-up duration of 12 months. The main outcome measures were intraocular pressure (IOP) and number of glaucoma medications.</p><p><strong>Results: </strong>We included 103 eyes of 97 patients, who were mostly Chinese (73.8%). The stent was removed in 43 eyes (41.7%), at a median of 12.3 (interquartile range: 4.1-18.4) postoperative weeks. The mean IOP reduction immediately following stent removal was -6.4 ± 5.0 mmHg, and there was a strong linear correlation with the IOP before stent removal (Pearson correlation -0.554; p < 0.001). No eyes developed hypotony after stent removal.</p><p><strong>Conclusions: </strong>Less than half of the eyes with PGI stented with intraluminal 6-0 polypropylene required stent removal. The IOP reduction achieved after stent removal correlated with the IOP before stent removal, and there were no complications of hypotony.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}