Clinical and Experimental Ophthalmology最新文献

Long-Term Local Control and Mortality After Transpupillary Thermotherapy of Small Uveal Melanomas. 小葡萄膜黑色素瘤经上膜热疗后的长期局部控制和死亡率。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-05-08 DOI: 10.1111/ceo.70126

Maria Fili, Malin Ermedahl Conradi, Maya Klaff Dahl, Shiva Sabazade, Manuel Casselholm De Salles, Gustav Stålhammar

{"title":"Long-Term Local Control and Mortality After Transpupillary Thermotherapy of Small Uveal Melanomas.","authors":"Maria Fili, Malin Ermedahl Conradi, Maya Klaff Dahl, Shiva Sabazade, Manuel Casselholm De Salles, Gustav Stålhammar","doi":"10.1111/ceo.70126","DOIUrl":"https://doi.org/10.1111/ceo.70126","url":null,"abstract":"Background: Transpupillary thermotherapy (TTT) is used for selected small choroidal melanocytic tumours, either as primary treatment or as an adjunct to plaque brachytherapy. We compared long-term local recurrence and mortality outcomes after primary TTT alone, plaque brachytherapy combined with TTT (brachy+TTT), and plaque brachytherapy alone (brachy alone).Methods: This retrospective cohort study included 850 patients with choroidal melanocytic tumours treated with eye-preserving modalities at St. Erik Eye Hospital, Stockholm, Sweden, 2008-2020. Primary treatment was TTT alone (n = 48), brachy+TTT (n = 105), or brachy alone (n = 697). Outcomes included local recurrence, local recurrence with extraocular extension (EXE), and mortality.Results: At 15 years, Kaplan-Meier local recurrence-free survival was 8% after TTT alone, 34% after brachy+TTT, and 86% after brachy alone (log-rank test for trend, p < 0.001). Disease-specific survival at 15 years was 46%, 85%, and 90%, respectively (p = 0.03). In multivariable Fine-Gray regression adjusting for American Joint Committee on Cancer stage, TTT alone was associated with a higher subdistribution hazard of local recurrence (sHR, 6.7; p < 0.001) and melanoma-related death (sHR, 3.9; p < 0.001). Among patients treated for local recurrence, subsequent recurrences occurred more frequently after TTT than after treatments involving brachytherapy. The risk of EXE increased with the number of TTT sessions.Conclusions: In this single-centre retrospective cohort, TTT was associated with higher rates of local recurrence and melanoma-related mortality compared with plaque brachytherapy. Future studies should assess whether similar results are observed in external long-term cohorts; such findings would inform whether the role of TTT in the management of choroidal melanocytic tumours warrants reconsideration.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Efficacy of Standalone Ab-Interno Canaloplasty Versus Ab-Interno Canaloplasty Combined With Phacoemulsification: A Systematic Review and Meta-Analysis. 单行Ab-Interno管道成形术与Ab-Interno管道成形术联合超声乳化术的疗效比较：系统综述和meta分析。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-05-05 DOI: 10.1111/ceo.70124

Hon Jen Wong, Jiankai Sheng, Devy Anggreni, Trevor J Yeong, Sheng Yang Lim, Bjorn Kaijun Betzler, Bryan Chin Hou Ang

{"title":"Comparative Efficacy of Standalone Ab-Interno Canaloplasty Versus Ab-Interno Canaloplasty Combined With Phacoemulsification: A Systematic Review and Meta-Analysis.","authors":"Hon Jen Wong, Jiankai Sheng, Devy Anggreni, Trevor J Yeong, Sheng Yang Lim, Bjorn Kaijun Betzler, Bryan Chin Hou Ang","doi":"10.1111/ceo.70124","DOIUrl":"https://doi.org/10.1111/ceo.70124","url":null,"abstract":"Background: Ab-interno canaloplasty (ABiC) may be performed as a standalone procedure or in combination with phacoemulsification (ABiC+Phaco). This study aims to examine the comparative surgical outcomes of both procedures.Methods: PubMed, EMBASE and CENTRAL were searched for randomised controlled trials, cohort studies and retrospective case series published from inception to 31 March 2025 that compared outcomes of standalone ABiC and ABiC+Phaco in the treatment of open-angle glaucoma (OAG). Random-effects meta-analysis was performed to pool the mean difference in intraocular pressure (IOP) and glaucoma medications compared to baseline.Results: Eight studies with a pooled total of 663 eyes were included in final analysis. There was no significant difference in IOP-lowering efficacy between ABiC+Phaco and standalone ABiC across all timepoints (6 months, 1 year, 2 years and 3 years) with a mean difference of 0.25 mmHg (95% CI: -0.98 to 1.48) at 3 years. There was also no significant difference in glaucoma medication reduction between ABiC+Phaco and standalone ABiC across all timepoints, with a mean difference of 0.03 medication reduction (95% CI: -0.18 to 0.23) at 3 years. A small IOP-lowering benefit of ABiC+Phaco versus standalone ABiC in primary OAG-only studies (mean difference 0.75 mmHg, 95% CI: 0.03-1.47) was observed at 3 years.Conclusion: Our meta-analysis suggests that phacoemulsification may not offer significant additional IOP and glaucoma medication reduction to standalone ABiC. However, results should be interpreted with caution due to a moderate risk of bias across all included studies. Regardless, our findings are consistent with existing literature on the effect of adjunctive phacoemulsification on other ab-interno MIGS.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Efficacy of Two Defocus Soft Contact Lenses on Axial Length and Choroid in High Myopic Adolescents. 两种离焦软性隐形眼镜对高度近视青少年眼轴长度和脉络膜的影响比较。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-24 DOI: 10.1111/ceo.70120

Jia Yu, Jie Zhao

{"title":"Comparative Efficacy of Two Defocus Soft Contact Lenses on Axial Length and Choroid in High Myopic Adolescents.","authors":"Jia Yu, Jie Zhao","doi":"10.1111/ceo.70120","DOIUrl":"https://doi.org/10.1111/ceo.70120","url":null,"abstract":"Background: To compare the 1-year myopia control efficacy of two defocus soft contact lenses (SCLs) versus single-vision spectacles in high myopic adolescents (spherical equivalent refraction [SER] of 6.00 diopters or more).Methods: 237 participants were randomised into three groups: peripheral gradual defocus SCLs (Group A), multipoint defocus SCLs (Group B) and single-vision spectacles (Group C), with 12-month follow-up. Outcomes included axial length change (ΔAL), SER change (ΔSER), choroidal thickness (CT) and choroidal vascular density (VDCC).Results: 217 subjects completed follow-up. From Month 3, Group B had the smallest ΔAL: 12-month ΔAL was (0.12 ± 0.08) mm, significantly lower than Groups A (0.25 ± 0.10 mm) and C (0.48 ± 0.12 mm), all p < 0.001. Group B's ΔSER (-0.13 ± 0.09 D) was also smaller than Groups A (-0.24 ± 0.11 D) and C (-0.45 ± 0.13 D) (all p value less than 0.05). Group B showed increased VDCC/CT (notably 3-mm foveal area), Group C decreased and Group A stabilised. Multiple regression indicated Group B intervention (β = -0.32, p = 0.002) and 3-mm CT change (β = -0.28, p = 0.006) independently correlated with smaller ΔAL (model R2 = 0.35, p value less than 0.001).Conclusion: Multipoint defocus SCLs outperform other methods in controlling high myopia and improving choroidal parameters.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is There a Causal Link Between GLP-1 Receptor Agonists and Non-Arteritic Anterior Ischaemic Optic Neuropathy? A Critique of the Clinical Evidence. GLP-1受体激动剂与非动脉性前缺血性视神经病变之间存在因果关系吗？临床证据的批判。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-22 DOI: 10.1111/ceo.70096

Helen V Danesh-Meyer, Joseph F Rizzo

{"title":"Is There a Causal Link Between GLP-1 Receptor Agonists and Non-Arteritic Anterior Ischaemic Optic Neuropathy? A Critique of the Clinical Evidence.","authors":"Helen V Danesh-Meyer, Joseph F Rizzo","doi":"10.1111/ceo.70096","DOIUrl":"https://doi.org/10.1111/ceo.70096","url":null,"abstract":"Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for managing Type 2 diabetes and obesity, with well-documented and significant cardiometabolic benefits. Recent observational reports and pharmacovigilance data have raised concerns about a possible association between GLP-1RAs-particularly semaglutide- and non-arteritic anterior ischaemic optic neuropathy (NAION), a rare cause of sudden vision loss. While case reports and spontaneous reporting systems suggest a potential signal, these sources are subject to confounding and reporting bias. Observational studies offer mixed findings, with some Scandinavian registry studies reporting elevated risks while large electronic health record EHR) analyses from the U.S. and multi-national databases have reported null or weak associations. Meta-analyses of randomised controlled trials- the gold standard for causal inference- currently lack power to reliably assess this rare outcome but suggest, at most, a comparatively moderate increase in risk (e.g., odds ratio of 2-3). Overall while a causal link cannot be excluded, the numerous studies that assert an 'association' between GLP-1 RA exposure and NAION should motivate larger pooled analyses of RCTs with adjudicated ocular outcome to definitely assess risk.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Fuchs Endothelial Corneal Dystrophy in a Dermatology Population. 富克斯角膜内皮营养不良在皮肤病人群中的患病率。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-21 DOI: 10.1111/ceo.70122

Henri Piteau, Christian Dorado-Cortez, Sylvain Poinard, Oliver Dorado-Cortez, Marie-Caroline Trone, Philippe Gain, Jean-Luc Perrot, Gilles Thuret

引用次数: 0

Randomised Controlled Trial: Influence of Subconjunctival Anaesthesia Duration on Pain Perception During Intravitreal Injections: Response. 随机对照试验：玻璃体内注射时结膜下麻醉时间对疼痛感觉的影响：反应。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-21 DOI: 10.1111/ceo.70121

Jiyeon Kim, Louis S Han, Logan Robinson, Tafadzwa Young-Zvandasara

引用次数: 0

Repeat Intraocular Sampling and Microbiological Testing in Infectious Endophthalmitis: Response. 感染性眼内炎的重复眼内取样和微生物检测：反应。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-21 DOI: 10.1111/ceo.70113

Pravena Kumaran, Maedbh Rhatigan, Zelia Chiu, Jasmine Lichtenstein, Penelope J Allen, Rosie C H Dawkins

引用次数: 0

Aligning Natural History Modelling With Therapeutic Timing in RPGR-Associated Retinal Degeneration. rgr相关性视网膜变性的自然历史模型与治疗时机的一致性。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-16 DOI: 10.1111/ceo.70119

Man Sun, Dan Zang, Jun Chen

引用次数: 0

Intraocular Metastasis: Global Oncologic Perspective With Emphasis on Breast Lobular Carcinoma. 眼内转移：以乳腺小叶癌为重点的全球肿瘤学观点。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-14 DOI: 10.1111/ceo.70117

Kadri Altundag

引用次数: 0

Prevalence, Treatment, and Outcomes of Corneal Disease in Aboriginal and Torres Strait Islander Peoples in Australia: A Systematic Review. 澳洲原住民与托雷斯海峡岛民角膜疾病的流行、治疗与结果：系统回顾。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-13 DOI: 10.1111/ceo.70118

Angus van der Nagel, Daniel Cool, Himal Kandel, Stephanie Watson

{"title":"Prevalence, Treatment, and Outcomes of Corneal Disease in Aboriginal and Torres Strait Islander Peoples in Australia: A Systematic Review.","authors":"Angus van der Nagel, Daniel Cool, Himal Kandel, Stephanie Watson","doi":"10.1111/ceo.70118","DOIUrl":"https://doi.org/10.1111/ceo.70118","url":null,"abstract":"Background: To synthesise available evidence on the prevalence, treatment strategies, and outcomes of corneal disease affecting Aboriginal and Torres Strait Islander peoples in Australia, and to identify gaps in the existing literature.Methods: A systematic review with narrative synthesis was conducted in accordance with PRISMA 2020 guidelines. PubMed, Embase, Scopus, and the Cochrane Library were searched from January 2010 to February 2025. Eligible studies reported epidemiology and/or treatment outcomes of corneal disease in Indigenous Australians. Due to heterogeneity, meta-analysis was not performed.Results: Twenty-one studies met inclusion criteria. Active trachoma prevalence declined over the past decade from approximately 14%-15% (1-5) to 3%-4% (6-8), with most jurisdictions reporting prevalence below endemic thresholds by 2022, although pockets of higher prevalence persisted in some remote communities (8). Trachomatous trichiasis was higher among Indigenous Australian adults compared with non-Indigenous Australian adults (~0.4%-0.5% vs. ~0.03%-0.05%) (5, 8, 9). Evidence for non-trachomatous corneal disease was limited to clinic and hospital-based cohort studies. These data suggested that pterygium was common among Indigenous Australians, although lacked population-level prevalence estimates. Hospital-based keratitis cohorts demonstrated worse visual outcomes among Indigenous patients, with distinct risk factor profiles characterised by lower contact lens use and higher rates of trauma and delayed presentation.Conclusions: While available data suggest progress in some corneal conditions among Indigenous Australians, major evidence gaps limit reliable estimates for several pathologies. Priorities include strengthening Indigenous-specific population data and developing prevention and treatment approaches tailored to environmental exposures and access barriers in remote communities.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0