Nicole Shu-Wen Chan, Seah Wei Hing, Naoki Okada, Li Hengtong, Maria Cecilia Aquino, Victor Koh Teck Chang, Katherine Wanxian Lun, Dawn Ka Ann Lim, Paul Tec Kuan Chew, Marcus Chun Jin Tan
{"title":"Outcomes of Stent Removal in Eyes With the Paul Glaucoma Implant With Intraluminal 6-0 Polypropylene.","authors":"Nicole Shu-Wen Chan, Seah Wei Hing, Naoki Okada, Li Hengtong, Maria Cecilia Aquino, Victor Koh Teck Chang, Katherine Wanxian Lun, Dawn Ka Ann Lim, Paul Tec Kuan Chew, Marcus Chun Jin Tan","doi":"10.1111/ceo.14549","DOIUrl":"https://doi.org/10.1111/ceo.14549","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the 12-month outcomes of stent removal in eyes with the Paul Glaucoma Implant (PGI) and intraluminal 6-0 polypropylene in an Asian population.</p><p><strong>Methods: </strong>Retrospective review of patients ≥ 18 years of age with glaucoma in a tertiary institution, who underwent the PGI stented with intraluminal 6-0 polypropylene (October 2018 to January 2023), with a minimum follow-up duration of 12 months. The main outcome measures were intraocular pressure (IOP) and number of glaucoma medications.</p><p><strong>Results: </strong>We included 103 eyes of 97 patients, who were mostly Chinese (73.8%). The stent was removed in 43 eyes (41.7%), at a median of 12.3 (interquartile range: 4.1-18.4) postoperative weeks. The mean IOP reduction immediately following stent removal was -6.4 ± 5.0 mmHg, and there was a strong linear correlation with the IOP before stent removal (Pearson correlation -0.554; p < 0.001). No eyes developed hypotony after stent removal.</p><p><strong>Conclusions: </strong>Less than half of the eyes with PGI stented with intraluminal 6-0 polypropylene required stent removal. The IOP reduction achieved after stent removal correlated with the IOP before stent removal, and there were no complications of hypotony.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seung Min Lee, Young Je Choi, Jee Myung Yang, Min Kim
{"title":"Multimodal Imaging Findings and Long-Term Surgical and Non-Surgical Treatment Outcomes of Retinal Vasoproliferative Tumours in Korean Patients.","authors":"Seung Min Lee, Young Je Choi, Jee Myung Yang, Min Kim","doi":"10.1111/ceo.14533","DOIUrl":"https://doi.org/10.1111/ceo.14533","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew Henderson, Sahib Y Tuteja, David Lockington
{"title":"Literature Review of Sex Hormones and Cataract Development, With Modern Implications.","authors":"Matthew Henderson, Sahib Y Tuteja, David Lockington","doi":"10.1111/ceo.14550","DOIUrl":"https://doi.org/10.1111/ceo.14550","url":null,"abstract":"<p><p>Administration of exogenous testosterone and oestrogen has a number of clinical indications, with increasing use as gender-affirming hormone therapy (GAHT) in young individuals. GAHT has been associated with increasing ocular manifestations, but cataracts have not been previously reported. A literature review was conducted to assess for any associations between sex hormone administration and cataracts. Sparse data exist regarding the relationship between androgens and cataract. We also reviewed current knowledge derived from animal studies about oestrogen's effects on the lens, possible biomechanisms and correlations with observational data on cataract incidence with varying estrogen levels. Data surrounding parity, menarche, menopause and hormone replacement therapy in women generally supports a protective role of endogenous and exogenous estrogen on the crystalline lens. Such protection could be suppressed due to long-term GAHT in susceptible individuals, but no relevant studies exist regarding cataract risk in this scenario. Further research via population-based studies would be useful to identify any potential cataractogenic risk factors from GAHT.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Longitudinal Visual Biomarkers in Dominant Optic Atrophy: A Systematic Review and Meta-Analysis.","authors":"Christopher A Ovens, John R Grigg, Clare L Fraser","doi":"10.1111/ceo.14543","DOIUrl":"https://doi.org/10.1111/ceo.14543","url":null,"abstract":"<p><strong>Background: </strong>Dominant Optic Atrophy (DOA) causes slowly progressive visual decline usually beginning in childhood. As new therapies come to clinical trial, the choice of biomarkers to be used as clinical trial endpoints has become a critical question to be addressed.</p><p><strong>Methods: </strong>We undertook a systematic review and meta-analysis of studies reporting longitudinal data of any biomarker in DOA patients.</p><p><strong>Results: </strong>In total, seven studies were included in the systematic review, and four presented paired results compatible with meta-analysis. Visual acuity was the only biomarker found with reported longitudinal data. Of the included studies in the meta-analysis, the rate of yearly visual acuity decline (0.022 LogMAR/year., 95% CI: -0.008 to 0.052) was not significantly different from zero (Z = 1.4, p = 0.155).</p><p><strong>Conclusion: </strong>Quantifying this slow rate of visual decline has implications for future study design and suggests that further natural history studies examining alternative biomarkers in DOA are warranted.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to \"Predicting Ophthalmic Clinic Non-Attendance Using Machine Learning: Development and Validation of Models Using Nationwide Data\".","authors":"","doi":"10.1111/ceo.14542","DOIUrl":"https://doi.org/10.1111/ceo.14542","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Presbyopia Correction in Lens Replacement Surgery: A Review.","authors":"Benjamin Stern, Damien Gatinel","doi":"10.1111/ceo.14535","DOIUrl":"https://doi.org/10.1111/ceo.14535","url":null,"abstract":"<p><p>Presbyopia affects approximately 1.8 billion individuals globally, posing significant challenges as life expectancy and near-vision demands, particularly with mobile phone use, grow. Addressing presbyopia during lens replacement surgery has become a key focus for cataract surgeons, aiming to reduce dependence on corrective eyewear. This review provides an overview of current intraocular lens (IOL) technologies and surgical strategies for presbyopia correction. Personalised decision-making is essential, considering each patient's visual needs, expectations, and ocular anatomy. Partial correction approaches, such as monovision and extended depth-of-focus IOLs, can improve intermediate vision but involve specific trade-offs compared to monofocal lenses, depending on the technology utilised. For complete presbyopia correction, multifocal IOLs remain the most effective option. A mix-and-match strategy involving unilateral multifocal implantation shows promise, while sulcus-fixated supplementary IOLs offer the advantage of easier reversibility. Careful IOL selection is particularly important for patients with atypical ocular anatomy or coexisting conditions, which may be progressive.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuen Keat Gan, Hong Kee Ng, William H Morgan, Dao-Yi Yu
{"title":"Long-Term Morphological Changes of Crosslinked Gelatin Stent.","authors":"Yuen Keat Gan, Hong Kee Ng, William H Morgan, Dao-Yi Yu","doi":"10.1111/ceo.14545","DOIUrl":"https://doi.org/10.1111/ceo.14545","url":null,"abstract":"<p><strong>Background: </strong>This study investigates the long-term morphological outcomes of crosslinked gelatin stents over a 10-year period.</p><p><strong>Methods: </strong>Participants from the FDA phase 1 and 2 trials for the XEN 140 stent were recalled for follow-up examinations between 9 and 12 years after their initial implantation. The stent area was evaluated using anterior segment optical coherence tomography (AS-OCT) in conjunction with clinical assessments. We focused on measuring specific alterations in stent dimensions, such as external surface pitting or 'nibbling', complete wall breaches and luminal obstruction.</p><p><strong>Results: </strong>We evaluated 11 eyes from 9 patients, with an average follow-up period of 11.2 years (SD ± 0.7). The mean preoperative intraocular pressure (IOP) was 22.5 mmHg (SD ± 4.9), which decreased to 14.7 mmHg (SD ± 1.2) a decade after surgery. Notably, four eyes no longer required antiglaucoma medication. Out of the 11 cases, only 8 yielded image quality suitable for analysis, all of which exhibited stent wall nibbling. The average nibbling depth was 70.17 μm (SD ± 36) in the intrascleral area, 79.5 μm (SD ± 18) in the proximal conjunctival region and 42.25 μm (SD ± 5) in the distal conjunctival region. Nibbling was most frequent in the proximal conjunctival area with 26 instances (p = 0.0006), followed by the intrascleral area, 21, and the distal conjunctival section, 9. Hyperreflective lumens were noted in five cases, with one complete stent wall discontinuity.</p><p><strong>Conclusion: </strong>In cases where imaging provided clear visibility, the stents exhibited signs of morphometric changes after 11 years. This degradation process seems to initiate externally, leading to luminal obstruction and eventual stent failure.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimising the Evaluation of Optic Neuritis YouTube Videos: A Call for Multimedia-Specific Tools and Audience-Oriented Approaches.","authors":"Yuwan Gao","doi":"10.1111/ceo.14548","DOIUrl":"https://doi.org/10.1111/ceo.14548","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correlation of Structure With Function: Future Utilities for Optical Coherence Tomography Angiography in Neuro-Ophthalmology.","authors":"Marzieh Tahmasebi Sarvestani, Sudha Cugati, Celia Chen","doi":"10.1111/ceo.14544","DOIUrl":"https://doi.org/10.1111/ceo.14544","url":null,"abstract":"<p><p>Optical coherence tomography angiography is a burgeoning imaging modality in Ophthalmology. In this review, we outline the breadth of potential utility for optical coherence tomography angiography for diagnosis and prognostication in neuro-ophthalmology. Further mapping of the characteristics and natural history of the optic disc vascular network in neuro-ophthalmic conditions is necessary to increase the utility of this imaging modality for neuro-ophthalmic conditions, as the specificity and sensitivity of optical coherence tomography angiography are currently limited by the small pool of available observational data.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}