Clinical and Experimental Ophthalmology最新文献_第2页

Orbital Rhabdomyosarcoma: A Comprehensive Review of Clinical Features, Molecular Advances and Current Management. 眼眶横纹肌肉瘤：临床特征、分子进展和当前治疗的综合综述。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-01 Epub Date: 2026-02-16 DOI: 10.1111/ceo.70075

Kamil Gabriël Laban, Nur Khatib, Johannes Hendrikus Maria Merks, Peerooz Saeed

{"title":"Orbital Rhabdomyosarcoma: A Comprehensive Review of Clinical Features, Molecular Advances and Current Management.","authors":"Kamil Gabriël Laban, Nur Khatib, Johannes Hendrikus Maria Merks, Peerooz Saeed","doi":"10.1111/ceo.70075","DOIUrl":"10.1111/ceo.70075","url":null,"abstract":"Orbital rhabdomyosarcoma (RMS) is the most common primary orbital malignant tumour in children. The majority of cases are of the embryonal subtype, which carries a favourable prognosis when promptly diagnosed and appropriately managed. Advances in molecular profiling have further refined risk stratification, distinguishing PAX3/7::FOXO1 fusion-negative embryonal from fusion-positive alveolar RMS. Imaging, particularly MRI, plays a central role in diagnosis and tumour extent. Current biopsy recommendations favour open incisional procedures for orbital RMS. Treatment follows risk-adapted protocols incorporating systemic chemotherapy with radiotherapy for local control. Emerging studies show the benefit of novel radiotherapeutic approaches that have high control rates but lower toxicity, including brachytherapy in the AMORE protocol. Despite overall excellent survival rates, challenges remain in reducing long-term morbidity and personalising treatment through genetic and molecular knowledge. This review offers current recommendations and highlights the importance of a multi-disciplinary approach in the diagnosis, staging and treatment of orbital RMS.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":"398-409"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146208248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Detection and Diagnosis of Intraocular Lymphoma Through Advanced Retinal Imaging. 先进视网膜成像增强眼内淋巴瘤的检测和诊断。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-01 DOI: 10.1111/ceo.70116

Francesco Pichi, David Sarraf

引用次数: 0

Ophthalmic Adverse Events of Systemic Immunotherapy and Targeted Cancer Therapy: A Review. 系统性免疫治疗和靶向肿瘤治疗的眼部不良事件综述。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-01 Epub Date: 2026-01-23 DOI: 10.1111/ceo.70059

Michael R Dong, Zelia K Chiu, Lyndell L Lim, Ming Lee Lin

引用次数: 0

Balancing Vision and Cancer Treatment: Perspectives on Modern Cancer Therapeutics and the Eye. 平衡视力和癌症治疗：现代癌症治疗和眼睛的观点。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-01 Epub Date: 2026-03-31 DOI: 10.1111/ceo.70115

Thellea K Leveque, Timothy M Janetos, Debra A Goldstein

引用次数: 0

Ocular Imaging in Intraocular Lymphoma: A Review. 眼内淋巴瘤的眼部影像学研究综述。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1111/ceo.70064

Amin Ibrahim, Vishal B Swaminathan, Wendy M Smith, Lauren A Dalvin

{"title":"Ocular Imaging in Intraocular Lymphoma: A Review.","authors":"Amin Ibrahim, Vishal B Swaminathan, Wendy M Smith, Lauren A Dalvin","doi":"10.1111/ceo.70064","DOIUrl":"10.1111/ceo.70064","url":null,"abstract":"Intraocular lymphomas, including vitreoretinal and choroidal lymphoma, can simulate the clinical presentation of other benign and malignant ocular diseases resulting in diagnostic delays. Multimodal imaging features can raise early clinical suspicion to support appropriate subspecialty referrals and treatment for patients affected by these conditions. This review synthesises current evidence on the diagnostic and prognostic value of characteristic imaging features of these rare malignancies. Findings are reviewed based on imaging modality, including fundus photography, optical coherence tomography, fundus autofluorescence, fluorescein angiography, indocyanine green angiography, optical coherence tomography angiography, and ultrasound. We emphasise discriminative biomarkers that heighten suspicion for either vitreoretinal or choroidal lymphoma, as well as key findings to discriminate between lymphoma and alternative diagnoses. We further describe longitudinal changes in multimodal imaging features that can facilitate tracking disease progression or treatment response. By consolidating modality-specific findings, this review aims to facilitate early referral and accurate diagnosis of these rare malignancies.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":"367-381"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12863966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contemporary Management of Malignant Eyelid Tumours: Surgical and Immunotherapeutic Advances. 眼睑恶性肿瘤的当代治疗：手术和免疫治疗的进展。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-01 Epub Date: 2026-01-28 DOI: 10.1111/ceo.70062

Madison Banlin, Michelle S Goh, Jwu Jin Khong

{"title":"Contemporary Management of Malignant Eyelid Tumours: Surgical and Immunotherapeutic Advances.","authors":"Madison Banlin, Michelle S Goh, Jwu Jin Khong","doi":"10.1111/ceo.70062","DOIUrl":"10.1111/ceo.70062","url":null,"abstract":"This review provides an updated overview of the contemporary management of malignant eyelid tumours, focusing on evidence-based advances in both surgical and immunotherapeutic approaches. Eyelid malignancies represent a significant health burden, particularly in Australia and New Zealand where skin cancer rates are the highest globally. The article details the epidemiology, clinical presentation, diagnosis, and risk stratification for the five most common eyelid cancers: basal cell carcinoma, squamous cell carcinoma, sebaceous gland carcinoma, melanoma, and Merkel cell carcinoma. Current best practises emphasise microscopically controlled surgical excision as the mainstay of curative therapy, with excision margins tailored according to tumour and histology type. Mohs micrographic surgery and peripheral and deep margin assessment techniques are highlighted for improved local control and eyelid preservation. The review discusses the expanding role of immuno- and targeted therapies such as checkpoint inhibitors including program cell death (PD-1) and programmed cell death ligand (PD-L1) inhibitors, as well as targeted hedgehog inhibitors for unresectable and metastatic disease in melanoma, Merkel cell carcinoma, and advanced squamous cell carcinoma, demonstrating enhanced progression-free survival and durable responses. Management algorithms are increasingly multidisciplinary, integrating ophthalmology, dermatology, oncology, pathology, and reconstructive surgery. Ongoing challenges include timely detection, management of adverse effects, and the risk of recurrence and metastasis, necessitating long-term surveillance and individualised care.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":"320-340"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146068595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pars Plana Vitrectomy Versus Anterior Vitrectomy in Scleral-Fixated Intraocular Lenses Implantation: A Systematic Review and Meta-Analysis. 巩膜固定人工晶状体植入术中睫状体前部切除术与睫状体前部切除术：系统回顾和荟萃分析。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-01 DOI: 10.1111/ceo.70107

Hashem Abu Serhan, Abdullah Ahmed, Mahrukh Chaudhry, Fakiha Ahmed, Arsalan Nadeem, Basum Hayat, Ahmed B Sallam

{"title":"Pars Plana Vitrectomy Versus Anterior Vitrectomy in Scleral-Fixated Intraocular Lenses Implantation: A Systematic Review and Meta-Analysis.","authors":"Hashem Abu Serhan, Abdullah Ahmed, Mahrukh Chaudhry, Fakiha Ahmed, Arsalan Nadeem, Basum Hayat, Ahmed B Sallam","doi":"10.1111/ceo.70107","DOIUrl":"https://doi.org/10.1111/ceo.70107","url":null,"abstract":"Background: To compare complication risks and visual outcomes between pars plana vitrectomy (PPV) and anterior vitrectomy (AV) in scleral-fixated intraocular lens (SFIOL) implantation.Methods: We searched PubMed, MEDLINE, Scopus, EMBASE, the Cochrane Library and Google Scholar. Primary outcomes included postoperative complications-retinal detachment (RD), vitreous prolapse, cystoid macular edema (CME), elevated intraocular pressure (IOP), vitreous Haemorrhage and intraocular lens (IOL) capture-and changes in best-corrected visual acuity (BCVA). We performed random-effects meta-analyses and assessed certainty of evidence using the GRADE framework.Results: We included five studies comprising 522 eyes. PPV was associated with lower odds of retinal detachment (RD) (OR = 0.11, 95% CI: 0.02-0.57, p < 0.01) and vitreous prolapse (OR = 0.10, 95% CI: 0.02-0.60, p < 0.01) compared with AV; however, no events occurred in the PPV arm for both outcomes. The two groups did not differ significantly in the risks of CME, elevated IOP, or vitreous haemorrhage. PPV was associated with a higher risk of IOL capture (OR = 3.12, 95% CI: 1.30-7.46, p < 0.01) and postoperative BCVA improvement was comparable (MD = -0.05, 95% CI: -0.12 to 0.02). GRADE certainty was very low to low.Conclusions: PPV may be associated with a reduced risk of retinal detachment and vitreous prolapse, but increased risk of IOL capture compared with AV in SFIOL implantation, with comparable visual outcomes. Given the lower certainty of evidence for most outcomes, surgeons should interpret these findings in the context of their surgical expertise and individual patient characteristics.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging of Ocular Surface Lesions Using Anterior Segment Optical Coherence Tomography. 眼表病变前段光学相干断层成像。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-01 Epub Date: 2026-02-18 DOI: 10.1111/ceo.70081

Wendy J Li, Pragat J Muthu, Anat Galor, Carol L Karp

引用次数: 0

Intraocular Metastasis: Differential Diagnosis and Management. 眼内转移：鉴别诊断和治疗。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2026-04-01 Epub Date: 2026-03-07 DOI: 10.1111/ceo.70100

Genovefa Μachairoudia, Dimitrios Kazantzis, Guy S Negretti, Mandeep S Sagoo

引用次数: 0

Uveal Melanoma Treatment: An Update. 葡萄膜黑色素瘤治疗：最新进展。