Clinical and Experimental Ophthalmology最新文献_第2页

Review of Retinopathy of Prematurity Management in the Anti-VEGF Era: Evolving Global Paradigms, Persistent Challenges and Our AI-Assisted Future. 抗vegf时代早产儿视网膜病变管理综述：不断发展的全球范式，持续的挑战和我们人工智能辅助的未来。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-09-04 DOI: 10.1111/ceo.14598

Kyle V Marra, Jimmy S Chen, Eric Nudleman, Shira L Robbins

{"title":"Review of Retinopathy of Prematurity Management in the Anti-VEGF Era: Evolving Global Paradigms, Persistent Challenges and Our AI-Assisted Future.","authors":"Kyle V Marra, Jimmy S Chen, Eric Nudleman, Shira L Robbins","doi":"10.1111/ceo.14598","DOIUrl":"https://doi.org/10.1111/ceo.14598","url":null,"abstract":"Retinopathy of prematurity (ROP) remains a major cause of preventable blindness in premature infants worldwide, with increasing incidence due to advancements in neonatal care. Management of ROP has been revolutionised by anti-vascular endothelial growth factor (anti-VEGF) treatments. Pivotal clinical trials have demonstrated the efficacy of anti-VEGF in the management of Type 1 ROP, while investigation of safety and long-term effects is ongoing. However, infants with ROP often have persistent avascular retina (PAR) despite treatment and require lifelong monitoring for myopia, glaucoma, amblyopia, strabismus, significant refractive error, retinal tears and detachment and adult reactivation of ROP. Alternative therapeutics, including beta-blockers, polyunsaturated fatty acids and vitamin A, remain under investigation. Alongside therapeutic advancements, artificial intelligence (AI) and telemedicine programmes have the potential to expand screening accessibility, particularly in underserved regions, and improve inter-observer variability, though challenges in implementation remain. Together, advanced therapeutics and AI-enhanced screening hold promise for improving outcomes and reducing ROP-related blindness globally.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eye Injury Epidemiology in Australia: A 25-Year Systematic Review and Public Health Perspective. 澳大利亚眼损伤流行病学：25年的系统回顾和公共卫生观点。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-08-27 DOI: 10.1111/ceo.14596

Qiang Li, Jocelyn J Drinkwater, Annette Hoskin, Angus W Turner

{"title":"Eye Injury Epidemiology in Australia: A 25-Year Systematic Review and Public Health Perspective.","authors":"Qiang Li, Jocelyn J Drinkwater, Annette Hoskin, Angus W Turner","doi":"10.1111/ceo.14596","DOIUrl":"https://doi.org/10.1111/ceo.14596","url":null,"abstract":"Background: Eye injuries are a significant cause of monocular blindness, contributing to individual morbidity and substantial healthcare costs. Despite this burden, eye injury prevention remains underrepresented in Australian public health initiatives. This systematic review (PROSPERO ID: CRD42024551054) aims to provide the first comprehensive nationwide synthesis of eye injury epidemiology in Australia.Methods: Three databases (MEDLINE, Embase, Web of Science) were searched to identify Australian studies on eye injuries from 1 January 2000 to 1 May 2024. Studies were excluded per the following criteria: not in English; did not exclusively evaluate eye injury (e.g., evaluated all causes of blindness); only evaluated outcomes after injury; sample size < 25; conference abstracts, editorials, letters to the editor/other review articles. Critical appraisals of included texts were performed using the Joanna Briggs Institute Checklist for Analytical Cross-Sectional Studies. Results were synthesised using the International Globe and Adnexal Trauma Epidemiology Study (IGATES) as a framework.Results: In total, 30 studies were included, ranging from statewide audits to nationwide surveys. Eye injuries were commonest among young males in occupational settings and older adults experiencing falls at home. Paediatric eye injuries frequently occurred during sport or at home. Rural Australians and First Nations women were disproportionately affected by assault-related injuries, including domestic violence.Conclusions: This review highlights key demographic and contextual risk factors for eye injury in Australia and establishes a robust evidence base to inform targeted, data-driven national prevention strategies. The main limitation of this review is the heterogeneity of included studies, which emphasises the importance of using international, standardised registries such as IGATES.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the Quality of Care Provided at Singapore's Primary Eye Care Model and Lessons Learned to Maintain Quality Care-Mixed-Methods Study. 检查新加坡初级眼保健模式提供的护理质量和维持高质量护理的经验教训-混合方法研究。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-08-26 DOI: 10.1111/ceo.14600

Wanfen Yip, Adeline Kon, Michelle Jessica Pereira, Joseph Antonio De Castro Molina, Kiok Liang Teow, Vernon Khet Yau Yong, Hon Tym Wong, Tock Han Lim, Vivien Cherng Hui Yip

引用次数: 0

Retinal Viral Gene Therapy: Impact of Route of Administration on Serious Adverse Events-A Systematic Review. 视网膜病毒基因治疗：给药途径对严重不良事件的影响——一项系统综述。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-08-21 DOI: 10.1111/ceo.14593

Aubrey Berger, Ciera D Johnson, Alan D Marmorstein, Brittni A Scruggs

{"title":"Retinal Viral Gene Therapy: Impact of Route of Administration on Serious Adverse Events-A Systematic Review.","authors":"Aubrey Berger, Ciera D Johnson, Alan D Marmorstein, Brittni A Scruggs","doi":"10.1111/ceo.14593","DOIUrl":"https://doi.org/10.1111/ceo.14593","url":null,"abstract":"Background: To explore the prevalence of serious adverse events (SAEs) associated with retinal viral gene therapy and to examine trends influencing SAE occurrences in human gene therapy surgeries and pre-clinical animal trials.Methods: Literature review was performed to identify peer-reviewed human and animal studies relevant to viral gene therapy, subretinal injections, and intravitreal injections. For clinical trials and post-approval LUXTURNA studies, only those that examined SAEs were included.Results: Of included clinical trial studies (n = 31), SAEs were recorded in 51 out of 438 eyes (11.6%) that received subretinal injections and in 11 out of 348 eyes (3.2%) that received intravitreal injections. There were fewer intravitreal-related SAEs and less vision loss compared to subretinal gene therapy. Inflammation was the predominant SAE following intravitreal injections, whereas unexplained vision loss was the most common for subretinal injections. Clinical trials utilising subretinal injections met primary or secondary efficacy endpoints more than intravitreal trials. Eighteen studies (429 eyes) of post-approval LUXTURNA were reviewed, and SAEs were reported in 24.7% of eyes, retinal degeneration being most common (20.7%). For 58 animal studies, SAEs were recorded in 17.3% of eyes that received subretinal injections and 8.7% of eyes that received intravitreal injections.Conclusions: Subretinal injections show higher efficacy than intravitreal injections but are associated with more serious adverse events. Consistent adverse event patterns in humans and large animals highlight their predictive value for safety. There is a need for optimised delivery methods, refined dosing protocols, and improved post-treatment monitoring to improve safety and effectiveness in gene therapy.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal Neuronal Changes and Kidney Dysfunction in Diabetes Mellitus. 糖尿病视网膜神经元改变与肾功能障碍。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-08-10 DOI: 10.1111/ceo.14592

Dan Cao, Qianhui Yang, Yueheng Hong, Rose Tan, Farah N I Ibrahim, Cynthia Lim, Jason Choo, Charumathi Sabanayagam, Thomas M Coffman, Tien Yin Wong, Gavin Siew Wei Tan

{"title":"Retinal Neuronal Changes and Kidney Dysfunction in Diabetes Mellitus.","authors":"Dan Cao, Qianhui Yang, Yueheng Hong, Rose Tan, Farah N I Ibrahim, Cynthia Lim, Jason Choo, Charumathi Sabanayagam, Thomas M Coffman, Tien Yin Wong, Gavin Siew Wei Tan","doi":"10.1111/ceo.14592","DOIUrl":"https://doi.org/10.1111/ceo.14592","url":null,"abstract":"Background: Diabetic kidney disease (DKD) and diabetic retinopathy (DR) share common microvascular pathophysiology, yet the relationship between retinal neuronal alterations and kidney dysfunction remains unclear. This cross-sectional study examines the association between individual retinal layer thickness and kidney indicators to identify novel optical coherence tomography (OCT) biomarkers for DKD.Methods: A total of 410 type 2 diabetes (T2D) patients (815 eyes) were recruited from the outpatient clinics of a tertiary eye centre in Singapore. Retinal layer thickness was measured using OCT with automated segmentation software (Orion). The association between the thickness of individual retinal layers and estimated glomerular filtration rate (eGFR) as well as urine albumin-to-creatinine ratio (UACR) categories was analysed using a Generalised Estimating Equation (GEE) approach.Results: GEE analysis identified a significant association between outer plexiform layer (OPL) thickness and both eGFR and UACR category, with perifoveal OPL thickness showing the strongest inverse association with eGFR (adjusted p = 0.0007) and positive association with the category of UACR (adjusted p = 0.005). After stratifying by retinal thickness, this association remained robust in eyes without macular oedema (foveal total retinal thickness < 320 μm). No significant associations were found for other retinal layers.Conclusions: OPL thickening serves as a potential indicator for DKD, and OCT imaging offers a noninvasive tool for investigating retinal-renal interactions. Further longitudinal studies are needed to evaluate its utility in monitoring DKD progression.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Premyopia Management With Ophthalmic Referral Slows Myopic Shift After School Entry: A Population-Based Longitudinal Study in Taiwan. 以眼科转诊治疗前近视减缓入学后近视转移：台湾人口为基础的纵向研究。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-08-09 DOI: 10.1111/ceo.14595

Yu-Chieh Yang, Hsin-Yu Yang, Chiao-Yu Wang, Shao-You Fang, Chia-Wei Lee, Pei-Wei Huang, Mong-Ping Shyong, Yen-Lin Chen, Nai-Wei Hsu, Der-Chong Tsai

{"title":"Premyopia Management With Ophthalmic Referral Slows Myopic Shift After School Entry: A Population-Based Longitudinal Study in Taiwan.","authors":"Yu-Chieh Yang, Hsin-Yu Yang, Chiao-Yu Wang, Shao-You Fang, Chia-Wei Lee, Pei-Wei Huang, Mong-Ping Shyong, Yen-Lin Chen, Nai-Wei Hsu, Der-Chong Tsai","doi":"10.1111/ceo.14595","DOIUrl":"https://doi.org/10.1111/ceo.14595","url":null,"abstract":"Background: This study aimed to evaluate the impact of early ophthalmic referral for premyopic preschoolers on myopic spherical equivalent (SE) shift after school entry; and to identify risk factors for nonadherence to follow-up care.Methods: A population-based longitudinal study followed 742 premyopic preschoolers (-0.5 D < SE ≤ +0.75 D) from a countywide screening in Yilan, Taiwan (2021-2022), into first or second grade in elementary school (2023). Cycloplegic autorefraction and caregiver questionnaires were collected at baseline and follow-up. Children screened in 2022 comprised the intervention cohort, while those screened in 2021 formed the comparison cohort. Multiple regression analyses assessed factors associated with myopic SE shift and nonadherence to follow-up care.Results: Amongst 742 premyopic children (mean [SD] age at follow-up, 7.2 [0.4] years; 57.8% boys), the overall SE progression was -0.19 (0.39) D/year and the incidence of myopia was 14.8 per 100 person-years. The intervention cohort had a slower myopic SE shift than the comparison cohort (-0.15 vs. -0.22 D/year; p = 0.009). Referral at baseline was independently associated with slower SE progression (β = 0.070; p = 0.03). Amongst those referred in the intervention cohort, 63.2% adhered to follow-up care. Nonadherence was associated with greater baseline hyperopia (adjusted OR, 3.77; 95% CI, 1.69-8.41) and rural residency (adjusted OR, 2.01; 95% CI, 1.23-3.30).Conclusions: Early ophthalmic referral reduced myopic progression, but follow-up adherence was suboptimal, especially in children with greater hyperopia or living in rural areas.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In the Race Against Time to Treat Vogt–Koyanagi–Harada Disease 与时间赛跑治疗Vogt-Koyanagi-Harada病

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-08-06 DOI: 10.1111/ceo.14584

Judy L. Chen, Edmund Tsui

引用次数: 0

Continuing Professional Development 持续专业发展

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-08-06 DOI: 10.1111/ceo.14581

引用次数: 0

Natural History and Biomarker Challenges in Dominant Optic Atrophy: Implications for Therapeutic Studies 显性视神经萎缩的自然历史和生物标志物挑战：对治疗研究的启示

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-08-06 DOI: 10.1111/ceo.14583

Joshua Paul Harvey, Eun Hee Hong, Patrick Yu-Wai-Man

引用次数: 0

Investigating Microinvasive Intra-Ocular Biopsy. 微创眼内活检的研究。

IF 5.6 2区医学

Clinical and Experimental Ophthalmology Pub Date : 2025-08-04 DOI: 10.1111/ceo.14591

Jared Ching, Shohei Kitahata, Hinako Ichikawa, Kazuaki Kadonosono

{"title":"Investigating Microinvasive Intra-Ocular Biopsy.","authors":"Jared Ching, Shohei Kitahata, Hinako Ichikawa, Kazuaki Kadonosono","doi":"10.1111/ceo.14591","DOIUrl":"https://doi.org/10.1111/ceo.14591","url":null,"abstract":"Background: Current minimally invasive methods of intraocular biopsy are confined to small gauge (G) needles and subretinal cannulae that can be prone to wound leakage at the biopsy site. We investigate the role of microneedles with internal diameters as small as 49G for intraocular biopsy in the posterior and anterior segments.Methods: Human uveal melanoma (UM 92-1) and retinoblastoma (Y79) cancer cell lines were aspirated using microneedles of different sizes with a vitrectomy set up, and cell viability was analysed. Suspensions of cancer cells with fluorescent microbeads were injected into the subretinal space of fresh ex vivo porcine eyes before simulating biopsy with microneedle retinal puncture, followed by imaging with optical coherence tomography (OCT) and histology. Anterior chamber puncture was performed with microneedles and imaged with anterior segment OCT and examined for aqueous leakage.Results: We find that microneedles can aspirate ocular cancer cells, both retinoblastoma and uveal melanoma, in vitro and retain a high level of cell viability, 72.83% (49G) compared to 97.00% (25G vitrector) in UM 92-1. Using an ex vivo porcine model, we find that a 49G microneedle creates a self-sealing retinal wound that does not reflux microbeads of 200 nm in diameter. Further, we find that anterior chamber puncture with a microneedle via a corneal paracentesis results in no evidence of an aqueous leak (0%) compared to a leakage rate of 100% and 66% when using a 30G and 34G needle, respectively.Conclusion: A microinvasive approach to biopsy intraocular specimens is feasible, warranting further in vivo studies.","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0