Clinical and Experimental Ophthalmology最新文献

{"title":"Predictive Potential of Retina-Based Biological Age in Assessing Chronic Obstructive Pulmonary Disease Risk.","authors":"Qingsheng Peng, Tyler Hyungtaek Rim, Zhi Da Soh, Miao Li Chee, Yih-Chung Tham, Zhuoting Zhu, Simon Nusinovici, Charumathi Sabanayagam, Ah Young Leem, Chan Joo Lee, Byoung Kwon Lee, Sungha Park, Sung Soo Kim, Hyeon Chang Kim, Marco Chak Yan Yu, Tien Yin Wong, Ching-Yu Cheng","doi":"10.1111/ceo.14501","DOIUrl":"https://doi.org/10.1111/ceo.14501","url":null,"abstract":"<p><strong>Background: </strong>Previously, based on retinal photographs, we developed a deep-learning algorithm to predict biological age (termed, RetiAGE) that was associated with future risks of morbidity and mortality. This study specifically aimed to evaluate the performance of RetiAGE in predicting future risks of chronic obstructive pulmonary disease (COPD).</p><p><strong>Methods: </strong>RetiAGE scores were generated from retinal images in the UK Biobank and stratified into tertiles. We used Cox proportional hazards models to evaluate the longitudinal association between RetiAGE and incident COPD, adjusting for calendar age, gender, smoking, asthma history, and socio-economic status. In addition, we performed a cross-sectional analysis using generalised linear models to examine the association between RetiAGE and baseline respiratory function, specifically the forced expiratory volume in 1 s to forced vital capacity ratio (FEV1/FVC) and peak expiratory flow (PEF), adjusting for the same confounders.</p><p><strong>Results: </strong>Among 45 438 UK Biobank participants without a history of COPD at baseline, 448 (0.9%) developed COPD over a mean follow-up period of 9.8 ± 0.7 years. Participants in the moderate-risk and high-risk tertiles of RetiAGE had significantly lower baseline respiratory function (all p < 0.05) and a higher risk of incident COPD (HR = 1.60; 95% CI, 1.18-2.19) compared to the low-risk tertile, after adjusting for confounders. Adding RetiAGE to the multivariable risk model improved predictive performance, as demonstrated by significant enhancements in C-statistics (p < 0.001) and likelihood ratio tests (p = 0.002).</p><p><strong>Conclusion: </strong>Our deep-learning-based retinal aging biomarker, RetiAGE, can potentially stratify the risk of developing COPD.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuing Professional Development","authors":"","doi":"10.1111/ceo.14476","DOIUrl":"https://doi.org/10.1111/ceo.14476","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 1","pages":"105-108"},"PeriodicalIF":4.9,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treat and Extend Anti-VEGF Treatment Regimens for Neovascular Age-Related Macular Degeneration: To Stop or Not to Stop?","authors":"Praveen J. Patel","doi":"10.1111/ceo.14495","DOIUrl":"https://doi.org/10.1111/ceo.14495","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 1","pages":"8-10"},"PeriodicalIF":4.9,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seeking best outcomes for patients living with vitreoretinal lymphoma","authors":"Justine R. Smith FRANZCO, PhD","doi":"10.1111/ceo.14473","DOIUrl":"https://doi.org/10.1111/ceo.14473","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 1","pages":"5-7"},"PeriodicalIF":4.9,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143110271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leber Hereditary Optic Neuropathy: Support, Genetic Prediction and Accurate Genetic Counselling Enhance Family Planning Choices.","authors":"Lisa S Kearns, Sandra E Staffieri, David A Mackey","doi":"10.1111/ceo.14493","DOIUrl":"https://doi.org/10.1111/ceo.14493","url":null,"abstract":"<p><p>With the increased availability of genetic testing and the addition of mitochondrial genetic variants on disease panels, accurate genetic counselling for individuals and families affected by, or at risk of, Leber hereditary optic neuropathy (LHON) is becoming increasingly relevant. Challenges in providing genetic counselling for LHON include its mitochondrial inheritance pattern, different haplogroups, incomplete penetrance and that it predominantly affects males. Accurate genetic counselling aims to avoid incorrect disease-risk assessment and delays in either diagnosis or implementation of psychosocial support. Families are also empowered to make autonomous health decisions regarding potential trigger factors for LHON vision loss and informed reproductive choices. Using clinical vignettes, this review demonstrates that an increased awareness of LHON amongst eye care, general and genetic health professionals can address challenges and misconceptions.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Abstracts","authors":"","doi":"10.1111/ceo.14486","DOIUrl":"10.1111/ceo.14486","url":null,"abstract":"<p><span><b>Artificial Intelligence</b></span></p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 S1","pages":"78-161"},"PeriodicalIF":4.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.14486","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Past Lecturers and Briefs for the Named Lectures: RANZCO Annual Scientific Congress","authors":"","doi":"10.1111/ceo.14479","DOIUrl":"10.1111/ceo.14479","url":null,"abstract":"<p>The Norman McAlister Gregg Lecture was established in 1958 by the Council of the Ophthalmological Society of Australia in recognition of the outstanding contribution made to ophthalmology by Sir Norman Gregg. The lecture covers a clinical or basic science topic that has clinical relevance and may cover some facet of work not previously published (both ophthalmologists and non-ophthalmologists can be considered). The presentation shall be for 25 min duration and will include 5 min for questions or discussion. The lecture becomes the property of the College. A “Gregg Medal” is presented, together with a certificate, to the lecturer at the conclusion of the lecture.\u0000 </p><p>The Council Lecture was established in 1963 to honour Fellows engaged in original work, or to establish a means whereby a Fellow can deliver an authoritative and distinguished lecture on a subject of which the Fellow has particular experience or knowledge. The presentation shall be for 25 min duration and will include 5 min for questions or discussion. The lecture becomes the property of the College. The Council Lecture provides an opportunity for Fellows who are not necessarily a member of an academic department to present their work. It generally goes to senior Fellows who have made a contribution to clinical ophthalmology. A certificate is presented to the lecturer at the conclusion of the lecture.\u0000 </p><p>The Dame Ida Mann Memorial Lecture was established in 1988 by the Council of the College in recognition of the outstanding contribution made to ophthalmology by Dame Ida Mann. The presentation shall be for 25 min duration and will include 5 min for questions or discussion to cover an important topic that is oriented to the basic or novel clinical sciences of ophthalmology with clinical relevance (not confined to Fellows). The lecture becomes the property of the College. A certificate is presented to the lecturer at the conclusion of the lecture.\u0000 </p><p>The Fred Hollows Lecture was established in 1999 to recognise the work Prof Fred Hollows did with Indigenous people and in raising the profile of ophthalmology. The Hollows Lecture is for Fellows involved in outreach or international ophthalmology. The presentation shall be for 25 min duration and will include 5 min for discussion to address a topic of applied public health research with a community focus. The lecture becomes the property of the College. A certificate is presented to the lecturer at the conclusion of the lecture.\u0000 </p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 S1","pages":"4-7"},"PeriodicalIF":4.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.14479","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sunday 03 November","authors":"","doi":"10.1111/ceo.14483","DOIUrl":"10.1111/ceo.14483","url":null,"abstract":"<p>\u0000 </p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 S1","pages":"38-55"},"PeriodicalIF":4.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.14483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Film Abstracts","authors":"","doi":"10.1111/ceo.14485","DOIUrl":"10.1111/ceo.14485","url":null,"abstract":"<p><b>C<span>ataract</span></b></p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 S1","pages":"71-77"},"PeriodicalIF":4.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.14485","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Royal Australian and New Zealand College of Ophthalmologists, 55th Annual Scientific Congress 1 – 4 November 2024Adelaide Convention Centre","authors":"","doi":"10.1111/ceo.14478","DOIUrl":"10.1111/ceo.14478","url":null,"abstract":"<p><span><b>Organising Committee</b></span></p><p>Mrs Alex Arancibia (RANZCO)</p><p>Mrs Anita Martin (Think Business Events)</p><p>Ms Denise Broeren (Think Business Events)</p><p>Dr Joanna Black (Congress Convenor)</p><p>Dr Matthew Little (Congress Convenor)</p><p><span><b>Scientific Program Committee – Executive</b></span></p><p>Prof Adrian Fung (Program Chair)</p><p>Prof Alex Hewitt</p><p>Dr Amy Cohn</p><p>Dr Andrea Ang</p><p>A/Prof Andrea Vincent</p><p>A/Prof Clare Fraser (Program Chair)</p><p>Dr Elsie Chan</p><p>Dr Graham Hay-Smith</p><p>Dr Mei-Hong Tan</p><p>Dr Sukhpal Sandhu</p><p><span><b>Scientific Program Committee – Reviewers</b></span></p><p>Dr Aanchal Gupta</p><p>Dr Alexandros Ioannidis</p><p>Prof Angus Turner</p><p>Dr Anu Mathew</p><p>Dr Caroline Catt</p><p>Dr Cheefoong Chong</p><p>Dr Christopher Go</p><p>Dr Colin Clement</p><p>Dr Daniel McKay</p><p>Dr David Sia</p><p>Dr Deepa Taranath</p><p>Dr Geoffrey Broadhead</p><p>Dr Hamish Dunn</p><p>Dr Jane Lock</p><p>Dr Jason Cheng</p><p>Dr Jennifer Fan Gaskin</p><p>Dr Jesse Gale</p><p>Dr Jessica Tong</p><p>A/Prof Jonathon Ng</p><p>Dr Jonathan Ruddle</p><p>Dr Kent Chow</p><p>Dr Krishna Tumuluri</p><p>Dr Laurence Sullivan</p><p>A/Prof Mitchell Lawlor</p><p>Dr Mo Ziaei</p><p>Clin A/Prof Nitin Verma AM</p><p>Dr Rahul Chakrabarti</p><p>Dr Robert Griffits</p><p>A/Prof Samantha Fraser-Bell</p><p>Dr Season Yeung</p><p>A/Prof Smita Agarwal</p><p>Dr Stephen Ng</p><p>Dr Tanya Trinh</p><p>Prof Timothy Sullivan</p><p>Dr Weng Onn Chan</p><p>Dr William Yates</p><p>Dr Yves Kerdraon</p><p><span><b>RANZCO Congress Organisers</b></span></p><p>Think Business Events</p><p>Level 1, 299 Elizabeth St</p><p>Sydney NSW 2000</p><p>Tel: +61 2 8251 0045</p><p>Fax: +61 2 8251 0097</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 S1","pages":"3"},"PeriodicalIF":4.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.14478","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}