Clinical and Experimental Ophthalmology最新文献

{"title":"Correlation of Structure With Function: Future Utilities for Optical Coherence Tomography Angiography in Neuro-Ophthalmology.","authors":"Marzieh Tahmasebi Sarvestani, Sudha Cugati, Celia Chen","doi":"10.1111/ceo.14544","DOIUrl":"https://doi.org/10.1111/ceo.14544","url":null,"abstract":"<p><p>Optical coherence tomography angiography is a burgeoning imaging modality in Ophthalmology. In this review, we outline the breadth of potential utility for optical coherence tomography angiography for diagnosis and prognostication in neuro-ophthalmology. Further mapping of the characteristics and natural history of the optic disc vascular network in neuro-ophthalmic conditions is necessary to increase the utility of this imaging modality for neuro-ophthalmic conditions, as the specificity and sensitivity of optical coherence tomography angiography are currently limited by the small pool of available observational data.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Factors for Uveitis Refractory to Treatment in Initial-Onset Acute Vogt-Koyanagi-Harada Disease.","authors":"Thomas J Gin, Sujan A Surendran, Sophie L Rogers, Lyndell L Lim","doi":"10.1111/ceo.14538","DOIUrl":"https://doi.org/10.1111/ceo.14538","url":null,"abstract":"<p><strong>Background: </strong>To identify predictive factors of uveitis refractory to treatment in initial-onset acute Vogt-Koyanagi-Harada disease.</p><p><strong>Methods: </strong>This was a retrospective chart review of patients with initial-onset acute Vogt-Koyanagi-Harada disease presenting to the Royal Victorian Eye and Ear Hospital, Melbourne, Australia between July 2001 and March 2023 inclusive. Factors predictive of uveitis refractory to treatment were determined using logistic regression models with, and without, adjustment for initial use of intravenous methylprednisolone.</p><p><strong>Results: </strong>Thirty-eight patients with initial-onset acute Vogt-Koyanagi-Harada were included, 27 of whom received initial intravenous corticosteroids (71%) and 23 met the criteria for uveitis refractory to treatment (61%). Comparing those who received intravenous corticosteroids to those who did not, the incidence of complications, time-to-quiescence, time-to-relapse, time-to-low dose corticosteroid or corticosteroid-sparing control of inflammation and time-to-remission were not statistically different (all p > 0.164). Factors at onset of treatment that were predictive for uveitis refractory to treatment included greater anterior chamber inflammation (p = 0.008), greater vitreous inflammation (p = 0.015), the absence of bacillary layer detachments on macular optical coherence tomography (p = 0.010) and commencement of systemic steroid therapy 1 week or longer after ocular symptom onset (p = 0.013). Absence of intravenous corticosteroids as initial therapy was not a statistically significant predictive factor for refractory disease (p = 0.802).</p><p><strong>Conclusions: </strong>Delayed commencement of systemic steroid therapy and higher severity of intraocular inflammation at presentation are predictive of initial-onset acute Vogt-Koyanagi-Harada disease evolving into disease refractory to treatment.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Association of Primary Angle-Closure Glaucoma and Disease Progression.","authors":"Yu Jing Liang, Anni Ling, Poemen P Chan, Jason C Yam, Chi Pui Pang, Clement C Tham, Li Jia Chen","doi":"10.1111/ceo.14539","DOIUrl":"https://doi.org/10.1111/ceo.14539","url":null,"abstract":"<p><strong>Background: </strong>To investigate single-nucleotide polymorphisms (SNPs) reported in the largest up-to-date systematic review and meta-analysis on primary angle-closure disease (PACD), on their associations with primary angle-closure glaucoma (PACG) and disease progression.</p><p><strong>Methods: </strong>This study involved a case-control design for PACG risk and a case-only design for PACG progression risk, including 628 PACG patients and 564 controls for disease association and 386 PACG patients with up to 10-year follow-up for PACG progression analysis. Associations of 17 SNPs in 15 genes with PACG were analysed using logistic regression. Sex-stratified association analysis was performed, followed by the Breslow-Day test. Genetic risk for PACG progression was evaluated using logistic regression. Bonferroni correction of p values was adopted for multiple comparisons.</p><p><strong>Results: </strong>LOXL1 rs3825942 (G153D; p = 0.0026; OR = 0.65) was significantly associated with PACG, while ABCC5 rs1401999 showed a nominal association (p = 0.023; OR = 1.32). ABCA1 rs2422493 was significantly associated with PACG in females (p = 0.0016; OR = 0.70) but not in males (p = 0.95; OR = 0.99); and the Breslow-Day Test (p = 0.046) suggested a sex-specific association in females. VAV3 rs6689476 showed nominal associations with PACG progression at 3-year (p = 0.045; OR = 2.86), 5-year (p = 0.037; OR = 2.84) and 10-year follow-ups (p = 0.03; OR = 2.74), but the p values could not withstand Bonferroni correction.</p><p><strong>Conclusion: </strong>This study demonstrated a role of LOXL1 in PACG and a sex-specific effect of ABCA1 in the Hong Kong Chinese population while suggesting a potential role of VAV3 in PACG progression, which has yet to be further confirmed.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are There Biomechanical Changes in Tomographically Progressive Keratoconus Corneas?","authors":"Elias Flockerzi, Tim Berger, Yaser Abu Dail, Berthold Seitz","doi":"10.1111/ceo.14540","DOIUrl":"https://doi.org/10.1111/ceo.14540","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Gene Therapy: Perceptions of Ophthalmologists in Australia and New Zealand.","authors":"John O T Britton, Heather G Mack, Andrea L Vincent, Lisa J Hill, Thomas L Edwards, Lauren N Ayton, Alexis Ceecee Britten-Jones","doi":"10.1111/ceo.14537","DOIUrl":"https://doi.org/10.1111/ceo.14537","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eyes Offshore: Reporting the Eye Health Needs of Refugees and Asylum Seekers in Australia's Offshore Detention Centres.","authors":"Marcel M Nejatian, Rosie Dawkins, Ebrar Al-Yasery, Hessom Razavi","doi":"10.1111/ceo.14508","DOIUrl":"https://doi.org/10.1111/ceo.14508","url":null,"abstract":"<p><strong>Background: </strong>In the last two decades, over 250 000 refugees and asylum seekers have arrived in Australia, many of whom experience significant health problems. Information about their eye health is scarce, particularly for those detained offshore. This is the first study to explore the eye health and services available to this population, helping inform future service planning.</p><p><strong>Methods: </strong>A mixed-methods design was employed, incorporating a multicentre audit of an ophthalmology service in Nauru and Manus Island detention centres (2015-2016) and a comparative analysis of this service against established standards of public eye care in mainland Australia. Outcomes included prevalence and causes of vision impairment, management required, and service performance using the Australian Health Performance Framework.</p><p><strong>Results: </strong>Eighty patients from 14 countries were included (3-57 years, 84% male). There were high rates of bilateral and unilateral vision impairment (19% and 25%, respectively) and bilateral and unilateral blindness (1% and 12%). Bilateral vision impairment was mostly avoidable (80%), with the commonest causes being refractive error and cataract. Ocular trauma accounted for 67% of unilateral blindness. Compared to mainland services, offshore eye care was sub-standard across all performance domains, including governance, information, workforce, safety, and effectiveness.</p><p><strong>Conclusions: </strong>Refugees and asylum seekers held in Australia's offshore detention centres had a high burden of eye disease and inadequate access to services. Ceasing offshore detention in favour of onshore processing, as recommended by numerous medical colleges, may help ensure people seeking asylum have access to appropriate eye care in Australia.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence on the Use of Topical Ciclosporin for Ocular Surface Disease: A Systematic Review and Meta-Analysis-Comment.","authors":"Jinyu Wu, Yun Liao","doi":"10.1111/ceo.14536","DOIUrl":"https://doi.org/10.1111/ceo.14536","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adalimumab Monotherapy or Combination Therapy With Methotrexate in Paediatric Uveitis: Data From the AIDA Network Uveitis Registry.","authors":"Carla Gaggiano, Alejandra de-la-Torre, Silvana Guerriero, Stefania Costi, Gaafar Ragab, Maria Pia Paroli, Emanuela Del Giudice, Luciana Breda, Saverio La Bella, Marco Cattalini, Maria Cristina Maggio, Alex Fonollosa, Ester Carreño, Maria Tarsia, Rosanna Dammacco, Soad Hashad, Antonio Vitale, Lampros Fotis, Stefano Gentileschi, Francesca Minoia, Germán Mejía-Salgado, Halah Etayari, Paola Saboya-Galindo, María Andrea Bernal-Valencia, Adele Civino, Maria Sole Chimenti, Valeria Caggiano, Maria Francesca Gicchino, Jurgen Sota, Angela Mauro, Giuseppe Lopalco, Kalpana Babu Murthy, Mohamed Tharwat Hegazy, Vishali Gupta, Francesco La Torre, Rana Hussein Amin, Bruno Frediani, Gian Marco Tosi, Luca Cantarini, Claudia Fabiani","doi":"10.1111/ceo.14534","DOIUrl":"https://doi.org/10.1111/ceo.14534","url":null,"abstract":"<p><strong>Background: </strong>The study objective was to compare the effectiveness of adalimumab (ADA) in monotherapy and in combination with methotrexate (MTX) for paediatric noninfectious uveitis (NIU).</p><p><strong>Methods: </strong>Registry-based observational study. Children receiving ADA for active uveitis were divided into the ADA monotherapy group (group 1) and the ADA plus MTX combination group (group 2).</p><p><strong>Results: </strong>Eighty four children were enrolled (146 eyes): 22 in group 1 (26.2%) and 62 in group 2 (73.8%). ADA effectiveness was complete in 48 children (57.1%), partial in 23 (27.4%) and absent in 4 (5.3%), without any differences across the groups (p = 0.89). Fewer relapses per 100 PY occurred after ADA treatment both in group 1 (280.0 vs. 23.0, p = 0.005) and in group 2 (297.9 vs. 86.0, p < 0.001). The final BCVA was similar between groups 1 and 2 [median 1.0 (IQR 0.3) and 1.0 (IQR 0.3), respectively, p = 0.55]. A statistically significant steroid-sparing effect was observed in the entire cohort and in group 2 at the 6-month (p = 0.01 and p = 0.01), 12-month (p = 0.02 and p = 0.02), and last follow-up (p = 0.045 and p = 0.045). The estimated ADA retention rate was 97.1% at 12 months, 87.7% at 24 months, and 82.6% at 36 months, without a statistically significant difference among the groups (p = 0.77).</p><p><strong>Conclusions: </strong>ADA monotherapy could be equally effective as its combination with MTX in both preventing uveitis relapses and preserving visual acuity in paediatric NIU, with comparable retention rates over 36 months of treatment. The steroid-sparing effect of ADA monotherapy warrants further extensive evaluation to define its optimal placement in the therapeutic strategy for paediatric NIU.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal Trends in HLA-B27-Associated Uveitis: A Commentary on Recent Findings-Response.","authors":"Priya D Samalia, James Brodie, Joanne L Sims, Rachael L Niederer","doi":"10.1111/ceo.14531","DOIUrl":"https://doi.org/10.1111/ceo.14531","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phototransduction in the Genomic Era: Mechanisms, Genetics and Therapeutic Advances","authors":"John R. Grigg,&nbsp;Robyn V. Jamieson","doi":"10.1111/ceo.14517","DOIUrl":"https://doi.org/10.1111/ceo.14517","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 3","pages":"229-231"},"PeriodicalIF":4.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}