Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献

{"title":"Low Skeletal Muscle Mass: A Strong Predictive Factor for Surgical Complications After Free Forearm Flap Reconstruction in Oral Cancer Patients.","authors":"E Ansari, N Carrillo Minulina, M A van Beers, R J J van Es, F J Dieleman, A J W P Rosenberg, L M Janssen, W W Braunius, E M Van Cann, R de Bree","doi":"10.1002/hed.28014","DOIUrl":"https://doi.org/10.1002/hed.28014","url":null,"abstract":"<p><strong>Background: </strong>Low skeletal muscle mass (SMM) is a predictive factor for complications in patients undergoing major head and neck cancer surgery. This study aims to identify the predictive value of low SMM for postoperative complications in patients who underwent free forearm flap (FAFF) reconstructions after oral cancer resections.</p><p><strong>Methods: </strong>A retrospective study was performed with all patients who underwent FFAF between 2003 and 2020 for an oral cavity reconstruction after cancer ablation. Free flap related, any postoperative complications and hospital stay were investigated.</p><p><strong>Results: </strong>Low SMM was associated with an increased risk of free flap associated complications (OR 2.14; 95% CI 1.02-4.39, p = 0.029). Low SMM was associated with severe complications (Clavien-Dindo ≥ III) (OR 1.46; 95% CI 1.20-2.09, p = 0.02).</p><p><strong>Conclusions: </strong>Low SMM is a strong predictive factor for free flap related surgical complications in patients undergoing FAFF reconstruction after resection of oral cancer.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142734776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA SNHG14 Facilitates Cisplatin Resistance Through Upregulating Notch2 via Binding to U2AF2 in Nasopharyngeal Carcinoma.","authors":"Sijia Yan, Puhua Zhang, Shuai Tan, Haiyun Mo, Yanlin Yang","doi":"10.1002/hed.28016","DOIUrl":"https://doi.org/10.1002/hed.28016","url":null,"abstract":"<p><strong>Background: </strong>Cisplatin (DDP) is one of the commonly used chemotherapeutic drugs for nasopharyngeal carcinoma (NPC) patients, and the resistance of tumor cells to cisplatin is main obstacle for NPC treatment. This study explored effect and possible mechanism of lncRNA small nucleolar RNA host gene 14 (SNHG14) on drug resistance of NPC cells to cisplatin.</p><p><strong>Methods: </strong>Levels of SNHG14 and Notch2 in NPC tissues and cells were confirmed using RT-qPCR. Western blot detected Notch2 and ABCB1 expression in NPC cells. IC50 of cisplatin-treated NPC cells was tested utilizing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Cell proliferation and apoptosis were evaluated utilizing colony formation experiment and flow cytometry, respectively. RNA immunoprecipitation (RIP) assay was utilized to validate the target genes of U2AF2. Notch2 mRNA stability was tested using actinomycin D.</p><p><strong>Results: </strong>SNHG14 level was increased in both cisplatin-resistant NPC tissues and cell lines. SNHG14 silencing in HNE1/DDP cells resulted in inhibition of chemoresistance to cisplatin. Conversely, upregulation of SNHG14 in HNE1 cells enhanced their resistance to cisplatin. SNHG14 exhibited an interaction with U2AF2, leading to stabilization of Notch2 mRNA. Finally, Notch2 was involved in SNHG14-mediated cisplatin resistance in NPC cells.</p><p><strong>Conclusion: </strong>Our findings demonstrate SNHG14 plays a significant role in promoting chemoresistance of NPC cells to cisplatin through U2AF2/Notch2 axis. These results highlight potential therapeutic targets for NPC treatment.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Dermis Graft Following Basal Cell Carcinoma Removal on the Nose: A Comparison of Scar Contracture Across Nasal Subunits.","authors":"Kyu-Il Lee, Ye-Won Choi, Seung-Kyu Han, Seong-Ho Jeong, Eun-Sang Dhong","doi":"10.1002/hed.28017","DOIUrl":"https://doi.org/10.1002/hed.28017","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the degree of scar contracture following artificial dermis grafting after excision of basal cell carcinoma on the nose categorized by defect location into three nasal subunits.</p><p><strong>Methods: </strong>Anthropometric analysis was conducted on seven parameters using patients' photographs to compare changes between preoperative and postoperative measurements based on nasal subunits. Defect locations were classified as: (1) dorsum and sidewalls (D zone), (2) tip (T zone), and (3) alar lobule (A zone).</p><p><strong>Results: </strong>The greatest change in alar height asymmetry was observed in zone A. Changes in nasal tip projection ratio and nasofrontal angle were the most significant in zone T. No other measurements showed statistically significant differences among the three zones.</p><p><strong>Conclusions: </strong>Careful consideration is recommended when applying artificial dermis grafting in zones A and T. Conversely, zone D appears to be the most suitable for artificial dermis grafting.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Gastrostomy Tube Placement in Head and Neck Cancer Patients Undergoing Radiation or Chemoradiotherapy: A Systematic Review.","authors":"Jenny B Xiao, Abhiram Cherukupalli, Khanh Linh Tran, Eitan Prisman","doi":"10.1002/hed.28010","DOIUrl":"https://doi.org/10.1002/hed.28010","url":null,"abstract":"<p><strong>Background: </strong>Malnutrition is a major problem in head and neck cancer (HNC) with up to half of patients requiring gastrostomy tube (G-tube) placement. Predicting this need remains complex given mixed evidence surrounding its usage.</p><p><strong>Methods: </strong>A comprehensive search was performed to identify studies examining risk factors associated with G-tube placement following radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) in HNC patients.</p><p><strong>Results: </strong>Sixteen retrospective studies were included (n = 11 015). The overall prevalence of G-tube placement was 44% with 76% of patients receiving reactive G-tube placement. Pretreatment dysphagia, pretreatment BMI < 18.5, and tumors in the hypopharynx were significant predictive factors for prophylactic G-tube placement. Type of chemotherapy regimen, tumors in the nasopharynx, and cytokine changes were significant predictive factors for reactive G-tube placement.</p><p><strong>Conclusion: </strong>Several factors were identified that contribute to increased risk of G-tube placement and may guide current decision-making algorithms.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Preoperative Facial Nerve Weakness and Facial Nerve Outcomes in the Management of Patients With Parotid Metastases of Cutaneous Squamous Cell Carcinoma.","authors":"Vivian Lin, Michael Zhang, Ruta Gupta, Michael S Elliott, Jonathan R Clark, James J Wykes, Sydney Ch'ng, Kerwin F Shannon, Carsten E Palme, Tsu-Hui Low","doi":"10.1002/hed.28005","DOIUrl":"https://doi.org/10.1002/hed.28005","url":null,"abstract":"<p><strong>Background: </strong>Cutaneous squamous cell carcinomas (cSCC) metastasizing to the parotid gland can cause facial nerve (FN) dysfunction secondary to direct invasion, perineural spread, or surgical ablation. This study aims to characterize the prevalence of preoperative FN involvement in metastatic cSCC to the parotid and identify risk factors resulting in FN sacrifice.</p><p><strong>Methods: </strong>Patients with parotid metastases from cSCC, treated surgically with parotidectomy with curative intent were identified through a retrospective cohort analysis of a prospectively maintained Sydney Head and Neck database from 1992 to 2021.</p><p><strong>Results: </strong>Of 408 patients identified, 39 (10%) were found to have preoperative FN weakness, of which 41% underwent concurrent temporal bone resection compared to 9.1% for the overall cohort. All patients with preoperative FN weakness underwent FN sacrifice. FN sacrifice occurred in n = 145 (36%), of which 88 (61%) required sacrifice of a trunk or division. The 5-year disease free survival and disease specific survival was worse for patients requiring sacrifice of the FN trunk compared to no sacrifice, however there was no difference in survival for patients requiring sacrifice of the FN division or branch. We found those with > 23.5 mm parotid deposits had an odds ratio of 9.9 for FN sacrifice (95% CI 3.0-32.8, p < 0.001).</p><p><strong>Conclusions: </strong>Preoperative FN weakness was present in 10% of patients and 36% had some part of the FN sacrificed. There was no significant difference in outcomes for patients with and without preoperative FN weakness. Patients who undergo sacrifice of the FN trunk have worse survival compared to those not requiring FN sacrifice, however similar outcomes were observed in those requiring lessor degrees of FN sacrifice. The likelihood FN sacrifice rises with increasing parotid deposit size.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Management Update of Oral Leukoplakia: A Review From the American Head and Neck Society Cancer Prevention Service.","authors":"James C Gates, Marianne Abouyared, Yelizaveta Shnayder, D Gregory Farwell, Andrew Day, Faizan Alawi, Michael Moore, Andrew J Holcomb, Andrew Birkeland, Joel Epstein","doi":"10.1002/hed.28013","DOIUrl":"https://doi.org/10.1002/hed.28013","url":null,"abstract":"<p><strong>Background: </strong>Oral potentially malignant disorders (OPMDs) occur in up to 4%-5% of the population, of which oral leukoplakia (OL) is the most common subtype. Predicting high-risk OL remains a challenge. Early diagnosis and effective treatment are thought to be of paramount importance to improve outcomes.</p><p><strong>Methods: </strong>We searched PubMed and Clinicaltrials.gov data for updates in the clinical management of OL from 2015 to current.</p><p><strong>Results: </strong>Recent publication of large cohorts of patients with OL aids in counseling patients regarding risk of malignant transformation. Management for OL includes surveillance, excision, and laser surgery, as well as local and systemic approaches to chemoprevention. Several new entities show promise regarding candidate biomarkers, chemoprevention agents, and diagnostic adjuncts, though all require further validation.</p><p><strong>Conclusion: </strong>This update serves to further inform clinical management of OL and provide impetus for future investigations.</p><p><strong>Trial registration: </strong>NCT00099021, NCT00951379, NCT05727761, NCT05727761.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Prospective Study on Single-Port Robotic Tongue Base Resection for Sleep Apnea.","authors":"Yeonsu Jeong, Min-Seok Rha, Chang-Hoon Kim, Hyung-Ju Cho","doi":"10.1002/hed.28007","DOIUrl":"https://doi.org/10.1002/hed.28007","url":null,"abstract":"<p><strong>Background: </strong>This first prospective study evaluates the efficacy and safety of single-port transoral robotic surgery (SP TORS) for tongue base resection (TBR) in obstructive sleep apnea (OSA) patients.</p><p><strong>Methods: </strong>A single-center, single-surgeon clinical investigation enrolled 25 subjects from April 2021 to September 2022. Pre- and postsurgery polysomnography reports and standardized sleep quality assessments were collected. Surgical parameters and complications were documented.</p><p><strong>Results: </strong>According to Sher's success criteria (50% reduction in AHI and AHI < 20), the success rate was 76% (19/25 patients). Preoperative AHI decreased from 58.56 ± 26.40 to 18.19 ± 22.02 postsurgery. Symptoms such as foreign body sensation and taste dysfunction improved within 3 months. Major complications, including hemorrhage, occurred in two patients (8%).</p><p><strong>Conclusions: </strong>SP TORS TBR effectively manages OSA, significantly improving AHI outcomes and safety. Its precision and targeted tissue removal highlight its advantages over traditional methods, warranting further clinical investigation. Traial Registration: ClinicalTrials.gov identifier: NCT04795817.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypofractionated Accelerated Radiotherapy for Head and Neck Cancer in Fragile Patients.","authors":"Segado-Guillot Salvador, García-Anaya María Jesús, Toledo-Serrano María Dolores, Calvo-Tudela Ángel, Prieto-Granados Patricia, Torres-Tabanera María Dolores, Medina-Carmona José Antonio, Gómez-Millán Jaime","doi":"10.1002/hed.27989","DOIUrl":"https://doi.org/10.1002/hed.27989","url":null,"abstract":"<p><strong>Background: </strong>Radiotherapy combined with chemotherapy is the treatment of choice for locally advanced non-metastatic head and neck cancer. Elderly and frail patients cannot always tolerate this therapy and no clear guidelines exist for their treatment. This retrospective study aims to analyze the efficacy and safety of hypofractionated radiotherapy for these patients.</p><p><strong>Methods: </strong>A retrospective analysis of 65 patients treated with hypofractionated radiotherapy, using a regimen of 57.5 Gy in 23 fractions of 2.5 Gy.</p><p><strong>Results: </strong>Most patients completed the prescribed treatment. Overall survival at 2 and 5 years was 55% and 33%. Locoregional control at 2 and 5 years was 76% and 51%, respectively. Performance status was an independent prognostic factor (p = 0.05).</p><p><strong>Conclusions: </strong>This radiotherapy schedule was well tolerated, showing a high rate of locoregional control and shortening the overall treatment time. Prospective studies are necessary to establish the most effective treatment for frail patients.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unsuspected Malignant Mimicry From Topical Vitamin E and Micro Spike Roller.","authors":"Jacob Hauser, Traeden Wilson, Chelsea Huang, Paul Walker","doi":"10.1002/hed.27996","DOIUrl":"https://doi.org/10.1002/hed.27996","url":null,"abstract":"<p><strong>Background: </strong>Topical vitamin E is commonly used for its antioxidant properties in a rapidly expanding anti-aging market. Cutaneous reaction to vitamin E is rare and can present a difficult diagnosis.</p><p><strong>Methods: </strong>We report a unique case of a 46-year-old female who developed a severe cutaneous inflammatory chin lesion after topical use of vitamin E oil with a micro-spike roller. Clinical examination found a friable and fungating mass which prompted biopsy due to suspected malignancy. Pathology ruled out malignancy and revealed chronic inflammation with xanthogranulomatous-like features.</p><p><strong>Results: </strong>The lesion was significantly improved with Kenalog injection treatment over 18 months. A scar excision procedure further enhanced the lesion cosmetically.</p><p><strong>Conclusions: </strong>This case highlights the rarity and clinical diversity of vitamin E skin reactions, and their potential to mimic malignancies.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and the Survival Outcomes of Patients With Laryngeal Squamous Cell Cancer.","authors":"Cameron McCann, Rhona Hurley, Josh McGovern, Katrina Knight, Nicholas J W Rattray, Catriona M Douglas","doi":"10.1002/hed.27951","DOIUrl":"https://doi.org/10.1002/hed.27951","url":null,"abstract":"<p><strong>Background: </strong>Frailty increases the risk of mortality in the head and neck cancer population. This study examines the association between frailty and survival outcomes in patients with laryngeal squamous cell cancer (LSCC).</p><p><strong>Method: </strong>Retrospective data collection from patients in the West of Scotland diagnosed with LSCC between 2014 and 2020. The Modified Five Item Frailty Index (mFI-5) measures frailty and categorizes patients according to their level of frailty. Statistical tests used were the Mann-Whitney U-test or ANOVA for differences in means and survival analyses for overall survival time.</p><p><strong>Results: </strong>There were 867 patients included. Seventy-eight percent (n = 676) of patients were deemed frail. Median survival for \"not frail\" patients was 78 months and \"severely frail\" was 23 months. The palliative treatment group had worse overall survival outcomes compared to curative (hazard ratio (HR) of 7.96, p < 0.001).</p><p><strong>Conclusion: </strong>This study demonstrates frailty is common in patients with LSCC and leads to worse mortality and survival outcomes.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}