Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献_第4页

Prognosis After Discontinued Treatment due to Immune-Related Adverse Events in Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma. 复发性和转移性头颈部鳞状细胞癌因免疫相关不良事件而停止治疗后的预后。

IF 2.2 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-09-12 DOI: 10.1002/hed.70043

Hiromasa Ishihara, Yuki Asahi, Masashi Kuroki, Ken Saijo, Ryo Kawaura, Rina Kato, Manato Matsubara, Saki Akita, Tatsuhiko Yamada, Ryota Iinuma, Hiroshi Okuda, Hirofumi Shibata, Takenori Ogawa

{"title":"Prognosis After Discontinued Treatment due to Immune-Related Adverse Events in Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma.","authors":"Hiromasa Ishihara, Yuki Asahi, Masashi Kuroki, Ken Saijo, Ryo Kawaura, Rina Kato, Manato Matsubara, Saki Akita, Tatsuhiko Yamada, Ryota Iinuma, Hiroshi Okuda, Hirofumi Shibata, Takenori Ogawa","doi":"10.1002/hed.70043","DOIUrl":"https://doi.org/10.1002/hed.70043","url":null,"abstract":"Background: The prognostic impact of immune-related adverse events (irAEs) in recurrent/metastatic head and neck squamous cell carcinoma (RM-HNSCC) remains unclear, particularly after treatment discontinuation.Methods: This retrospective study included RM-HNSCC patients treated with nivolumab or pembrolizumab. The association between irAEs, treatment response, and prognosis was analyzed. To minimize immortal time bias, survival was assessed at multiple time points. Outcomes after permanent discontinuation due to irAEs were also evaluated.Results: Among 92 cases, 25 cases (27.2%) experienced irAEs. Cases that experienced irAEs showed better progression-free survival than those who did not experience irAEs. Eight cases permanently discontinued treatment due to irAEs, and six cases maintained tumor shrinkage after discontinuing ICI.Conclusions: In this study, irAEs were associated with a good prognosis. Furthermore, it was revealed that many of the cases in which treatment was permanently discontinued due to irAEs continued a durable response even after treatment ended.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Nomogram for Risk Stratification After Transoral Surgery in HPV-Related Oropharyngeal Cancer. hpv相关口咽癌经口手术后风险分层的预测Nomogram。

IF 2.2 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-09-12 DOI: 10.1002/hed.70038

Andrea Costantino, Vinidh Paleri, F Christopher Holsinger, Uthman Alamoudi, Bruce H Haughey, J Scott Magnuson

{"title":"Predictive Nomogram for Risk Stratification After Transoral Surgery in HPV-Related Oropharyngeal Cancer.","authors":"Andrea Costantino, Vinidh Paleri, F Christopher Holsinger, Uthman Alamoudi, Bruce H Haughey, J Scott Magnuson","doi":"10.1002/hed.70038","DOIUrl":"https://doi.org/10.1002/hed.70038","url":null,"abstract":"Background: This study develops a predictive model that stratifies patients with HPV-related oropharyngeal squamous cell carcinoma (OPSCC) by survival outcomes based on adjuvant treatment received following transoral surgery (TOS).Methods: Patients receiving primary TOS with or without adjuvant were included from the National Cancer Database. A predictive nomogram was constructed using a multivariable Cox regression model.Results: A total of 5569 patients were included. The model based on 11 demographic, socioeconomic, and clinical variables stratified patients into low-risk (57%), intermediate-risk (35.5%), and high-risk (7.5%) cohorts, with significant differences in survival between the risk groups. No association with better survival was found for adjuvant treatment in the low-risk group. A significant association between adjuvant treatment and improved survival was measured in the intermediate-risk and high-risk cohorts.Conclusions: This predictive model effectively stratified OPSCC patients by risk, revealing outcome differences based on adjuvant treatment. Further studies are required to validate these findings.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transoral Robotic Surgery (TORS) Versus Open Surgery for Recurrent Oropharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. 经口机器人手术（TORS）与开放手术治疗复发性口咽鳞状细胞癌：系统回顾和荟萃分析。

IF 2.2 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-09-10 DOI: 10.1002/hed.70042

Francisco Laxague, Drosa Zabihi-Pour, Claudia C Correa Roa, Josefina Principe, Adrian Mendez, Juan Manuel Fernandez Vila, Anthony C Nichols

{"title":"Transoral Robotic Surgery (TORS) Versus Open Surgery for Recurrent Oropharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.","authors":"Francisco Laxague, Drosa Zabihi-Pour, Claudia C Correa Roa, Josefina Principe, Adrian Mendez, Juan Manuel Fernandez Vila, Anthony C Nichols","doi":"10.1002/hed.70042","DOIUrl":"https://doi.org/10.1002/hed.70042","url":null,"abstract":"Background: Salvage surgery (SS) is one of the best treatment options for recurrent oropharyngeal squamous cell carcinoma (OPSCC) after prior definitive radiation.Methods: A Medline literature search of articles on open (OSS) and transoral robotic surgery (TORS) for the treatment of recurrent OPSCC was performed. Surgical, functional, and oncological outcomes were analyzed and compared.Results: A total of 18 studies including 567 (66.2%) patients undergoing OSS and 290 (33.8%) undergoing TORS were included. Patients undergoing TORS vs. OSS had early T- and N-classification tumors, p < 0.01, respectively. OSS patients had higher rates of feeding tube and tracheostomy dependence compared with TORS (p < 0.01). The mean 2-year overall survival in patients undergoing TORS was 68.5% versus 45.9% in the OSS group, p = 0.03.Conclusion: Patients undergoing TORS had smaller tumors and less advanced nodal disease. Furthermore, they developed less postoperative feeding tube and tracheostomy dependency, and had better 2-year overall survival than patients undergoing OSS.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoglossal Neuropathy in the Pathogenesis of Fibrosis-Related Late-Radiation Associated Dysphagia: A Correlative Analysis Utilizing Electromyography to Explore the Frequency of Clinical and Subclinical Neuropathy in a Pilot Dysphagia Trial. 舌下神经病变在纤维化相关晚期放射相关吞咽困难发病机制中的作用：在一项吞咽困难试点试验中利用肌电图探讨临床和亚临床神经病变频率的相关分析。

IF 2.2 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-09-10 DOI: 10.1002/hed.70024

Holly McMillan, Christine Okoro, Sheila Buoy, Karin Woodman, Nicolaas Anderson, Clifton Fuller, Stephen Y Lai, Katherine Hutcheson

{"title":"Hypoglossal Neuropathy in the Pathogenesis of Fibrosis-Related Late-Radiation Associated Dysphagia: A Correlative Analysis Utilizing Electromyography to Explore the Frequency of Clinical and Subclinical Neuropathy in a Pilot Dysphagia Trial.","authors":"Holly McMillan, Christine Okoro, Sheila Buoy, Karin Woodman, Nicolaas Anderson, Clifton Fuller, Stephen Y Lai, Katherine Hutcheson","doi":"10.1002/hed.70024","DOIUrl":"https://doi.org/10.1002/hed.70024","url":null,"abstract":"Background: Late radiation-associated dysphagia (late-RAD) commonly presents in patients with signs of hypoglossal neuropathy, with hallmark clinical features including lingual atrophy, deviation, and fasciculation. Gold-standard electromyography (EMG) has not been used to explore the frequency of hypoglossal neuropathy in patients with late-RAD.Methods: Exploratory post hoc secondary analysis of MANTLE trial (NCT03612531) was completed. The presence of cranial nerve XII (CN XII) neuropathy was classified by (1) features of clinical assessment as well as (2) intramuscular genioglossus EMG pre-MANTLE intervention in disease-free HNC survivors ≥ 2 years post-radiotherapy (RT) with grade ≥ 2 fibrosis and dysphagia.Results: All 13 patients with late-RAD (median 8.3 years post-RT) who consecutively underwent needle EMG had neurophysiological evidence of hypoglossal neuropathy, while 31% of neuropathy cases were subclinical without clear clinical signs of denervation. Exploratory subgroup analyses revealed worse function and fibrosis among late-RAD cases whose neuropathy had progressed to clinical stages.Conclusions: Findings suggest that hypoglossal neuropathy is universally present in patients with fibrosis-related late-RAD, supporting a hypothesis that cranial neuropathy is in the mechanistic pathway. Subclinical hypoglossal neuropathy is evident on EMG assessment before clinical presentation at earlier stages of functional impairment.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neoadjuvant Chemotherapy Followed by Surgery-A Promising Strategy to Reduce Morbidity in Locally Advanced Tongue Cancer. 手术后新辅助化疗-降低局部晚期舌癌发病率的一种有希望的策略。

IF 2.2 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-09-09 DOI: 10.1002/hed.70035

G A Deshpande, S Rai, A Singh, V Gautam, S Goyal, R Saha, S Tandon, M Gairola, S Upadhya, M Agarwal

{"title":"Neoadjuvant Chemotherapy Followed by Surgery-A Promising Strategy to Reduce Morbidity in Locally Advanced Tongue Cancer.","authors":"G A Deshpande, S Rai, A Singh, V Gautam, S Goyal, R Saha, S Tandon, M Gairola, S Upadhya, M Agarwal","doi":"10.1002/hed.70035","DOIUrl":"https://doi.org/10.1002/hed.70035","url":null,"abstract":"Background: Though neoadjuvant chemotherapy (NACT) has not improved survival in oral cancers, its role in tongue cancer remains uncertain.Methods: This was a retrospective study of patients with locally advanced oral tongue cancer (Stage III-IVB) to assess response rates, mandibular preservation, and surgical extent post-NACT, along with recurrence and survival outcomes.Results: Of 72 patients, 20 (27.8%) received NACT, while 52 (72.2%) underwent upfront surgery. In the NACT group, 15 (75%) received TPF chemotherapy for a median of 3 cycles. One patient (5%) had a complete response, and 13 (65%) had a partial response. The clinical benefit rate was 85%. Tumor downstaging occurred in 14 (70%) patients, with 6 (42.9%) requiring less extensive surgery. The mandibular preservation rate was 75%. The pathological complete response was 10%. Local and distant control rates, disease-free survival, and overall survival were comparable.Conclusion: Despite its retrospective design and small sample size, this study suggests that NACT can downstage tumors, improve response rates, and enable less extensive surgery in locally advanced tongue cancer.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flap Complications Following Maxillectomy, Reconstructive Surgery, and Postoperative Proton Radiotherapy: A Cohort Study and Considerations for Risk Mitigation. 上颌切除术、重建手术和术后质子放疗后皮瓣并发症：一项队列研究和降低风险的考虑

IF 2.2 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-09-08 DOI: 10.1002/hed.70040

Amir H Safavi, Fan Yang, Yingzhi Wu, Ian Ganly, Evan Matros, Geoffrey E Hespe, Tony K W Hung, Daphna Y Gelblum, Marc A Cohen, Richard J Wong, Brian Shen, Kevin Sine, Dong Han, Dennis Mah, Nancy Y Lee

{"title":"Flap Complications Following Maxillectomy, Reconstructive Surgery, and Postoperative Proton Radiotherapy: A Cohort Study and Considerations for Risk Mitigation.","authors":"Amir H Safavi, Fan Yang, Yingzhi Wu, Ian Ganly, Evan Matros, Geoffrey E Hespe, Tony K W Hung, Daphna Y Gelblum, Marc A Cohen, Richard J Wong, Brian Shen, Kevin Sine, Dong Han, Dennis Mah, Nancy Y Lee","doi":"10.1002/hed.70040","DOIUrl":"https://doi.org/10.1002/hed.70040","url":null,"abstract":"Background: Flap complications following maxillectomy, reconstruction, and adjuvant proton beam therapy (PBT) for primary maxillary and sinonasal malignancies are not well described.Methods: This retrospective cohort study included consecutive patients treated between 2016 and 2023 from a single-institutional database.Results: Thirteen patients were identified with a median follow-up of 26 months. No immediate post-operative complications occurred, with a median time between surgery and PBT of 61 days. Nine patients (69.2%) had high-risk postoperative pathology and required 66+ Gy(RBE), including five (38.5%) with gross disease receiving 70 Gy(RBE). Flap necrosis and fistulization occurred in three patients (23.1%) following PBT (median time from PBT to complication, 112 days). Higher flap mean and minimum dose, flap volume receiving at least 66 Gy[RBE], and minimum dose to 50% flap volume were associated with complications.Conclusions: Careful patient selection and planning strategies should be considered to mitigate flap complication risk following adjuvant PBT for high-risk post-operative pathology.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiparametric Ultrasound for Preoperative Assessment of Parotid Tumors: A Novel Diagnostic Pathway. 多参数超声用于腮腺肿瘤术前评估：一种新的诊断途径。

IF 2.2 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-09-06 DOI: 10.1002/hed.70036

Wakonig Katharina Margherita, Lerchbaumer Markus Herbert, Arens Philipp, Olze Heidi, Dommerich Steffen, Fischer Thomas

{"title":"Multiparametric Ultrasound for Preoperative Assessment of Parotid Tumors: A Novel Diagnostic Pathway.","authors":"Wakonig Katharina Margherita, Lerchbaumer Markus Herbert, Arens Philipp, Olze Heidi, Dommerich Steffen, Fischer Thomas","doi":"10.1002/hed.70036","DOIUrl":"https://doi.org/10.1002/hed.70036","url":null,"abstract":"Background: Accurate preoperative differentiation of parotid gland tumors (PGTs) is essential for facial nerve preservation. This study evaluates a novel, real-time multiparametric ultrasound (mpUS) approach combining B-mode, shear wave elastography (SWE), and contrast-enhanced ultrasound (CEUS), based on qualitative image interpretation.Methods: Eighty-nine patients with 91 PGTs underwent mpUS prior to surgery or ultrasound-guided biopsy. Two blinded experts independently reviewed the images and reached consensus through real-time discussion. Only qualitative features were assessed. Histopathology served as the reference.Results: mpUS achieved 83% sensitivity (95% CI: 62.6-94.0), 94% specificity (95% CI: 84.3-98.1), and 91% accuracy (95% CI: 82.4-96.3). CEUS and SWE provided complementary perfusion and stiffness data. CCDS was excluded due to limited value.Conclusion: mpUS improves diagnostic accuracy compared to single-modality US and supports early, targeted treatment. Limitations include the small number of malignancies, single-center design, and qualitative evaluation. Broader use may require training and equipment access.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Wound Coverage to Functional Healing: A Narrative Review of Biomaterial Applications in Head and Neck Mucosal Defects. 从伤口覆盖到功能性愈合：生物材料在头颈部粘膜缺损中的应用述评。

IF 2.2 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-09-05 DOI: 10.1002/hed.70037

Kohei Okuyama, Kala Chand Debnath, Shajedul Islam, Souichi Yanamoto

{"title":"From Wound Coverage to Functional Healing: A Narrative Review of Biomaterial Applications in Head and Neck Mucosal Defects.","authors":"Kohei Okuyama, Kala Chand Debnath, Shajedul Islam, Souichi Yanamoto","doi":"10.1002/hed.70037","DOIUrl":"https://doi.org/10.1002/hed.70037","url":null,"abstract":"Background: Reconstruction of head and neck mucosal defects presents unique challenges due to the anatomical complexity and functional demands of the region. Artificial biomaterials such as collagen and polyglycolic acid (PGA) sheets have gained clinical traction owing to their ease of use and reduced surgical burden. However, limitations such as local inflammation, degradation-related complications, and mechanical instability-particularly in highly mobile areas like the tongue-continue to hinder their broader application.Methods: A narrative review was performed, categorizing currently available biomaterials and evaluating their clinical performance, with particular attention to inflammatory responses and wound healing outcomes. Emerging materials, including fish skin-derived matrices, ex vivo-produced oral mucosal equivalents (EVPOME), bioactive glasses (BAG), PLGA-based drug delivery systems, and electrospun membranes, are also explored.Results: These next-generation biomaterials aim to provide more than passive wound coverage by incorporating functionalities such as anti-inflammatory effects, antimicrobial activity, and sustained drug release.Conclusions: Infection control, mucosal mobility, and material customization remain significant challenges. Biomaterials capable of actively regulating inflammation and promoting functional mucosal regeneration are garnering increasing interest as promising platforms, with high expectations for their future development, preclinical validation, and eventual clinical application. This review provides a comprehensive overview of both current and future biomaterial strategies for head and neck mucosal repair, and outlines future directions for the development of more effective and functional biomaterials.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-Dimensional Presentation of Tongue Squamous Cell Carcinoma Histopathology and Magnetic Resonance Imaging-A Novel Image Fusion Method. 舌鳞状细胞癌组织病理学和磁共振成像的三维表现——一种新的图像融合方法。

IF 2.2 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-09-04 DOI: 10.1002/hed.70032

Anne Koivuholma, Heli J Sistonen, Katri Aro, Alexandria L Irace, Antti Mäkitie, Jaana Hagström, Timo Atula

{"title":"Three-Dimensional Presentation of Tongue Squamous Cell Carcinoma Histopathology and Magnetic Resonance Imaging-A Novel Image Fusion Method.","authors":"Anne Koivuholma, Heli J Sistonen, Katri Aro, Alexandria L Irace, Antti Mäkitie, Jaana Hagström, Timo Atula","doi":"10.1002/hed.70032","DOIUrl":"https://doi.org/10.1002/hed.70032","url":null,"abstract":"Background: Three-dimensional (3D) modeling has been used in the management of bony head and neck tumors, but not in soft tissue tumors. Currently, histopathological findings of oral squamous cell carcinomas (OSCC) are presented as two-dimensional images. Previously, we developed a 3D image fusion method that presents tumor histopathology and MRI in 3D form. In this study, we sought to test our method in a series of OSCCs.Methods: A 3D table scanner, 3D Slicer software, and 3D modeling software were used to produce 3D image fusions of nine OSCCs.Results: Nine OSCCs are presented as digital, 3D image fusions, showing the resected specimen and the tumor within based on histopathology and MRI.Conclusions: The fused 3D model allows for a better visual understanding of tumor orientation within the resected specimen, provides a tool to compare tumor volume and dimensions between MRI images and histopathology slides, and facilitates multidisciplinary discussion.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Stratified Surgical Margins on Survival Outcomes in Oral Cavity Squamous Cell Carcinoma: A Multicenter Analysis. 分层手术切缘对口腔鳞状细胞癌患者生存结局的影响：一项多中心分析。

IF 2.2 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-09-04 DOI: 10.1002/hed.70029

Timothy Liu, Jonathan Clark, Michael David, Andrew Schache, Mandeep S Bajwa, Tsu-Hui Low, Ruta Gupta, Martin D Batstone

{"title":"The Impact of Stratified Surgical Margins on Survival Outcomes in Oral Cavity Squamous Cell Carcinoma: A Multicenter Analysis.","authors":"Timothy Liu, Jonathan Clark, Michael David, Andrew Schache, Mandeep S Bajwa, Tsu-Hui Low, Ruta Gupta, Martin D Batstone","doi":"10.1002/hed.70029","DOIUrl":"https://doi.org/10.1002/hed.70029","url":null,"abstract":"Background: This multicenter study examines the impact of stratified surgical margins on treatment outcomes in oral SCC.Methods: Margins were stratified into 1 mm increments from 0 to ≥ 5 mm. Outcomes included local recurrence, overall and disease-specific survivals. Sub-analyses assessed the impact of margin status by risk factors, oral subsites, and peripheral versus deep margins.Results: Among 2737 patients, ≥ 2 to < 3 mm margins were associated with improved outcomes compared to 0 mm. Further benefits were observed in the ≥ 4 to < 5 mm group. The differences between these two groups were not statistically significant. Improved outcomes were observed with ≥ 2 mm deep margins, but not for peripheral margins. High-risk tumors had better overall and disease-specific survivals with ≥ 2 mm margins. Subsites of the tongue, palate, mandible, and floor of the mouth had improved local control with ≥ 2 mm margins.Conclusion: Margins beyond 4 mm do not confer additional oncological benefit, while achieving ≥ 2 mm, especially in deep margins or high-risk tumors, is critical for optimal outcomes.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0