Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献

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Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta-analysis 头颈癌老年营养风险指数的预后效用:系统回顾和荟萃分析。
IF 2.3 3区 医学
Yao-Te Tsai MD, Liang-Tseng Kuo MD, Yun-Ting Wang MD, Andrea De Vito PhD, Sheng-Po Hao MD, Ku-Hao Fang MD, Yi-Chan Lee MD, Kuan-Yin Chen DDS, Chia-Hsuan Lai MD, Yuan-Hsiung Tsai PhD, Ethan I. Huang PhD, Ming-Shao Tsai MD, Cheng-Ming Hsu PhD, Geng-He Chang PhD, Chih-Wei Luan MD
{"title":"Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta-analysis","authors":"Yao-Te Tsai MD,&nbsp;Liang-Tseng Kuo MD,&nbsp;Yun-Ting Wang MD,&nbsp;Andrea De Vito PhD,&nbsp;Sheng-Po Hao MD,&nbsp;Ku-Hao Fang MD,&nbsp;Yi-Chan Lee MD,&nbsp;Kuan-Yin Chen DDS,&nbsp;Chia-Hsuan Lai MD,&nbsp;Yuan-Hsiung Tsai PhD,&nbsp;Ethan I. Huang PhD,&nbsp;Ming-Shao Tsai MD,&nbsp;Cheng-Ming Hsu PhD,&nbsp;Geng-He Chang PhD,&nbsp;Chih-Wei Luan MD","doi":"10.1002/hed.27842","DOIUrl":"10.1002/hed.27842","url":null,"abstract":"<p>We conducted a systematic review of the literature to assess the potential prognostic utility of geriatric nutritional risk index (GNRI) for head and neck cancer (HNC). We selected studies and extracted data after searching the Cochrane Library, EMBASE, and PubMed databases. The associations between GNRI and survival outcomes were explored by calculating hazard ratios (HRs) and 95% confidence intervals (CIs) through a random-effects meta-analysis. We included 11 studies that involved 2887 patients with HNC. The combined HR demonstrated significant associations of low GNRI with unfavorable progression-free survival (HR = 1.87, 95% CI = 1.32–2.65, <i>p</i> &lt; 0.001) and overall survival (HR = 3.04, 95% CI = 2.30–4.03, <i>p</i> &lt; 0.001). The association between the GNRI and overall survival persisted across various subgroups. The GNRI could serve as a valuable prognostic biomarker for patients with HNC. Low GNRI scores are significantly associated with unfavorable survival outcomes.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parotidectomy for deep lobe pleomorphic adenomas is associated with higher rates of complications and recurrence. 腮腺切除术治疗深叶多形性腺瘤的并发症和复发率较高。
IF 2.9 3区 医学
Helena Levyn, Tejas Subramanian, Alana Eagan, Nora Katabi, Johanna Goldberg, Daniel W Scholfield, Giovanna L Caxeiro, Richard J Wong, Marc A Cohen, Jatin P Shah, Snehal G Patel, Ian Ganly
{"title":"Parotidectomy for deep lobe pleomorphic adenomas is associated with higher rates of complications and recurrence.","authors":"Helena Levyn, Tejas Subramanian, Alana Eagan, Nora Katabi, Johanna Goldberg, Daniel W Scholfield, Giovanna L Caxeiro, Richard J Wong, Marc A Cohen, Jatin P Shah, Snehal G Patel, Ian Ganly","doi":"10.1002/hed.27840","DOIUrl":"https://doi.org/10.1002/hed.27840","url":null,"abstract":"<p><strong>Background: </strong>Pleomorphic adenoma (PA) is a common parotid tumor, yet due to the relative rarity of deep lobe PA (DLPA), there is a paucity of information about its clinical presentation and surgical outcomes.</p><p><strong>Methods: </strong>We reviewed the charts of patients with previously untreated parotid PA between the years 1990 and 2015. Clinical parameters and surgical outcomes were compared between superficial lobe PA (SLPA) and DLPA.</p><p><strong>Results: </strong>The cohort comprised 147 cases of DLPA and 222 cases of SLPA. DLPA were larger (median 2.6 cm vs. 2.0 cm, p < 0.001), more often discovered incidentally on imaging (33%, n = 48) and had unique presentations (pharyngeal mass, dysphagia, otalgia). Postsurgical complications were more frequently observed in DLPA (41% vs. 30% in SLPA, p = 0.025), mainly transient facial nerve weakness. DLPA also showed higher recurrence rates (n = 6, 4.1% vs. n = 1, 0.4%, p = 0.016).</p><p><strong>Conclusions: </strong>Parotidectomy for DLPA carries a higher risk of complications and recurrence compared to SLPA.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and external validation of a head and neck cancer risk prediction model 头颈部癌症风险预测模型的开发和外部验证。
IF 2.3 3区 医学
Craig D. L. Smith BSc, Alex D. McMahon PhD, Donald M. Lyall PhD, Mariel Goulart MSc, Gareth J. Inman PhD, Al Ross PhD, Mark Gormley PhD, Tom Dudding PhD, Gary J. Macfarlane PhD, Max Robinson PhD, Lorenzo Richiardi PhD, Diego Serraino PhD, Jerry Polesel PhD, Cristina Canova PhD, Wolfgang Ahrens PhD, Claire M. Healy PhD, Pagona Lagiou PhD, Ivana Holcatova PhD, Laia Alemany PhD, Ariana Znoar PhD, Tim Waterboer PhD, Paul Brennan PhD, Shama Virani PhD, David I. Conway PhD
{"title":"Development and external validation of a head and neck cancer risk prediction model","authors":"Craig D. L. Smith BSc,&nbsp;Alex D. McMahon PhD,&nbsp;Donald M. Lyall PhD,&nbsp;Mariel Goulart MSc,&nbsp;Gareth J. Inman PhD,&nbsp;Al Ross PhD,&nbsp;Mark Gormley PhD,&nbsp;Tom Dudding PhD,&nbsp;Gary J. Macfarlane PhD,&nbsp;Max Robinson PhD,&nbsp;Lorenzo Richiardi PhD,&nbsp;Diego Serraino PhD,&nbsp;Jerry Polesel PhD,&nbsp;Cristina Canova PhD,&nbsp;Wolfgang Ahrens PhD,&nbsp;Claire M. Healy PhD,&nbsp;Pagona Lagiou PhD,&nbsp;Ivana Holcatova PhD,&nbsp;Laia Alemany PhD,&nbsp;Ariana Znoar PhD,&nbsp;Tim Waterboer PhD,&nbsp;Paul Brennan PhD,&nbsp;Shama Virani PhD,&nbsp;David I. Conway PhD","doi":"10.1002/hed.27834","DOIUrl":"10.1002/hed.27834","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Head and neck cancer (HNC) incidence is on the rise, often diagnosed at late stage and associated with poor prognoses. Risk prediction tools have a potential role in prevention and early detection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The IARC-ARCAGE European case–control study was used as the model development dataset. A clinical HNC risk prediction model using behavioral and demographic predictors was developed via multivariable logistic regression analyses. The model was then externally validated in the UK Biobank cohort. Model performance was tested using discrimination and calibration metrics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>1926 HNC cases and 2043 controls were used for the development of the model. The development dataset model including sociodemographic, smoking, and alcohol variables had moderate discrimination, with an area under curve (AUC) value of 0.75 (95% CI, 0.74–0.77); the calibration slope (0.75) and tests were suggestive of good calibration. 384 616 UK Biobank participants (with 1177 HNC cases) were available for external validation of the model. Upon external validation, the model had an AUC of 0.62 (95% CI, 0.61–0.64).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We developed and externally validated a HNC risk prediction model using the ARCAGE and UK Biobank studies, respectively. This model had moderate performance in the development population and acceptable performance in the validation dataset. Demographics and risk behaviors are strong predictors of HNC, and this model may be a helpful tool in primary dental care settings to promote prevention and determine recall intervals for dental examination. Future addition of HPV serology or genetic factors could further enhance individual risk prediction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.27834","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of submental island flap closing advanced mandibular MRONJ lesion in malignancy patients 下颌岛状皮瓣关闭恶性肿瘤患者晚期下颌骨 MRONJ 病变的疗效。
IF 2.3 3区 医学
Hongyuan Huang BS, Qiao Qiao PhD, Ning Zhao PhD, Ying Zhou BS, Yiwen Zou BS, Qingxiang Li PhD, Siyuan Li MASc, Biao Zhou MASc, Yi Zhang MD, Chuanbin Guo MD, Yuxing Guo MD
{"title":"Efficacy of submental island flap closing advanced mandibular MRONJ lesion in malignancy patients","authors":"Hongyuan Huang BS,&nbsp;Qiao Qiao PhD,&nbsp;Ning Zhao PhD,&nbsp;Ying Zhou BS,&nbsp;Yiwen Zou BS,&nbsp;Qingxiang Li PhD,&nbsp;Siyuan Li MASc,&nbsp;Biao Zhou MASc,&nbsp;Yi Zhang MD,&nbsp;Chuanbin Guo MD,&nbsp;Yuxing Guo MD","doi":"10.1002/hed.27837","DOIUrl":"10.1002/hed.27837","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study evaluated the effectiveness of a submental island flap in closing advanced mandibular medication-related osteonecrosis of the jaw (MRONJ) wounds in patients with malignant tumors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Subjects and methods</h3>\u0000 \u0000 <p>A total of 85 patients with stage II and III MRONJ of mandible with malignant tumor as their primary disease were retrospectively analyzed. All patients underwent surgical treatment, and the soft tissue wound closure was performed either with a submental island flap (SIF) or mucoperiosteal flap (MF). Univariate and multifactorial models were applied to analyze the factors influencing patients' prognosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Univariate analysis (<i>p</i> = 0.004, OR 0.075–0.575, 95% CI) and binary logistic regression (<i>p</i> = 0.017, OR 0.032–0.713, 95% CI) suggested that the surgical prognosis of SIF wound closure was significantly better than that of MF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Closure of wound after resection of mandibular MRONJ lesions in patients with malignant tumors using SIF had a better clinical prognosis compared with MF.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor desmoplasia outperforms preoperative serum calcitonin as surgical biomarker in sporadic medullary thyroid cancer. 作为散发性甲状腺髓样癌的手术生物标志物,肿瘤脱落细胞的作用优于术前血清降钙素。
IF 2.9 3区 医学
Andreas Machens, Kerstin Lorenz, Claudia Bensch, Claudia Wickenhauser, Henning Dralle
{"title":"Tumor desmoplasia outperforms preoperative serum calcitonin as surgical biomarker in sporadic medullary thyroid cancer.","authors":"Andreas Machens, Kerstin Lorenz, Claudia Bensch, Claudia Wickenhauser, Henning Dralle","doi":"10.1002/hed.27827","DOIUrl":"https://doi.org/10.1002/hed.27827","url":null,"abstract":"<p><strong>Background: </strong>Conceptually, thyroid tumor desmoplasia may be better suited for excluding node metastases in sporadic MTC than preoperative serum calcitonin levels.</p><p><strong>Methods: </strong>This analysis included 181 patients with unilateral sporadic MTC graded on the 7-grade desmoplasia scale after thyroidectomy and neck dissection.</p><p><strong>Results: </strong>When thyroid tumor desmoplasia reached 1% and ≥50%, node metastases increased from 0% to 7% (median of 0 metastases) and 83% (median of 7.5 metastases), microscopic lymphatic invasion from 0% to 3% and 35%, extrathyroid extension from 0% to 5% and 22%, and extranodal growth from 0% to 0% and 44%, whereas biochemical cure declined from 100% to 95% and 25%. Thyroid tumor diameters and basal calcitonin overlapped widely among the seven desmoplasia groups, precluding differentiation by thyroid tumor size or serum calcitonin levels.</p><p><strong>Conclusions: </strong>Thyroid tumor desmoplasia, unlike serum calcitonin levels, discriminates extremely well between node-negative and node-positive sporadic MTC, opening new avenues for precision surgery.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microvascular reconstruction of midface osteoradionecrosis. 面中部骨坏死的微血管重建术
IF 2.9 3区 医学
Larissa Sweeny, Neeraja Konuthula, Ryan Jackson, Mark K Wax, Joseph M Curry, Sara Yang, Dev Amin, Anne C Kane, Steve B Cannady, Kendall Tasche, Michael DiLeo, Daniel Lander, Alexandra E Kejner, Patrik Pipkorn
{"title":"Microvascular reconstruction of midface osteoradionecrosis.","authors":"Larissa Sweeny, Neeraja Konuthula, Ryan Jackson, Mark K Wax, Joseph M Curry, Sara Yang, Dev Amin, Anne C Kane, Steve B Cannady, Kendall Tasche, Michael DiLeo, Daniel Lander, Alexandra E Kejner, Patrik Pipkorn","doi":"10.1002/hed.27824","DOIUrl":"https://doi.org/10.1002/hed.27824","url":null,"abstract":"<p><strong>Background: </strong>Head and neck osteoradionecrosis (ORN) of the midface requiring free flap (FF) reconstruction is uncommon. This multi-institutional study was designed to review outcomes for this rare patient population.</p><p><strong>Methods: </strong>Retrospective multi-institutional review of FF reconstruction for midface ORN (2005-2022; n = 54).</p><p><strong>Results: </strong>The FF survival rate was 87% (n = 54). Patients were less likely to be tolerating a regular diet at 3 months postoperative if they had a preoperative history of prior head and surgery (80% vs. 95%; p = 0.02), a pathologic fracture (50% vs. 90%; p = 0.04), exposed bone intraorally (43% vs. 94%; p = 0.002), or a fistula (67% vs. 96%; p = 0.03). Mean albumin was higher in patients whose FF survived (3.6 ± 0.5 vs. 2.7 ± 1.4; p = 0.03). Patients with low prealbumin were more likely to undergo a hematoma evacuation (27% vs. 0%; p = 0.02).</p><p><strong>Conclusion: </strong>In this series of midface ORN requiring FF reconstruction preoperative nutritional status impacted postoperative complications. Preoperative occurrence of a fistula, pathologic fracture, and intraoral bone exposure correlated with decreased tolerance of a regular diet following reconstruction.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Free fibula mandible reconstruction for osteoradionecrosis is more challenging than for primary cancer. 与原发性癌症相比,骨软化症的游离腓骨下颌骨重建更具挑战性。
IF 2.9 3区 医学
Z-Hye Lee, John W Shuck, Rene D Largo, Edward I Chang, Matthew M Hanasono, Peirong Yu, Patrick B Garvey
{"title":"Free fibula mandible reconstruction for osteoradionecrosis is more challenging than for primary cancer.","authors":"Z-Hye Lee, John W Shuck, Rene D Largo, Edward I Chang, Matthew M Hanasono, Peirong Yu, Patrick B Garvey","doi":"10.1002/hed.27823","DOIUrl":"https://doi.org/10.1002/hed.27823","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoradionecrosis (ORN) of the mandible is an unfortunate potential sequela of radiotherapy for head and neck cancer. In advanced cases of ORN, mandibulectomy, and free fibula flap reconstruction are required. We hypothesized that patients undergoing fibula free flap reconstruction and mandibulectomy for ORN pose unique challenges and experience more complications than patients undergoing fibula free flaps after oncologic mandibulectomy.</p><p><strong>Methods: </strong>After IRB approval, we created a database of all free fibula flaps for mandible reconstruction from April 2005 through February 2019. Medical records were retrospectively reviewed for patient and surgical characteristics and postoperative outcomes.</p><p><strong>Results: </strong>Four-hundred seventy-nine patients met the inclusion criteria (168 ORN vs. 311 non-ORN patients). Propensity-matching was performed based on age, BMI, smoking status, preoperative chemotherapy, and virtual surgery planning use, which yielded 159 patients in each group. ORN patients received more double-skin-island fibula flaps than non-OR patients (20.8% vs. 5.7%, p < 0.001). Recipient artery other than the facial artery was utilized more commonly in ORN patients (42.1% vs. 17.0%, p < 0.001). In the unmatched cohort, ORN patients had higher rates of delayed wound healing (26.2% vs. 16.8%, p = 0.01) and surgical site infections (21.4% vs. 13.2%, p = 0.02). Rates of flap loss, return to the operating room, hematoma, operative time, and length of stay were similar between the groups. On logistic regression analysis, osteoradionecrosis was an independent risk factor for delayed wound healing.</p><p><strong>Conclusion: </strong>Based on these data, mandibular reconstruction with fibula flaps for osteoradionecrosis appears more complicated than mandible reconstruction following de novo cancer resection. Surgeons should anticipate employing two skin islands for intraoral and extraoral resurfacing, utilizing unconventional recipient vessels, and managing the delayed wound healing that ensues more commonly than non-ORN patients.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a plant-based surgical training model for fluorescence-guided cancer surgery 开发基于植物的荧光引导癌症手术训练模型。
IF 2.3 3区 医学
Mayu Shigeyama MD, Naoki Nishio MD, PhD, Akihisa Wada MD, PhD, Sohei Mitani MD, PhD, Gaku Morimoto MSc, Sayaka Yokoi MD, PhD, Nobuaki Mukoyama MD, PhD, Mai Yokoi MD, Stan van Keulen MD, DDS, PhD, Eben Rosenthal MD, Michihiko Sone MD, PhD
{"title":"Development of a plant-based surgical training model for fluorescence-guided cancer surgery","authors":"Mayu Shigeyama MD,&nbsp;Naoki Nishio MD, PhD,&nbsp;Akihisa Wada MD, PhD,&nbsp;Sohei Mitani MD, PhD,&nbsp;Gaku Morimoto MSc,&nbsp;Sayaka Yokoi MD, PhD,&nbsp;Nobuaki Mukoyama MD, PhD,&nbsp;Mai Yokoi MD,&nbsp;Stan van Keulen MD, DDS, PhD,&nbsp;Eben Rosenthal MD,&nbsp;Michihiko Sone MD, PhD","doi":"10.1002/hed.27835","DOIUrl":"10.1002/hed.27835","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Fluorescence-guided surgery (FGS) can help surgeons to discriminate tumor tissue from adjacent normal tissues using fluorescent tracers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We developed a surgical training model, manufactured using sustainable vegetable organic material with indocyanine green (ICG)-containing “tumor.” Surgeons evaluated the model with both the closed-field and endoscopic fluorescence imaging devices and assessed its efficacy to identify residual tumor after enucleation using electrocautery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Strong correlations of fluorescence were obtained at all working distance (3, 5, 7, and 10 cm), showing the robustness of fluorescence signal for the closed-field and endoscopic fluorescence imaging devices. The higher fluorescence signals were obtained in the wound bed in the closed-field fluorescence imaging device and the residual tumor could be clearly identified by fluorescence endoscopy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our FGS training model may provide experience for surgeons unfamiliar with optical surgery and subsequent tissue interactions. The model seemed particularly helpful in teaching surgeons the principles of FGS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.27835","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of upfront neck dissection in definitive radiotherapy for locally advanced hypopharyngeal squamous cell carcinoma: A single-center retrospective analysis. 局部晚期下咽鳞状细胞癌确定性放疗中前期颈部切除术的作用:单中心回顾性分析。
IF 2.9 3区 医学
Atsuto Katano, Hideomi Yamashita
{"title":"The role of upfront neck dissection in definitive radiotherapy for locally advanced hypopharyngeal squamous cell carcinoma: A single-center retrospective analysis.","authors":"Atsuto Katano, Hideomi Yamashita","doi":"10.1002/hed.27839","DOIUrl":"https://doi.org/10.1002/hed.27839","url":null,"abstract":"<p><strong>Background: </strong>Hypopharyngeal cancer, constituting 3%-5% of head and neck cancers, predominantly presents as squamous cell carcinoma, with a 5-year overall survival rate of approximately 40%. Treatment modalities for locally advanced cases include chemoradiotherapy; however, the role of upfront neck dissection (UND) remains controversial. This study aimed to investigate the effect of UND on definitive radiotherapy in locally advanced hypopharyngeal carcinoma.</p><p><strong>Methods: </strong>This retrospective analysis included consecutive patients with locally advanced hypopharyngeal squamous cell carcinoma who were treated in our department between January 2007 and June 2023. All patients underwent definitive radiotherapy (dRT) at a total dose of 70 Gy in 35 fractions. The patients were categorized into two groups: dRT (radiotherapy with or without chemotherapy) and UND-dRT (surgical neck dissection followed by radiotherapy). Univariate Cox models and multivariate analyses were conducted to investigate the independent prognostic factors for overall survival and locoregional control rate.</p><p><strong>Results: </strong>This study included 115 patients, predominantly male (109/115), with a median age of 66 years. Clinical stage and chemotherapy distribution differed significantly between the dRT and UND-dRT groups. The 3-year overall survival and locoregional control rates for all patients were 63.8% and was 63.3%, respectively. The UND-dRT group exhibited a trend toward improved locoregional control, although this difference was not statistically significant. The multivariate analysis revealed that UND was an independent factor significantly associated with improved overall survival and locoregional control.</p><p><strong>Conclusion: </strong>This study provided evidence supporting the effectiveness of UND in conjunction with definitive radiotherapy for locally advanced hypopharyngeal carcinoma. Future research should focus on validating and refining these findings through well-designed prospective multicenter trials.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Salvage total laryngectomy for squamous cell carcinoma of the larynx and hypopharynx: Validated prognostic nomograms predicting oncological outcomes” 喉和下咽鳞状细胞癌抢救性全喉切除术:经过验证的预测肿瘤预后的提名图"。
IF 2.3 3区 医学
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