Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献

{"title":"Risk of Malignant Transformation of Oral Lichen Planus and Oral Lichenoid Lesions: A Single Centre, 10-Year Review.","authors":"Kelsey V Won, Karl K Cuddy, Deepika Chugh, Marco Magalhaes","doi":"10.1002/hed.28070","DOIUrl":"https://doi.org/10.1002/hed.28070","url":null,"abstract":"<p><strong>Background: </strong>Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are common chronic inflammatory diseases associated with malignant transformation. Risk factors associated with malignant transformation of OLP and OLL are not well defined.</p><p><strong>Methods: </strong>A retrospective chart review assessed risk factors for progression of OLP and OLL to oral epithelial dysplasia (OED) or oral squamous cell carcinoma (OSCC) at a tertiary care centre in Toronto, Canada.</p><p><strong>Results: </strong>Five-hundred-fifty-five patients identified with biopsy proven OLP or OLL met the inclusion criteria. In total, 3.2% (n = 18) progressed to OED (1.8%, n = 10) or OSCC (1.4%, n = 8). Risk factors associated with transformation included the plaque-like subtype (OR = 40.33, p < 0.001) and lesions located on the tongue (OR = 6.81, p = 0.008).</p><p><strong>Conclusions: </strong>Clinical examination to identify lesion subtype and location provides useful indicators for risk of progression in patients with OLL and OLP.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Diagnostic Value of 18F-FDG PET/CT Versus Diffusion-Weighted MRI in Detection of Residual or Recurrent Tumors After Definitive (Chemo) Radiotherapy for Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: A Prospective Study”","authors":"","doi":"10.1002/hed.28069","DOIUrl":"10.1002/hed.28069","url":null,"abstract":"<p>S. Y. Kim, D. Crook, J. Rosskopf, and J.-H. Lee, “Diagnostic Value of 18F-FDG PET/CT Versus Diffusion-Weighted MRI in Detection of Residual or Recurrent Tumors After Definitive (Chemo) Radiotherapy for Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: A Prospective Study,” <i>Head &amp; Neck</i> 46, no. 9 (2024): 2284–2291, https://doi.org/10.1002/hed.27796.</p><p>In the author list section, the order of authors was incorrect. The correct order is “Crook D, Rosskopf J, Kim SY, Lee JH.” Crook D should be the first author, Kim SY and Lee JH should be the co-last authors, co-corresponding authors.</p><p>Therefore, the indications of author list and affiliation should read:</p><p>David Cook¹, Johannes Rosskopf^2,3, Soung Yung Kim^1,*, Jung-Hyun Lee^4,*</p><p>¹Department of Radiology, Spital Muri, Muri, Switzerland</p><p>²BKH Günzburg, Günzburg, Germany</p><p>³Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Ulm, Germany</p><p>⁴Department of Life Science, University of Seoul, Seoul, Republic of Korea</p><p>*Co-last authors and co-corresponding authors</p><p>We apologize for this error.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 3","pages":"1065"},"PeriodicalIF":2.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.28069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Local Extent of Tumor on the Survival Outcomes for Surgically Treated Tongue Cancers","authors":"Arjun Gurmeet Singh,&nbsp;Shwetabh Sinha,&nbsp;Rathan Shetty,&nbsp;Poonam Joshi,&nbsp;Sudhir Vasudevan Nair,&nbsp;Pankaj Chaturvedi","doi":"10.1002/hed.28072","DOIUrl":"10.1002/hed.28072","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The current classification of tongue cancers does not discriminate stages based on factors of local spread.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Integrating factors of local spread that impact disease-specific survival (DSS) in a modified classification to improve prognostication compared with the current staging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This was a retrospective analysis of 399 previously untreated oral tongue squamous carcinomas operated between 2016 and 2018. Factors related to the local extent of a primary tumor that impacted the DSS were studied. Multivariable analyses adjusted for pT, pN stage, and adjuvant therapy. Candidate staging systems were developed based on factors that significantly impacted DSS, and validated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>Base tongue involvement (<i>p</i> = 0.021), DOI &gt; 20 mm (<i>p</i> value = 0.040), and tumor crossing the midline (<i>p</i> value = 0.047) significantly impacted the DSS. The preferred model included base tongue involvement in T3 stage, and DOI &gt; 20 mm and tumor crossing the midline into T4 stage (Model 2), which was superior to the current classification system in AIC (830.55 vs. 845.43), C-index (0.65 vs. 0.61), and visual inspection of Kaplan–Meier curves.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Identifying and possibly including these clinical factors in addition to the current T-stage criteria could result in better prognostication of tongue cancers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance</h3>\u0000 \u0000 <p>Integration of proposed classification could improve the discrimination between stages.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 5","pages":"1497-1503"},"PeriodicalIF":2.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Quantitative MRI Biomarkers of Head and Neck Post-Radiation Lymphedema and Fibrosis: Post Hoc Analysis of a Prospective Trial","authors":"MD Anderson Head and Neck Cancer Symptom Working Group,&nbsp;Shitong Mao,&nbsp;Jihong Wang,&nbsp;Holly McMillan,&nbsp;Abdallah Sherif Radwan Mohamed,&nbsp;Sheila Buoy,&nbsp;Sara Ahmed,&nbsp;Samuel L. Mulder,&nbsp;Mohamed A. Naser,&nbsp;Renjie He,&nbsp;Kareem A. Wahid,&nbsp;Melissa Mei Chen,&nbsp;Yao Ding,&nbsp;Amy C. Moreno,&nbsp;Stephen Y. Lai,&nbsp;Clifton David Fuller,&nbsp;Katherine Arnold Hutcheson","doi":"10.1002/hed.28062","DOIUrl":"10.1002/hed.28062","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Quantifying head and neck lymphedema and fibrosis (HN-LEF) is crucial in the investigation and management of treatment sequelae in head and neck cancer (HNC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The T1- and T2-weighted MRI signal intensity (SI) was examined in relation to HN-LEF categories per physical/tactile examination (No-LEF, A-B = edema, C = edema + fibrosis, D = fibrosis), and MRI structural volumes were examined in relation to a novel 10-point HN-LEF score in the intraoral and submental regions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified differences in ranks among HN-LEF categories in relation to the MRI SI (A-B and C are higher than D and No-LEF for T2 SI, and A-B is the highest for T1). Furthermore, six pairs of FOM volumes on MRI demonstrated a strong negative correlation (<i>p</i> &lt; 0.05) with the HN-LEF score at adjacent palpable sites.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Both MRI SI and structural volumes can potentially be imaging biomarkers of edematous soft tissue states in HNC patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 5","pages":"1487-1496"},"PeriodicalIF":2.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified Technique for Difficult Secondary Tracheoesophageal Puncture","authors":"Michelle Yoon,&nbsp;Justin Joseph,&nbsp;Ricardo Ramirez,&nbsp;Cindy Ganz,&nbsp;Michael S. Smith,&nbsp;Mark L. Urken","doi":"10.1002/hed.28068","DOIUrl":"10.1002/hed.28068","url":null,"abstract":"<div>\u0000 \u0000 <p>Tracheoesophageal puncture (TEP) with voice prosthesis (VP) placement is commonly used to restore voice in laryngectomy patients. The conventional procedure utilizes a rigid esophagoscope to open and visualize the pharyngeal inlet. However, this approach is challenging in patients with postradiation changes, reduced neck extension, or trismus. Here, we demonstrate a modified technique involving flexible endoscopy and endotracheal tube placement to reestablish the TEP tract in a patient with a challenging anatomic profile. This step-by-step video demonstrates retrieval of a dislodged prosthesis and TEP/VP placement under general anesthesia, which results in effective voice restoration. This modified technique can safely and effectively restore voice in patients with difficult exposure.</p>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 3","pages":"1062-1064"},"PeriodicalIF":2.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Investigations for Suspected Head and Neck Carcinoma of the Unknown Primary: A HNCIG and IFHNOS International Survey of Practice","authors":"Andrew Williamson,&nbsp;Paul Nankivell,&nbsp;Ahmad K. Abou-Foul,&nbsp;Mohamed Ahmed,&nbsp;Hisham Mehanna,&nbsp;HNCIG and IFHNOS CUP programme","doi":"10.1002/hed.28065","DOIUrl":"10.1002/hed.28065","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim of this clinical survey was to assess variations in head and neck squamous cell carcinoma from an unknown primary (HNSCCUP) diagnostic practices across international centers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Clinical practice survey of experts nominated by Head and Neck Cancer International Group (HNCIG) and International Federation of Head and Neck Oncologic Societies (IFHNOS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Responses were received from 48/49 (97.9%) participants. Outpatient laryngoscopy, CT, and 18-FDG-PETCT were used always or most of the time by 81.3%, 77.1%, and 79.2%, but only 50% regularly used MRI. Unilateral and bilateral tonsillectomy were frequently performed in 41.6% and 27.1% of unilateral nodal disease, and in 18.8% and 52.1% for bilateral disease. Ipsilateral Tongue Base Mucosectomy (TBM) was used always or most of the time in 12.5% of unilateral and 6.3% of bilateral HNSCCUP. Bilateral TBM was used in 10.4% for unilateral and 22.9% for bilateral cancers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>While there is broad agreement regarding examination and cross-sectional imaging, there are considerable differences in the surgical strategies used to identify occult primaries.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 5","pages":"1478-1486"},"PeriodicalIF":2.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of Sentinel Nodes in Atypical Territories in Surgically Treated Patients With T1-2N0 Oral Squamous Cell Carcinoma","authors":"Alejandro Mazarro Campos,&nbsp;Manel Sáez Barba,&nbsp;Alba de Pablo García-Cuenca,&nbsp;Jorge Pamias-Romero,&nbsp;Isabel Roca-Bielsa,&nbsp;Margarita Alberola-Ferranti,&nbsp;Coro Bescós-Atín","doi":"10.1002/hed.28067","DOIUrl":"https://doi.org/10.1002/hed.28067","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To assess the usefulness of sentinel lymph node biopsy (SLNB) in patients with early-stage oral squamous cell carcinoma (OSCC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Seventy-five patients (mean age 62 years) diagnosed with cT1-2 N0 underwent SLNB with ^99mTc, lymphoscintigraphy/SPECT–CT, and gamma probe detection with intraoperative histological examination of the resected sentinel lymph nodes (SLNs). Elective neck dissection was performed during the same surgical procedure of primary tumor resection when malignant deposits were detected microscopically.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The rate of occult metastases was 10.1% (26 out of 258 SLNs) and 24% (18 out of 75 patients). In 61 cases of well-lateralized tumors, metastases were detected in 11.1% (23 out of 208 SLNs), with an 11.5% metastatic rate in necks with ipsilateral drainage and 1.0% in necks with contralateral drainage patterns. In 28 patients with SLNs removed beyond Levels I–III, the rate of skip metastasis was 1.3%. The SLNB procedure for the detection of metastasis in patients with OSCC stage cT1-2 N0 showed a sensitivity of 94.7%, a specificity of 100%, a negative predictive value of 98.2%, a positive predictive value of 100%, and an overall diagnostic accuracy of 98.7%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The analysis of atypical SLN plays an important role in refining the characterization of cervical involvement and tailoring the therapeutic approach to the actual extent of the disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 5","pages":"1471-1477"},"PeriodicalIF":2.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flow-Through Flaps as a Robust Method for Advanced Free Flap Reconstruction in the Head and Neck: A Multi-Institutional Experience","authors":"Eric V. Mastrolonardo,&nbsp;Sarah Sussman,&nbsp;Pablo Llerena,&nbsp;Dev R. Amin,&nbsp;Kathryn Nunes,&nbsp;Kelly Bridgham,&nbsp;Emma De Ravin,&nbsp;Daniel J. Campbell,&nbsp;Aarti Agarwal,&nbsp;Ramez Philips,&nbsp;Fahad Rind,&nbsp;Ryan Ivancic,&nbsp;Wesley McIlwain,&nbsp;Stephen Y. Kang,&nbsp;Yadranko Ducic,&nbsp;Larissa Sweeny,&nbsp;Mauricio A. Moreno,&nbsp;René P. Myers,&nbsp;Carissa M. Thomas,&nbsp;Karthik Rajasekaran,&nbsp;Mark Wax,&nbsp;Joseph M. Curry,&nbsp;Matthew M. Hanasono","doi":"10.1002/hed.28061","DOIUrl":"10.1002/hed.28061","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Flow-through flaps (FTFs) are an advanced technique in which a free flap is anastomosed to the pedicle of another free flap to reconstruct extensive head and neck defects when recipient vessels are scarce.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A multi-institutional cohort of FTFs used for head and neck reconstruction were reviewed. For comparison, FTF outcomes were compared to free flaps that required vein grafts (VG) to reach distant recipient vessels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of forty-two patients underwent surgery using a FTF configuration, including 32 simultaneous and 10 sequential FTFs. There were no instances of flap failure compared to a 7% flap failure rate in the VG group (<i>n</i> = 54). The overall postoperative complication rate was 28% compared to a 46% complication rate in the VG group (<i>p</i> = 0.093).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>FTFs are a reliable option for reconstruction of extensive head and neck defects when recipient blood vessel availability is limited.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 5","pages":"1462-1470"},"PeriodicalIF":2.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of the Superior Thyroid Artery as a Recipient Artery in Head and Neck Free Flap Reconstruction: Effects on Post-Operative Hypothyroidism","authors":"Kaitlynne Y. Pak,&nbsp;Alberto Nunez,&nbsp;Harsh Patel,&nbsp;Allen S. Ho,&nbsp;Jon Mallen-St. Clair","doi":"10.1002/hed.28049","DOIUrl":"10.1002/hed.28049","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The superior thyroid artery (STA) as a recipient vessel in free flap reconstruction may theoretically impact thyroid function. This study aimed to assess whether the use of the STA has an adverse effect on thyroid function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective review of 101 head and neck reconstructive cases. Thyroid function tests were reviewed within 1 year of surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The STA was used in 40 cases. The STA cohort had significantly higher TSH levels than the non-STA cohort (7.34 v. 2.87 mU/L, <i>p</i> = 0.02). About 27.5% developed subclinical post-operative hypothyroidism and 17.5% required new levothyroxine supplementation in the STA group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This represents the first study to our knowledge assessing the impact of the STA as a recipient vessel on postoperative thyroid function. While we found a statistically significant difference in average TSH after using the STA, the average TSH/FT4 values were subclinical. Post-operative monitoring for hypothyroidism is warranted in this population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 5","pages":"1455-1461"},"PeriodicalIF":2.3,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dedifferentiation of a Chondrosarcoma of the Larynx: A Case Report","authors":"Steven J. Charous,&nbsp;Brian Yuhan,&nbsp;Kerstin M. Stenson,&nbsp;Vidit Talati,&nbsp;Phillip McMullen","doi":"10.1002/hed.28004","DOIUrl":"10.1002/hed.28004","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chondrosarcomas of the larynx, relatively rare tumors with low grade pathology in approximately 95% of cases, can most often be managed with conservation laryngeal procedures. Dedifferentiated chondrosarcomas are much more rare and aggressive requiring more aggressive surgical extirpation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A patient underwent three debulking procedures for a laryngeal chondrosarcoma Grade I/II histologically over a 2.5 year period of time during which slow growth was closely monitored. He then presented with relatively rapid onset of hoarseness and shortness of breath. Fiberoptic laryngoscopy demonstrated new bilateral vocal fold fixation with near occlusion of his subglottis by soft tissue mass.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total laryngectomy was performed that pathologically demonstrated a Grade III dedifferentiated chondrosarcoma. Shortly thereafter, the patient developed regional metastases, then distant metastases and then succumbed to the disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This first case of a Grade III dedifferentiating chondrosarcoma arising from closely monitored and multiple debulked previously Grade I/II tumor demonstrates the potential change in aggressiveness in low-grade chondrosarcomas of the larynx. Sudden increase in growth along with a soft tissue component to the tumor based on exam and/or imaging should heighten suspicion for dedifferentiation of the tumor and necessitates a more aggressive surgical resection. However, the chance of cure once dedifferentiation occurs is drastically reduced.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 5","pages":"E58-E63"},"PeriodicalIF":2.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}