Impact of Extranodal Extension in Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Systematic Review and Meta-Analysis.

IF 2.2 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-07-14 DOI:10.1002/hed.28251

Andrea Costantino, Gian Marco Pace, Camilla Zimello, Elena Russo, Antonio Greco, Antonella Polimeni, J Scott Magnuson, Armando De Virgilio

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引用次数: 0

Abstract

Objective: The aim of this study is to analyze the impact of extranodal extension (ENE) on survival outcomes for patients with metastatic cutaneous head and neck squamous cell carcinoma (cHNSCC).

Methods: The pooled hazard ratios (HRs) and the 95% confidence interval (CI) were calculated to define the impact of ENE on overall survival (OS) and disease-free survival (DFS).

Results: A total of 2076 patients (males: 84.4%) with a median age of 73.3 years were included. The incidence of ENE was 65.6% (N = 1299/1979). The median follow-up time was 38.4 months (95% CI: 21-38.4). The estimated pooled HRs were 1.31 (95% CI: 0.72-2.39; p = 0.28) and 1.80 (95% CI: 0.53-6.10; p = 0.22) for OS and DFS, respectively.

Conclusions: ENE may not be a reliable prognostic factor in metastatic cHNSCC. Further prospective studies are needed to refine risk stratification and improve the current nodal classification system.

查看原文本刊更多论文

结外延伸对头颈部转移性皮肤鳞状细胞癌的影响：系统回顾和荟萃分析。

目的：本研究的目的是分析结外延伸（ENE）对转移性皮肤头颈部鳞状细胞癌（cHNSCC）患者生存结局的影响。方法：计算合并风险比（hr）和95%置信区间（CI），确定ENE对总生存期（OS）和无病生存期（DFS）的影响。结果：共纳入2076例患者，男性占84.4%，中位年龄73.3岁。ENE的发生率为65.6% （N = 1299/1979）。中位随访时间为38.4个月（95% CI: 21-38.4）。估计合并hr为1.31 (95% CI: 0.72-2.39；p = 0.28)和1.80 (95% CI: 0.53-6.10；p = 0.22)，分别为OS和DFS。结论：ENE可能不是转移性肺癌的可靠预后因素。需要进一步的前瞻性研究来完善风险分层和改进当前的淋巴结分类系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.