Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献

{"title":"Alternative MYB Promoter Activity Is a Potential Prognostic Biomarker in Head and Neck Adenoid Cystic Carcinoma.","authors":"Fredrik Jäwert, André Fehr, Marta Persson, Adel K El-Naggar, Göran Stenman, Mattias K Andersson","doi":"10.1002/hed.28123","DOIUrl":"https://doi.org/10.1002/hed.28123","url":null,"abstract":"<p><strong>Background: </strong>Adenoid cystic carcinoma (ACC) is an aggressive therapy-resistant head and neck cancer with a high frequency of local recurrences and distant metastases. Activation of the MYB gene, encoding an oncogenic master transcription factor, is the key genomic hallmark of ACC and a potential therapeutic target. Here, we have investigated the clinical significance of alternative MYB promoter (MYB TSS2) activation in primary ACCs.</p><p><strong>Methods: </strong>MYB TSS2 activity was studied in 28 ACCs using MYB exon-specific qPCR assays. Overall survival (OS) and risk analyses were done to estimate the outcomes of MYB TSS2 high and low cases, respectively. The genomic and transcriptomic profiles of the ACCs were also analyzed in relation to MYB TSS2 activity.</p><p><strong>Results: </strong>OS was significantly shorter among patients in the MYB TSS2 high group compared to the MYB TSS2 low group (p = 0.02). Multivariate analysis indicated that MYB TSS2 activity was a significant prognostic biomarker for OS (p = 0.03) that was independent of tumor grade and NOTCH1 mutation status. There was markedly higher MYB TSS2 activity in ACCs with 6q deletions compared to those without deletions (p = 0.04). Moreover, MYB TSS2 high tumors had an increased expression of cell cycle genes and known MYB target genes.</p><p><strong>Conclusion: </strong>The study demonstrates that alternative MYB promoter activity is a new potential prognostic biomarker for ACC and further strengthens the relevance of MYB-targeted therapy. Our findings indicate that MYB TSS2 high primary tumors are more aggressive and have a worse prognosis than MYB TSS2 low tumors.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Stage Head and Neck Cancer Diagnosis: HEADSpAcE Consortium Health Systems Benchmarking Survey.","authors":"Grant Creaney, Mariél de Aquino Goulart, Alex McMahon, Claire Paterson, James McCaul, Sandra Perdomo, Laura Mendoza, Laia Alemany, Lidia Maria Rebolho Arantes, Paula Andrea Rodriguez Urrego, Tom Dudding, Mirana Pring, Marta Vilensky, Cecilia Cuffini, Silvia Adriana Lopez de Blanc, José Carlos de Oliveira, Shahid Pervez, Pierre Saintigny, Mauricio Cuello, Jaroslav Betka, Luis Felipe Ribeiro Pinto, Maria Paula Curado, Kazem Zendehdel, Lorenzo Richiardi, Maja Popovic, José Roberto de Podesta, Sandra Ventorin von Zeidler, Ricardo Mai Rocha, Shaymaa Alwaheidi, Paul Brennan, Shama Virani, Al Ross, David I Conway","doi":"10.1002/hed.28094","DOIUrl":"https://doi.org/10.1002/hed.28094","url":null,"abstract":"<p><strong>Background: </strong>Globally, most people with head and neck cancers (HNCs) are diagnosed with advanced-stage disease. HNC diagnostic stage has multifactorial explanations, with the role of health system factors not yet fully investigated.</p><p><strong>Methods: </strong>HNC centres (n = 18) from the HEADSpAcE Consortium were surveyed via a bespoke health system questionnaire covering a range of factors. Centres were compared using the least square means for the presence/absence of each health system factor to their proportion of advanced-stage HNC.</p><p><strong>Results: </strong>Health system factors associated with lower proportion in advanced-stage diagnosis were formal referral triaging (14%, 95% CI-0.26, -0.03), routine monitoring of time from referral to diagnosis (16%, 95% CI-0.27, -0.05), and fully publicly funded systems (17%, 95% CI-0.29, -0.06). Several health systems factors had no routinely available data.</p><p><strong>Conclusions: </strong>Through identifying and monitoring health systems factors associated with lower proportions of advanced stage HNC, interventions could be developed, and systems redesigned, to improve early diagnosis.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 13-Year Retrospective Study on Tracheoesophageal Prosthesis Outcomes From a Single Institution.","authors":"Nathalia Peres Borges Dos Santos, Izabella Costa Santos, Ana Catarina Alves E Silva, Andressa Silva de Freitas, Fernando Luiz Dias","doi":"10.1002/hed.28112","DOIUrl":"https://doi.org/10.1002/hed.28112","url":null,"abstract":"<p><strong>Introduction: </strong>Tracheoesophageal voice prosthesis (TEP) is considered the gold standard among vocal rehabilitation methods. The evaluation of the clinical and epidemiological profile of patients rehabilitated with TEP is essential to describe the determining factors of rehabilitation with good functional results.</p><p><strong>Objective: </strong>To describe the population of patients with total laryngectomy rehabilitated with TEP and to identify the variables associated with the outcome of vocal rehabilitation with TEP at the Brazilian National Cancer Institute (BNCI), between 2006 and 2019.</p><p><strong>Method: </strong>Retrospective cohort study of patients with total laryngectomy enrolled in the Head and Neck Surgery Section of BNCI. Secondary data were collected through physical and electronic medical records, located through the database of patients undergoing vocal rehabilitation with TEP at BNCI from 2006 to 2019.</p><p><strong>Results: </strong>A total of 165 patients with total laryngectomy were eligible for vocal rehabilitation with TEP. With 140 (84.8%) patients being male, 112 (67.9%) married and 112 (67.9%) with low education, 127 (77%) smokers and 126 (76.4%) heavy drinkers. Removal of the TEP occurred in 48 (29.1%) patients due to complications or the manifestation of a new tumor. And 157 (95.15%) patients were able to achieve phonation with TEP.</p><p><strong>Conclusion: </strong>Older patients, with more advanced tumors, undergoing salvage laryngectomy or primary placement seem to be more likely to have complications and/or aphonia. Regular follow-up by a multidisciplinary team and consistent speech therapy with periodic assessments of the shunt/tract and voice prosthesis are crucial to preventing major complications and TEP removal.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue-Plug Modification of Pectoralis Major Myocutaneous Flap for Intractable Pharyngocutaneous Fistula Repair.","authors":"Chia-Kai Hsu, Fang-Yu Hsu, Hung-Chi Chen, Jian-You Ji, En-Wei Liu","doi":"10.1002/hed.28111","DOIUrl":"https://doi.org/10.1002/hed.28111","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the feasibility and effectiveness of a novel tissue-plug modification of the pectoralis major myocutaneous flap for repairing intractable pharyngocutaneous fistulas, especially in difficult-to-access defects.</p><p><strong>Materials and methods: </strong>The novel technique involved designing a tissue-plug modification of pectoralis major myocutaneous flap and suspension sutures. Cadaver studies were performed to refine the surgical method before clinical application. This method was applied to five patients. Postoperative outcomes, complications, and follow-up data were analyzed.</p><p><strong>Results: </strong>All five patients underwent successful fistula repair using the tissue-plug method. Healing was achieved without recurrent leakage in four patients, while one required permanent enteral feeding due to preexisting tongue dysfunction. Two patients experienced tracheal strictures, which were resolved with additional interventions. Swallowing function improved, and imaging confirmed fistula resolution.</p><p><strong>Conclusion: </strong>The tissue-plug modification of the pectoralis major myocutaneous flap is a viable and effective approach for managing intractable pharyngocutaneous fistulas, particularly in cases with posterior oropharyngeal defects or prior radiation exposure. Further studies with larger cohorts are needed to validate its long-term efficacy and outcomes.</p><p><strong>Level of evidence: </strong>Level 4.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic Surgical Assist Arm for Head and Neck Reconstructive Surgery.","authors":"Sofia Torres-Small, Daron B Harrison, Camron Davies, Tate Naylor, Anas Eid, C Burton Wood, John P Gleysteen","doi":"10.1002/hed.28102","DOIUrl":"https://doi.org/10.1002/hed.28102","url":null,"abstract":"<p><p>This video demonstrates the use of a robotic surgical assist arm, specifically the Zimmer Biomet WalterLorenz arm, in a complex head and neck reconstructive surgery involving a scapular tip/latissimus dorsi free flap for a 67-year-old patient with advanced squamous cell carcinoma of the oral cavity. The key objective is to showcase how the robotic arm enhances surgical precision and efficiency by providing stable retraction, reducing the need for additional assistants, and minimizing fatigue-related challenges during prolonged procedures. The video highlights the setup, positioning, and intraoperative use of the robotic arm, including its role in maintaining optimal visualization and facilitating delicate dissections and osteotomies. The clinical significance of this technology lies in its ability to improve surgical ergonomics and outcomes by enabling the surgical team to focus more effectively on the intricate aspects of the procedure. This video serves as a valuable resource for surgeons interested in integrating robotic assist technology into head and neck reconstructive surgeries.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical Markers of Sarcopenia as Predictors of Outcomes Among Patients Undergoing Laryngectomy.","authors":"Marianne Abouyared, Angela A Colback, Alexander Jones, Michael G Moore, Matthew Mifsud, Bailin Alexander, Sidharth Puram, Joseph Roh, Akina Tamaki, Andrea Ziegler, Eric Thorpe, Sean Abbott, Rusha Patel","doi":"10.1002/hed.28110","DOIUrl":"https://doi.org/10.1002/hed.28110","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia, the systemic loss of skeletal muscle mass and function, is prevalent and particularly detrimental to head and neck cancer (HNC) patients. Cancer-associated sarcopenia involves complex mechanisms of poor nutrition and inflammation, highlighting the necessity for preoperative identification of these high-risk patients.</p><p><strong>Methods: </strong>A multi-site retrospective chart review (2016-2021) was performed on HNC patients undergoing total laryngectomy with or without reconstruction. Preoperative lab values were utilized to calculate markers of sarcopenia including systemic immune inflammation index (SII), nutrition-related index (NRI), geriatric NRI (GNRI), and neutrophil-to-lymphocyte ratio (NLR). Comparative analyses, ROC curves, and logistic regressions were conducted to evaluate the predictive value of these indices on 30-day postoperative outcomes.</p><p><strong>Results: </strong>In a cohort of 520 laryngectomy patients (75.8% salvage), postoperative fistula, major complication, and prolonged PO intake > 30 days were recorded in 22.7%, 25.4%, and 26.2% of patients, respectively. NLR was higher in patients with prolonged PO intake, while the NRI/GNRI was lower in patients with delayed PO intake. There were no significant differences in patient indices with or without fistula and major complications. All nutritional indices on ROC curves had areas under the curve < 0.600. After adjusting for confounding on multivariate logistic regression, the NLR (OR = 0.95) and SII (OR = 0.98) were predictive of major postoperative complications, while the NRI/GNRI (OR = 0.96) was predictive of delayed PO intake.</p><p><strong>Conclusions: </strong>Nutritional indices may be valuable to predict adverse postoperative laryngectomy outcomes. Prospective studies are needed to validate these findings.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crossing the Boundaries of Conflict: Analyzing Epidemiology & Outcomes of Afghan Oral Squamous Cell Carcinoma Patients at a Pakistani Cancer Hospital.","authors":"Hasnain Haider, Muhammad Awais Kanwal, Muhammad Mohaymin Ali, Afshan Khanum, Shayan Khalid, Kashif Iqbal Malik, Syed Raza Hussain, Muhammad Faisal","doi":"10.1002/hed.28118","DOIUrl":"https://doi.org/10.1002/hed.28118","url":null,"abstract":"<p><strong>Background: </strong>This study investigates oral cavity squamous cell carcinoma (OSCC) among Afghan patients treated at a Pakistani cancer center, focusing on epidemiology, tumor characteristics, outcomes, and healthcare challenges faced by patients from conflict-affected regions.</p><p><strong>Methods: </strong>A retrospective analysis of Afghan OSCC patients (2010-2023) was conducted. Demographic, clinical, and treatment data were evaluated, with survival outcomes analyzed using Kaplan-Meier survival analysis.</p><p><strong>Results: </strong>Of the 117 patients, 47.1% had risk factors, predominantly smokeless tobacco use (61.8%). Tumors were common in oral subsites, especially the tongue (47.86%), with advanced-stage disease (Stage IV) in 34.2%. Mean overall survival was 56.29 months, and mean disease-free survival was 45.54 months. The 5-year overall and disease-free survival rates were 57.7% and 56.5%, respectively.</p><p><strong>Conclusion: </strong>The study highlights a high prevalence of advanced OSCC, underscoring the need for early detection, public health initiatives, and enhanced cancer care in Afghanistan. International collaboration is essential to improve healthcare access and reduce regional healthcare burdens.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggressive Head and Neck Squamous Cell Carcinoma in the Setting of GATA2 Deficiency.","authors":"Brejjette Aljabi, James A Stewart, Kirk Withrow, Carissa M Thomas","doi":"10.1002/hed.28117","DOIUrl":"https://doi.org/10.1002/hed.28117","url":null,"abstract":"<p><strong>Background: </strong>GATA2 deficiency is a rare genetic disorder associated with hematologic, infectious, and neoplastic complications. We report a case of a patient with GATA2 deficiency who developed aggressive squamous cell carcinoma (SCC) of the head and neck, an atypical manifestation of this condition.</p><p><strong>Methods: </strong>A 34-year-old Hispanic male, a nonsmoker, presented with a large, exophytic right facial mass. Biopsy revealed HPV-negative SCC. Computed tomography (CT) showed a right periorbital mass invading the nasal cavity and a contralateral mass in the left parotid extending into the masticator space. The patient underwent extensive surgery, including right orbital exenteration, total rhinectomy, partial glossectomy, left radical parotidectomy, excision of the left mandibular condyle, and bilateral neck dissections. Reconstruction included a left temporalis muscle flap, internal fixation of the left zygoma, intermaxillary fixation, and a staged anterolateral thigh (ALT) free flap for the right facial defect. He developed postoperative Pseudomonas surgical site infections in the left face and ALT donor site and was treated with antibiotics and antifungals based on intraoperative culture results. The patient's postoperative course involved multiple interventions to address complications and support recovery. He developed bilateral local and regional recurrences rapidly after surgery and ultimately elected for palliative care.</p><p><strong>Results: </strong>Due to the aggressive nature of this case in a young, nonsmoking patient, combined with the atypical infections, genetic testing was performed for immunodeficiency syndromes. He was ultimately diagnosed with GATA2 deficiency.</p><p><strong>Conclusion: </strong>This case highlights the aggressive nature of SCC in the context of GATA2 deficiency and underscores the importance of genetic testing in patients with unusual malignancy presentations and suspected immunodeficiency. Genetic testing in the patient's children allows for early diagnosis of GATA2 deficiency and provides an opportunity for curative intervention through hematopoietic stem cell transplantation.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Management Following Endoscopic Skull Base Reconstruction: A Multidisciplinary Cross-Sectional Survey.","authors":"Khodayar Goshtasbi, Arash Abiri, Vidit Talati, Jagatkumar A Patel, Theodore V Nguyen, Jonathan C Pang, John R Craig, Peter Papagiannopoulos, Katie M Phillips, Bobby A Tajudeen, Nithin D Adappa, James N Palmer, Ahmad R Sedaghat, Eric W Wang, Shirley Y Su, Edward C Kuan","doi":"10.1002/hed.28116","DOIUrl":"https://doi.org/10.1002/hed.28116","url":null,"abstract":"<p><strong>Background: </strong>There is limited consensus on management protocols and practice patterns following endoscopic skull base surgery (ESBS).</p><p><strong>Methods: </strong>An online-based survey focusing on ESBS practice patterns was anonymously distributed to the American Rhinologic Society, North American Skull Base Society, and American Head and Neck Society Skull Base Section membership.</p><p><strong>Results: </strong>A total of 130 surgeons (81.5% in academic positions) completed the survey. Regarding reconstructive materials, 36.9% always used autologous as opposed to synthetic materials, with variation in specific materials used. Lumbar drain was never used by 22.3% of respondents, while high BMI or suspected intracranial hypertension (43.1%) and high-flow leak or large dural defects (50.0%) were indications for lumbar drain usage. There was significant variation in types of nasal packing, type, and duration of postoperative activity restrictions, antibiotic use, and debridement protocols.</p><p><strong>Conclusion: </strong>Postoperative management following endoscopic skull base reconstruction is highly complex, with a wide variety of practice patterns.</p><p><strong>Level of evidence: </strong>N/A.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper Aerodigestive Tract Liposarcoma: Four Cases of a Rare Entity and a Review of the Literature.","authors":"Uma Ramesh, Antonio Bon Nieves, Maria Feucht, Naomi Wang, Rahul Alapati, Chelsea S Hamill, Shannon Kraft, James Garnett, Devin Shrock, Omar Karadaghy, Ethan Craig, Andrés M Bur","doi":"10.1002/hed.28114","DOIUrl":"https://doi.org/10.1002/hed.28114","url":null,"abstract":"<p><strong>Background: </strong>Liposarcomas involving the upper aerodigestive tract (UADT) are extremely rare. Consequently, consensus regarding the treatment approach and surveillance is not well established.</p><p><strong>Methods: </strong>We present four cases of UADT liposarcoma. All patients presented with either dysphagia or respiratory difficulty and underwent endoscopic examination as part of their diagnostic workup. Surgical excision, either endoscopic or open resection, was performed for all patients.</p><p><strong>Results: </strong>All patients had a pathologic diagnosis of well-differentiated liposarcoma without nodal or distant disease involvement. One patient underwent complete resection with no recurrences. Another patient experienced several recurrences, and his tumor ultimately underwent rapid disease progression and pathologic transformation into dedifferentiated liposarcoma, necessitating total laryngectomy. Of the two patients with positive surgical margins at their initial resections, one was lost to follow-up from our institution. The other three patients, including the second patient with positive margins, continue to follow up with endoscopic surveillance at our institution with no evidence of residual disease.</p><p><strong>Conclusions: </strong>UADT liposarcoma is a locally aggressive tumor that may frequently recur. Stringent surveillance is necessary to monitor disease progression, particularly if positive margins are noted during surgical excision. The role of adjuvant therapy has yet to be established.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}