{"title":"Effectiveness and outcomes of endoscopic resection for superficial pharyngeal squamous cell carcinomas.","authors":"Naohiro Nakamura, Tomofumi Sakagami, Minaki Shimizu, Kensuke Suzuki, Takuo Fujisawa, Takuya Shijimaya, Sanshiro Kobayashi, Yu Takahashi, Tomomitsu Tahara, Yuri Noda, Koji Tsuta, Makoto Naganuma","doi":"10.1002/hed.27924","DOIUrl":"10.1002/hed.27924","url":null,"abstract":"<p><strong>Background: </strong>With the development of endoscopic imaging, superficial pharyngeal squamous cell carcinoma can now be detected during routine endoscopy. Recently, the effectiveness of endoscopic resection for superficial pharyngeal squamous cell carcinoma have been reported.</p><p><strong>Methods: </strong>This study had a retrospective single-center design that included patients with superficial pharyngeal squamous cell carcinoma who underwent endoscopic resection. A total 47 patients with 53 lesions were analyzed.</p><p><strong>Results: </strong>En bloc and R0 resection rates were 83.0% and 56.6%. Local recurrence and cervical lymph node metastasis (CLNM) were detected in 1 and 3 patients during follow-up. The macroscopic type 0-I was an independent factor for CLNM. The 3-year cumulative incidence of metachronous pharyngeal squamous cell carcinoma following endoscopic resection was 33.0%, and the 5-year overall survival rate was 89.2%.</p><p><strong>Conclusions: </strong>Endoscopic resection is an effective treatment for superficial pharyngeal squamous cell carcinomas, and the macroscopic type 0-I is a useful predictor of CLNM.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"463-471"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shreya Sriram, Akua Owusu-Boahene, Rebecca A Gersten, Christine G Gourin
{"title":"Provider Perspectives and Access to Palliative Care: An American Head and Neck Society (AHNS) Survey.","authors":"Shreya Sriram, Akua Owusu-Boahene, Rebecca A Gersten, Christine G Gourin","doi":"10.1002/hed.27957","DOIUrl":"10.1002/hed.27957","url":null,"abstract":"<p><strong>Background: </strong>To explore provider perspectives about palliative care (PC) in head and neck cancer (HNC) care.</p><p><strong>Methods: </strong>A 25-question electronic survey was disseminated to the membership of the American Head and Neck Society (AHNS) from April 10, 2023, through June 13, 2023.</p><p><strong>Results: </strong>Respondents were most likely to refer to PC at symptomatic disease progression (52%) or terminal diagnosis (29%) rather than at initial diagnosis (17%). Participants less likely to refer to PC were less likely to refer to symptomatic progression (8% vs. 39%, p = 0.0006) or address advance directives (62% vs. 87%, p = 0.0406). Symptom burden questionnaires were used by only 29% of respondents. Discordance was identified between self-reported and actual access to local inpatient and outpatient PC services.</p><p><strong>Conclusions: </strong>Barriers to PC identified include a lack of established optimal timing of PC referral, a perceived lack of local access to PC, and a lack of uniform standardized assessment of symptom burden.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"657-666"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lise J van de Velde, W F Julius Scheurleer, W Weibel Braunius, Caroline M Speksnijder, Mischa de Ridder, Lot A Devriese, Remco de Bree, Gerben E Breimer, Johannes A Rijken, Boukje A C van Dijk
{"title":"Sinonasal Squamous Cell Carcinoma in the Netherlands: A Population-Based Study of 568 Cases Diagnosed in 2008-2021.","authors":"Lise J van de Velde, W F Julius Scheurleer, W Weibel Braunius, Caroline M Speksnijder, Mischa de Ridder, Lot A Devriese, Remco de Bree, Gerben E Breimer, Johannes A Rijken, Boukje A C van Dijk","doi":"10.1002/hed.27961","DOIUrl":"10.1002/hed.27961","url":null,"abstract":"<p><strong>Background: </strong>Sinonasal squamous cell carcinoma is known for its rarity and poor prognosis. This study aims to investigate the trends in the incidence of sinonasal squamous cell carcinoma in the Netherlands and to analyze patient characteristics and treatment practices in order to assess their relation with patient outcomes.</p><p><strong>Methods: </strong>In this prospectively designed population-based cohort study, all patients diagnosed with sinonasal squamous cell carcinoma between 2008 and 2021 in the Netherlands were included. Patients with a squamous cell carcinoma of the nasal vestibule were excluded, leading to a definitive study population of 568 cases.</p><p><strong>Results: </strong>The annual incidence rate for the overall population displayed a slight upward trend over the inclusion period with an annual percentage change of 1.6%. The 5-year overall, disease-free, and relative survival were 43.0%, 52.0%, and 47.2%, respectively. Relative survival decreased marginally over the course of the inclusion period.</p><p><strong>Conclusion: </strong>Sinonasal squamous cell carcinoma is rare with approximately stable incidence rates. There is a limited, non-statistically significant, decrease in survival between 2008 and 2021. Therefore, there is a clear need for innovative treatment approaches to improve outcomes for patients with sinonasal squamous cell carcinoma.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"695-705"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diversity in U.S. Clinical Trials for Head and Neck Cancer: Are We Improving?","authors":"Melani Camryn Zuckerman, Heather Ann Edwards","doi":"10.1002/hed.27943","DOIUrl":"10.1002/hed.27943","url":null,"abstract":"<p><strong>Background: </strong>This study assesses whether national initiatives undertaken to improve diversity in clinical trial enrollment have been successful within head and neck cancer (HNC) trials.</p><p><strong>Methods: </strong>A retrospective analysis was conducted of HNC trials published on clinicaltrials.gov with start dates between 2000 and 2023. Demographic data for 8998 HNC trial enrollees was abstracted and analyzed to investigate potential demographic shifts.</p><p><strong>Results: </strong>In the past 20 years, the percentage of White patients increased 6.1%, Asian patient population decreased 3.1%, and Black patient population increased 0.8%. Compared with previously published SEER data, HNC trials have significantly more White patients, fewer Black patients, and fewer Asian/Native-Hawaiian patients than HNC patients at large.</p><p><strong>Conclusions: </strong>Despite efforts to increase diversity in HNC clinical trials in the United States, diversity has significantly decreased in the past 10 years. As current approaches are failing to show improvement, novel approaches to improving representation in clinical trials are necessitated.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"679-686"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bin Zhang, Yu-Zhong Qiu, Lei-Ming Cao, Zi-Zhan Li, Guang-Rui Wang, Yao Xiao, Han-Yue Luo, Bing Liu, Yi-Feng Ni, Zhi-Li Zhao, Lin-Lin Bu
{"title":"Complications in Deep Circumflex Iliac Artery-Related Vascularized Free Iliac Flap.","authors":"Bin Zhang, Yu-Zhong Qiu, Lei-Ming Cao, Zi-Zhan Li, Guang-Rui Wang, Yao Xiao, Han-Yue Luo, Bing Liu, Yi-Feng Ni, Zhi-Li Zhao, Lin-Lin Bu","doi":"10.1002/hed.28012","DOIUrl":"10.1002/hed.28012","url":null,"abstract":"<p><strong>Background: </strong>Since its first application in 1978, the vascularized free iliac flap (VFIF) has gradually become a mainstay for tissue defect reconstruction. However, the complications associated with harvesting the bone flap and its corresponding reconstruction surgery cannot be overlooked.</p><p><strong>Methods: </strong>We conducted a narrative review through literature search to identify the types, incidence, influencing factors, measurement methods, and treatment approaches of complications related to DCIA-related VFIF.</p><p><strong>Results: </strong>We propose the \"LIP\" rule (Loss, Injury, Postoperative) for classifying donor site complications. For the four most common recipient sites, mandible, maxilla, extremities, and hip joint, we list the common and rare complications that may occur. Additionally, we provide a summary of the methods and advances in preventing these complications.</p><p><strong>Conclusions: </strong>We comprehensively describe the complications observed in the application of DCIA-related VFIF and introduce the \"LIP\" principle and other strategies to minimize or avoid adverse outcomes.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"742-758"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaoxuan Chen, Kiran Abraham-Aggarwal, David I Kutler
{"title":"A Rare Case of Ewing Sarcoma of the Left Ethmoid Sinus With Orbital Extension.","authors":"Xiaoxuan Chen, Kiran Abraham-Aggarwal, David I Kutler","doi":"10.1002/hed.27993","DOIUrl":"10.1002/hed.27993","url":null,"abstract":"<p><strong>Background: </strong>Ewing sarcoma (ES) of the ethmoid sinus with orbital involvement in an adult is very rare, with 16 reported cases in the literature. Immunohistochemical studies show small blue round cells positive for CD99 and fluorescence in situ hybridization (FISH) testing reveals positivity for the EWSR1 gene.</p><p><strong>Methods: </strong>A 38-year-old male with a diagnosis of ES of the ethmoid sinus presented with left-sided periorbital pain and edema, rhinorrhea, and proptosis. The patient underwent neoadjuvant chemotherapy, surgical resection of the left skull base, and postoperative proton radiotherapy.</p><p><strong>Results: </strong>The patient tolerated chemotherapy, surgical resection, and adjuvant proton radiotherapy well with resolution of proptosis, diplopia, and pain. Due to local recurrence, he is currently undergoing adjuvant chemotherapy.</p><p><strong>Conclusion: </strong>Our findings provide insight on the clinical presentation and appropriate management of extraosseous ES, specifically in the ethmoid sinus in the adult population.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"E23-E27"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcelo Elias Schempf Cattan, Talita de Carvalho Kimura, Luccas Lavareze, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano
{"title":"Head and neck sarcomas: Thirty years of experience in a tertiary referral center in Brazil.","authors":"Marcelo Elias Schempf Cattan, Talita de Carvalho Kimura, Luccas Lavareze, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano","doi":"10.1002/hed.27933","DOIUrl":"10.1002/hed.27933","url":null,"abstract":"<p><strong>Purpose: </strong>This study analyzed the demographics, clinicopathological, treatment, and survival characteristics of head and neck sarcomas (HNS) diagnosed in a tertiary reference center in Brazil.</p><p><strong>Materials and methods: </strong>HNS cases were retrospectively retrieved from the Department of Pathological Anatomy of the School of Medical Sciences of the State University of Campinas. The medical records were examined to extract demographic, clinicopathological, and follow-up information. The Pearson chi-square test, Kaplan-Meier curve, and Cox proportional hazards regression model were employed to identify survival and potential prognostic factors.</p><p><strong>Results: </strong>A total of 47 patients were included in the study. The majority were men (61.7%) with a mean age of 38.9 years. The nasal cavity (34.0%) was the most common anatomical site. The lesions are usually presented as volume increases (78.7%). The most common histological subtypes were chondrosarcoma, osteosarcoma, and alveolar rhabdomyosarcoma. Surgical excision alone was the most common treatment modality. Local recurrence was observed in 10 cases, and metastases in 3 cases. During a mean follow-up period of 71.9 months, from diagnosis to the last follow-up, 31 patients (65.9%) were alive without the disease. A total of 10 patients (21.3%) died of the HNS for a mean follow-up period of 14.3 months. The time to presentation of more than 6 months (p = 0.0309) and the presence of metastases (p = 0.0315) were identified as prognostic factors for survival, while male sex was found to be an independent prognostic factor for recurrence.</p><p><strong>Conclusion: </strong>In conclusion, the results of this study indicate that the occurrence of a shorter lesion time to presentation and the presence of metastases were associated with a reduction in survival rates in patients with HNS.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"549-558"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amara Naseer, Sinead Brennan, Denise MacCarthy, John Edward O'Connell, Eleanor O'Sullivan, Michelle Leech
{"title":"Prevention of osteoradionecrosis in patients with head and neck cancer treated with radiation therapy.","authors":"Amara Naseer, Sinead Brennan, Denise MacCarthy, John Edward O'Connell, Eleanor O'Sullivan, Michelle Leech","doi":"10.1002/hed.27927","DOIUrl":"10.1002/hed.27927","url":null,"abstract":"<p><strong>Background: </strong>Osteoradionecrosis is a long-term, serious side effect of head and neck radiation therapy and is associated with significant morbidity and quality of life issues.</p><p><strong>Methods: </strong>This paper sought to determine consensus on the prevention and management of osteoradionecrosis by an international panel of multidisciplinary professionals expert in the management of patients with head and neck cancer using a Delphi methodology. Unique to this work is our direct inclusion of the views of patients and carers in our findings.</p><p><strong>Results: </strong>This study reached consensus on the importance of pre and post oral health assessment and education for patients with head and neck cancer. This was also noted by the patients and carers who took part in the study.</p><p><strong>Conclusions: </strong>This work highlights the need for a standardized oral health assessment tool and multidisciplinary care of patients to prevent and manage osteoradionecrosis.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"472-484"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Claes Mercke, Signe Friesland, Anders Berglund, Gun Wickart Johansson, Gregori Margolin, Michael Gubanski, Einar Björgvinsson, Josef Nilsson
{"title":"\"High-risk\" tumors of the lip treated with external beam radiotherapy and high-dose-rate brachytherapy: Long-term outcome.","authors":"Claes Mercke, Signe Friesland, Anders Berglund, Gun Wickart Johansson, Gregori Margolin, Michael Gubanski, Einar Björgvinsson, Josef Nilsson","doi":"10.1002/hed.27936","DOIUrl":"10.1002/hed.27936","url":null,"abstract":"<p><strong>Background: </strong>Radiotherapy is a well-established treatment for lip cancer, with external radiotherapy (EBRT) or brachytherapy (BT).</p><p><strong>Methods: </strong>This study evaluated outcome, tumor control, and aesthetics, for 101 patients with carcinoma of the lip, not suitable for surgery, treated with combined EBRT and BT.</p><p><strong>Results: </strong>Squamous cell carcinoma was seen in 78 patients, basal cell carcinoma in 15, and other histologies in 8 patients. Tumors were advanced: 73% in category T2-T4. Local control at 3 and 5 years was 89%. Local failure appeared in 4/56 patients (7%) with primary RT compared to 7/45 (16%) in those with prior surgery, regional recurrence in 5 patients. Toxicity was mild. Cosmetic outcome, 87 patients evaluated, was bad for 9/40 patients with upfront surgery compared to 1/47 for primary RT patients (p = 0.003). Seven patients died from lip cancer (7%), three with originally N+ disease (43%).</p><p><strong>Conclusions: </strong>Combined EBRT and BT could be considered for lip tumors not candidates for surgery.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"586-598"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Keyue Liu, Linsong Lu, Yuan Zhi, Moxin Zi, Xiangyu Zhang, Kun Wu, Zhaojian Gong
{"title":"Effect of Low Molecular Weight Heparin Calcium on Prevention of Lower Limb Deep Venous Thrombosis in Oral Cancer Patients With Anterolateral Thigh Flap Reconstruction.","authors":"Keyue Liu, Linsong Lu, Yuan Zhi, Moxin Zi, Xiangyu Zhang, Kun Wu, Zhaojian Gong","doi":"10.1002/hed.27947","DOIUrl":"10.1002/hed.27947","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the effect of low molecular weight heparin calcium (LMWH-Ca) on the prevention of deep venous thrombosis (DVT) in patients with anterolateral thigh (ALT) flap reconstruction.</p><p><strong>Methods: </strong>In total, 1001 patients with oral cancer who underwent ALT flap reconstruction were recruited. Based on the postoperative use of LMWH-Ca, the patients were divided into case (n = 633) and control groups (n = 368). The incidence of postoperative DVT was compared between groups.</p><p><strong>Results: </strong>There was no significant difference in DVT incidence between the two groups. Among patients older than 60 years, the incidence of lower limb DVT in the case group (0.813%) was significantly lower than that in the control group (8.108%, p = 0.012).</p><p><strong>Conclusion: </strong>The postoperative use of LMWH in oral cancer patients with ALT flap transfer does not prevent the development of lower limb DVT. However, patients older than 60 years old benefited from the postoperative use of LMWH-Ca.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"713-719"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}