Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献

{"title":"Validation of Current Staging Systems in HNCSCC: A Multinational Cohort Study.","authors":"Fábio Muradás Girardi, Vivian Petersen Wagner, Cristian David Cardona Machado, Ashley Wysong, Nina A Ran, Emily E Granger, Shlomo A Koyfman, Allison T Vidimos, David R Carr, Kathryn T Shahwan, Kelsey E Hirotsu, John A Carucci, Joi B Carter, Aaron R Mangold, Divya Srivastava, David G Brodland, John A Zitelli, Tyler J Willenbrink, Anokhi Jambusaria-Pahlajani, Rajiv I Nijhawan, Emily S Ruiz, Javier Cañueto","doi":"10.1002/hed.28259","DOIUrl":"https://doi.org/10.1002/hed.28259","url":null,"abstract":"<p><strong>Importance: </strong>Risk stratification of cutaneous squamous cell carcinoma (CSCC) is central to effective management. Despite advancements in the 8th edition of the American Joint Committee on Cancer (AJCC8) staging system, the distinctiveness of T-stages remains limited.</p><p><strong>Objective: </strong>To evaluate the effectiveness of the Brigham and Women's Hospital (BWH) and the AJCC8 staging systems in predicting poor outcomes in head and neck (HN) CSCC.</p><p><strong>Design: </strong>A retrospective, multinational cohort study of CSCCs diagnosed between January 10, 1991, and December 31, 2023.</p><p><strong>Setting: </strong>Twelve centers across the United States (10), Spain (1), and Brazil (1).</p><p><strong>Participants: </strong>Patients with invasive CSCC who underwent curative-intent surgical treatment. Exclusions included cases of lip CSCC, cases with prior HN cancer with associated regional disease, patients with a history of chemotherapy/radiotherapy for other HN neoplasms, and recurrent primary tumors.</p><p><strong>Exposure: </strong>Tumors were staged according to both the AJCC8 TNM staging system and the BWH tumor classification.</p><p><strong>Main outcomes and measures: </strong>Local recurrence (LR), nodal recurrence (NR), distant recurrence (DR), and disease-specific death (DSD).</p><p><strong>Results: </strong>A total of 9852 excised tumors from 3168 patients were included. The 2 systems had comparable monotonicity and homogeneity. Significant differences could be observed in 5-year cumulative incidence for DSD in both BWH and AJCC8, and also for LR in BWH. Higher T-stages exhibited similar curves regarding NR and DR for both AJCC8 and BWH staging systems. Overall, we observed high specificity and NPV, low sensitivity and PPV, and moderately high c-indices for both the BWH and AJCC8 staging systems in predicting the main outcomes for HNCSCC.</p><p><strong>Conclusion and relevance: </strong>Current AJCC8 and BWH staging systems can accurately predict survival in HNCSCC, although there are still important characteristics to be addressed in future staging systems for better stratification according to the other main outcomes.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Head and Neck Cancer-Related Lymphoedema Using Indocyanine Green Lymphography-A Pilot Study.","authors":"Katrina Gaitatzis, Belinda Thompson, Hiroo Suami, Fiona Tisdall Blake, Asha Heydon-White, Puma Sundaresan, Dion Forstner, Louise Koelmeyer","doi":"10.1002/hed.28252","DOIUrl":"https://doi.org/10.1002/hed.28252","url":null,"abstract":"<p><strong>Background: </strong>Head and neck cancer treatments can cause head and neck lymphoedema (HNL), impacting quality of life (QoL). This study examined lymphatic drainage changes in HNL using Indocyanine Green Lymphography (ICG-L) and assessed QoL, physical, and functional outcomes.</p><p><strong>Methods: </strong>Twenty individuals with HNL and 10 healthy controls completed the Lymphedema Symptom Intensity and Distress survey, bioimpedance spectroscopy (BIS), skin assessments, percent water content, and ICG-L. Analysis included non-parametric and Kruskal-Wallis tests.</p><p><strong>Results: </strong>ICG-L showed preserved original lymphatic drainage in non-surgical and unilaterally treated individuals, while bilateral treatment disrupted original pathways, prompting compensatory drainage. Individuals with HNL reported significantly higher scores in soft tissue sensation, neurological symptoms, and biobehavioral symptoms (p < 0.001). Skin assessments revealed swelling and fibrosis. Significant differences were observed in lymphatic dysfunction (p = 0.002), BIS-derived skeletal muscle mass percent (p = 0.015), and phase angle (p = 0.002).</p><p><strong>Conclusions: </strong>This study highlights the symptom burden and altered lymphatic drainage in HNL, with ICG-L showing potential for refining management strategies.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional Disparities in Head and Neck Cancer Management: A Global Cross-Sectional Survey of the World Federation of ENT Societies.","authors":"Antonino Maniaci, Jérôme R Lechien, Carlos Chiesa-Estomba, Victorine Maso, Isabelle Gengler, Johannes J Fagan, Sheng-Po Hao, Luiz P Kowalski, Bernard Lyons, Emmanuel Babin, Mohamad Yunus Mohd Razif, Hani Z Marzouki, Angel Ramos Macias, Hector E Ruiz, Bernard Fraysse, Matthew White, Justin Michel, Nicolas Fakhry","doi":"10.1002/hed.28257","DOIUrl":"https://doi.org/10.1002/hed.28257","url":null,"abstract":"<p><strong>Objective: </strong>To outline global variations in head and neck cancer care practices and resource availability across disparate geographic locations and sites of care.</p><p><strong>Methods: </strong>We conducted a cross-sectional worldwide survey following STROBE and CHERRIES guidelines in September-December 2024 under the aegis of the World Federation of ENT Societies (IFOS) and Young Otolaryngologists of IFOS (YO-IFOS). The survey was conducted in the form of standardized case vignettes for common clinical scenarios for various head and neck subsites, practice setting characteristics, and resource availability assessment. Head and neck condition specialists were approached by professional organizations from seven geographic locations. Statistical analysis involved chi-square testing and Benjamini-Hochberg adjustment for multiple comparisons.</p><p><strong>Results: </strong>One hundred eighty-five European specialists, 27 North American specialists, 50 Central/South American specialists, 123 Asian specialists, 53 African specialists, 12 Oceania specialists, and 114 Middle East/North African specialists responded to the survey. Management of standardized case vignettes was very different by region (p < 0.001). The rate of TORS for early oropharyngeal cancer differed significantly between nations (59.1% in North America, 52.3% in Europe, 14.8% in Asia, and 7.1% in Africa). Preferred management of advanced laryngeal cancer was also heterogeneous, with primary chemoradiotherapy being the option for 72.7% of North Americans but only 43.5% of Asians, 21.9% of Europeans, and 4.8% of Africans. Wide resource variations existed globally, with the most advanced treatment, such as IMRT, being available in 86.9% of European but only 75.6% of Central/South American and 27.1% of African centers. By contrast, tumor board review by an interdisciplinary team in all patients was noted in 91.2% of cases in Europe and Oceania compared with 48.8% in Asia and 22.4% in Central/South America. Economic barriers to access varied geographically and were noted in 83.7% of African, 63% of Central/South American, and 44.4% of North American, but just 8.9% of European respondents.</p><p><strong>Conclusions: </strong>This global survey documents notable variations in the management of head and neck cancer reflecting complex interactions between training models, resource settings, and cultural paradigms. These findings identify regional variations in clinical decision-making for standardized case presentations, confirming the need for resource-adjusted guideline development and country-specific education programs. Future research must tackle the way in which these patterns of treatment influence outcomes in diverse healthcare systems.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-Network Deep Learning for Accelerated Head and Neck MRI: Enhanced Image Quality and Reduced Scan Time.","authors":"Shuang Li, Weijie Yan, Xiaoyong Zhang, Wei Hu, Lin Ji, Qiang Yue","doi":"10.1002/hed.28255","DOIUrl":"https://doi.org/10.1002/hed.28255","url":null,"abstract":"<p><strong>Background: </strong>Head-and-neck MRI faces inherent challenges, including motion artifacts and trade-offs between spatial resolution and acquisition time. We aimed to evaluate a dual-network deep learning (DL) super-resolution method for improving image quality and reducing scan time in T1- and T2-weighted head-and-neck MRI.</p><p><strong>Methods: </strong>In this prospective study, 97 patients with head-and-neck masses were enrolled at xx from August 2023 to August 2024. After exclusions, 58 participants underwent paired conventional and accelerated T1WI and T2WI MRI sequences, with the accelerated sequences being reconstructed using a dual-network DL framework for super-resolution. Image quality was assessed both quantitatively (signal-to-noise ratio [SNR], contrast-to-noise ratio [CNR], contrast ratio [CR]) and qualitatively by two blinded radiologists using a 5-point Likert scale for image sharpness, lesion conspicuity, structure delineation, and artifacts. Wilcoxon signed-rank tests were used to compare paired outcomes.</p><p><strong>Results: </strong>Among 58 participants (34 men, 24 women; mean age 51.37 ± 13.24 years), DL reconstruction reduced scan times by 46.3% (T1WI) and 26.9% (T2WI). Quantitative analysis showed significant improvements in SNR (T1WI: 26.33 vs. 20.65; T2WI: 14.14 vs. 11.26) and CR (T1WI: 0.20 vs. 0.18; T2WI: 0.34 vs. 0.30; all p < 0.001), with comparable CNR (p > 0.05). Qualitatively, image sharpness, lesion conspicuity, and structure delineation improved significantly (p < 0.05), while artifact scores remained similar (all p > 0.05).</p><p><strong>Conclusions: </strong>The dual-network DL method significantly enhanced image quality and reduced scan times in head-and-neck MRI while maintaining diagnostic performance comparable to conventional methods. This approach offers potential for improved workflow efficiency and patient comfort.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vein Selection for Optimal Flap Outcomes in the Radial Forearm Free Flap: A Systematic Review and Meta-Regression.","authors":"Christian Chong, Justin Lindsay, Lois Nguapa, Kevin G Wu, Timothy N Crawford, Mark Wax, Yadranko Ducic, Mohamedkazim Alwani, Sameep P Kadakia","doi":"10.1002/hed.28256","DOIUrl":"https://doi.org/10.1002/hed.28256","url":null,"abstract":"<p><strong>Background: </strong>Radial forearm free flaps represent a workhorse reconstructive modality in microsurgical rehabilitation. The reliable anatomy, availability of thin, pliable tissue, and a long pedicle afford the surgeon a significant latitude of reconstructive freedom, allowing this flap to be useful for a multitude of body sites. Although the arterial anatomy is straightforward, the venous outflow of the flap is generally through a circuit utilizing a superficial, deep, and united venous system. This has allowed surgeons a variety of venous options to utilize, but has also generated debate in the community regarding the optimal vessel choice. This manuscript seeks to examine published studies in the literature in an effort to determine if a statistically significant difference exists among venous outflow options as they lead to microsurgical success.</p><p><strong>Methods: </strong>A systematic review and meta-regression were conducted examining 14 studies with a total of 1182 radial forearm flaps. A university-based statistician was recruited to perform a detailed analysis of the results.</p><p><strong>Results: </strong>Results show that there is no statistically significant difference in flap outcomes among the superficial, deep, and united venous drainage systems when outflow is deemed to be favorable intraoperatively.</p><p><strong>Conclusions: </strong>The choice of venous outflow system does not impact outcomes of the radial forearm flap. Surgeon preference, technical skill, and patient anatomy should be the guiding factors in determining vein choice so long as the venous outflow is favorable.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Flight Plan for Embolization Technique Based on Carotid Body Tumor Angiography to Improve Surgical Treatment of the Lesion: Report of Two Cases.","authors":"Haotian Huanggu, Guangchao Gu, Fangda Li, Rong Zeng, Yuehong Zheng","doi":"10.1002/hed.28254","DOIUrl":"https://doi.org/10.1002/hed.28254","url":null,"abstract":"<p><strong>Background: </strong>Carotid body tumor (CBT) is a rare type of paraganglioma in head and neck region, with a high risk of surgical bleeding and nerve damage. Here we applied a new imaging tool termed \"Flight Plan for Embolization\" (FPFE) technique to better identify tumors' feeding arteries so that better dissection and bleeding control can be made to improve surgical outcomes.</p><p><strong>Methods: </strong>One 55-year-old female and one 67-year-old male patient presented to our hospital with an asymptomatic CBT on the right and left neck, respectively. Surgical resection was proposed due to the lesions' nature of being able to gradually enlarge to cause significant neurovascular invasion and even malignancy transformation. The two patients underwent a 3D-digital subtracted angiography (DSA) for tumors before surgery. With the FPFE technique, the blood supply source and intra-tumoral distribution of CBTs were clearly identified from the 3D-DSA data.</p><p><strong>Results: </strong>Surgery was performed for the female and male patients at 17 and 3 days after the angiography, respectively. With the guidance of FPFE, we could easily identify and control feeding vessels of the lesions and resect CBTs with minimal bleeding and nerve damage.</p><p><strong>Conclusions: </strong>In our experience, \"FPFE\" technique can effectively identify CBTs' main blood supply source, and might help to improve the surgical treatment by providing better bleeding control and clearer surgical field.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes and Social Reintegration After Salvage Open Partial Horizontal Laryngectomy Type II/III for Radiation Failure.","authors":"Shunsuke Miyamoto, Koichi Kano, Shohei Tsutsumi, Kaho Momiyama, Kohei Hagiwara, Takashi Matsuki, Taku Yamashita","doi":"10.1002/hed.28253","DOIUrl":"https://doi.org/10.1002/hed.28253","url":null,"abstract":"<p><strong>Background: </strong>The long-term outcomes and social reintegration following open partial horizontal laryngectomy (OPHL) type II/III after radiation failure remain unclear. This study aimed to evaluate the outcomes of salvage OPHL.</p><p><strong>Methods: </strong>We retrospectively analyzed 56 recurrent cases after radiotherapy and 84 unirradiated cases who underwent OPHL type II/III at Kitasato University Hospital between November 1997 and October 2023. Overall survival (OS), disease-free survival (DFS), larynx preservation (LP), laryngo-esophageal dysfunction-free survival (LEDFS), and return to work (RTW) were evaluated.</p><p><strong>Results: </strong>At 10 years, OS, DFS, LP, and LEDFS were 76%, 73%, 93%, and 67% in recurrent cases and 65%, 58%, 94%, and 58% in unirradiated cases, with no significant difference. RTW rates were 87% and 81%, respectively (p = 0.57).</p><p><strong>Conclusions: </strong>OPHL type II/III after radiation failure demonstrated favorable long-term outcomes and RTW rates, supporting its role as a valuable salvage option.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Factors of Malignancy in Cervical Paragangliomas: A Retrospective Study.","authors":"Garance Haw, Maxime Fieux, Anthime Flaus, Hélène Lasolle, Juliette Abeillon, Myriam Decaussin-Petrucci, Dylan Pavie, Benjamin Verillaud, Philippe Herman, Patrick Feugier, Fatima Ameur, Pierre Philouze, Françoise Borson-Chazot, Philippe Ceruse","doi":"10.1002/hed.28250","DOIUrl":"https://doi.org/10.1002/hed.28250","url":null,"abstract":"<p><strong>Background: </strong>Early predictive factors of metastatic cervical paragangliomas (cPG) are lacking.</p><p><strong>Methods: </strong>This multicenter retrospective study included patients with at least one cPG. Metastatic cPG were defined by the histological presence of lymph node metastases or distant metastases. Clinical, radiological, intraoperative, histological, and mutational status characteristics were collected. Predictive factors of metastatic cPG were searched using logistic regression.</p><p><strong>Results: </strong>Sixty-seven patients were included, corresponding to 86 cPG; 12.8% of these were metastatic. The seven newly identified risk factors were: presence of necrosis (OR = 12.36, 95% CI: [3.03-55.66]), extracapsular extension (OR = 33.42, 95% CI: [2.48-4752.00]), and pathological lymph nodes (OR = 25.00, 95% CI: [3.96-276.07]) on morphological imaging (MRI and/or CT); heterogeneous tumor uptake (OR = 15.5, 95% CI: [2.31-143.68]) and abnormal lymph node uptake (OR = 16.5, 95% CI: [2.04-174.94]) on functional imaging (FDG-PET-CT); invasion of adjacent tissues (OR = 34.63, 95% CI: [3.82-4602.65]) and sacrifice of noble structures (OR = 75.9, 95% CI: [7.99-10230.73]) in patients who underwent surgery.</p><p><strong>Conclusion: </strong>These risk factors could be combined to promptly identify aggressive cPG and adapt therapeutic strategy.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Small Molecule Inhibitor of the Wnt-β-Catenin Pathway, CWP232291, Inhibits Tumor Growth in Preclinical Models of Salivary Gland Adenoid Cystic Carcinoma.","authors":"Joseph O Humtsoe, Bhumsuk Keam, Hyun-Su Kim, Leilani Jones, Brandon Leonard, Anita Pothukuchi, Sarah Honjo, Annemieke van Zante, Susan Lee, Patrick K Ha","doi":"10.1002/hed.28249","DOIUrl":"https://doi.org/10.1002/hed.28249","url":null,"abstract":"<p><strong>Background: </strong>Salivary gland adenoid cystic carcinoma (ACC) is a rare and challenging form of head and neck cancer, particularly difficult to treat once it progresses to recurrent or metastatic disease. In this study, we evaluate the cytotoxicity and anti-tumorigenic effects of CWP232291, a first-in-class small molecule inhibitor targeting the Wnt-β-catenin signaling pathway.</p><p><strong>Methods: </strong>Tumor microarrays of ACC patients and patient-derived xenografts (PDX) were evaluated by immunohistochemistry, RNA-seq, and qRT-PCR analysis for β-catenin. The effects of CWP232291 were determined by cytotoxic, qRT-PCR, and immunoblotting analysis. In vivo anti-tumorigenic effects of CWP232291 were evaluated using cell line xenograft and PDX models.</p><p><strong>Results: </strong>Immunohistochemistry analysis revealed that high β-catenin expression correlated with reduced overall survival in ACC patients. Expression of genes involved in the Wnt-β-catenin pathway was enriched in PDX samples. In vitro cytotoxicity and biochemical assays using MDA-ACC-01 and UM-HACC-2A cell lines revealed that ACC cells were susceptible to CWP232291. Furthermore, CWP232291 treatment attenuated in vivo tumor growth in both cell line xenograft and PDX models.</p><p><strong>Conclusions: </strong>Abnormal Wnt-β-catenin signaling may play an active role in ACC pathogenesis, and its inhibition by CWP232291 may offer therapeutic potential, representing a promising avenue for further investigation.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swallowing and Communication Outcomes Post Chemoradiotherapy for Low-Risk Human Papillomavirus (HPV)-Associated Oropharyngeal Squamous Cell Carcinoma: A Substudy of TROG 12.01.","authors":"Rhys Hughes, June Corry, Danny Rischin, Mathias Bressel, Lizbeth Kenny, Belinda Lehn, Laurelie Wishart, Laurie-Anne Minslow, Jacqui Frowen","doi":"10.1002/hed.28245","DOIUrl":"https://doi.org/10.1002/hed.28245","url":null,"abstract":"<p><strong>Background: </strong>This substudy aimed to assess swallow and communication outcomes in patients undergoing treatment for low-risk human papillomavirus-associated oropharyngeal squamous cell carcinoma.</p><p><strong>Methods: </strong>Videofluoroscopy swallowing studies (VFSS) were conducted pre-treatment, 12 and 24 months post treatment, alongside quality of life and symptom severity measures for patients receiving 70Gy radiotherapy with either weekly cisplatin or cetuximab.</p><p><strong>Results: </strong>Of 126 patients who underwent VFSS, there were no differences in swallowing outcomes between cisplatin and cetuximab arms. VFSS outcomes were worst at 12 months and improved by 24 months, with low aspiration rates and high swallow function at all timepoints. Older age, higher T-stage, and base of tongue tumors (versus tonsil) were associated with poorer swallowing. Clinician-and patient-reported speech and voice problems were minimal.</p><p><strong>Conclusions: </strong>Swallowing was safe and efficient, and communication highly intelligible at 24 months post treatment. Both 'objective' and patient-reported measures are important to understand the impact of new treatment approaches on swallowing-related outcomes.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}