Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献

{"title":"Malignant Transformation of Oral Leukoplakia and Proliferative Verrucous Leukoplakia and Its Biomarker Predictors: A Systematic Umbrella Review.","authors":"Mohammed Taib Fatih, Mohammed Khalid Mahmood, Balkees Taha Garib, Yad Mariwan Mohammed Amin, Ranjdar Mahmood Talabani, Tara Ali Rasheed, Handren Ameer Kurda, Balen Hamid Qadir, Zana Fuad Noori, Mohammed Aso Abdulghafor, Ariwan Othman Saeed, Herve Tassery, Delphine Tardivo, Romain Lan","doi":"10.1002/hed.70073","DOIUrl":"https://doi.org/10.1002/hed.70073","url":null,"abstract":"<p><strong>Background: </strong>Oral leukoplakia (OL) represents the most common oral potentially malignant disorder globally, with highly variable reported malignant transformation (MT) rates creating challenges for evidence-based clinical management.</p><p><strong>Objective: </strong>To systematically synthesize evidence on MT prevalence in OL and evaluate potential predictive biomarkers through an umbrella review of systematic reviews and meta-analyses.</p><p><strong>Methods: </strong>Following PRISMA guidelines, we searched PubMed, MEDLINE, Scopus, and Embase databases through July 2025. Twenty-seven systematic reviews encompassing more than 125,000 patients were included. Meta-analyses were conducted using random-effects models, with quality assessed using AMSTAR 2 and GRADE approaches.</p><p><strong>Results: </strong>Transformation rates were considerably higher in proliferative verrucous leukoplakia (48%) than in OL (6%). Females exhibited almost twice the MT rate of males (64% vs. 35%), while tongue lesions showed the highest site-specific risk (39%). The most promising predictive biomarker with a moderate level of evidence quality was DNA aneuploidy.</p><p><strong>Conclusions: </strong>Because of its high malignant potential, OL necessitates risk-based surveillance protocols. While the bulk of other predictors requires further investigation, DNA aneuploidy shows potential for clinical application.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Risk-Adapted Approach for Elective Neck Dissection in Salvage Total Laryngectomy: Revisiting the Role of Tumor Subsite and Occult Nodal Disease.","authors":"Chiesa-Estomba Carlos M, Melkane Antoine, Dequanter Didier, Brunet Aina, Maniaci Antonino, Karra Khawla, Jerome R Lechien, Droppelman-Alvarez Paulina, Roldan-Fidalgo Amaya, Palacios Jose, Baguda Eva, Ayad Tareck","doi":"10.1002/hed.70072","DOIUrl":"https://doi.org/10.1002/hed.70072","url":null,"abstract":"<p><strong>Background: </strong>The role of elective neck dissection (END) during salvage total laryngectomy (STL) in clinically node-negative (cN0) patients remains controversial due to variable risks of occult nodal metastasis and surgical morbidity.</p><p><strong>Methods: </strong>We conducted a multicenter retrospective study of 178 cN0 patients undergoing STL after radiotherapy (RT) or chemoradiotherapy (CRT). Rates of occult nodal disease, survival outcomes, and predictive factors were analyzed.</p><p><strong>Results: </strong>Occult nodal metastases were found in 19.7% of cases, highest in hypopharyngeal (35.7%) and supraglottic (24.5%) tumors. Tumor subsite and lymphovascular invasion were independent predictors of nodal positivity, while prior chemotherapy reduced risk. Patients with occult nodal disease had significantly worse three-year overall and disease-specific survival.</p><p><strong>Conclusions: </strong>A risk-adapted approach to END in STL is recommended, particularly for supraglottic and hypopharyngeal tumors. Routine END may be unnecessary in low-risk subsites like glottic tumors. Prospective studies are needed to refine management strategies.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Should Elective Neck Dissection Be Considered for Early-Stage Oral Cavity Tumors? Insights From a Multicenter Study of 1109 Patients and Development of a Multiparametric Predictive Model.","authors":"Luca Calabrese, Monir Abousiam, Marta Tagliabue, Marco Ferrari, Rita De Berardinis, Gerardo Petruzzi, Francesco Mazzola, Alberto Grammatica, Davide Mattavelli, Remo Accorona, Alberto Vito Marcuzzo, Pierre Guarino, Francesco Mattioli, Alessia Rubini, Matteo Fermi, Andrea Sacchetto, Elisa Laura, Riccardo Nocini, Fabiola Incandela, Pietro De Luca, Andrea Iandelli, Filippo Marchi, Mario Turri Zanoni, Leone Giordano, Andrea Galli, Simone Mauramati, Virginia Corazzi, Chiara Bianchini, Mario Ciniglio Appiani, Matteo Garotta, Maria Silvia Lazio, Domenico Michele Modica, Salvatore Poma, Martina Renna, Annalisa Tosi, Melania Franco, Davide Di Santo, Giulia Togo, Paola Stritoni, Cecilia Albi, Ilaria Girolami, Enrico Fazio, Fabrizio Russo, Daniele Spada, Angela Gasparini, Virginia Dallari, Sara Bassani, Bianca Maria Festa, Dario Gregori, Carlotta Borghini, Gloria Brigiari, Francesca Angioletti, Alessandra Sordi, Milena Fior, Alessandra Ruaro, Valero Arietti, Giulia Gobbo, Francesco Uderzo, Rossana Bussani, Maurizio Pinamonti, Giuseppe Maruccio, Guglielmo Ronzani, Elisa Castelluccio, Pasquale d'Alessio, Daria Salsi, Roberto Di Carlo, Stefano Pelucchi, Giuseppe Bertolini, Massimo Ducci, Alberto Dragonetti, Mario Galfano, Franco Ionna, Doriano Politi, Roberto Saetti, Vincenzo Saita, Antonio Sarno, Giandomenico Maggiore, Angelo Camaioni, Luca De Campora, Luca Sacchetto, Paolo Castelnuovo, Marco Radici, Claudio Donadio Caporale, Domenico Cuda, Alberto Deganello, Andy Bertolin, Marco Benazzo, Giorgio Peretti, Mario Bussi, Daniele Marchioni, Livio Presutti, Giancarlo Tirelli, Mohssen Ansarin, Cesare Piazza, Piero Nicolai, Raul Pellini, Gabriele Molteni, Luca Gazzini","doi":"10.1002/hed.70064","DOIUrl":"https://doi.org/10.1002/hed.70064","url":null,"abstract":"<p><strong>Background: </strong>Nodal metastases significantly affect prognosis in oral cavity squamous cell carcinoma (OCSCC). In early-stage OCSCC (cT1-T2 cN0), management of the clinically negative neck (cN0) remains controversial. Depth of invasion (DOI) is a key determinant for END, but other histopathological parameters, such as grading, perineural invasion (PNI), lymphovascular invasion (LVI), and worst pattern of invasion (WPOI), are emerging prognostic factors.</p><p><strong>Methods: </strong>This multicenter retrospective study analyzed 1109 patients with cT1-T2 cN0 OCSCC treated at 30 Italian hospitals since 2017. Data on histopathological parameters, tumor characteristics, and patient outcomes were collected via the REDCap platform. Simple and multivariable logistic regression models were developed to assess predictors of occult nodal metastases.</p><p><strong>Results: </strong>A total of 585 patients were clinically classified as cT1 tumors (53%), 503 as cT2 (45%), and cTis (1.9%). Of the 1109 patients, 193 (28%) had occult nodal metastases, with DOI, LVI, PNI, WPOI, and grading emerging as significant predictors. A predictive model integrating these variables demonstrated superior accuracy compared to a DOI-only model (AUROC comparison, p < 0.01).</p><p><strong>Conclusion: </strong>This study highlights the importance of incorporating multiple histopathological parameters into risk models for occult nodal metastases, overcoming the fixed DOI as a cutoff. The proposed predictive model offers a more precise method for guiding END in early-stage OCSCC, allowing individualized risk estimation.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trend in Initial Management of T4 Laryngeal Squamous Cell Carcinoma.","authors":"Anna J Orr, Michael C Topf, Robert P Zitsch, Patrick T Tassone","doi":"10.1002/hed.70067","DOIUrl":"https://doi.org/10.1002/hed.70067","url":null,"abstract":"<p><strong>Background: </strong>Contemporary initial management trends for locally advanced laryngeal carcinoma remain unclear. This study evaluated whether initial treatment for clinical tumor stage 4a (cT4a) laryngeal cancer has changed over time and associated survival.</p><p><strong>Methods: </strong>Retrospective cohort study using the National Cancer Database (NCDB) from 2004 to 2022 of patients with cT4a laryngeal squamous cell carcinoma. Survival outcomes were analyzed with the Mann-Kendall test, Kaplan-Meier method, logistic regression, Cox-proportional hazards, and log-rank tests.</p><p><strong>Results: </strong>Among 12 142 cT4a laryngeal cancer patients (81.3% male, mean age 60.9 years), initial surgical management increased from 41.0% in 2004 to 65.3% in 2022. Two-year overall survival increased from 58.2% (2004) to 70.3% (2021). Upfront surgery was independently associated with higher 2-year overall survival on multivariable analysis, Kaplan-Meier, and log-rank testing (p < 0.001).</p><p><strong>Conclusion: </strong>For patients with cT4a laryngeal cancer, management with initial surgery has become more popular and may offer improved overall survival compared to initial nonsurgical management.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Segmental Tracheal Resection for Thyroid Cancer: Perioperative Morbidity, Locoregional Control, and Survival.","authors":"Anastasios Maniakas, David C Wilde, Isabelle Fournier, Emily K Hyde, Li Xu, Jennifer R Wang, Neil D Gross, Erich M Sturgis, Victoria Banuchi, Naifa L Busaidy, Maria E Cabanillas, Priyanka Iyer, Ramona Dadu, Steven G Waguespack, Mimi I Hu, G Brandon Gunn, Michael Kwon, Salmaan Ahmed, Michelle D Williams, Mark E Zafereo","doi":"10.1002/hed.70045","DOIUrl":"https://doi.org/10.1002/hed.70045","url":null,"abstract":"<p><strong>Background: </strong>Segmental tracheal resection is rarely needed for advanced thyroid cancer but is among the most complex, high-risk thyroid surgeries.</p><p><strong>Methods: </strong>Retrospective study of patients undergoing segmental tracheal resection for thyroid cancer at MD Anderson Cancer Center (2005-2024).</p><p><strong>Results: </strong>We identified 120 patients with a median follow-up of 4.6 years (range 0.02-16.38). Papillary thyroid cancer was most common (68%). The median number of tracheal rings resected was 4 (range 1-9). Seventeen (14%) patients had a new tracheostomy placed at the time of surgery, with 11 (9%) remaining trach-dependent at last follow-up. Twenty-six (22%) patients had a return to the operating room within 30 days, while 3 (3%) patients suffered perioperative mortality. The more common postoperative complications included tracheostomy tube placement (10%), hematoma (7%), and anastomotic air leak (6%). Median hospitalization was 6 days (range 2-67). Locoregional control (LRC) and overall survival (OS) were 79% and 77% at 5 years, respectively.</p><p><strong>Conclusions: </strong>Segmental tracheal resection for advanced thyroid cancer is technically complex and high-risk, but most patients stay recurrence-free 5 years post-surgery.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of Cervical Metastases and Implications for Neck Management in Minor Salivary Gland Cancer Treatment.","authors":"Eduardo Wanderley Estanislau da Costa, Pedro Nicolau-Neto, Paula Moretz-Sohn, Bernardo Cacciari Peryassu, Emilson de Queiroz Freitas, Luis Felipe Ribeiro Pinto, Fernando Luiz Dias","doi":"10.1002/hed.70044","DOIUrl":"https://doi.org/10.1002/hed.70044","url":null,"abstract":"<p><strong>Objectives: </strong>Minor salivary gland cancer (MiSGC) is a rare and heterogeneous disease, with different degrees of tumor aggressiveness. The scarce data in the literature show that the presence of lymph node metastases (LNMs) negatively impacts the prognosis. Furthermore, there is a lack of information about the patterns and extension of LNMs in MiSGC. Therefore, it is necessary to identify the clinical and pathological features associated with LNMs in MiSGC to guide the cervical dissection intent of those patients. This study's endpoints were the identification of clinicopathological features associated with LNMs, identification of spread patterns of clinical and occult LNMs, and the impact of LNMs on the patient's outcome.</p><p><strong>Materials and methods: </strong>This single-center retrospective cohort study analyzed data from 437 patients with MiSGC of the oral cavity and oropharynx treated at the Instituto Nacional de Câncer (INCA), the Brazilian National Cancer Institute.</p><p><strong>Results: </strong>LNMs were observed in 59 patients (13.5%). Cervical levels I and II were the most affected neck levels in the total sample, and in MiSGC of the oral cavity, whereas Levels II and III were the most affected in MiSGC of the oropharynx. Adenocarcinoma histotype, floor of the mouth and base of the tongue subsites, late-stage tumor, and lymphovascular invasion were associated with LNMs. LNMs were associated with worse overall and disease-specific survival rates.</p><p><strong>Conclusion: </strong>There are LNMs spread specific to the site of the MiSGC, with an impact on the patient's prognosis. Adenocarcinoma, tumor subsite, and lymphovascular invasion were associated with LNMs.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Performance of Automatic Speaking Valves and Fixation Devices Enabling Hands-Free Speech Following Total Laryngectomy-A Systematic Review.","authors":"Max J Dullaart, Sebastiaan R de Vreugd, Maartje Leemans, Rob van Son, Arjan Malekzadeh, Maarten J A van Alphen, Lisette van der Molen, Michiel W M van den Brekel, Luc H E Karssemakers, Richard Dirven","doi":"10.1002/hed.70046","DOIUrl":"https://doi.org/10.1002/hed.70046","url":null,"abstract":"<p><strong>Background: </strong>The percentage of daily automatic speaking valve use (AU) in laryngectomized patients has remained at ~25% since their invention. To increase this percentage, understanding the performance of existent devices is essential. Therefore, we reviewed studies reporting AU, fixation device lifetime (FDL), compliance, and voice and speech assessment outcomes (VSAOs).</p><p><strong>Methods: </strong>Studies published until 23 April 2025 were included. Quality assessment was performed using RoB2, ROBINS-I, and JBI tools.</p><p><strong>Results: </strong>Twenty studies were included, which were of poor methodological quality. AU and FDL were 3-13.25 h/day and 0.17-24 h/day. Baseline daily ASV compliance rate was 25%, increasing short-term but decreasing long-term. Reasons for non-compliance were inadequate fixation, skin problems, and voicing being too tiresome. There were no significant differences across ASVs in VSAOs.</p><p><strong>Conclusion: </strong>No single ASV or fixation device outperformed others. Personalized approaches, tailored to ASV experience, tracheostoma anatomy, and patient needs, may increase AU, FDL, and long-term compliance.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Home-Based Exercise Program on Muscle Mass, Fatigue, and Health-Related Quality of Life Among Patients with Oral Cancer: A Randomized Trial.","authors":"Camilla Wallmander, Ingvar Bosaeus, Ewa Silander, Hedda Haugen Cange, Jan Nyman, Monika Fagevik Olsén, Elisabet Blomsterwall, Malin Berg, Eva Hammerlid","doi":"10.1002/hed.70063","DOIUrl":"https://doi.org/10.1002/hed.70063","url":null,"abstract":"<p><strong>Background: </strong>Patients with head and neck cancer (HNC) often experience deteriorated health-related quality of life (HRQoL) and loss of body weight and muscle mass. The primary aim was to determine if a home-based exercise program, aiming to increase physical activity (PA), could reduce muscle mass loss and fatigue.</p><p><strong>Methods: </strong>Oral cancer patients were randomized to an exercise group (EG) or a control group (CG). The EG received a home-based exercise program, and both groups were followed for 1 year. The Frändin/Grimby activity scale, bioelectrical impedance analysis, and HRQoL questionnaires were used to assess PA, muscle mass, and fatigue.</p><p><strong>Results: </strong>In total, 119 patients were included. The EG increased their PA, but no differences in muscle mass were found between groups. A tendency toward less fatigue and better global QoL was observed in the EG.</p><p><strong>Conclusion: </strong>Future studies are needed to explore the possible benefits of PA in patients with HNC.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraglandular Dissemination Is a Risk Factor for Lymph Node Metastasis and Recurrence in Papillary Thyroid Carcinoma: A Propensity Score Matching Analysis.","authors":"Tiantian Yu, Zishuo Liu, Jingyu Ma, Peng Su, Xiaoyu Ji, Nan Liu, Changyuan Ding, Zhenpeng Yang, Weili Liang, Bin Lv","doi":"10.1002/hed.70058","DOIUrl":"https://doi.org/10.1002/hed.70058","url":null,"abstract":"<p><strong>Background: </strong>Intraglandular dissemination (ID) is an important clinicopathological feature, but the statistical evidence of its relationship with lymph node metastasis (LNM) and the prognosis of papillary thyroid carcinoma (PTC) has not been widely reported in the literature. The purpose of this study was to investigate the potential correlation between ID, LNM, and prognosis in PTC patients.</p><p><strong>Methods: </strong>Patients with PTC were retrospectively collected from Qilu Hospital of Shandong University from 2017 to 2019 and categorized into two groups based on postoperative routine pathology: intraglandular dissemination group (ID group) and the non-intraglandular dissemination group (NID group). The propensity score matching (PSM) was used to analyze and compare the differences in LNM and prognosis between groups.</p><p><strong>Results: </strong>Among the 2845 patients included in the study, 6.85% had ID. After PSM matching, ID was associated with an increased risk of LNM (OR: 2.143, 95% CI: 1.279-3.591, p = 0.004) and recurrence in PTC patients (HR: 6.585, 95% CI: 1.782-24.335, p = 0.005). Kaplan-Meier curves showed that the recurrence-free survival (RFS) of the ID group before and after PSM was worse than that of the NID group (95.3% vs. 99.0%, p < 0.001; 95.0% vs. 99.0%, p = 0.011).</p><p><strong>Conclusion: </strong>ID is an independent risk factor for LNM (includes microscopic metastasis) and postoperative recurrence in PTC patients. The recurrence rate of ID-PTC patients with markers of aggressive disease is higher than that of ID-PTC patients alone. Patients with ID-PTC require more intensive follow-up to monitor for recurrence. The necessity of more extensive lymph node dissection for these patients may need to be validated by future multi-center, prospective studies.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Interaction Between Sex and Race in Outcomes of Head and Neck Squamous Cell Carcinoma.","authors":"Geena Jung, Ashley Stone, Shaynie Segal, Juan Lin, Bradley Schiff, Thomas Ow, Vikas Mehta, Richard V Smith","doi":"10.1002/hed.70057","DOIUrl":"https://doi.org/10.1002/hed.70057","url":null,"abstract":"<p><strong>Background: </strong>This study elucidated sex disparities in head and neck squamous cell carcinoma (HNSCC) outcomes and investigated their interaction with race.</p><p><strong>Methods: </strong>A total of 452 patients diagnosed with HNSCC were grouped by sex and race. Survival was analyzed using Kaplan-Meier curves with log rank tests and multivariable Cox models to assess sex/race associations while adjusting for confounders.</p><p><strong>Results: </strong>Males were more likely to have advanced-stage cancer (79.6%, n = 257 vs. 70.5%, n = 91; p = 0.040). African American females had the best 5-year overall survival, followed by White females and Hispanic males. African American males had the worst survival (p = 0.0334). This sex disparity within the African American population persisted when controlling for confounding variables (HR = 0.343; 95% CI: 0.154-0.766; p = 0.0090) and was more pronounced in HPV-negative cases (HR = 0.184, 95% CI = 0.043-0.786).</p><p><strong>Conclusions: </strong>Race-stratified analysis revealed a survival advantage for African American females over males. Further analysis shows that HPV status, alongside race, moderates the effect of sex on HNSCC outcomes.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}