Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献

{"title":"Stomal Bleeding in a Laryngectomized Patient as a Consequence of an Infected Innominate Artery Stent: A Case Report.","authors":"Edward S Sim, Omar A Karadaghy, Daniel G Deschler","doi":"10.1002/hed.28158","DOIUrl":"https://doi.org/10.1002/hed.28158","url":null,"abstract":"<p><strong>Background: </strong>Laryngectomized patients can present with stomal bleeding for a variety of etiologies that all warrant urgent evaluation and management.</p><p><strong>Methods: </strong>Here, we report a case of a patient who presented with large volume stomal bleeding at least three decades following her total laryngectomy for a dysfunctional larynx secondary to adjuvant radiation therapy she received for thyroid cancer. Her radiation therapy was also complicated by severe stenosis of her innominate-carotid artery system requiring multiple vascular interventions ultimately leading to calcified and infected arterial stents. On presentation, a tracheoscopy demonstrated an ulcerated area in the anterior tracheal wall. During the diagnostic workup for this patient, it became apparent that there was no blood flow through the distal portion of her innominate artery and that a trachea-innominate fistula, although high on the differential, was not the source of her stomal bleeding. Her clinical presentation was also complicated by bacteremia of unknown etiology.</p><p><strong>Results: </strong>The patient ultimately underwent surgical exploration to remove the diseased portion of her tracheostoma and an infected innominate arterial stent abutting the tracheal wall. Stomal reconstruction then took place with no further bleeding episodes postoperatively. Pathologic evaluation of the resected fibrotic tissue demonstrated bacterial species and evidence of chronic inflammation.</p><p><strong>Conclusion: </strong>Stomal bleeding in a laryngectomized patient should be evaluated promptly as consequences could be fatal. Although evaluation for major vessel compromise is paramount, other etiologies warrant consideration. Compromised stents of adjacent vasculature should be considered as a potential etiology in the diagnostic evaluation and management of stomal bleeding.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Outcomes of the Patients With Advanced Hypopharyngeal Squamous Cell Carcinoma Treated With Chemoradiotherapy and Total Pharyngolaryngectomy Based on Reports of Head and Neck Cancer Registry of Japan.","authors":"Yuto Horichi, Hirotaka Shinomiya, Megumi Kitayama, Daisuke Kawakita, Takeshi Kodaira, Munenaga Nakamizo, Seiichi Yoshimoto, Ken-Ichi Nibu","doi":"10.1002/hed.28162","DOIUrl":"https://doi.org/10.1002/hed.28162","url":null,"abstract":"<p><strong>Background: </strong>For laryngeal preservation in locally advanced hypopharyngeal cancer (HPC), the role of induction chemotherapy (ICT) and chemoradiotherapy (CRT) as alternatives to total pharyngolaryngectomy (TPL) remains unclear.</p><p><strong>Methods: </strong>We analyzed 825 patients with T3N0-2M0 and 900 with T4aN0-2M0 HPC from the Head and Neck Cancer Registry of Japan (2011-2015). Oncological outcomes of ICT, CRT, and TPL were evaluated. Propensity score matching analysis (PSM) was performed between TPL and CRT, excluding ICT.</p><p><strong>Results: </strong>In T4aN0-2M0 patients, ICT followed by TPL significantly improved overall survival and local recurrence-free survival (LRFS) compared with TPL, and ICT followed by CRT significantly improved LRFS compared with CRT. No significant differences in survival were observed between TPL and CRT in both T3N0-2M0 and T4aN0-2M0 patients in PSM.</p><p><strong>Conclusions: </strong>ICT benefited T4aN0-2M0 patients. CRT did not compromise survival compared with TPL in T3-4aN0-2M0 patients, supporting the rationale of ICT and CRT for advanced HPC.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPV-Positive Squamous Cell Carcinoma Metastasis Without Clinical Evidence of Primary: The Posterior Oropharyngeal Wall May Be an Overlooked Location.","authors":"Sannia Sjöstedt, Martin Garset-Zamani, Kirsten Korsholm, Tina Klitmøller Agander, Tobias Todsen, Irene Wessel","doi":"10.1002/hed.28159","DOIUrl":"https://doi.org/10.1002/hed.28159","url":null,"abstract":"<p><strong>Background: </strong>Oropharyngeal squamous cell carcinoma (SCC) can present as cancer of unknown primary, where only cervical lymph node metastases are identified. Most tumors, particularly human-papillomavirus-associated ones, are located in the palatine/lingual tonsils. When this is not the case, additional imaging with 2-deoxy-2-[¹⁸F]fluoro-D-glucose positron emission tomography ([¹⁸F]FDG-PET) and ultrasound can be helpful.</p><p><strong>Methods: </strong>A 68-year-old male with bilateral cervical metastasis from an HPV-positive SCC, no primary tumor was identified despite thorough examination. [¹⁸F]FDG-PET revealed bilateral cervical metastases and a possible primary tumor in the posterior oropharynx. Guided by perioperative transoral ultrasound, a biopsy for frozen sectioning was obtained.</p><p><strong>Results: </strong>Frozen sectioning of the posterior tumor revealed SCC. Final histology confirmed the posterior wall tumor as the primary cancer.</p><p><strong>Conclusions: </strong>The posterior oropharynx wall must be carefully investigated during the diagnostic workup for SCC of an unknown primary tumor as it can be the site of the primary tumor. Identification of the primary tumor reduces the need for further diagnostic surgery.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic Disparities in Head Neck Cancer Incidence and Mortality: Regional Wealth-Dependent Analysis in Seniors Cohorts.","authors":"Małgorzata Wierzbicka, Dorota Świątek, Jakub Sikora, Wirginia Likus, Wioletta Pietruszewska, Jarosław Markowski","doi":"10.1002/hed.28156","DOIUrl":"https://doi.org/10.1002/hed.28156","url":null,"abstract":"<p><strong>Background: </strong>Head and neck cancer (HNC) shows a \"diverging scissors\" pattern, with incidence and mortality linked to regional economic status.</p><p><strong>Objective: </strong>We aim to investigate whether socioeconomic disparities between regions correlate with widening gaps in HNC incidence and mortality rates, with particular emphasis on age-related patterns among elderly populations.</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>Data from the National Cancer Registry for females from 2003 to 2019.</p><p><strong>Patients: </strong>76 649 patients, 49 858 males, 26 791 females from 2003 to 2019 in age cohorts: 60-69, 70-79, and 80+, covering all voivodeships in Poland.</p><p><strong>Measurements: </strong>Five Groups were established based on the Wealth Indicator (WI) value, from 54,72 to 243,66 EUR in G1-G5, respectively. Trend lines for incidence and mortality rates were calculated, and slope tests were used to determine statistical significance: positive incidence rate (IR)(+), mortality rate (MR)(+), neutral (IR(0), MR(0)), or negative (IR(-), MR(-)). Comparative analyses included slope differences between incidence and mortality trends (IR>MR, IR=MR, IR<MR) using tests with Bonferroni correction.</p><p><strong>Results: </strong>HNC incidence and mortality rates have risen consistently over two decades, regardless of regional economic status. More affluent regions show a better incidence-to-mortality ratio, but no improvement is seen in the 80+ age group. Female patients achieve consistently better outcomes than males across all regions and age groups.</p><p><strong>Limitations: </strong>Despite the optimal selection of the WI (Wealth Indicator) indicator, it does not fully reflect the income stratification issue, particularly in the G5, the wealthiest group. The analysis does not capture the problem of increased incidence rates in the most industrialized region.</p><p><strong>Conclusion: </strong>The findings highlight the need for enhanced screening protocols for males to address gender disparities in HNC outcomes and tailored therapeutic strategies for the 80+ age group.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Imaging and [18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography-Guided Therapy Improves Survival in Upper Aerodigestive Tract NK/T-Cell Lymphoma, Nasal Type: A Prospective Cohort Study.","authors":"Quanguang Ren, Yue Cui, He Huang, Xueying Li, Huangming Hong, Zhao Wang, Xiaojie Fang, Chengcheng Guo, Yuyi Yao, Zegeng Chen, Ying Huang, Zhiming Li, Qingqing Cai, Ying Tian, Hanyu Wang, Xiaoping Lin, Wei Fan, Lie Zheng, Suxia Lin, Ying Guo, Tongyu Lin","doi":"10.1002/hed.28137","DOIUrl":"https://doi.org/10.1002/hed.28137","url":null,"abstract":"<p><strong>Background: </strong>To investigate the value of pretreatment nasopharyngeal and neck magnetic resonance imaging (NN-MRI) combined with positron emission tomography (PET)/CT-guided therapy for improving survival in upper aerodigestive tract NK/T-cell lymphoma (UADT-NKTL) patients.</p><p><strong>Methods: </strong>We performed a prospective cohort study including 171 untreated patients histologically diagnosed with UADT-NKTL, of whom 71 patients received PET/CT combined with NN-MRI and the other 100 patients received PET/CT alone. The clinical stage of every patient was classified according to the Ann Arbor and TNM staging systems. Clinical stage, target volume delineation, and survival were evaluated and compared for PET/CT with and without NN-MRI.</p><p><strong>Results: </strong>By detecting additional local lesions, NN-MRI upgraded the clinical stages on the basis of the Ann Arbor staging system and TNM staging system compared to the results of PET/CT (9/71, p = 0.011; 11/71, p = 0.019, respectively), which revised the target volume delineation of radiotherapy (9/71) in the PET/CT-MRI group. Compared with those in the PET/CT group, 3-year local recurrence-free survival was prolonged in the PET/CT-MRI group (100% vs. 74.9%; p < 0.001), and 3-year overall survival and progression-free survival were better in the PET/CT-MRI group (84.5% vs. 76.3%, p = 0.04 and 78.3% vs. 67.3%, p = 0.03, respectively).</p><p><strong>Conclusion: </strong>NN-MRI and PET/CT-guided therapy could complementarily assist in optimizing the determination of clinical stage and target delineation, which could improve the prognosis of UADT-NKTL patients.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-Hypofractionated Radiotherapy for Early-Stage Glottic Cancer: Real-World Data From a Single Center.","authors":"Mete Gundog, Esin Kiraz","doi":"10.1002/hed.28139","DOIUrl":"https://doi.org/10.1002/hed.28139","url":null,"abstract":"<p><strong>Background: </strong>In recent years, smaller-volume radiotherapy has attracted attention. It appears to be a safe and effective treatment for glottic laryngeal cancer. This study evaluated the results of ultra-hypofractionated radiotherapy for early glottic laryngeal cancer in unfit patients.</p><p><strong>Methods: </strong>This retrospective study analyzed 22 patients diagnosed with early glottic cancer between June 2017 and January 2021. The involved vocal cord was treated with 35-42.5 Gy in 5 fractions.</p><p><strong>Results: </strong>On a 59-month median follow-up, the 5-year overall survival and local control rate were 68.2% and 94.7%, respectively. However, the 5-year larynx preservation rate was 89.7%. Chondronecrosis was observed in one patient (4.5%), and soft tissue necrosis in one patient (4.5%). PTV_D98 (> 41.08 Gy) was found to be statistically significant in surgery-needed events (HR: 22.4, 95% CI: 1.9-252.1, p = 0.01).</p><p><strong>Conclusion: </strong>Single-cord ultra-hypofractionated radiotherapy appears to be an effective treatment for local control. However, the risk of radionecrosis is higher at doses above 41.08 Gy.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early and Long-Term Thyroid Dysfunction in Patients With Head and Neck Squamous Cell Carcinoma After External Radiotherapy: Clinicopathological Risk Factors.","authors":"Adriana Russo Fiore, Gustavo Jacob Lourenço, Eduardo Baldon Pereira, Luciana Freire De Almeida Dos Anjos, Carmen Silvia Passos Lima, Denise Engelbrecht Zantut-Wittmann","doi":"10.1002/hed.28150","DOIUrl":"https://doi.org/10.1002/hed.28150","url":null,"abstract":"<p><strong>Background: </strong>To evaluate thyroid dysfunction(TD) among patients with head and neck squamous cell carcinoma (HNSCC) submitted to external radiotherapy (RT).</p><p><strong>Methods: </strong>The study focused on early and long-term TD in 285 HNSCC patients treated with RT alone or combined with radiochemotherapy and/or surgery.</p><p><strong>Results: </strong>A total of 156 (54.7%) patients presented TD during follow-up, 153 (53.7%) TD in long-term. Subclinical hypothyroidism (SCH) was the TD first identified in 43.5%; persisted in 68.5%, evolved to overt hypothyroidism in 21%, central hypothyroidism in 0.8%, returned to euthyroidism in 9.7%. TD first detection was 7.2 months after RT, 3.85 months for subclinical thyrotoxicosis, 17.77 months for SCH. Type 2 diabetes mellitus (DM2), metastatic lymph nodes, no tumor resection were TD risk factors. All patients with TSH ≥ 7.5 mIU/mL developed primary/SCH, 19.5% with TSH < 7.5 mIU/mL remained euthyroid at long-term follow-up.</p><p><strong>Conclusion: </strong>Frequent monitoring of thyroid function is necessary in patients with HNSCC after RT, particularly with DM2, lymph node involvement, no surgical tumor resection.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase II Trial of Chemotherapy, Cetuximab, and Erlotinib in Patients With Metastatic or Recurrent Squamous Cell Carcinoma of the Head and Neck.","authors":"Aarti Bhatia, Ranee Mehra, Jessica Bauman, Saad A Khan, Wei Wei, Veronique Neumeister, Teresa Sandoval-Schaefer, R Katherine Alpaugh, Miriam Lango, David L Rimm, John A Ridge, Barbara Burtness","doi":"10.1002/hed.28152","DOIUrl":"https://doi.org/10.1002/hed.28152","url":null,"abstract":"<p><p>Prognosis for patients with recurrent/metastatic (R/M) head and neck squamous cell cancer (HNSCC) remains poor. We hypothesized that the addition of an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) to standard therapy would improve responses by inhibiting nuclear translocation of EGFR and designed a phase 2 trial of chemotherapy, cetuximab, and erlotinib in patients with R/M HNSCC. A 24 patients were enrolled and treated with carboplatin, paclitaxel, and cetuximab administered in 21-day cycles. Erlotinib was added with cycle 2. The primary end point was the objective response rate (ORR). The secondary end points were toxicity, overall survival (OS) and laboratory correlates. Median age was 65.5 years. Median duration on treatment was 4.6 months. ORR with cycle 1 of treatment was 33.3%, and for cycle 2 and beyond was 58.3%. Median progression-free survival (PFS) was 6.2 months, and median OS was 10.6 months. Most common treatment-related adverse events included anemia, neutropenia, skin rash, diarrhea, and hypomagnesemia. Dual EGFR blockade was tolerable and efficacious in this small patient sample. With an ORR of 58.3%, the study met its primary endpoint. PFS and OS were comparable to historical controls. Dual EGFR targeting without the chemotherapy backbone is worthy of further study. Trail Registration: ClinicalTrials.gov identifier: NCT01316757.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Adjuvant Radioactive Iodine Therapy in Histological Variants of DTC: A Scoping Review.","authors":"Brian A Keith, Evan S Chernov, Shaun A Nguyen, Jyotika K Fernandes, William G Albergotti","doi":"10.1002/hed.28155","DOIUrl":"https://doi.org/10.1002/hed.28155","url":null,"abstract":"<p><strong>Background: </strong>The efficacy of adjuvant radioactive iodine (RAI) therapy in intermediate- and high-risk differentiated thyroid carcinoma (DTC) remains unclear, particularly for papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC).</p><p><strong>Methods: </strong>This scoping review, following PRISMA-ScR guidelines, analyzed studies from PubMed, Scopus, and CINAHL through July 14, 2023. Data on demographics, cancer characteristics, treatment details, and clinical outcomes were extracted. A limited meta-analysis of continuous measures, proportions, and hazard ratios was performed.</p><p><strong>Results: </strong>Nineteen studies were included, revealing significant variability across studies. Meta-analysis was limited to overall survival (OS) in intermediate-risk PTC due to methodological heterogeneity across studies. Kaplan-Meier survival curves were inconsistent, RAI activity was often unreported, and complications of RAI were rarely addressed.</p><p><strong>Conclusions: </strong>Methodological heterogeneity hinders the assessment of adjuvant RAI efficacy between histological variants. Further randomized trials with extended follow-up and improved reporting are needed to better compare the effects of adjuvant RAI in PTC and FTC.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Intensity Modulated Proton Therapy for Salivary Gland Carcinoma: High Local Control and Quality of Life Preservation.","authors":"Gaku Takano, Daisuke Kawakita, Hiromitsu Iwata, Yukiko Hattori, Koichiro Nakajima, Yusuke Tsuzuki, Shuou Sudo, Toshiyuki Toshito, Kensuke Hayashi, Takuma Matoba, Michi Sawabe, Kiyoshi Minohara, Sho Iwaki, Kazuyuki Nakai, Yu Iwase, Shinichi Iwasaki, Hiroyuki Ogino","doi":"10.1002/hed.28149","DOIUrl":"https://doi.org/10.1002/hed.28149","url":null,"abstract":"<p><strong>Background: </strong>In recent years, particle therapy has shown promise as a local treatment for salivary gland carcinoma (SGC); however, its efficacy and safety remain unclear. This study aimed to evaluate the clinical outcomes of intensity-modulated proton therapy (IMPT) for SGC.</p><p><strong>Methods: </strong>We performed a single-institution retrospective analysis of patients with SGC who underwent IMPT.</p><p><strong>Results: </strong>IMPT was performed on 28 SGC patients, of which 18 were for definitive treatment and 10 were for postoperative treatment. The 2-year overall survival (OS), progression-free survival (PFS), and local control (LC) rates for definitive treatment cases were 70.1%, 25.0%, and 82.5%, respectively. The 2-year OS, PFS, and LC rates for postoperative treatment cases were 100%, 80.0%, and 90.0%, respectively. Quality of life scores in the EORTC QLQ-C30 and QLQ-HN35 were preserved for 1 year after treatment.</p><p><strong>Conclusions: </strong>Our study suggests the efficacy and safety of IMPT in SGC patients.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}