Effect of a Home-Based Exercise Program on Muscle Mass, Fatigue, and Health-Related Quality of Life Among Patients with Oral Cancer: A Randomized Trial.

IF 2.2 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-10-08 DOI:10.1002/hed.70063

Camilla Wallmander, Ingvar Bosaeus, Ewa Silander, Hedda Haugen Cange, Jan Nyman, Monika Fagevik Olsén, Elisabet Blomsterwall, Malin Berg, Eva Hammerlid

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Abstract

Background: Patients with head and neck cancer (HNC) often experience deteriorated health-related quality of life (HRQoL) and loss of body weight and muscle mass. The primary aim was to determine if a home-based exercise program, aiming to increase physical activity (PA), could reduce muscle mass loss and fatigue.

Methods: Oral cancer patients were randomized to an exercise group (EG) or a control group (CG). The EG received a home-based exercise program, and both groups were followed for 1 year. The Frändin/Grimby activity scale, bioelectrical impedance analysis, and HRQoL questionnaires were used to assess PA, muscle mass, and fatigue.

Results: In total, 119 patients were included. The EG increased their PA, but no differences in muscle mass were found between groups. A tendency toward less fatigue and better global QoL was observed in the EG.

Conclusion: Future studies are needed to explore the possible benefits of PA in patients with HNC.

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家庭运动计划对口腔癌患者肌肉质量、疲劳和健康相关生活质量的影响：一项随机试验

背景：头颈癌（HNC）患者经常经历健康相关生活质量（HRQoL）恶化，体重和肌肉质量下降。研究的主要目的是确定以增加体力活动（PA）为目标的家庭锻炼计划是否可以减少肌肉质量损失和疲劳。方法：将口腔癌患者随机分为运动组（EG）和对照组（CG）。EG接受以家庭为基础的锻炼计划，两组随访1年。使用Frändin/Grimby活动量表、生物电阻抗分析和HRQoL问卷来评估PA、肌肉质量和疲劳。结果：共纳入119例患者。EG组增加了它们的PA，但肌肉质量在组间没有差异。在EG中观察到疲劳程度降低和总体生活质量提高的趋势。结论：需要进一步的研究来探索PA对HNC患者可能的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.