Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献_第2页

Comparative effectiveness and cost-effectiveness of endoscopic nasopharyngectomy versus intensity-modulated radiotherapy in the treatment of recurrent nasopharyngeal carcinoma: A microsimulation analysis. 治疗复发性鼻咽癌的内窥镜鼻咽切除术与调强放射治疗的有效性和成本效益比较：微观模拟分析。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-02-01 Epub Date: 2024-09-23 DOI: 10.1002/hed.27942

Mingjun Rui, Yingcheng Wang

{"title":"Comparative effectiveness and cost-effectiveness of endoscopic nasopharyngectomy versus intensity-modulated radiotherapy in the treatment of recurrent nasopharyngeal carcinoma: A microsimulation analysis.","authors":"Mingjun Rui, Yingcheng Wang","doi":"10.1002/hed.27942","DOIUrl":"10.1002/hed.27942","url":null,"abstract":"Background: Nasopharyngeal carcinoma (NPC) is a significant health concern in southern China, like Guangdong and Hong Kong. This study aims to predict the effectiveness and cost-effectiveness of two prevalent NPC treatments, intensity-modulated radiotherapy (IMRT) and endoscopic nasopharyngectomy (ENPG).Methods: A microsimulation model was developed to project the long-term outcomes of IMRT and ENPG, simulating 5000 patients with hypothetical locally recurrent NPC for each treatment option. The tumors of patients confined to the nasopharyngeal cavity, the post-naris or nasal septum, the superficial parapharyngeal space, or the base wall of the sphenoid sinus. Analyses were performed from the healthcare system perspectives of Mainland China and the healthcare provider perspective of Hong Kong, with input parameters sourced from the existing literature and databases. The robustness of findings was evaluated through one-way and probabilistic sensitivity analyses.Results: For DFS, ENPG showed a 29% reduction in risk with an HR of 0.71 (95% CI: 0.64-0.77) compared to IMRT. ENPG demonstrated a significant survival benefit in OS with an HR of 0.59 (95% CI: 0.54-0.65), equating to a 41% reduction in mortality risk. In Hong Kong, IMRT and ENPG yielded QALY gains of 4.59 and 6.29, respectively, with ENPG exhibiting an incremental cost-effectiveness ratio (ICUR) of USD 13 057 per QALY. For Mainland China, ENPG denominated the IMRT and the ICUR was USD -1450 QALY. Probabilistic sensitivity analysis showed a 100% probability of ENPG being cost-effective at the willingness-to-pay thresholds of USD 130 490 per QALY in Hong Kong and USD 12 741 per QALY in Mainland China.Conclusion: The analysis confirms that ENPG is more effective and cost-effective than IMRT for treating recurrent NPC in both Hong Kong and Mainland China.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"529-537"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor Microenvironment-Based Risk Stratification of Oropharyngeal Squamous Cell Carcinoma. 基于肿瘤微环境的口咽鳞状细胞癌风险分层。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-02-01 Epub Date: 2024-09-28 DOI: 10.1002/hed.27945

Alhadi Almangush, Lauri Jouhi, Caj Haglund, Jaana Hagström, Antti A Mäkitie, Ilmo Leivo

{"title":"Tumor Microenvironment-Based Risk Stratification of Oropharyngeal Squamous Cell Carcinoma.","authors":"Alhadi Almangush, Lauri Jouhi, Caj Haglund, Jaana Hagström, Antti A Mäkitie, Ilmo Leivo","doi":"10.1002/hed.27945","DOIUrl":"10.1002/hed.27945","url":null,"abstract":"Background: Evaluation of the prognostic impact of tumor microenvironment (TME) has received attention in recent years. We introduce a TME-based risk stratification for oropharyngeal squamous cell carcinoma (OPSCC).Material and methods: A total of 182 patients treated for OPSCC at the Helsinki University Hospital were included. TME-based risk stratification was designed combining tumor-stroma ratio and stromal tumor-infiltrating lymphocytes assessed in hematoxylin and eosin-stained sections.Results: In multivariable analysis, TME-based risk stratification associated with poor disease-free survival with a hazard ratio (HR) of 2.68 (95% CI 1.11-6.48, p = 0.029). In addition, the proposed risk stratification was associated with poor disease-specific survival (HR 2.687, 95% CI 1.28-5.66, p = 0.009) and poor overall survival (HR 2.21, 95% CI 1.23-3.99, p = 0.008).Conclusion: Our TME-based risk stratification provides a powerful prognostic tool that can be used in daily treatment planning of OPSCC together with tumor-related prognostic markers.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"599-605"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CYLD Alterations Are Associated With Metastasis and Poor Prognosis in Human Papilloma Virus-Positive Head and Neck Cancer. CYLD改变与人类乳头状瘤病毒阳性头颈癌的转移和预后不良有关

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-02-01 Epub Date: 2024-09-30 DOI: 10.1002/hed.27944

Zhibin Cui, Hyunseok Kang, Hua Li, Eliot D Lee, Yoon Se Lee, Christopher N Peterson, Steven R Long, Jennifer R Grandis, Daniel E Johnson

{"title":"CYLD Alterations Are Associated With Metastasis and Poor Prognosis in Human Papilloma Virus-Positive Head and Neck Cancer.","authors":"Zhibin Cui, Hyunseok Kang, Hua Li, Eliot D Lee, Yoon Se Lee, Christopher N Peterson, Steven R Long, Jennifer R Grandis, Daniel E Johnson","doi":"10.1002/hed.27944","DOIUrl":"10.1002/hed.27944","url":null,"abstract":"Background: Human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is an emerging epidemic and a subset of HPV-positive patients experience aggressive disease with metastases. The CYLD gene is frequently altered in HPV-positive HNSCC, but the role of these alterations in disease progression is poorly understood.Methods: We identified 11 HPV-positive HNSCC patients with CYLD alterations and assessed their clinical course. We also characterized a unique, HPV-positive, metastatic, HNSCC patient-derived xenograft (PDX).Results: All 11 patients developed metastasis with reduced overall survival when compared with metastatic HPV-positive patients with wild-type CYLD. The metastatic PDX harbored a CYLD mutation (S371*) and exhibited reduced expression of connexin 43, a potentially antimetastatic protein. We also investigated the functional impact of the S371* mutation, as well as 2 CYLD mutations from our 11-patient cohort.Conclusion: Our findings indicate that alterations in CYLD in HPV-positive HNSCC are associated with metastasis and poor prognosis.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"606-614"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative Real-Time Image-Guided Fibular Harvest and Mandibular Reconstruction: A Feasibility Study on Cadaveric Specimens. 术中实时图像引导的腓骨摘除和下颌骨重建：尸体标本可行性研究

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-02-01 Epub Date: 2024-10-04 DOI: 10.1002/hed.27954

Georgia Grzybowski, Molly Murray Stewart, Thomas D Milner, Anat Bahat Dinur, Orla M McGee, Amir Pakdel, Khanh Linh Tran, Sidney S Fels, Antony J Hodgson, Eitan Prisman

{"title":"Intraoperative Real-Time Image-Guided Fibular Harvest and Mandibular Reconstruction: A Feasibility Study on Cadaveric Specimens.","authors":"Georgia Grzybowski, Molly Murray Stewart, Thomas D Milner, Anat Bahat Dinur, Orla M McGee, Amir Pakdel, Khanh Linh Tran, Sidney S Fels, Antony J Hodgson, Eitan Prisman","doi":"10.1002/hed.27954","DOIUrl":"10.1002/hed.27954","url":null,"abstract":"Background: This study assesses the feasibility of real-time surgical navigation to plan and guide sequential steps during mandible reconstruction on a series of cadaveric specimens.Methods: An image-guided surgical (IGS) system was designed including customized mandible and fibula fixation devices with navigation reference frames and an accompanied image-guided software. The mandibular and fibular segmental osteotomies were performed using the IGS in all five cadaveric patients. Procedural time and cephalometric measurements were recorded.Results: Five real-time IGS mandibulectomy and fibular reconstruction were successfully performed. The mean Dice score and Hausdorff-95 distance between the planned and actual mandible reconstructions was 0.8 ± 0.08 and 7.29 ± 4.81 mm, respectively. Intercoronoid width, interangle width, and mandible projection differences were 1.15 ± 1.17 mm, 0.9 ± 0.56 mm, and 1.47 ± 1.62 mm, respectively.Conclusion: This study presents the first demonstration of a comprehensive image-guided workflow for mandibulectomy and fibular flap reconstruction on cadaveric specimens and resulted in adequate cephalometric accuracy.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"640-650"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing Thyroid Nodules in Brain-Dead Donors: Our Experience and a Review of the Literature. 管理脑死亡捐献者的甲状腺结节：我们的经验和文献综述。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-02-01 Epub Date: 2024-10-06 DOI: 10.1002/hed.27946

Luca Giovanni Locatello, Nicole Caiazza, Federico Cavallo Ronchi, Anna Maria Bergamin-Bracale, Cesare Miani

{"title":"Managing Thyroid Nodules in Brain-Dead Donors: Our Experience and a Review of the Literature.","authors":"Luca Giovanni Locatello, Nicole Caiazza, Federico Cavallo Ronchi, Anna Maria Bergamin-Bracale, Cesare Miani","doi":"10.1002/hed.27946","DOIUrl":"10.1002/hed.27946","url":null,"abstract":"Background: Thyroid nodules are common findings during the diagnostic work-up in potential organ donors. A fast yet thorough assessment to rule out cancer is mandatory but their management remains heterogeneous among hospitals and the evidence in this field is scarce. We present our institutional experience and review the most recent literature on this topic.Methods: Retrospective case series and systematic review of the literature.Results: In the years 2000-2023, 47 total thyroidectomies were performed on potential brain-dead donors. Intraoperative frozen section (FS) revealed 6 cases (13.9%) of papillary carcinoma that led to organ discarding in 3 cases (6.9%). The mean operative time of the procedures was 42.75 min and no procurement-delaying complications were registered.Conclusion: Total thyroidectomy with an intraoperative FS is a sound method for assessing suspicious nodules before organ harvesting. Future randomized studies comparing its performance against fine needle aspiration biopsy are needed to define the most cost-effective and time-saving strategy.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"651-656"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bending the rules: A novel approach to laryngeal surgery in a body donor study. 打破常规：供体研究中的喉部手术新方法。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-02-01 Epub Date: 2024-09-26 DOI: 10.1002/hed.27939

Linus L Kienle, Leon R Schild, Felix Boehm, Viola D Hahn, Jens Greve, Adrian von Witzleben, Thomas K Hoffmann, Patrick J Schuler

{"title":"Bending the rules: A novel approach to laryngeal surgery in a body donor study.","authors":"Linus L Kienle, Leon R Schild, Felix Boehm, Viola D Hahn, Jens Greve, Adrian von Witzleben, Thomas K Hoffmann, Patrick J Schuler","doi":"10.1002/hed.27939","DOIUrl":"10.1002/hed.27939","url":null,"abstract":"Background: Transoral laser microsurgery, the standard surgical approach for early-stage laryngeal cancer, necessitates an unobstructed line of sight to the operating field. However, achieving adequate laryngeal exposure can be challenging, potentially compromising treatment outcomes.Methods: We developed a 3D-printed curved laryngoscope (sMAC), designed to match the upper airway anatomy. In a user study (n = 15) with a human body donor we compared the sMAC system to conventional microlaryngoscopy regarding laryngeal exposure and accessibility in a difficult exposure scenario.Results: All 15 participants achieved complete glottic exposure and successfully manipulated laryngeal landmarks using the sMAC system. Only four participants achieved partial exposure using microlaryngoscopy. Positioning of the sMAC system was significantly faster (p = 0.023). A vocal cord resection was conducted successfully (n = 2) using the sMAC system.Conclusion: The sMAC system effectively addresses challenges associated with transoral laryngeal surgery. Ongoing development aims to overcome current limitations of the system and prepare first clinical trials.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"575-585"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Axial split step osteotomy of free iliac crest flaps for mandible reconstruction: Preliminary results. 用于下颌骨重建的游离髂嵴瓣轴向劈开阶梯截骨术：初步结果

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-02-01 Epub Date: 2024-09-25 DOI: 10.1002/hed.27941

Shu Yi, Xiaoming Lyu, Wei Wang, Mingwei Huang, Shuming Liu, Jie Zhang

{"title":"Axial split step osteotomy of free iliac crest flaps for mandible reconstruction: Preliminary results.","authors":"Shu Yi, Xiaoming Lyu, Wei Wang, Mingwei Huang, Shuming Liu, Jie Zhang","doi":"10.1002/hed.27941","DOIUrl":"10.1002/hed.27941","url":null,"abstract":"Background: Vascularized bone grafting (VBG) is preferred for mandibular reconstruction post-tumor ablation. Although various bone-free flaps are used, their application is compromised by limitations including insufficient bone volume and poor shape. Here, we report mandibular reconstruction using axial split-step osteotomy with an iliac crest-free flap.Methods: Over December 2018-November 2020, 12 patients underwent mandibular reconstruction via axial split osteotomy using a free iliac-crest flap.Results: The preoperative iliac-crest length was 5.7-9.5 mm (median, 7.5 cm); the mean post-axial split-osteotomy iliac-crest length increased to 9.59 mm (range, 6.34-15.15 mm). All patients presented with initial healing 2 weeks postoperation; good bone healing was achieved in all grafted flaps by the third month of follow-up.Conclusions: We propose a new axial split-step osteotomy technique using free iliac-crest flaps for mandibular reconstruction. We demonstrated this novel technique's reliability for safe and effective bone lengthening and establishing a reliable occlusal relationship.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"567-574"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Oncologic Outcomes of Thermal Ablation Techniques in the Treatment of Primary Low-Risk Papillary Thyroid Carcinoma: A Systematic Review and Network Meta-Analysis. 热消融技术治疗原发性低危甲状腺乳头状癌的疗效和肿瘤预后：系统综述和网络荟萃分析。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-02-01 Epub Date: 2024-12-23 DOI: 10.1002/hed.28029

Van Cuong Nguyen, Jeong Seon Park, Chang Myeon Song, Yong Bae Ji, Jin Hyeok Jeong, Kyung Tae

{"title":"Efficacy and Oncologic Outcomes of Thermal Ablation Techniques in the Treatment of Primary Low-Risk Papillary Thyroid Carcinoma: A Systematic Review and Network Meta-Analysis.","authors":"Van Cuong Nguyen, Jeong Seon Park, Chang Myeon Song, Yong Bae Ji, Jin Hyeok Jeong, Kyung Tae","doi":"10.1002/hed.28029","DOIUrl":"10.1002/hed.28029","url":null,"abstract":"Background: This study aimed to evaluate the safety, efficacy, and oncologic outcomes of thermal ablation techniques, including radiofrequency, laser, and microwave ablation, in treating primary thyroid cancer compared with surgical resection.Method: We conducted a systematic review and network meta-analysis, which included 21 comparative studies and 40 noncomparative studies.Results: The three thermal ablation techniques showed significant superiority over surgical resection in terms of operative time, pain, cost, quality of life, and complications. Three years after the procedure, the tumor volume reduction and complete disappearance rates for the three thermal ablation techniques were similar, at approximately 99% and 93%-95%, respectively. The recurrence rate remained comparable (approximately 2%-3%) among the three thermal ablation techniques and surgical resection during a follow-up period exceeding 3 years.Conclusions: The safety, efficacy, and oncologic outcomes of thermal ablation techniques may be acceptable and comparable to surgical resection for selected cases of primary thyroid cancer.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"759-775"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single Stage Reconstruction of Composite Rhinectomy Defects Using Osteocutaneous Radial Forearm Free Flap. 前臂桡骨皮游离皮瓣一期重建复合鼻切除缺损。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-02-01 Epub Date: 2024-12-20 DOI: 10.1002/hed.28042

Omar A Karadaghy, Allen L Feng

{"title":"Single Stage Reconstruction of Composite Rhinectomy Defects Using Osteocutaneous Radial Forearm Free Flap.","authors":"Omar A Karadaghy, Allen L Feng","doi":"10.1002/hed.28042","DOIUrl":"10.1002/hed.28042","url":null,"abstract":"Background: Composite rhinectomy defects pose significant challenges due to the nose's complex structure and role in facial esthetics and function. Traditional nasal reconstructions often require multiple stages to restore mucosal lining, structural support, and external skin.Methods: This case series examines the use of a single-stage osteocutaneous radial forearm free flap (OCRFFF) for composite rhinectomy reconstruction. Three patients who underwent composite rhinectomy due to malignancy were treated using OCRFFF, which allows for simultaneous reconstruction of composite nasal defects by incorporating skin, bone, and fascial tissue.Results: All three cases achieved successful postoperative outcomes, demonstrating both cosmetic and functional success without significant long-term complications. The single-stage approach streamlined the reconstructive process, reducing patient recovery time and the need for additional surgeries.Conclusions: OCRFFF is an effective, transformative technique for single-stage nasal reconstruction for composite rhinectomy defects, providing reliable functional and esthetic outcomes, and contributing to advancements in complex nasal defect management.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"776-782"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prognostic Importance of Radiologic Extranodal Extension in Hypopharyngeal Carcinoma. 下咽癌放射学结节外扩展的预后意义

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-02-01 Epub Date: 2024-11-04 DOI: 10.1002/hed.27978

Yu-Hao Liao, Ya-Fang Chen, Min-Shu Hsieh, Mei-Chun Lin, Chun-Wei Wang, Cheng-Ping Wang, Pei-Jen Lou, Tseng-Cheng Chen

{"title":"The Prognostic Importance of Radiologic Extranodal Extension in Hypopharyngeal Carcinoma.","authors":"Yu-Hao Liao, Ya-Fang Chen, Min-Shu Hsieh, Mei-Chun Lin, Chun-Wei Wang, Cheng-Ping Wang, Pei-Jen Lou, Tseng-Cheng Chen","doi":"10.1002/hed.27978","DOIUrl":"10.1002/hed.27978","url":null,"abstract":"Background: Extranodal extension (ENE) had been included in the latest cancer staging system in hypopharyngeal squamous cell carcinoma (HypoSCC). However, the impact of ENE on HypoSCC survival and treatment outcomes are still unclear.Methods: Records from all HypoSCC patients diagnosed at the National Taiwan University Hospital from January 2007 to December 2018 were reviewed. All patients were divided into two groups, with or without ENE. Clinical features, pathological factors, and survival rates between the two groups were reviewed.Results: We analyzed data from 388 HypoSCC patients, 125 (32.22%) with and 263 (67.78%) without ENE. The 5-year overall survival of the HypoSCC patients with radiological ENE, pathological ENE, and without ENE were 22.9%, 40.3%, and 55.5%. From the multivariate analysis, primary T3/T4 classification (p = 0.001) and radiological ENE (p < 0.001) were independent risk factors for disease-free and overall survival (OS). Finally, upfront neck dissection may significantly benefit disease-free survival (DFS) and neck nodal control in ENE+ (p = 0.002 and p = 0.007, respectively) or ENE- patients (p = 0.003 and p = 0.02, respectively).Conclusion: More than one-third of HypoSCC patients have ENE, with significantly lower OS and DFS. The upfront neck dissection could provide better DFS and neck nodal control.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"667-678"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0