Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献

{"title":"Associations of Pain, Anxiety, and Depressive Symptoms With Sleep Outcomes in Patients With Head and Neck Squamous Cell Carcinoma: A Cross-Sectional Observational Study.","authors":"Giseli Mitsuy Kayahara, Bruna Amélia Moreira Sarafim-Costa, Marcus Vinícius Branco de Oliveira, Antônio Mendes Fontanelli, Yi Ye, Vitor Bonetti Valente, Eder Ricardo Biasoli, Glauco Issamu Miyahara, Daniel Galera Bernabé","doi":"10.1002/hed.28147","DOIUrl":"https://doi.org/10.1002/hed.28147","url":null,"abstract":"<p><strong>Background: </strong>This exploratory cross-sectional observational study sought to characterize sleep quality and evaluate its association with sociodemographic, clinicopathological, behavioral, and psychological variables in patients with head and neck squamous cell carcinoma (HNSCC).</p><p><strong>Patients and methods: </strong>Sleep problems from 132 HNC patients were assessed before starting oncological treatment through the questionnaires Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and STOP-Bang. Anxiety and depression symptoms were evaluated using the Hospital Anxiety and Depression Scale. Univariate analysis and multivariate logistic regression were performed to evaluate factors associated with sleep problems in HNSCC patients.</p><p><strong>Results: </strong>About 50% of the HNSCC patients reported poor overall sleep quality on the PSQI. Insomnia, excessive daytime sleepiness, and high risk of apnea were observed in 19%, 15%, and 54% of HNSCC patients, respectively. Our results showed that pain was associated with overall poor PSQI sleep quality and lower PSQI sleep efficiency, while the presence of regional metastasis was linked to overall PSQI good sleep. No other clinicopathological or behavioral (i.e., alcohol and tobacco use) variables were related to sleep outcomes. Higher occurrence of anxiety symptoms was related to poor overall PSQI sleep quality, decreased PSQI sleep efficiency, PSQI daytime dysfunction, and ISI insomnia. Moreover, higher occurrence of depression symptoms was associated with lower PSQI sleep latency and PSQI duration, and the occurrence of ESS excessive daytime sleepiness.</p><p><strong>Conclusion: </strong>Pain, anxiety, and depressive symptoms were associated with poor sleep quality and sleep problems in HNSCC patients before starting treatment. No sociodemographic or behavioral (i.e., alcohol and tobacco use) variables were related to sleep outcomes. Likewise, tumor location, T classification, and clinical staging were not linked to sleep quality and disorders in HNSCC patients.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Stratification for Extranodal Extension in Head and Neck Cancers-Implication for Treatment Intensification.","authors":"Smriti Panda, Rajeev Kumar, Aanchal Kakkar, Sandipta Mitra, Vishwajeet Singh, Alok Thakar, Chirom Amit Singh, Kapil Sikka, Anup Singh, Kavneet Kaur, Aman Sharma, Akash Kumar, Amit Kumar, Rachit Sood, Karthika Chettuvatti, Areej Moideen, Nongthombam Surjalata Devi","doi":"10.1002/hed.28144","DOIUrl":"https://doi.org/10.1002/hed.28144","url":null,"abstract":"<p><strong>Background: </strong>Extranodal extension (ENE) is an important adverse prognostic indicator for head and neck cancers. However, ENE needs further risk stratification in terms of optimum cutoff for the extent of ENE and interaction with clinicopathological risk factors.</p><p><strong>Methods: </strong>Retrospective single-center study on patients with treatment-naïve head and neck cancer with final histology indicating ENE.</p><p><strong>Results: </strong>Pathological ENE was observed in 122 patients (12.4%). With the 2 mm cutoff separating Mi-ENE and Ma-ENE, no difference was observed in overall survival (OS) and disease-free survival (DFS) for unmatched (OS: 40.9% vs. 33.6%, p = 0.7; DFS: 34.05% vs. 26.12%, p = 0.5) as well as propensity score-matched cohort (OS: HR 1.08, p = 0.82; DFS: HR 0.95, p = 0.89). Receiver-operator curve (ROC) analysis showed the highest area under the curve with a 4 mm cutoff for the extent of ENE (AUC: 0.52). On assessing the impact of adjuvant chemoradiation (CRT) on Ma-ENE and Mi-ENE, only Ma-ENE showed OS (HR: 0.42, 95% CI: 0.18-0.9) and DFS (HR: 0.33, 95% CI: 0.15-0.70) benefit with CRT, which was statistically significant. The revised 4 mm cutoff was predictive of therapeutic benefit with adjuvant CRT (HR: 0.27, 95% CI: 0.1-0.73). Clinicopathological factors with statistically significant interaction with ENE in worsening OS and DFS were tumor location in tongue/floor of mouth (OS), T3/T4 category (OS), depth of invasion greater than 10 mm (OS), ≥ 5 nodes with metastasis (OS), and male sex (DFS).</p><p><strong>Conclusion: </strong>The standard 2 mm cutoff for the extent of ENE failed to reveal sufficient hazard discrimination for OS/DFS. Instead, the 4 mm cutoff determined on ROC analysis was found to have the best predictive ability for DFS.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in PD-L1, PD-L2, and EGFR Expression Between Naive and Recurrent Tumors in Patients With Head and Neck Squamous Cell Carcinoma: A Retrospective Study.","authors":"Ryosuke Sato, Takahiro Inoue, Risa Wakisaka, Hiroki Komatsuda, Michihisa Kono, Hidekiyo Yamaki, Kenzo Ohara, Takumi Kumai, Akemi Kosaka, Takayuki Ohkuri, Toshihiro Nagato, Kan Kishibe, Hiroya Kobayashi, Miki Takahara","doi":"10.1002/hed.28151","DOIUrl":"https://doi.org/10.1002/hed.28151","url":null,"abstract":"<p><strong>Background: </strong>The efficacy of anti-PD-1 and EGFR therapies for head and neck squamous cell carcinoma (HNSCC) can be predicted using various markers; however, the stability of these markers remains unclear.</p><p><strong>Methods: </strong>In this retrospective study, laboratory findings and tissue expression of PD-L1, PD-L2, and EGFR were analyzed in 79 paired naive and recurrent HNSCC tumors. Laboratory findings were also analyzed in nonrecurrent patients using a propensity score-matched analysis. PD-L1 and PD-L2 expression levels were assessed using tumor proportion score (TPS) and combined positive score (CPS), whereas EGFR was evaluated using the H-score.</p><p><strong>Results: </strong>White blood cell, neutrophil, lymphocyte, and monocyte counts and lymphocyte-monocyte ratios were significantly lower in the patients after the first-line treatment regardless of recurrence. PD-L1, PD-L2, and EGFR expression changed in 30%-40% of tumor pairs. Immune but not tumoral PD-L1 positivity rates were significantly higher in the patients with early recurrence.</p><p><strong>Conclusions: </strong>The expression of immune checkpoints including PD-L1 in naive tumors does not reflect those in recurrent tumors. Increasing PD-L1 expression in immune cells may cause early recurrence of HNSCC.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Evaluation of Superficial Temporal Artery and Its Terminal Branches: Implications for Clinical Practice.","authors":"Helin Yücedağ Gündoğdu, Onur Gündoğdu, Bahattin Paslı, Atiye C Karabörk Kılıç, Burcu Erçakmak Güneş","doi":"10.1002/hed.28141","DOIUrl":"https://doi.org/10.1002/hed.28141","url":null,"abstract":"<p><strong>Background: </strong>The superficial temporal artery (STA) and its terminal branches are crucial in various clinical procedures, including reconstructive surgeries and aesthetic interventions. Understanding the depth and course of these arteries is essential to minimize complications during such procedures.</p><p><strong>Methods: </strong>This retrospective cross-sectional study analyzed head and neck computed tomography (CT) angiograms from 209 individuals aged 25-93. Parameters were evaluated using three-dimensional volume rendering technique (3D-VRT), thin-slab axial, and maximum intensity projection (MIP) images.</p><p><strong>Results: </strong>In total, 418 STAs were examined. The STA diameter decreased and became more superficial from its origin to the bifurcation point. The mean depths of the frontal branch from the skin closest to the jugale point and the zygomatic process were 0.27 ± 0.11 cm and 0.21 ± 0.08 cm, respectively. A significant relationship was found between gender and the depth and diameter of the STA. Age-related changes were observed, with arterial diameters increasing with age.</p><p><strong>Conclusion: </strong>Detailed anatomical data on the STA and its branches can guide the creation of safe zones and surgical planning, reducing the risk of complications in reconstructive and aesthetic procedures. This study highlights the importance of understanding the anatomical variations and the course of the STA for safe and effective clinical interventions.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Instant Intraoperative Histopathological Assessment of Fresh Parathyroid Tissue: Higher Harmonic Generation Microscopy as a Potential Alternative to Frozen Section.","authors":"P M Rodriguez Schaap, S van den Bosch, S Spies, S van Eeden, E J M Nieveen van Dijkum, M L Groot, A F Engelsman","doi":"10.1002/hed.28146","DOIUrl":"https://doi.org/10.1002/hed.28146","url":null,"abstract":"<p><strong>Background: </strong>Hypoparathyroidism is a complication associated with significant morbidity and results from inadvertent removal of the parathyroid during thyroid surgery. Therefore, intra-operative identification of parathyroid tissue is essential to minimize the risk of hypoparathyroidism. Current identification techniques come with significant limitations in logistics and accuracy. We therefore propose higher-harmonic generation microscopy (HHGM), a rapid, non-invasive, label-free method for the real-time visualization of human tissue, as a potential alternative.</p><p><strong>Methods: </strong>A prospective proof-of-concept study was conducted at the Amsterdam University Medical Centers from February to April 2024. Intra-operative HHGM imaging of presumed parathyroid tissue samples was performed, and the results were compared with conventional histopathology by an expert endocrine pathologist in order to evaluate the sensitivity and specificity of HHGM. The logistical process and its potentially associated benefits were also evaluated.</p><p><strong>Results: </strong>Intraoperative imaging was performed on 32 fresh, unprocessed tissue samples from 18 patients. HHGM demonstrated a high sensitivity (85%) and specificity (83.3%) for the detection of parathyroid tissue. HHGM imaging was found to be more time-efficient than frozen section, taking ~5 min per biopsy compared to 30 min for FS. HHGM was able to produce high-quality images in cases where frozen section analysis was inconclusive due to insufficient tissue. Logistical challenges and extra workload associated with HHGM were minimal.</p><p><strong>Conclusion: </strong>This proof-of-concept study demonstrates that HHGM could be a promising intraoperative diagnostic imaging modality, offering rapid imaging and detailed visualization capabilities. These features suggest that HHGM might potentially reduce surgery duration and decrease demand on pathology resources.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Thyroid Ima Arteries Arising From the Brachiocephalic Trunk: A First Case Report.","authors":"Ziqiang Wang, Deguang Zhang, Qiwei Du, Weijun Zhang, Nian Liu, Rongguo Li","doi":"10.1002/hed.28148","DOIUrl":"https://doi.org/10.1002/hed.28148","url":null,"abstract":"<p><strong>Rationale: </strong>Bilateral thyroid ima artery (TIA) arising from the brachiocephalic trunk is an extremely rare anatomical variation, with no prior cases reported. Recognizing such vascular anomalies is crucial for optimizing surgical outcomes in thyroid and mediastinal procedures, as failure to identify these variations can lead to severe intraoperative complications.</p><p><strong>Patient concerns: </strong>A 28-year-old female presented for surgical management of a thyroid nodule detected during a routine physical examination. The patient reported no significant medical history or prior neck surgeries. Preoperative ultrasonography revealed a high malignancy risk and evidence of cervical and mediastinal lymph node involvement.</p><p><strong>Diagnoses: </strong>Intraoperative findings unexpectedly identified two small arteries originating from the brachiocephalic trunk. These were later confirmed as bilateral TIAs through postoperative imaging and 3D reconstruction.</p><p><strong>Interventions: </strong>The patient underwent total thyroidectomy, bilateral modified radical neck dissection, and mediastinal lymph node dissection. Appropriate measures were taken to preserve these vessels during the procedures.</p><p><strong>Outcomes: </strong>The patient recovered uneventfully, with no complications. Postoperative imaging validated the intraoperative findings, confirming the unique vascular variation.</p><p><strong>Lessons: </strong>This case highlights the importance of detailed intraoperative assessment and advanced imaging techniques in surgical planning. Awareness of rare vascular anomalies, such as bilateral TIA, is vital for minimizing surgical risks and improving patient outcomes. This report provides valuable insights into vascular anatomy and clinical practice.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Outcomes of Squamous Cell Carcinoma of the Soft Palate and the Prognostic Significance of HPV/p16 Status.","authors":"Meng-Hua Li, Xing Zhang, Feng-Jiao Li, Xian-Lu Gao, Shi-da Yan, Qiao-Hong Lin, Xi-Yuan Li, Jian Meng, Ying Zhang, Shi-Ting Zhang, Shu-Wei Chen, Ming Song","doi":"10.1002/hed.28143","DOIUrl":"https://doi.org/10.1002/hed.28143","url":null,"abstract":"<p><strong>Background: </strong>Squamous cell carcinoma of the soft palate (SCCSP) represents a rare subtype of oropharyngeal cancer. This study aims to evaluate the treatment outcomes of SCCSP and to assess the prognostic significance of HPV status.</p><p><strong>Methods: </strong>Patients diagnosed with SCCSP between January 1981 and December 2021 were collected. Survival outcomes were compared. RESULTS $$ MATHRM{RESULTS} $$: In univariate analysis, primary surgery resulted in superior progression-free survival (PFS), overall survival (OS), and disease-specific survival (DSS) compared with definitive radiotherapy (p < 0.05). Furthermore, multivariate analysis revealed that primary surgery independently correlated with superior PFS (HR = 0.37, p = 0.002), OS (HR = 0.55, p = 0.012), and DSS (HR = 0.45, p = 0.020) in early-stage SCCSPs. Additionally, no significant prognostic differences were observed between HPV/p16 positive and HPV/p16 negative SCCSPs (p > 0.05). CONCLUSION $$ MATHRM{CONCLUSION} $$: Surgery yields superior oncological outcomes for early-stage SCCSP patients. HPV status does not demonstrate prognostic significance in SCCSP.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free Flap Surgery and Oncologic Care of the Pregnant Head and Neck Cancer Patient.","authors":"Sida Chen, Ricardo J Ramirez, Mohemmed N Khan, Mark L Urken, Yara Sifri, Jill A Berkin, Scott A Roof","doi":"10.1002/hed.28142","DOIUrl":"https://doi.org/10.1002/hed.28142","url":null,"abstract":"<p><strong>Background: </strong>Although head and neck cancer (HNC) in pregnant patients is rare, the incidence of oral cavity cancer has increased in younger women of childbearing age. We detail the complexities of two cases of HNC during pregnancy requiring surgical resection with free flap reconstruction, followed by general guidelines for HNC care of this population.</p><p><strong>Methods: </strong>We report two cases of head and neck cancer management in the pregnant patient.</p><p><strong>Results: </strong>Both patients underwent similar free flap reconstruction for oral cavity cancer. One was able to avoid adjuvant and deliver a healthy child at term, while the second required early termination followed by chemotherapy and radiation. Both remain disease free.</p><p><strong>Conclusions: </strong>Multidisciplinary management is crucial in care for the pregnant HNC patient. Goals include cumulative radiation dose exposures below 100 mGy, operating in the second trimester when the risk is lowest to the fetus and mother, and avoiding chemotherapy or radiation in the first trimester when possible.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Suicide Among Head and Neck Cancer Patients: A Systematic Review and Meta-Analysis.","authors":"Sami I Nassar, Ryan A Durgham, Shaun A Nguyen, Jason G Newman, Alexandra E Kejner, William G Albergotti","doi":"10.1002/hed.28145","DOIUrl":"https://doi.org/10.1002/hed.28145","url":null,"abstract":"<p><strong>Background: </strong>Head and neck cancer (HNC) patients have an elevated suicide risk. This study examines suicide risk factors among HNC patients.</p><p><strong>Methods: </strong>Databases were reviewed through June 2024 for articles examining HNC patient suicide. HNC patients, non-HNC cancer patients, and suicide case numbers were stratified by patient variables. Meta-analyses of proportions and relative risk (RR) were performed.</p><p><strong>Results: </strong>Twenty-one studies with 1 610 031 HNC and 16 857 218 non-HNC cancer patients were included. HNC patients had a higher suicide risk than non-HNC cancer (RR 2.369) and general population (RR 26.991) cohorts. Non-Hispanic ethnicity (RR 3.773), male sex (RR 2.721), and oropharyngeal (RR 1.241) or laryngeal (RR 1.182) cancers increased risk. Being Black (RR 0.316), Hispanic (RR 0.265), and female (RR 0.367) decreased risk. Excluding studies only examining laryngeal cancer intensified sex and race effects on suicide risk.</p><p><strong>Conclusions: </strong>HNC patients have a higher suicide risk than other cancer patients. Laryngeal cancer attenuates the effects of other variables.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracheoesophageal Voicing Following Resistance-Based Dysphagia Rehabilitation: An Exploratory Multidimensional Assessment.","authors":"Marise Neijman, Klaske E van Sluis, Rob J J H van Son, Martijn M Stuiver, Frans J M Hilgers, Michiel W M van den Brekel, Maarten J A van Alphen, Lisette van der Molen","doi":"10.1002/hed.28136","DOIUrl":"https://doi.org/10.1002/hed.28136","url":null,"abstract":"<p><strong>Background: </strong>This exploratory study investigated tracheoesophageal voicing following 6 weeks of resistance-based dysphagia rehabilitation with the SEA2.0, using a multidimensional assessment approach.</p><p><strong>Methods: </strong>Twenty laryngectomized participants were assessed at T0 (baseline), T1 (after 6 weeks training), and T2 (after 8 weeks rest). Training included the chin tuck, jaw opening, and effortful swallow against resistance. Multidimensional assessments included acoustic analysis (AVQI, intensity, dynamic range), clinician-rated perceptual evaluations (voice tonicity, intelligibility), PROMs (VHI-10, V-RQOL, CPIB-10), and tracheal manometry and pharyngeal-/esophageal high-resolution impedance manometry during voicing.</p><p><strong>Results: </strong>No significant changes in mean AVQI, intensity, dynamic range, voice tonicity, intelligibility, PROMs, and physical outcomes (manometry) were found. However, several clinically relevant changes, mostly improvements, were noted in 14 participants for AVQI and PROMs.</p><p><strong>Conclusion: </strong>Tracheoesophageal voice, on average, is not affected by resistance-based muscle training for swallowing rehabilitation. For some participants, however, several clinically relevant improvements in voice quality and quality of life were noticeable.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}