Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献

{"title":"Letter to Editor Following \"Visualization of Scattered Tumor Regression Following Neoadjuvant Chemoimmunotherapy With a Novel Intraoperative PET/CT Scanner\".","authors":"Lise-Marie Roussel, Florian Clatot, Sébastien Hapdey","doi":"10.1002/hed.70413","DOIUrl":"10.1002/hed.70413","url":null,"abstract":"","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"3222-3224"},"PeriodicalIF":2.2,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigation-Assisted Pure Endoscopic Transoral Styloidectomy for Recurrent Eagle Syndrome: A Pictorial Essay.","authors":"Ziyi Wang, Jianhui Zhao, Yibei Wang, Jun Han, Jianfeng Liu","doi":"10.1002/hed.70453","DOIUrl":"10.1002/hed.70453","url":null,"abstract":"<p><strong>Background: </strong>Complete resection of the styloid process at its skull-base origin is challenging in recurrent Eagle syndrome because of postoperative fibrosis, distorted anatomy, and proximity to the internal carotid artery (ICA).</p><p><strong>Methods: </strong>Bilateral dissections of two silicone-injected cadaveric heads defined a pure endoscopic transoral trans-medial pterygomandibular corridor to the styloid base. The technique was applied in a patient with recurrent Eagle syndrome after previous transoral styloid shortening.</p><p><strong>Results: </strong>Cadaveric dissections demonstrated a reproducible route to the styloid base through the parapharyngeal space using the medial pterygoid muscle, styloid musculature, and carotid sheath as key anatomical landmarks. Navigation guidance and Doppler localization of the ICA facilitated complete styloid base resection in the clinical case. Postoperative imaging confirmed complete removal, with sustained symptom resolution and no complications at 9 months.</p><p><strong>Conclusions: </strong>Navigation-assisted pure endoscopic transoral styloidectomy provides a reproducible and minimally invasive approach for complete styloid base resection in recurrent Eagle syndrome.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"3214-3221"},"PeriodicalIF":2.2,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction and Facial Reanimation After Temporal Bone Resection: A Multi-Institution Experience.","authors":"John F Ryan, Stephen P Hadford, Jason C Nellis, Dane J Genther, Michael A Fritz, Patrick J Byrne, Kofi D O Boahene, Shaun C Desai","doi":"10.1002/hed.70336","DOIUrl":"10.1002/hed.70336","url":null,"abstract":"<p><strong>Background: </strong>Temporal bone resection (TBR) may result in large defects and facial nerve sacrifice.</p><p><strong>Methods: </strong>Retrospective review of adults undergoing TBR from 2008 to 2019.</p><p><strong>Results: </strong>One hundred and forty patients were reviewed. The extent of TBR was lateral (n = 135), subtotal (n = 2), and total (n = 3). Defects were reconstructed with free flaps (n = 72), regional flaps (n = 45), and cervicofacial flaps (n = 31). Complications included wound dehiscence (n = 20), infection (n = 15), hematoma (n = 6), cerebrospinal fluid leak (n = 2), and meningitis (n = 1). Smoking history was associated with wound complications (OR = 1.23, p = 0.03). Prior resection (OR = 2.34, p = 0.03) and advanced T stage (OR = 1.38, p = 0.04) were associated with free flap reconstruction. Forty-seven patients underwent facial nerve sacrifice. Facial reanimation techniques included primary neurorrhaphy (n = 2), interposition nerve grafting (n = 28), masseteric (n = 7), or hypoglossal (n = 5) to nerve transfers, temporalis tendon transfer (n = 21), ectropion repair (n = 31), brow lift (n = 21), and upper eyelid loading (n = 40).</p><p><strong>Conclusion: </strong>Advanced T stage and re-resection are associated with free flap reconstruction after TBR.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":"3173-3179"},"PeriodicalIF":2.2,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response-Adapted Surgery Following Neoadjuvant Chemotherapy in Oral Cavity Squamous Cell Carcinoma: An Era-Based Retrospective Cohort Study.","authors":"Shreya Rai, Mudit Agarwal, Abhishek Singh, Pradyumna Singh, Kshitiz Bansal, P Karthik, Abhishek Gugliani, Neha Garg, P Leela, Sarthak Tandon, Jitin Goyal, Manoj Gupta, Rashmi Bansal, Rajat Saha, Parveen Ahlawat, Sunil Pasricha, Munish Gairola","doi":"10.1002/hed.70532","DOIUrl":"https://doi.org/10.1002/hed.70532","url":null,"abstract":"<p><strong>Background: </strong>Evidence regarding response-adapted resection after neoadjuvant chemotherapy (NACT) in oral cavity squamous cell carcinoma remains limited.</p><p><strong>Methods: </strong>We compared conventional-era (2018-2021) and response-adapted-era (2022-2024) surgery after NACT. Margins, recurrence, 2-year survival, and surgical outcomes were assessed.</p><p><strong>Results: </strong>Among 129 patients (58 conventional; 71 response-adapted), positive margins occurred in 3.4% versus 1.4% and local recurrence in 12.1% versus 7.0%. Two-year disease-free survival (DFS) was 56.6% versus 67.8% (log-rank p = 0.135). Adjusted DFS HR for the response-adapted era was 0.54 (95% CI 0.28-1.04; p = 0.066). ENE predicted inferior DFS (HR 3.60; p < 0.001). Responder-only analysis showed no significant survival difference.</p><p><strong>Conclusions: </strong>No observed increase in positive margins or local recurrence accompanied the later surgical strategy. Retrospective selection, unequal follow-up, and limited events preclude conclusions of noninferiority or a causal survival benefit.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149290073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Outcomes in Osteosarcoma of the Head and Neck: A Systematic Review and Meta-Analysis.","authors":"Angela Magri, Andrea Quaiattini, Alex Mlynarek, Keith Richardson, Michael Hier, Nader Sadeghi, Ramy Saleh, Ahmed Aoude, Khalil Sultanem, Salvatore Di Maio, Tamara Mijovic, Marco Mascarella, Emily Kay-Rivest","doi":"10.1002/hed.70452","DOIUrl":"https://doi.org/10.1002/hed.70452","url":null,"abstract":"<p><strong>Background: </strong>Head and neck osteosarcomas (HNOS) are rare, accounting for ~1% of head and neck malignancies. This study systematically evaluated the role of chemotherapy (CT) and radiotherapy (RT) on survival outcomes.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were performed following PRISMA guidelines across six databases. Treatment arms included surgery alone or combined with CT and/or RT, given in neoadjuvant or adjuvant settings. Primary outcomes were overall survival (OS) and disease-free survival (DFS).</p><p><strong>Results: </strong>Thirty-one studies comprising 2006 patients were included. Jaw tumors had superior OS compared to skull base tumors. CT significantly improved OS (HR 0.75, 95% CI 0.62-0.89) and DFS (HR 0.79, 95% CI 0.63-0.98), particularly in the neoadjuvant setting, whereas RT showed no survival benefit.</p><p><strong>Conclusions: </strong>Systemic therapy in combination with surgery improves OS and DFS in HNOS, reinforcing its importance as part of curative-intent treatment.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149290119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effectiveness and Safety of Energy Devices for Thyroidectomy: An Outcome-Specific Network Meta-Analysis of Randomized Controlled Trials.","authors":"Do Hyun Kim, David W Jang, Se Hwan Hwang","doi":"10.1002/hed.70524","DOIUrl":"https://doi.org/10.1002/hed.70524","url":null,"abstract":"<p><strong>Background: </strong>We performed an outcome-specific network meta-analysis comparing contemporary energy devices in thyroidectomy.</p><p><strong>Methods: </strong>Randomized controlled trials comparing conventional hemostasis with Harmonic, LigaSure, Thunderbeat, or other advanced energy devices during thyroidectomy were included. Frequentist random-effects network meta-analyses were performed per outcome, with treatments ranked by P-scores and consistency assessed via design-by-treatment interaction and node-splitting analyses.</p><p><strong>Results: </strong>Compared to conventional hemostasis, Harmonic significantly reduced operative time (SMD, -1.88), blood loss (SMD, -2.29), drainage volume (SMD, -1.77), hospital stay (SMD, -0.74), transient hypocalcemia (OR, 0.61), transient recurrent laryngeal nerve palsy (OR, 0.63), and postoperative bleeding (OR, 0.56). LigaSure improved operative efficiency but showed less consistent recovery and safety benefits. Harmonic ranked highest across most outcomes.</p><p><strong>Conclusions: </strong>Harmonic showed the most favorable relative effects across the evaluated outcomes. However, these findings do not establish overall device superiority; selection should consider absolute benefits and device-specific characteristics.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149290097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence Risk in Lateralized Floor of Mouth Carcinoma: Depth of Invasion Versus Midline Distance.","authors":"Jannik Ketschau, Alex Grabenhorst, Hannes Singer, Helena Kram, Nils Krautkremer, Cornelius Leopold, Jonathan Mohr, Katharina Pippich, Klaus-Dietrich Wolff, Chaim Ohayon, Lucas M Ritschl","doi":"10.1002/hed.70528","DOIUrl":"https://doi.org/10.1002/hed.70528","url":null,"abstract":"<p><strong>Background: </strong>Contralateral nodal recurrence in lateralized floor-of-mouth squamous cell carcinoma (OSCC) remains difficult to predict, and objective preoperative parameters to guide contralateral neck management in tumors without midline crossing are lacking.</p><p><strong>Methods: </strong>This retrospective cohort study included 97 patients with lateral floor-of-mouth OSCC treated by surgical resection and neck dissection. Depth of invasion (DOI) was evaluated using endpoint-specific univariable Cox regression. Contralateral nodal disease was analyzed in patients without midline crossing (n = 68) using a composite endpoint of occult contralateral nodal metastasis and/or subsequent contralateral nodal recurrence. Tumor-to-midline distance was assessed on standardized multiplanar preoperative CT or MRI.</p><p><strong>Results: </strong>DOI was associated with local recurrence (HR 1.322 per mm, 95% CI 1.131-1.545, p < 0.001) and ipsilateral regional recurrence (HR 1.199, 95% CI 1.052-1.367, p = 0.007), but not with contralateral recurrence (HR 1.030, 95% CI 0.834-1.272, p = 0.782). Among 68 patients without midline crossing, no occult contralateral metastases were identified in 19 clinically contralateral node-negative patients undergoing elective contralateral neck dissection. Four patients (5.9%) developed subsequent contralateral nodal recurrence. Midline distance was smaller in patients with an event (median 3.15 vs. 6.40 mm; p = 0.022; AUC 0.845). All four events occurred at < 5 mm (4/21 [19.0%] vs. 0/42 [0%]; Fisher p = 0.010). In time-to-event analysis, greater midline distance was associated with a lower hazard of contralateral recurrence (HR 0.622 per mm, 95% CI 0.395-0.981, p = 0.041).</p><p><strong>Conclusion: </strong>DOI showed an outcome-specific association with local and ipsilateral, but not contralateral, recurrence. In tumors without midline crossing, quantitative proximity to the midline was associated with subsequent contralateral nodal failure. The observed 5-mm threshold is exploratory and requires external validation before it can inform clinical decision-making.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149277140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Splitting of the Temporalis Muscle Flap for Postradiation Skull Base Osteoradionecrosis: A Prospective and Single-Arm Clinical Study.","authors":"Huiyi Deng, Jinfen Wang, Tian Yuan, Xiaoping Lai, Weifen Kong, Xinwei Xiong, Qintai Yang, Xifu Wu, Bowen Zheng, Zhaohui Shi","doi":"10.1002/hed.70504","DOIUrl":"https://doi.org/10.1002/hed.70504","url":null,"abstract":"<p><strong>Background: </strong>Temporalis muscle flap (TMF) reconstruction is common for postradiation skull base osteoradionecrosis (ORN). However, the whole TMF may be too large, causing difficult tunnel passage, tearing, and choanal atresia, while an overly small TMF risks pedicle damage and incomplete coverage. Safely harvesting an appropriate TMF remains challenging. We evaluated the feasibility and long-term outcome of precise TMF splitting and explored necrosis risk factors.</p><p><strong>Study design: </strong>Prospective, single-arm clinical study.</p><p><strong>Setting: </strong>Comparison of inter-group ultrasonographic parameters of the anterior/posterior deep temporal arteries (ADTA/PDTA), analyzed flap survival rate, risk factors for flap necrosis.</p><p><strong>Methods: </strong>Sixty ORN patients who underwent TMF reconstruction were included. Preoperative ultrasonography mapped ADTA/PDTA to guide TMF splitting. Surgical outcomes and complications were recorded. Univariate analysis and multivariate Firth's penalized logistic regression were used to identify independent risk factors for flap necrosis.</p><p><strong>Results: </strong>Overall flap survival rate was 95.00% (57/60). Univariate analysis identified prolonged operative time (p = 0.006), tumor recurrence (p = 0.049), and low preoperative prealbumin (p = 0.033) as risk factors. Multivariate analysis confirmed operative time as an independent risk factor (OR = 1.007, p = 0.035). The optimal operative time cutoff for predicting necrosis was 635 min (AUC = 0.824, p = 0.032), which is presented as an exploratory threshold requiring validation in future cohorts.</p><p><strong>Conclusions: </strong>Precise TMF harvesting is suitable for predominantly unilateral nasopharyngeal reconstruction, especially for necrosis invading the internal carotid artery, avoiding complications such as temporal depression, choanal atresia/stenosis from an oversized flap, and necrosis from difficult tunnel passage.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149277152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring G-Tube Timing and Clinical Outcomes in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck Receiving Chemoradiation.","authors":"Cameron Chalker, Jason C Burton, Andy Kaempf, Jeong Youn Lim, Sarah Lowry, Erynn A Beeson, Katherine Bagwell, Timur Mitin, Chetan V Vakkalagadda, Jeremy Cetnar, Eric J Roeland","doi":"10.1002/hed.70518","DOIUrl":"https://doi.org/10.1002/hed.70518","url":null,"abstract":"<p><strong>Background: </strong>G-tube placement timing remains poorly characterized in patients with localized head and neck cancer (HNSCC) undergoing definitive chemoradiation (dCRT).</p><p><strong>Methods: </strong>We retrospectively analyzed 144 patients with HNSCC who received dCRT (2019-2024), categorized by \"upfront\" or \"as-needed\" G-tube strategy, to explore factors associated with timing and outcomes using propensity score weighting.</p><p><strong>Results: </strong>Most patients were White (85%) and male (83%); median age was 63 years. Upfront G-tube placement occurred in 60 patients (42%) and was more common among women (64% vs. 37%, p = 0.015) and those with dysphagia (55% vs. 28%, p = 0.001) or receiving induction chemotherapy (71% vs. 38%, p = 0.023). dCRT duration, weight loss, ED visits, hospitalizations, ICU admissions, and survival did not differ. Upfront placement was associated with lower odds of chemotherapy modification (73% lower, p = 0.007) and fewer infusion clinic visits (average 3 fewer, p = 0.038).</p><p><strong>Conclusion: </strong>These findings suggest multiple factors influence G-tube timing and outcomes, warranting prospective validation.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149247560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphoedema in Head and Neck Cancer Survivors: Healthcare Professionals' Perspectives.","authors":"Kadriye Yusra Sert, Purnima Sundaresan, Emma Charters, Rebecca Venchiarutti, Chindhu Shunmuga Sundaram, Melissa Thorne, Haryana M Dhillon","doi":"10.1002/hed.70526","DOIUrl":"https://doi.org/10.1002/hed.70526","url":null,"abstract":"<p><strong>Introduction: </strong>Improvements in head and neck cancer (HNC) treatment have increased survival rates, resulting in survivors living with side effects, such as head and neck lymphoedema (HNL). We aimed to document healthcare professionals' perceptions of HNL, approaches to managing HNL, and integration of HNL management into routine practice in Australia and New Zealand.</p><p><strong>Methods: </strong>We conducted an online, 51-item survey between February and October 2024. The survey comprised two main sections: (i) all healthcare professionals working with HNC and HNL; and (ii) only HNL therapists.</p><p><strong>Results: </strong>Participants included in the analysis of the (i) HNC healthcare professionals section (n = 73/113), and (ii) HNL therapists section (n = 40/46). 45% (n = 33/73) of the participants reported not having access to a specialized multidisciplinary team for HNL management. 55% (n = 22/40) of HNL therapists reported not having standardized institutional lymphoedema management protocols.</p><p><strong>Conclusions: </strong>Findings highlight the need for system-level guidelines, clearer pathways, improved education resources, and coordinated MDTs to improve HNL management.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149247640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}