Assessing Head and Neck Cancer-Related Lymphoedema Using Indocyanine Green Lymphography-A Pilot Study.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-07-24 DOI:10.1002/hed.28252

Katrina Gaitatzis, Belinda Thompson, Hiroo Suami, Fiona Tisdall Blake, Asha Heydon-White, Puma Sundaresan, Dion Forstner, Louise Koelmeyer

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引用次数: 0

Abstract

Background: Head and neck cancer treatments can cause head and neck lymphoedema (HNL), impacting quality of life (QoL). This study examined lymphatic drainage changes in HNL using Indocyanine Green Lymphography (ICG-L) and assessed QoL, physical, and functional outcomes.

Methods: Twenty individuals with HNL and 10 healthy controls completed the Lymphedema Symptom Intensity and Distress survey, bioimpedance spectroscopy (BIS), skin assessments, percent water content, and ICG-L. Analysis included non-parametric and Kruskal-Wallis tests.

Results: ICG-L showed preserved original lymphatic drainage in non-surgical and unilaterally treated individuals, while bilateral treatment disrupted original pathways, prompting compensatory drainage. Individuals with HNL reported significantly higher scores in soft tissue sensation, neurological symptoms, and biobehavioral symptoms (p < 0.001). Skin assessments revealed swelling and fibrosis. Significant differences were observed in lymphatic dysfunction (p = 0.002), BIS-derived skeletal muscle mass percent (p = 0.015), and phase angle (p = 0.002).

Conclusions: This study highlights the symptom burden and altered lymphatic drainage in HNL, with ICG-L showing potential for refining management strategies.

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使用吲哚菁绿淋巴图评估头颈部肿瘤相关淋巴水肿-一项初步研究。

背景：头颈部肿瘤治疗可引起头颈部淋巴水肿（HNL），影响生活质量（QoL）。本研究使用吲哚菁绿淋巴造影（ICG-L）检查HNL的淋巴引流改变，并评估生活质量、身体和功能结果。方法：20例HNL患者和10例健康对照者完成了淋巴水肿症状强度和痛苦调查、生物阻抗谱（BIS）、皮肤评估、百分比含水量和ICG-L。分析包括非参数检验和Kruskal-Wallis检验。结果：ICG-L显示，非手术和单侧治疗个体保留了原有的淋巴引流，而双侧治疗破坏了原有的淋巴通路，促使代偿性引流。HNL患者在软组织感觉、神经症状和生物行为症状方面的评分明显较高(p)。结论：本研究强调了HNL患者的症状负担和淋巴引流的改变，ICG-L显示了改进治疗策略的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.