Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献

{"title":"Dual-Network Deep Learning for Accelerated Head and Neck MRI: Enhanced Image Quality and Reduced Scan Time.","authors":"Shuang Li, Weijie Yan, Xiaoyong Zhang, Wei Hu, Lin Ji, Qiang Yue","doi":"10.1002/hed.28255","DOIUrl":"https://doi.org/10.1002/hed.28255","url":null,"abstract":"<p><strong>Background: </strong>Head-and-neck MRI faces inherent challenges, including motion artifacts and trade-offs between spatial resolution and acquisition time. We aimed to evaluate a dual-network deep learning (DL) super-resolution method for improving image quality and reducing scan time in T1- and T2-weighted head-and-neck MRI.</p><p><strong>Methods: </strong>In this prospective study, 97 patients with head-and-neck masses were enrolled at xx from August 2023 to August 2024. After exclusions, 58 participants underwent paired conventional and accelerated T1WI and T2WI MRI sequences, with the accelerated sequences being reconstructed using a dual-network DL framework for super-resolution. Image quality was assessed both quantitatively (signal-to-noise ratio [SNR], contrast-to-noise ratio [CNR], contrast ratio [CR]) and qualitatively by two blinded radiologists using a 5-point Likert scale for image sharpness, lesion conspicuity, structure delineation, and artifacts. Wilcoxon signed-rank tests were used to compare paired outcomes.</p><p><strong>Results: </strong>Among 58 participants (34 men, 24 women; mean age 51.37 ± 13.24 years), DL reconstruction reduced scan times by 46.3% (T1WI) and 26.9% (T2WI). Quantitative analysis showed significant improvements in SNR (T1WI: 26.33 vs. 20.65; T2WI: 14.14 vs. 11.26) and CR (T1WI: 0.20 vs. 0.18; T2WI: 0.34 vs. 0.30; all p < 0.001), with comparable CNR (p > 0.05). Qualitatively, image sharpness, lesion conspicuity, and structure delineation improved significantly (p < 0.05), while artifact scores remained similar (all p > 0.05).</p><p><strong>Conclusions: </strong>The dual-network DL method significantly enhanced image quality and reduced scan times in head-and-neck MRI while maintaining diagnostic performance comparable to conventional methods. This approach offers potential for improved workflow efficiency and patient comfort.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vein Selection for Optimal Flap Outcomes in the Radial Forearm Free Flap: A Systematic Review and Meta-Regression","authors":"Christian Chong,&nbsp;Justin Lindsay,&nbsp;Lois Nguapa,&nbsp;Kevin G. Wu,&nbsp;Timothy N. Crawford,&nbsp;Mark Wax,&nbsp;Yadranko Ducic,&nbsp;Mohamedkazim Alwani,&nbsp;Sameep P. Kadakia","doi":"10.1002/hed.28256","DOIUrl":"10.1002/hed.28256","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Radial forearm free flaps represent a workhorse reconstructive modality in microsurgical rehabilitation. The reliable anatomy, availability of thin, pliable tissue, and a long pedicle afford the surgeon a significant latitude of reconstructive freedom, allowing this flap to be useful for a multitude of body sites. Although the arterial anatomy is straightforward, the venous outflow of the flap is generally through a circuit utilizing a superficial, deep, and united venous system. This has allowed surgeons a variety of venous options to utilize, but has also generated debate in the community regarding the optimal vessel choice. This manuscript seeks to examine published studies in the literature in an effort to determine if a statistically significant difference exists among venous outflow options as they lead to microsurgical success.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic review and meta-regression were conducted examining 14 studies with a total of 1182 radial forearm flaps. A university-based statistician was recruited to perform a detailed analysis of the results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Results show that there is no statistically significant difference in flap outcomes among the superficial, deep, and united venous drainage systems when outflow is deemed to be favorable intraoperatively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The choice of venous outflow system does not impact outcomes of the radial forearm flap. Surgeon preference, technical skill, and patient anatomy should be the guiding factors in determining vein choice so long as the venous outflow is favorable.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 9","pages":"2622-2626"},"PeriodicalIF":2.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Flight Plan for Embolization Technique Based on Carotid Body Tumor Angiography to Improve Surgical Treatment of the Lesion: Report of Two Cases.","authors":"Haotian Huanggu, Guangchao Gu, Fangda Li, Rong Zeng, Yuehong Zheng","doi":"10.1002/hed.28254","DOIUrl":"https://doi.org/10.1002/hed.28254","url":null,"abstract":"<p><strong>Background: </strong>Carotid body tumor (CBT) is a rare type of paraganglioma in head and neck region, with a high risk of surgical bleeding and nerve damage. Here we applied a new imaging tool termed \"Flight Plan for Embolization\" (FPFE) technique to better identify tumors' feeding arteries so that better dissection and bleeding control can be made to improve surgical outcomes.</p><p><strong>Methods: </strong>One 55-year-old female and one 67-year-old male patient presented to our hospital with an asymptomatic CBT on the right and left neck, respectively. Surgical resection was proposed due to the lesions' nature of being able to gradually enlarge to cause significant neurovascular invasion and even malignancy transformation. The two patients underwent a 3D-digital subtracted angiography (DSA) for tumors before surgery. With the FPFE technique, the blood supply source and intra-tumoral distribution of CBTs were clearly identified from the 3D-DSA data.</p><p><strong>Results: </strong>Surgery was performed for the female and male patients at 17 and 3 days after the angiography, respectively. With the guidance of FPFE, we could easily identify and control feeding vessels of the lesions and resect CBTs with minimal bleeding and nerve damage.</p><p><strong>Conclusions: </strong>In our experience, \"FPFE\" technique can effectively identify CBTs' main blood supply source, and might help to improve the surgical treatment by providing better bleeding control and clearer surgical field.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes and Social Reintegration After Salvage Open Partial Horizontal Laryngectomy Type II/III for Radiation Failure.","authors":"Shunsuke Miyamoto, Koichi Kano, Shohei Tsutsumi, Kaho Momiyama, Kohei Hagiwara, Takashi Matsuki, Taku Yamashita","doi":"10.1002/hed.28253","DOIUrl":"https://doi.org/10.1002/hed.28253","url":null,"abstract":"<p><strong>Background: </strong>The long-term outcomes and social reintegration following open partial horizontal laryngectomy (OPHL) type II/III after radiation failure remain unclear. This study aimed to evaluate the outcomes of salvage OPHL.</p><p><strong>Methods: </strong>We retrospectively analyzed 56 recurrent cases after radiotherapy and 84 unirradiated cases who underwent OPHL type II/III at Kitasato University Hospital between November 1997 and October 2023. Overall survival (OS), disease-free survival (DFS), larynx preservation (LP), laryngo-esophageal dysfunction-free survival (LEDFS), and return to work (RTW) were evaluated.</p><p><strong>Results: </strong>At 10 years, OS, DFS, LP, and LEDFS were 76%, 73%, 93%, and 67% in recurrent cases and 65%, 58%, 94%, and 58% in unirradiated cases, with no significant difference. RTW rates were 87% and 81%, respectively (p = 0.57).</p><p><strong>Conclusions: </strong>OPHL type II/III after radiation failure demonstrated favorable long-term outcomes and RTW rates, supporting its role as a valuable salvage option.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Factors of Malignancy in Cervical Paragangliomas: A Retrospective Study.","authors":"Garance Haw, Maxime Fieux, Anthime Flaus, Hélène Lasolle, Juliette Abeillon, Myriam Decaussin-Petrucci, Dylan Pavie, Benjamin Verillaud, Philippe Herman, Patrick Feugier, Fatima Ameur, Pierre Philouze, Françoise Borson-Chazot, Philippe Ceruse","doi":"10.1002/hed.28250","DOIUrl":"https://doi.org/10.1002/hed.28250","url":null,"abstract":"<p><strong>Background: </strong>Early predictive factors of metastatic cervical paragangliomas (cPG) are lacking.</p><p><strong>Methods: </strong>This multicenter retrospective study included patients with at least one cPG. Metastatic cPG were defined by the histological presence of lymph node metastases or distant metastases. Clinical, radiological, intraoperative, histological, and mutational status characteristics were collected. Predictive factors of metastatic cPG were searched using logistic regression.</p><p><strong>Results: </strong>Sixty-seven patients were included, corresponding to 86 cPG; 12.8% of these were metastatic. The seven newly identified risk factors were: presence of necrosis (OR = 12.36, 95% CI: [3.03-55.66]), extracapsular extension (OR = 33.42, 95% CI: [2.48-4752.00]), and pathological lymph nodes (OR = 25.00, 95% CI: [3.96-276.07]) on morphological imaging (MRI and/or CT); heterogeneous tumor uptake (OR = 15.5, 95% CI: [2.31-143.68]) and abnormal lymph node uptake (OR = 16.5, 95% CI: [2.04-174.94]) on functional imaging (FDG-PET-CT); invasion of adjacent tissues (OR = 34.63, 95% CI: [3.82-4602.65]) and sacrifice of noble structures (OR = 75.9, 95% CI: [7.99-10230.73]) in patients who underwent surgery.</p><p><strong>Conclusion: </strong>These risk factors could be combined to promptly identify aggressive cPG and adapt therapeutic strategy.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Small Molecule Inhibitor of the Wnt-β-Catenin Pathway, CWP232291, Inhibits Tumor Growth in Preclinical Models of Salivary Gland Adenoid Cystic Carcinoma.","authors":"Joseph O Humtsoe, Bhumsuk Keam, Hyun-Su Kim, Leilani Jones, Brandon Leonard, Anita Pothukuchi, Sarah Honjo, Annemieke van Zante, Susan Lee, Patrick K Ha","doi":"10.1002/hed.28249","DOIUrl":"https://doi.org/10.1002/hed.28249","url":null,"abstract":"<p><strong>Background: </strong>Salivary gland adenoid cystic carcinoma (ACC) is a rare and challenging form of head and neck cancer, particularly difficult to treat once it progresses to recurrent or metastatic disease. In this study, we evaluate the cytotoxicity and anti-tumorigenic effects of CWP232291, a first-in-class small molecule inhibitor targeting the Wnt-β-catenin signaling pathway.</p><p><strong>Methods: </strong>Tumor microarrays of ACC patients and patient-derived xenografts (PDX) were evaluated by immunohistochemistry, RNA-seq, and qRT-PCR analysis for β-catenin. The effects of CWP232291 were determined by cytotoxic, qRT-PCR, and immunoblotting analysis. In vivo anti-tumorigenic effects of CWP232291 were evaluated using cell line xenograft and PDX models.</p><p><strong>Results: </strong>Immunohistochemistry analysis revealed that high β-catenin expression correlated with reduced overall survival in ACC patients. Expression of genes involved in the Wnt-β-catenin pathway was enriched in PDX samples. In vitro cytotoxicity and biochemical assays using MDA-ACC-01 and UM-HACC-2A cell lines revealed that ACC cells were susceptible to CWP232291. Furthermore, CWP232291 treatment attenuated in vivo tumor growth in both cell line xenograft and PDX models.</p><p><strong>Conclusions: </strong>Abnormal Wnt-β-catenin signaling may play an active role in ACC pathogenesis, and its inhibition by CWP232291 may offer therapeutic potential, representing a promising avenue for further investigation.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swallowing and Communication Outcomes Post Chemoradiotherapy for Low-Risk Human Papillomavirus (HPV)-Associated Oropharyngeal Squamous Cell Carcinoma: A Substudy of TROG 12.01.","authors":"Rhys Hughes, June Corry, Danny Rischin, Mathias Bressel, Lizbeth Kenny, Belinda Lehn, Laurelie Wishart, Laurie-Anne Minslow, Jacqui Frowen","doi":"10.1002/hed.28245","DOIUrl":"https://doi.org/10.1002/hed.28245","url":null,"abstract":"<p><strong>Background: </strong>This substudy aimed to assess swallow and communication outcomes in patients undergoing treatment for low-risk human papillomavirus-associated oropharyngeal squamous cell carcinoma.</p><p><strong>Methods: </strong>Videofluoroscopy swallowing studies (VFSS) were conducted pre-treatment, 12 and 24 months post treatment, alongside quality of life and symptom severity measures for patients receiving 70Gy radiotherapy with either weekly cisplatin or cetuximab.</p><p><strong>Results: </strong>Of 126 patients who underwent VFSS, there were no differences in swallowing outcomes between cisplatin and cetuximab arms. VFSS outcomes were worst at 12 months and improved by 24 months, with low aspiration rates and high swallow function at all timepoints. Older age, higher T-stage, and base of tongue tumors (versus tonsil) were associated with poorer swallowing. Clinician-and patient-reported speech and voice problems were minimal.</p><p><strong>Conclusions: </strong>Swallowing was safe and efficient, and communication highly intelligible at 24 months post treatment. Both 'objective' and patient-reported measures are important to understand the impact of new treatment approaches on swallowing-related outcomes.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant External Beam Radiotherapy in Differentiated Thyroid Cancers: An Audit of Clinical Practice, Adapting to New Evidence.","authors":"Sarbani Ghosh Laskar, Samarpita Mohanty, Shwetabh Sinha, Anuj Kumar, Gouri Pantvaidya, Shivakumar Thiagarajan, Ashwini Budrukkar, Monali Swain, Anuja Deshmukh, Deepa Nair, Richa Vaish, Vidisha Tuljapurkar, Chandrashekhar Dravid, Sudhir Nair, Poonam Joshi, Rathan Shetty, Arjun Gurmeet Singh, Pankaj Chaturvedi","doi":"10.1002/hed.28222","DOIUrl":"https://doi.org/10.1002/hed.28222","url":null,"abstract":"<p><strong>Introduction: </strong>There is limited evidence on the role of adjuvant external beam radiotherapy in differentiated thyroid cancer (DTC).</p><p><strong>Methods: </strong>We conducted a retrospective study of patients with DTC treated with adjuvant Intensity Modulated radiotherapy (IMRT) from 2011 to 2024.</p><p><strong>Results: </strong>Fifty-nine patients were analyzed with median follow-up of 53 months. All the patients had undergone total thyroidectomy. Gross extrathyroidal extension was seen in 76% of patients, while 54% had R1/R2 resection. High-risk histological types were seen in 51% of patients, while 34% had recurrent disease. The 5-year locoregional control (LRC) was 89.3% while 5-year overall survival (OS) was 84.6%. Acute Grade 3 dermatitis and dysphagia were seen in 12% and 10%, respectively. Late toxicity, including tracheostomy placement and feeding tube dependence, was seen in three and one patient, respectively.</p><p><strong>Conclusion: </strong>Adjuvant IMRT in patients with DTC with high risk of locoregional recurrence resulted in good LRC with acceptable toxicities.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the Annual Healthcare Expenditure Costs and Utilization of Thyroid Disorders in the United States.","authors":"Anne Y Feng, Justin M Soffer, Margaret B Mitchell, Lauren C Williams, Amr H Abdelhamid Ahmed, Gregory W Randolph, Neil Bhattacharyya","doi":"10.1002/hed.28223","DOIUrl":"https://doi.org/10.1002/hed.28223","url":null,"abstract":"<p><strong>Background: </strong>We sought to determine healthcare utilization and expenditure associated with thyroid disorders annually.</p><p><strong>Methods: </strong>We used the 2018 Medical Expenditure Panel Survey (MEPS) to compare patients with versus without thyroid disorders to determine differences in healthcare utilization and expenditures using a multivariate model controlling for demographic factors and comorbidities.</p><p><strong>Results: </strong>The estimated prevalence (± standard error) of thyroid disorders in the US in 2018 was 19.8 ± 0.8 million adult patients. Patients diagnosed with thyroid disorders had 3 ± 0.5 more office visits/year and 9.2 ± 0.7 more prescription fills/year. The mean total healthcare expenditure per thyroid disorder patient/year was $14 548 ± $939 versus $11 438 ± $397 for patients without a thyroid disorder. The overall healthcare expenditure associated with thyroid disorders is estimated to be $61.5 billion in 2018.</p><p><strong>Conclusions: </strong>Thyroid disorders are associated with higher healthcare utilization and expenditure for both individual patients and the healthcare system.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic Versus Reactive (PvR) Feeding in Patients Undergoing (Chemo)radiation in Head and Neck Cancers: Results of a Phase III Randomized Controlled Trial.","authors":"Sarbani Ghosh Laskar, Shwetabh Sinha, Meenakshi Jeeva, Meetakshi Gupta, Shreyasee Karmakar, Anuj Kumar, Samarpita Mohanty, Purabi Mahajan, Shivashankar Timmanpyati, Arun Balaji, Ashwini Budrukkar, Monali Swain, Faizalam Khan, Gouri Pantvaidya, Anuja Deshmukh, Deepa Nair, Devendra Chaukar, Prathamesh Pai, Shiva Thiagarajan, Richa Vaish, Vidisha Tuljapurkar, Pankaj Chaturvedi","doi":"10.1002/hed.28244","DOIUrl":"https://doi.org/10.1002/hed.28244","url":null,"abstract":"<p><strong>Background: </strong>Optimal feeding strategy (Prophylactic vs. Reactive) during Radiation Therapy (RT) for Head and Neck Cancers (HNC) remains to be established.</p><p><strong>Methods: </strong>This phase III trial randomized (1:1) patients of HNC to prophylactic [nasogastric tube (NGT) placed at least 1 day before RT starting] versus reactive arm (NGT when required). The primary endpoint was the incidence of significant weight loss at 6 months. Secondary endpoints were weight changes, tube duration, dependence, and compliance.</p><p><strong>Results: </strong>Due to high denial rates, the trial was prematurely closed. Eighty-four patients (40-prophylactic, 44-reactive) were analyzed intention-to-treat. Seventeen patients (39%) required a reactive tube insertion. The proportion of patients with significant weight loss at 6 months in the prophylactic versus reactive arms was 13 (32.5%) versus 10 (15.9%), p = 0.44. The median tube duration was 56 days (IQR: 16.5-91) versus 47 days (IQR: 24-59), p = 0.255.</p><p><strong>Conclusion: </strong>Our limited analysis found that a reactive NGT should be considered for most HNC patients undergoing RT.</p><p><strong>Trial registration: </strong>Clinical trials registry of India: CTRI/2020/01/023049.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}