Andrea Costantino, Gian Marco Pace, Camilla Zimello, Elena Russo, Antonio Greco, Antonella Polimeni, J Scott Magnuson, Armando De Virgilio
{"title":"结外延伸对头颈部转移性皮肤鳞状细胞癌的影响：系统回顾和荟萃分析。","authors":"Andrea Costantino, Gian Marco Pace, Camilla Zimello, Elena Russo, Antonio Greco, Antonella Polimeni, J Scott Magnuson, Armando De Virgilio","doi":"10.1002/hed.28251","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to analyze the impact of extranodal extension (ENE) on survival outcomes for patients with metastatic cutaneous head and neck squamous cell carcinoma (cHNSCC).</p><p><strong>Methods: </strong>The pooled hazard ratios (HRs) and the 95% confidence interval (CI) were calculated to define the impact of ENE on overall survival (OS) and disease-free survival (DFS).</p><p><strong>Results: </strong>A total of 2076 patients (males: 84.4%) with a median age of 73.3 years were included. The incidence of ENE was 65.6% (N = 1299/1979). The median follow-up time was 38.4 months (95% CI: 21-38.4). The estimated pooled HRs were 1.31 (95% CI: 0.72-2.39; p = 0.28) and 1.80 (95% CI: 0.53-6.10; p = 0.22) for OS and DFS, respectively.</p><p><strong>Conclusions: </strong>ENE may not be a reliable prognostic factor in metastatic cHNSCC. Further prospective studies are needed to refine risk stratification and improve the current nodal classification system.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of Extranodal Extension in Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Systematic Review and Meta-Analysis.\",\"authors\":\"Andrea Costantino, Gian Marco Pace, Camilla Zimello, Elena Russo, Antonio Greco, Antonella Polimeni, J Scott Magnuson, Armando De Virgilio\",\"doi\":\"10.1002/hed.28251\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The aim of this study is to analyze the impact of extranodal extension (ENE) on survival outcomes for patients with metastatic cutaneous head and neck squamous cell carcinoma (cHNSCC).</p><p><strong>Methods: </strong>The pooled hazard ratios (HRs) and the 95% confidence interval (CI) were calculated to define the impact of ENE on overall survival (OS) and disease-free survival (DFS).</p><p><strong>Results: </strong>A total of 2076 patients (males: 84.4%) with a median age of 73.3 years were included. The incidence of ENE was 65.6% (N = 1299/1979). The median follow-up time was 38.4 months (95% CI: 21-38.4). The estimated pooled HRs were 1.31 (95% CI: 0.72-2.39; p = 0.28) and 1.80 (95% CI: 0.53-6.10; p = 0.22) for OS and DFS, respectively.</p><p><strong>Conclusions: </strong>ENE may not be a reliable prognostic factor in metastatic cHNSCC. Further prospective studies are needed to refine risk stratification and improve the current nodal classification system.</p>\",\"PeriodicalId\":55072,\"journal\":{\"name\":\"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/hed.28251\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/hed.28251","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Impact of Extranodal Extension in Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Systematic Review and Meta-Analysis.
Objective: The aim of this study is to analyze the impact of extranodal extension (ENE) on survival outcomes for patients with metastatic cutaneous head and neck squamous cell carcinoma (cHNSCC).
Methods: The pooled hazard ratios (HRs) and the 95% confidence interval (CI) were calculated to define the impact of ENE on overall survival (OS) and disease-free survival (DFS).
Results: A total of 2076 patients (males: 84.4%) with a median age of 73.3 years were included. The incidence of ENE was 65.6% (N = 1299/1979). The median follow-up time was 38.4 months (95% CI: 21-38.4). The estimated pooled HRs were 1.31 (95% CI: 0.72-2.39; p = 0.28) and 1.80 (95% CI: 0.53-6.10; p = 0.22) for OS and DFS, respectively.
Conclusions: ENE may not be a reliable prognostic factor in metastatic cHNSCC. Further prospective studies are needed to refine risk stratification and improve the current nodal classification system.
期刊介绍：
Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.
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