Sinonasal Intestinal-Type Adenocarcinoma in the Netherlands: A Nationwide Study (2008-2022).

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-04-22 DOI:10.1002/hed.28171

Lise J van de Velde, Gerben E Breimer, W F Julius Scheurleer, Mischa de Ridder, Lot A Devriese, Weibel W Braunius, Remco de Bree, Boukje A C van Dijk, Johannes A Rijken

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引用次数: 0

Abstract

Background: Intestinal-type adenocarcinoma (ITAC) is a rare sinonasal malignancy with poor survival. By creating a clinical and epidemiological overview of the Dutch ITAC population between 2008 and 2022, this study aims to identify areas for improvement in ITAC management.

Methods: A systematic query within the Netherlands Cancer Registry (NCR) was performed to assemble the nationwide ITAC cohort. Incidence calculations were performed alongside overall survival (OS) and relative survival (RS) estimations.

Results: 171 patients were included. Yearly incidence was low (0.04-0.12 per 100 000 person-years) and showed a non-significant, slight upward tendency. The population was predominantly male (92.5%), diagnosed at advanced stages (55% ≥ cT3) and sparsely presented with regional (4.7%) and/or distant metastases (5.9%). The 5-year OS (47.8%, 95% CI: 39.4%-55.6%) and RS (55.5%, 95% CI: 45.8%-64.6%) rates were poor. The addition of radiotherapy to surgery yielded better OS and RS compared to surgery alone.

Conclusion: ITAC incidence shows a minimal upward tendency in the Netherlands, and survival chances remain poor. Ongoing vigilance in high-risk industries and the further implementation of adjuvant radiotherapy may lead to improved outcomes in the future. Biology-driven research is warranted to additionally tailor treatment strategies.

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荷兰鼻窦肠型腺癌：一项全国性研究（2008-2022）。

背景：肠型腺癌（ITAC）是一种罕见的鼻窦恶性肿瘤，生存率低。通过创建2008年至2022年间荷兰ITAC人群的临床和流行病学概况，本研究旨在确定ITAC管理改进的领域。方法：在荷兰癌症登记处（NCR）进行系统查询，以组装全国ITAC队列。发生率计算与总生存期（OS）和相对生存期（RS）估计一起进行。结果：纳入171例患者。年发病率较低（0.04-0.12 / 10万人-年），呈不显著的轻微上升趋势。人群以男性为主（92.5%），诊断为晚期（55%≥cT3），稀疏表现为区域性（4.7%）和/或远处转移（5.9%）。5年OS （47.8%, 95% CI: 39.4% ~ 55.6%）和RS （55.5%, 95% CI: 45.8% ~ 64.6%）较差。与单纯手术相比，在手术基础上加放疗获得了更好的OS和RS。结论：ITAC在荷兰的发病率呈轻微上升趋势，生存机会仍然很低。对高风险行业的持续警惕和进一步实施辅助放疗可能会改善未来的预后。生物学驱动的研究是必要的额外定制治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.