Full Title: Surgical Versus Non-Surgical Treatment of Advanced Oropharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-04-19 DOI:10.1002/hed.28167

Megan K Scharner, Johnny M Owen, Shaun A Nguyen, Alexandra E Kejner, Jason G Newman, Emily Brennan, W Greer Albergotti

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引用次数: 0

Abstract

Background: This review aims to compare survival outcomes of surgical versus non-surgical treatment of advanced-stage OPSCC.

Methods: CINAHL, Cochrane Library, PubMed, and Scopus were searched. Studies comparing the survival of patients with advanced OPSCC treated surgically (±adjuvant therapy) or non-surgically were included. Meta-analyses hazard ratio (HR) and proportions (%) were performed for the outcomes of 2-, 3-, and 5-year overall (OS), disease-free (DFS), disease-specific (DSS), and relapse-free (RFS) survival.

Results: Forty-four studies reporting on (N = 35 681) patients were included, with a mean age of 58.9. For advanced-stage disease, primary treatment with surgery and chemoradiotherapy (CRT) demonstrated the best 5-year OS, at 67.1% (95% CI 55.6-77.6). Survival outcomes favored Surgery + CRT over other primary treatment modalities.

Conclusions: Surgical treatment with adjuvant CRT may be associated with better OS outcomes compared with non-surgical treatment. Further research is needed to determine superior treatment modalities in OPSCC subgroups, such as HPV+ tumors.

查看原文本刊更多论文

手术与非手术治疗晚期口咽鳞状细胞癌：系统回顾和荟萃分析。

背景：本综述旨在比较手术与非手术治疗晚期OPSCC的生存结果。方法：检索CINAHL、Cochrane Library、PubMed、Scopus。比较手术（±辅助治疗）或非手术治疗晚期OPSCC患者的生存率的研究包括在内。对2年、3年和5年总生存率（OS）、无病生存率（DFS）、疾病特异性生存率（DSS）和无复发生存率（RFS）进行meta分析风险比（HR）和比例（%）。结果：纳入44项研究报告（N = 35681）例患者，平均年龄58.9岁。对于晚期疾病，手术和放化疗（CRT）的主要治疗显示出最佳的5年OS，为67.1% （95% CI 55.6-77.6）。生存结果优于其他主要治疗方式的手术+ CRT。结论：与非手术治疗相比，手术辅助CRT治疗可能具有更好的OS结果。需要进一步的研究来确定OPSCC亚组（如HPV+肿瘤）的优越治疗方式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.