Lise J van de Velde, Gerben E Breimer, W F Julius Scheurleer, Mischa de Ridder, Lot A Devriese, Weibel W Braunius, Remco de Bree, Boukje A C van Dijk, Johannes A Rijken
{"title":"荷兰鼻窦肠型腺癌：一项全国性研究（2008-2022）。","authors":"Lise J van de Velde, Gerben E Breimer, W F Julius Scheurleer, Mischa de Ridder, Lot A Devriese, Weibel W Braunius, Remco de Bree, Boukje A C van Dijk, Johannes A Rijken","doi":"10.1002/hed.28171","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Intestinal-type adenocarcinoma (ITAC) is a rare sinonasal malignancy with poor survival. By creating a clinical and epidemiological overview of the Dutch ITAC population between 2008 and 2022, this study aims to identify areas for improvement in ITAC management.</p><p><strong>Methods: </strong>A systematic query within the Netherlands Cancer Registry (NCR) was performed to assemble the nationwide ITAC cohort. Incidence calculations were performed alongside overall survival (OS) and relative survival (RS) estimations.</p><p><strong>Results: </strong>171 patients were included. Yearly incidence was low (0.04-0.12 per 100 000 person-years) and showed a non-significant, slight upward tendency. The population was predominantly male (92.5%), diagnosed at advanced stages (55% ≥ cT3) and sparsely presented with regional (4.7%) and/or distant metastases (5.9%). The 5-year OS (47.8%, 95% CI: 39.4%-55.6%) and RS (55.5%, 95% CI: 45.8%-64.6%) rates were poor. The addition of radiotherapy to surgery yielded better OS and RS compared to surgery alone.</p><p><strong>Conclusion: </strong>ITAC incidence shows a minimal upward tendency in the Netherlands, and survival chances remain poor. Ongoing vigilance in high-risk industries and the further implementation of adjuvant radiotherapy may lead to improved outcomes in the future. Biology-driven research is warranted to additionally tailor treatment strategies.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sinonasal Intestinal-Type Adenocarcinoma in the Netherlands: A Nationwide Study (2008-2022).\",\"authors\":\"Lise J van de Velde, Gerben E Breimer, W F Julius Scheurleer, Mischa de Ridder, Lot A Devriese, Weibel W Braunius, Remco de Bree, Boukje A C van Dijk, Johannes A Rijken\",\"doi\":\"10.1002/hed.28171\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Intestinal-type adenocarcinoma (ITAC) is a rare sinonasal malignancy with poor survival. By creating a clinical and epidemiological overview of the Dutch ITAC population between 2008 and 2022, this study aims to identify areas for improvement in ITAC management.</p><p><strong>Methods: </strong>A systematic query within the Netherlands Cancer Registry (NCR) was performed to assemble the nationwide ITAC cohort. Incidence calculations were performed alongside overall survival (OS) and relative survival (RS) estimations.</p><p><strong>Results: </strong>171 patients were included. Yearly incidence was low (0.04-0.12 per 100 000 person-years) and showed a non-significant, slight upward tendency. The population was predominantly male (92.5%), diagnosed at advanced stages (55% ≥ cT3) and sparsely presented with regional (4.7%) and/or distant metastases (5.9%). The 5-year OS (47.8%, 95% CI: 39.4%-55.6%) and RS (55.5%, 95% CI: 45.8%-64.6%) rates were poor. The addition of radiotherapy to surgery yielded better OS and RS compared to surgery alone.</p><p><strong>Conclusion: </strong>ITAC incidence shows a minimal upward tendency in the Netherlands, and survival chances remain poor. Ongoing vigilance in high-risk industries and the further implementation of adjuvant radiotherapy may lead to improved outcomes in the future. Biology-driven research is warranted to additionally tailor treatment strategies.</p>\",\"PeriodicalId\":55072,\"journal\":{\"name\":\"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-04-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/hed.28171\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/hed.28171","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Sinonasal Intestinal-Type Adenocarcinoma in the Netherlands: A Nationwide Study (2008-2022).
Background: Intestinal-type adenocarcinoma (ITAC) is a rare sinonasal malignancy with poor survival. By creating a clinical and epidemiological overview of the Dutch ITAC population between 2008 and 2022, this study aims to identify areas for improvement in ITAC management.
Methods: A systematic query within the Netherlands Cancer Registry (NCR) was performed to assemble the nationwide ITAC cohort. Incidence calculations were performed alongside overall survival (OS) and relative survival (RS) estimations.
Results: 171 patients were included. Yearly incidence was low (0.04-0.12 per 100 000 person-years) and showed a non-significant, slight upward tendency. The population was predominantly male (92.5%), diagnosed at advanced stages (55% ≥ cT3) and sparsely presented with regional (4.7%) and/or distant metastases (5.9%). The 5-year OS (47.8%, 95% CI: 39.4%-55.6%) and RS (55.5%, 95% CI: 45.8%-64.6%) rates were poor. The addition of radiotherapy to surgery yielded better OS and RS compared to surgery alone.
Conclusion: ITAC incidence shows a minimal upward tendency in the Netherlands, and survival chances remain poor. Ongoing vigilance in high-risk industries and the further implementation of adjuvant radiotherapy may lead to improved outcomes in the future. Biology-driven research is warranted to additionally tailor treatment strategies.
期刊介绍：
Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.
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