Application of Biomaterials for the Prevention of Pharyngeal Fistulae: A Systematic Review.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-04-22 DOI:10.1002/hed.28175

Emilien Chabrillac, Audrey Tourrette, Michel Habib, Marilys Blanchy, Céline Des Courtils, Grégoire D'Andréa, Philippe Lavalle, Agnès Dupret-Bories

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引用次数: 0

Abstract

Background: PharyngoCutaneous Fistulae (PCF) represent a significant clinical challenge in otorhinolaryngology practice. The use of biomaterials could improve outcomes or even replace the use of a flap in pharyngolaryngeal surgery.

Methods: This systematic review included all studies evaluating the application of biomaterials for the prevention of PCF after pharyngeal surgery.

Results: A total of 19 articles (12 clinical and 7 animal studies) were included. They assessed the use of a biomaterial to cover mucosal sutures (n = 15) or to replace a mucosal defect and guide secondary healing (n = 4). Most studies evaluated commercialized biomaterials (n = 11) rather than experimental devices (n = 5) or platelet-derived autologous medical devices (n = 4).

Conclusion: There are already strong arguments to support the use of several biomaterials to cover pharyngeal sutures in order to decrease the rate of PCF after TL or TPL. Replacing a pharyngeal mucosal defect by a biomaterial is currently a more elusive goal.

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生物材料在预防咽瘘中的应用综述。

背景：咽皮瘘（PCF）是耳鼻喉科实践中的一个重大临床挑战。生物材料的使用可以改善咽外科手术的效果，甚至可以取代皮瓣的使用。方法：本系统综述纳入了所有评价生物材料在咽部手术后预防PCF应用的研究。结果：共纳入19篇文章（12篇临床研究和7篇动物研究）。他们评估了使用生物材料覆盖粘膜缝合线（n = 15）或替代粘膜缺损并引导二次愈合（n = 4）。大多数研究评估商业化的生物材料（n = 11），而不是实验装置（n = 5）或血小板来源的自体医疗装置（n = 4）。结论：已经有强有力的证据支持使用几种生物材料覆盖咽缝，以降低TL或TPL后PCF的发生率。用生物材料替代咽粘膜缺损目前是一个更难以捉摸的目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.