New Microbiologica最新文献_第5页

Stenotrophomonas maltophilia infections: Could eravacycline be a new weapon for clinicians? 嗜麦芽窄养单胞菌感染：依拉瓦环素能成为临床医生的新武器吗？

IF 1 4区医学

New Microbiologica Pub Date : 2025-10-01

Simone Giuliano, Luca Martini, Francesca Prataviera, Chiara Moreal, Sarah Flammini, Davide Lazzarotto, Giovanni Terrosu, Lucio De Cecchis, Renato Fanin, Carlo Tascini

{"title":"Stenotrophomonas maltophilia infections: Could eravacycline be a new weapon for clinicians?","authors":"Simone Giuliano, Luca Martini, Francesca Prataviera, Chiara Moreal, Sarah Flammini, Davide Lazzarotto, Giovanni Terrosu, Lucio De Cecchis, Renato Fanin, Carlo Tascini","doi":"","DOIUrl":"","url":null,"abstract":"Stenotrophomonas maltophilia is an emerging, multidrug-resistant pathogen increasingly associated with nosocomial infections, particularly in immunocompromised patients such as those undergoing allogeneic hematopoietic stem cell transplantation or affected by oncological diseases. Therapeutic options are limited due to intrinsic and acquired resistance mechanisms, including β-lactamases and efflux pumps. Although minocycline and trimethoprim-ulfamethoxazole are standard treatments, recent evidence suggests that eravacycline, a novel fluorocycline, may be effective in vitro, though clinical data remain scarce. Two cases of S. maltophilia bloodstream infection (BSI) in immunocompromised patients were reviewed. Both patients received eravacycline as part of combination therapy, following microbiological identification of the pathogen. Clinical course, microbiological outcomes, and antibiotic regimens were analyzed. Both patients, affected by acute myeloid leukemia and cholangiocarcinoma, developed S. maltophilia BSI after prolonged exposure to broad-spectrum antibiotics. Eravacycline (1 mg/kg every 12 hours) was included in both regimens. Blood cultures cleared within 48 hours in both cases. One patient died due to fungal complications, but S. maltophilia BSI was microbiologically controlled in both. These findings suggest a potential role for eravacycline in treating S. maltophilia BSI when standard options are limited. Further clinical studies are needed to establish efficacy and appropriate therapeutic use.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"48 3","pages":"276-279"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shifting antiretroviral drug distribution from Outpatient Clinics to Hospital Pharmacies in Italy. Evolution of ART delivery methods and impact on treatment adherence. 将抗逆转录病毒药物分发从门诊诊所转移到意大利的医院药房。抗逆转录病毒治疗方法的演变及其对治疗依从性的影响。

IF 1 4区医学

New Microbiologica Pub Date : 2025-10-01

Lucia Taramasso, Giorgia Brucci, Silvia Dettori, Veronica Busin, Antonio Vena, Federica Mina, Davide Malucelli, Sara Mora, Mauro Giacomini, Sabrina Beltramini, Matteo Bassetti, Antonio Di Biagio

{"title":"Shifting antiretroviral drug distribution from Outpatient Clinics to Hospital Pharmacies in Italy. Evolution of ART delivery methods and impact on treatment adherence.","authors":"Lucia Taramasso, Giorgia Brucci, Silvia Dettori, Veronica Busin, Antonio Vena, Federica Mina, Davide Malucelli, Sara Mora, Mauro Giacomini, Sabrina Beltramini, Matteo Bassetti, Antonio Di Biagio","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: This retrospective observational study assesses adherence to antiretroviral therapy before and after the transition to pharmacy-based treatment dispensation.Methods: Two 14-month periods were identified: before (P1) and after (P2) the transition to pharmacy-based provision of antiretrovirals. P2 also coincided with the SARS-CoV-2 pandemic. Adherence was assessed using a mathematical index to estimate the delay in refilling medication (delay index Di).Results: 1,266 people with HIV were included. Higher values of Di were found to be associated with P2 (ß 0.17, 95%CI 0.04-0.07), primarily driven by a significant delay in the initial months of the SARSCoV-2 pandemic in Italy, with Di +0.051 ± 0.13 from March to May 2020 vs. Di +0.048 ±0.12 in the rest of P2. Higher Di was also associated with multi-tablet regimens (ß 0.06, 95%CI 0.006-0.03), whereas switching regimens was associated with lower Di (ß -0.06, 95%CI -0.07-0.04). The odds of HIV RNA>50 copies/mL were higher with higher Di (OR 2.78; 95%CI 1.14-6.75), but lower in P2 compared to P1 (OR 0.38; 95%CI 0.27-0.53).Conclusions: Despite an apparent adherence decline due to delays in treatment refills during the first months of the SARS-CoV-2 pandemic, the transition to pharmacy-based antiretrovirals supply was associated with lower frequency of uncontrolled HIV replication.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"48 3","pages":"238-242"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Invasive Fungal Infection: Clinical Strategies in Critical Care from a Multidisciplinary Consensus. 侵袭性真菌感染的管理：来自多学科共识的重症监护临床策略。

IF 1 4区医学

New Microbiologica Pub Date : 2025-10-01

Chiara Moreal, Jacopo Angelini, Sergio Venturini, Cristian Deana, Sarah Flammini, Manuela Lugano, Umberto Lucangelo, Luca Montanari, Tommaso Pellis, Erik Roman-Pognuz, Ornella Schioppa, Verena Zerbato, Flavio Bassi, Simone Giuliano, Carlo Tascini

{"title":"Management of Invasive Fungal Infection: Clinical Strategies in Critical Care from a Multidisciplinary Consensus.","authors":"Chiara Moreal, Jacopo Angelini, Sergio Venturini, Cristian Deana, Sarah Flammini, Manuela Lugano, Umberto Lucangelo, Luca Montanari, Tommaso Pellis, Erik Roman-Pognuz, Ornella Schioppa, Verena Zerbato, Flavio Bassi, Simone Giuliano, Carlo Tascini","doi":"","DOIUrl":"","url":null,"abstract":"Fungal infections pose a growing threat in hospital settings, particularly among critically ill or immunocompromised patients. A multidisciplinary consensus among fifteen clinical experts from Northern Italy examined the increasing challenge of invasive fungal infections, especially in patients with high-risk complications and in critical settings. The report emphasizes early diagnostic integration through clinical assessment, biomarker evaluation, and the essential role of therapeutic drug monitoring in optimizing outcomes. This consensus aims to consolidate clinical strategies for timely diagnosis, personalized pharmacologic intervention, and antifungal stewardship. Azoles are identified as first-line treatment options. Isavuconazole emerged as a preferred therapeutic agent due to its favorable pharmacokinetic profile, safety in renal impairment, and lack of QT interval prolongation. This consensus supports integrated strategies combining early recognition, rapid diagnostics, individualized pharmacology, and antifungal stewardship to improve outcomes, particularly in critical care settings.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"48 3","pages":"211-214"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Pregnant Woman With Syphilitic Gumma Presenting Atypical Skin Involvement Accompanied by Ocular Syphilis: A Case Report. 孕妇梅毒牙龈表现为非典型皮肤累及伴眼梅毒1例。

IF 1 4区医学

New Microbiologica Pub Date : 2025-10-01

Cengizhan Tanyel, Elif Tanyel, Derya Seyman, Hande Berk Cam, Ayşegül Seremet Keskin

引用次数: 0

β-Lactamase inhibitors, cefiderocol and delafloxacin: evaluating promising antibiotics options for Pseudomonas aeruginosa in adults with cystic fibrosis. β-内酰胺酶抑制剂，头孢地罗和德拉沙星：评估成人囊性纤维化铜绿假单胞菌有希望的抗生素选择

IF 1 4区医学

New Microbiologica Pub Date : 2025-10-01

Caroline Loïez, Audrey Charlet, Claire Duployez, Rémi Le Guern, Frédéric Wallet

引用次数: 0

The characteristic of virulence and antibiotic resistance of metallo-carbapenemases-producing Klebsiella spp. in a tertiary hospital in China. 中国某三级医院产金属碳青霉烯酶克雷伯氏菌的毒力及耐药性特点。

IF 1 4区医学

New Microbiologica Pub Date : 2025-10-01

Ruixue Ma, Yu Jingying, Yinyun Lu, Yongchun Ruan, Jinnan Duan, Dan Wang, Guofeng Mao, Minghui Li, Yiqing Zhou

{"title":"The characteristic of virulence and antibiotic resistance of metallo-carbapenemases-producing Klebsiella spp. in a tertiary hospital in China.","authors":"Ruixue Ma, Yu Jingying, Yinyun Lu, Yongchun Ruan, Jinnan Duan, Dan Wang, Guofeng Mao, Minghui Li, Yiqing Zhou","doi":"","DOIUrl":"","url":null,"abstract":"The emergence and global dissemination of carbapenem-resistant Klebsiella spp. have seriously threatened global public health. Few genomic analyses of ceftazidime-avibactam-resistant and carbapenem-resistant Klebsiella spp. (CAR-CRKS) have been performed to date. This was a retrospective study of 12 CAR - CRKS isolates from 99 Klebsiella spp. collected in a Chinese tertiary hospital between 2018 and 2020. K. pneumoniae (eight cases, 66.67%), K. variicola (two cases, 16.67%), and K. quasipneumoniae (two cases, 16.67%) were identified in these isolates. Most of these patients had underlying hepatobiliary diseases or a history of receiving interventional procedures, and were hospitalised recurrently. The isolates were sensitive to amikacin, tigecycline, and polymyxin. blaIMP-4 was detected in six isolates, whereas blaNDM-1, blaNDM-5 and blaNDM-9 were detected in three, two, and one isolates, respectively. Only one strain harboured the rmpA, and exhibited a hypermucinous phenotype. The aerobactin (iucABCD) and yersiniabactin genes were absent in most of the strains. The strains containing blaIMP-4 exhibited higher virulence. These findings are of great significance for understanding the characteristics of CAR - CRKS and developing treatment strategies.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"48 3","pages":"255-261"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy in women living with HIV: Experience of IRCCS San Gerardo dei Tintori and a narrative review. 携带艾滋病毒的妇女怀孕：圣杰拉尔多-丁托里国际艾滋病防治中心的经验和一篇叙述性综述。

IF 1 4区医学

New Microbiologica Pub Date : 2025-10-01

Alice Ranzani, Giuseppe Lapadula, Fabiana D'Aloia, Sara Ornaghi, Anna Locatelli, Paolo Bonfanti, Francesca Sabbatini

引用次数: 0

HIV and Sexual Health Awareness Among University Students: Findings from a World AIDS Day Survey in Milan. 大学生的艾滋病毒和性健康意识：米兰世界艾滋病日调查的结果。

IF 1 4区医学

New Microbiologica Pub Date : 2025-10-01

Angelo Roberto Raccagni, Camilla Abello, Vincenzo Stabile, Nicolò Capra, Riccardo Lolatto, Giuliana Uslenghi, Sonia Levi, Andrea Fossati, Massimo Reichlin, Francesco De Cobelli, Silvia Nozza, Antonella Castagna

引用次数: 0

Rare Peritoneal Dialysis-Associated Peritonitis Caused by Plectosphaerella cucumerina: A Case Report. 罕见的腹膜透析相关性腹膜炎由黄瓜衣球菌引起1例。

IF 1 4区医学

New Microbiologica Pub Date : 2025-10-01

Guofeng Mao, Meichun Liang, Qiaoli Wu, Yaoqin Wang

引用次数: 0

In silico and Experimental Evaluation of Antiviral Activity of Acutumine and Dauricumine against SARS-CoV-2. acuumine和Dauricumine对SARS-CoV-2抗病毒活性的计算机模拟和实验评价。

IF 1.2 4区医学

New Microbiologica Pub Date : 2025-10-01

Leena Hussein Bajrai, Sayed Sartaj Sohrab, Rabie Saleh Al-Nahas, Mohd Rehan, Esam Ibraheem Azhar

{"title":"In silico and Experimental Evaluation of Antiviral Activity of Acutumine and Dauricumine against SARS-CoV-2.","authors":"Leena Hussein Bajrai, Sayed Sartaj Sohrab, Rabie Saleh Al-Nahas, Mohd Rehan, Esam Ibraheem Azhar","doi":"","DOIUrl":"","url":null,"abstract":"The unusual pneumonia outbreak that originated in the city of Wuhan, China in December 2019 was found to be caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or COVID-19. In this study, we have evaluated the antiviral activity of Acutumine and Dauricumine compounds isolated from the Menispermum plant against SARS-CoV-2. The cells were infected by virus in 3 different experimental assay designs and treated at various concentrations from 0 to 48 hours post infection. The selected compounds were further tested under light-dependent anti-viral activities to measure the reduction of viral load using quantitative real-time polymerase chain reaction (qRT-PCR) on the cell culture assay. The in-silico results revealed that the active compounds known as Acutumine and Dauricumine could be better antiviral compounds with essential proteins of this virus, mainly protease (Mpro). Interestingly, the Acutumine and Dauricumine mixture (1:1 ratio100 mg/mL of each) of both compounds showed effective anti-viral activity in Vero E6 cells. Therefore, the results of Acutumine and Dauricumine compounds used in this study showed significant anti-viral and virucidal effects in the following increasing order of potency: Acutumine alone, Dauricumine alone, and mixture of both compounds or effective on SARS-CoV-2 infectious cycle. Thus, based on the outcome of this study, it is concluded that Dauricumine alone or in a mixture could be a better option as an antiviral than Acutumine alone against SARS-CoV-2.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"48 3","pages":"243-254"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0