New Microbiologica最新文献_第5页

Pre-exposure prophylaxis for COVID-19 with Tixagevimab/Cilgavimab in kidney transplant recipients in the Kraken variant (XBB.1.5) era: A Single-center Experience. Kraken变体（XBB.1.5）时代肾移植受者使用Tixagevimab/Cilgavimab进行COVID-19暴露前预防：单中心经验。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-11-01

Biagio Pinchera, Rosa Carrano, Fabrizio Salemi, Amerigo Piccione, Elisa Schettino, Paolo Romano, Emilia Trucillo, Alessia D'Agostino, Marina Sarno, Emanuela Zappulo, Ivan Gentile

{"title":"Pre-exposure prophylaxis for COVID-19 with Tixagevimab/Cilgavimab in kidney transplant recipients in the Kraken variant (XBB.1.5) era: A Single-center Experience.","authors":"Biagio Pinchera, Rosa Carrano, Fabrizio Salemi, Amerigo Piccione, Elisa Schettino, Paolo Romano, Emilia Trucillo, Alessia D'Agostino, Marina Sarno, Emanuela Zappulo, Ivan Gentile","doi":"","DOIUrl":"","url":null,"abstract":"Pre-exposure prophylaxis for COVID-19 with Tixagevimab/Cilgavimab in immunocompromised patients has reduced the risk of breakthrough infection, disease, hospitalization, and COVID-19 related mortality. However, the advent of the Kraken variant (XBB.1.5) has limited the use of this monoclonal antibody, based on poor efficacy in in vitro studies The objective of the study was to evaluate the risk of breakthrough infection, symptomatic disease, hospitalization, intensive care admission, and COVID-19 related death in kidney transplant recipients receiving pre-exposure prophylaxis with Tixagevimab/Cilgavimab for COVID-19 in the era of the Kraken variant (XBB.1.5). In a prospective, observational study, we enrolled kidney transplant patients undergoing pre-exposure prophylaxis for COVID-19 with Tixagevimab/Cilgavimab at the Division of Infectious Diseases of Federico II University of Naples from February 2023 to August 2023. Each patient subsequently underwent a six-month follow-up with symptom monitoring and surveillance nasopharyngeal swab for SARS-CoV-2 RNA detection every 30 days, regardless of symptoms. Thirty-four kidney transplant patients were enrolled, and in the follow-up period only one tested positive for the nasopharyngeal swab for SARSCoV-2 research with asymptomatic infection and virological recovery on the eighth day after diagnosis of infection. Therefore, no patient developed disease, no patient needed hospitalization, and no death occurred. No adverse drug reaction to Tixagevimab/Cilgavimab occurred. Our data, although derived from a limited and uncontrolled sample, show the potential of Tixagevimab/Cilgavimab as a valid and viable therapeutic strategy in pre-exposure prophylaxis for immunocompromised patients. These findings highlight the importance of conducting clinical studies on this topic.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 3","pages":"265-268"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Converting biomass waste into valuable biomaterials and bioactive compounds: an overview of antimicrobial activities in the pursuit of global sustainability and health. 将生物质废物转化为有价值的生物材料和生物活性化合物：为实现全球可持续性和健康而开展的抗菌活动综述。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-07-01

Elena Iacono, Giulia Sciandrone, Carolina Filipponi, Giulia Freer, Michele Lai, Mauro Pistello

引用次数: 0

Research on bacteria isolated from ocular infections, their antibiotic susceptibility patterns and impact on selection of appropriate therapy. 研究从眼部感染中分离出的细菌、其对抗生素的敏感性模式以及对选择适当疗法的影响。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-07-01

Jorann Attracta De Araújo, Rudolf Kukla, Marie Vajrychová, Lenka Ryšková, Pavel Boštík

{"title":"Research on bacteria isolated from ocular infections, their antibiotic susceptibility patterns and impact on selection of appropriate therapy.","authors":"Jorann Attracta De Araújo, Rudolf Kukla, Marie Vajrychová, Lenka Ryšková, Pavel Boštík","doi":"","DOIUrl":"","url":null,"abstract":"Bacterial ocular infections represent a common public health problem affecting people of all age groups. These infections can lead to damage of ocular structures or even a loss of vision. The spectrum of isolated bacteria and their susceptibilities to antibiotics, however, shows geographical variabilities, which can affect the success of most empirically-administered antimicrobial therapies. The aim of this study was thus to analyse bacterial aetiology in culture-positive acute and chronic ocular infections and its antimicrobial susceptibility profile in a large cohort of patients in the Czech Republic. The study also focused on corynebacteria identification, particularly on the prevalence of Corynebacterium macginleyi. A total of 2500 bacterial isolates obtained from 2015 to 2020 in University Hospital Hradec Kralove were included in the study. A total of 2320 (92.8%) bacterial isolates were Gram-positive and 180 (7.2%) were Gram-negative. Staphylococcus aureus was the predominant pathogen, isolated from 15.3% of ocular infections, followed by Enterobacterales, Streptococcus pneumoniae and Haemophilus influenzae, isolated in 2.9%, 1.6% and 1.0%, respectively. Corynebacterium macginleyi was confirmed as the most prevalent species of corynebacteria. Most bacteria showed good susceptibility to fluoroquinolones, chloramphenicol, and aminoglycosides. Gram-positive bacteria were also susceptible to tetracycline. To conclude, this study presents a 5-year assessment of bacterial aetiology of ocular infections in the East Bohemian region. The survey showed clear differences in the susceptibilities of several bacteria to select antibiotics compared to studies from other geographical regions in Europe. This clearly shows that local surveillance of the aetiology and antimicrobial susceptibility of bacteria is essential for adequate empirical therapy of ocular infections.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 2","pages":"137-145"},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seroprevalence of hepatitis D virus in Bulgarian outpatients with history of liver dysfunction. 保加利亚肝功能异常门诊患者丁型肝炎病毒血清阳性率。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-07-01

Denitsa Tsaneva-Damyanova

引用次数: 0

Antifungal susceptibility pattern of Candida auris strains: Analysis of clinical strains in a tertiary-care educational university hospital. 念珠菌菌株的抗真菌药敏模式：分析一家三级医疗大学医院的临床菌株。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-07-01

Amira Khairy, Suha Hejres, Umran Elbahr, Farouq Dayyab, Clark Steven Delos Reyes, Jennie Ann Pastrana, Chithra Vineeth, Shruti Prem Sudha, Ozge Keskin, Shiv Singh Rana, Elias Fadel, Hakan Erdem, Oguz Resat Sipahi

{"title":"Antifungal susceptibility pattern of Candida auris strains: Analysis of clinical strains in a tertiary-care educational university hospital.","authors":"Amira Khairy, Suha Hejres, Umran Elbahr, Farouq Dayyab, Clark Steven Delos Reyes, Jennie Ann Pastrana, Chithra Vineeth, Shruti Prem Sudha, Ozge Keskin, Shiv Singh Rana, Elias Fadel, Hakan Erdem, Oguz Resat Sipahi","doi":"","DOIUrl":"","url":null,"abstract":"Herein, we aimed to investigate the antifungal susceptibility pattern of Candida auris clinical strains in our setting Bahrain Oncology Center-King Hamad University Hospital-Bahrain. C. auris strains isolated from different clinical specimens in the Microbiology Laboratory from October-2021 to November-2022 were evaluated. Species-level identification of fungi was performed by MALDI-TOF (Bruker, Germany). Minimum inhibitory concentration (MIC) was determined either by E-test strips or by MICRONAUT MIC system based on CDC guidelines for C. auris antifungal interpretation. Fluconazole, amphotericin-B, voriconazole, and caspofungin susceptibility data of the clinical strains were analyzed. A total of 40 clinical isolates were included: 25% were blood culture isolates, 65% were urinary, and 10% were soft tissue isolates. Only 29 strains could be tested for amphotericin-B and 32 for voriconazole. Overall resistance pattern was as follows: 100% resistance to fluconazole, 2.5% resistance to caspofungin, and 0% resistance to amphotericin b. Median voriconazole MIC was 0.015 ug/ml (min 0.08, max= 0.064 ug/ml). We had no fluconazole-sensitive strain and only one caspofungin-resistant strain. A single isolate (2.5%), which was associated with candidemia, demonstrated resistance to two antifungal agents: fluconazole and caspofungin. No triple or quadruple drug resistant strain existed.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 2","pages":"152-156"},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracking the phylogenetic profile of HEV in swine and wild boar in Europe. 追踪欧洲猪和野猪中 HEV 的系统发育概况。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-07-01

Gjergji Koja, Elida Mataj, Roberto Giuseppetti, Umbertina Villano, Roberto Bruni, Anna Rita Ciccaglione, Alessandra Lo Presti

{"title":"Tracking the phylogenetic profile of HEV in swine and wild boar in Europe.","authors":"Gjergji Koja, Elida Mataj, Roberto Giuseppetti, Umbertina Villano, Roberto Bruni, Anna Rita Ciccaglione, Alessandra Lo Presti","doi":"","DOIUrl":"","url":null,"abstract":"Hepatitis E virus (HEV) infection is prevalent among domestic pigs and wild boar in Europe. This study focused on the genetic diversity of HEV subtypes 3c, 3e and 3f among swine and wild boar in Europe as well as their circulation. Phylogenetic analysis and Bayesian phylogenetic inference were applied on the selected ORF2 capsid HEV sequences to co-estimate the viral circulation, the mean evolutionary rates and the dated trees. The estimated mean values of the HEV ORF2 capsid gene evolutionary rate were 8.29 x 10-3, 5.96 x 10-3, and 1.107 x 10-2 substitutions/site/year, respectively for 3c, 3e and 3f. The majority of the HEV 3c and 3e supported clusters did not show intermixing between swine and wild boar. Thus, although the intermixing observed in a minority of HEV 3c and 3e supported clusters suggests that transmission/circulation of these subtypes between swine and wild boar can potentially occur, 3c and 3e European wild boar HEV populations remained mainly segregated. In contrast, one half of the HEV 3f supported clusters showed intermixing between swine and wild boar, providing evidence for transfer/circulation to swine. The data suggest that continued virologic surveillance in swine and wild boar is necessary, together with targeted measures to reduce the chance of HEV transmission to humans.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 2","pages":"157-163"},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatitis C Virus (HCV) genotypes distribution in South-Eastern Tuscany: a ten-year retrospective study. 托斯卡纳东南部的丙型肝炎病毒 (HCV) 基因型分布：一项为期十年的回顾性研究。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-07-01

Agostino Ognibene, Giulio Camarlinghi, Maria Lorubbio, Manuela Mafucci, Alessandro Saracini, Alessandro Pancrazzi, Silvana Gervino, Gianluca Viti, Augusto Maddalena, Danilo Tacconi, Eva Maria Parisio, Francesca Borgia, Giampiero Caldarelli, Simona Dei, Assunta De Luca, Antonio D'Urso

{"title":"Hepatitis C Virus (HCV) genotypes distribution in South-Eastern Tuscany: a ten-year retrospective study.","authors":"Agostino Ognibene, Giulio Camarlinghi, Maria Lorubbio, Manuela Mafucci, Alessandro Saracini, Alessandro Pancrazzi, Silvana Gervino, Gianluca Viti, Augusto Maddalena, Danilo Tacconi, Eva Maria Parisio, Francesca Borgia, Giampiero Caldarelli, Simona Dei, Assunta De Luca, Antonio D'Urso","doi":"","DOIUrl":"","url":null,"abstract":"Italy is recognized as having the highest Hepatitis C virus (HCV) prevalence in Europe. The Tuscany region, where the prevalence of HCV infection is approximately 0.8%, implemented two programs for the control of chronic hepatitis C in Tuscany from 2018 to 2022. This retrospective study aims to investigate the incidence of HCV in a population screened in Southeastern Tuscany from 2013 to 2022. The study population included 246,137 patients from the provincial area of Arezzo and Grosseto, Tuscany, spanning from January 2013 to October 2022. Among the subjects included in the study, 3,190 (1.29%) tested positive for anti-HCV antibodies. Of this population, 2,119 patients (66.43%) also tested positive for HCV-RNA quantification, leading to their enrolment for subsequent viral genotyping. 1,106 patients had genotype (GT) 1 (52.2%), 484 had GT 3 (22.8%), 371 had GT 2 (17.5%), and 158 had GT 4 (7.5%). Our study underscores the prevalence of HCV GTs 1 and 3 as the most predominant GTs in the Southeast Tuscany region. We also observe a correlation between age, sex and HCV genotypic distribution.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 2","pages":"172-179"},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-O1 and non-O139 Vibrio cholerae Septicemia and Cellulitis: a Case Report. 非 O1 和非 O139 霍乱弧菌败血症和蜂窝组织炎：病例报告。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-07-01

Marcella Negri, Floriana Gona, Chiara Tassan Din, Angelo Roberto Raccagni, Costanza Bertoni, Matteo Moro, Laura Villa, Massimo Locatelli, Antonella Castagna, Monica Guffanti

{"title":"Non-O1 and non-O139 Vibrio cholerae Septicemia and Cellulitis: a Case Report.","authors":"Marcella Negri, Floriana Gona, Chiara Tassan Din, Angelo Roberto Raccagni, Costanza Bertoni, Matteo Moro, Laura Villa, Massimo Locatelli, Antonella Castagna, Monica Guffanti","doi":"","DOIUrl":"","url":null,"abstract":"Non-O1 and non-O139 Vibrio cholerae (NOVC) are serogroups that do not produce cholera toxin and are not responsible for epidemics. Even though rarely encountered in clinical practice, they can cause a spectrum of different conditions ranging from mild gastrointestinal syndrome to extraintestinal diseases, of which bacteremia and wound infections are the most severe. Risk factors for severe disease are cirrhosis, neoplasms, and diabetes mellitus. The mortality rate of NOVC bacteremia in hospitalized patients ranges from 24 to 61.5%. Incidence of NOVC infections is still rare, and consensus recommendations on treatment are not available. We report a case of NOVC bacteremia associated with severe cellulitis in an immunocompetent 75-year-old man who had eaten raw seafood in a location by the northern Adriatic Sea (Italy). Twenty-four hours after intake, he developed a high fever and vomiting. Afterwards, he started noticing the appearance of cellulitis in his right leg, which worsened in a matter of hours. The patient had a history of compensated type 2 diabetes mellitus. NOVC was isolated from both blood cultures and the leg ulcer. The non-O1, non-O139 serogroup was confirmed, and the detection of the cholera toxin gene was negative. Both tests were performed by the Reference National Laboratory of Istituto Superiore di Sanità (ISS). Multiple antimicrobial regimens were administered, with complete recovery. In conclusion, considering the severity of NOVC-associated manifestations, it is of pivotal importance to reach etiological diagnosis for a target antimicrobial therapy and to consider V. cholerae infection in the differential diagnosis in the presence of risk factors and potential exposure.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 2","pages":"190-193"},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Etiological structure and antibiotic resistance pattern of burn wound infections in hospitalized patients - a one-center study in Varna, Bulgaria. 住院患者烧伤创面感染的病因结构和抗生素耐药性模式--保加利亚瓦尔纳的一项单中心研究。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-07-01

Gergana Nedelcheva, Dajana Dobreva, Teofan Kuyumdzhiev, Gabriela Tsankova, Tatina Todorova

{"title":"Etiological structure and antibiotic resistance pattern of burn wound infections in hospitalized patients - a one-center study in Varna, Bulgaria.","authors":"Gergana Nedelcheva, Dajana Dobreva, Teofan Kuyumdzhiev, Gabriela Tsankova, Tatina Todorova","doi":"","DOIUrl":"","url":null,"abstract":"In the present retrospective study, we have evaluated bacterial pathogens isolated from patients admitted to the Burn Care Unit at the Military Medical Academy, Varna, Bulgaria over a three-year period (January 2019 - December 2021). We also tried to summarize the corresponding antibiotic resistance pattern of the isolated infectious agents. A total of 1030 isolates were obtained from 1912 burn wound samples investigated. There were 553 Gram-positive (53.7%) and 477 Gram-negative (46.3%) isolates. The most common isolates for the study period were coagulase-negative staphylococci (CoNS) (25%), Pseudomonas aeruginosa (17.7%), Staphylococcus aureus (16.6%), Acinetobacter baumannii (7.7%), Enterobacter spp. (7.1%), Escherichia coli (4.4%), Proteus spp. (3.4%), and Klebsiella spp. (2.9%). Glycopeptide antibiotics and linezolid were the most effective drugs against gram-positive isolates, followed by amikacin (for synergistic combinations), whereas colistin, imipenem, meropenem, cefoperazon/sulbactam, and piperacillin/tazobactam were the most active drugs against Gram-negative isolates, and colistin, ampicillin/sulbactam - against A. baumannii.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 2","pages":"146-151"},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rethinking Combination Therapy for S. aureus bacteremia: A Fading Paradigm. 反思金黄色葡萄球菌菌血症的联合疗法：渐行渐远的范例。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-07-01

Sergio Venturini, Ingrid Reffo, Manuela Avolio, Giancarlo Basaglia, Giovanni Del Fabro, Astrid Callegari, Igor Bramuzzo, Maurizio Tonizzo, Riccardo Lucis, Elisa Pontoni, Laura De Santi, Massimo Crapis

引用次数: 0