反思金黄色葡萄球菌菌血症的联合疗法：渐行渐远的范例。

IF 1.5 4区医学 Q4 MICROBIOLOGY

New Microbiologica Pub Date : 2024-07-01

Sergio Venturini, Ingrid Reffo, Manuela Avolio, Giancarlo Basaglia, Giovanni Del Fabro, Astrid Callegari, Igor Bramuzzo, Maurizio Tonizzo, Riccardo Lucis, Elisa Pontoni, Laura De Santi, Massimo Crapis

{"title":"反思金黄色葡萄球菌菌血症的联合疗法：渐行渐远的范例。","authors":"Sergio Venturini, Ingrid Reffo, Manuela Avolio, Giancarlo Basaglia, Giovanni Del Fabro, Astrid Callegari, Igor Bramuzzo, Maurizio Tonizzo, Riccardo Lucis, Elisa Pontoni, Laura De Santi, Massimo Crapis","doi":"","DOIUrl":null,"url":null,"abstract":"Staphylococcus aureus bacteremia presents clinical complexities, with prolonged duration associated with unfavorable outcomes. This research delves into unconventional treatments, such as combinations involving daptomycin, oxacillin, ceftaroline, and fosfomycin, with the aim of swiftly sterilizing bloodstream infection to reduce complications. Our examination of 30 MSSA bacteremia patients with infective endocarditis uncovers differing results between single-agent therapies (oxacillin or daptomycin) and combined treatment plans. Microbiologic clearance at the 72 hour mark demonstrates greater efficacy within the combination cohort (bacteremia persistence 29%) versus monotherapy (bacteremia persistence 78%). This limited case series suggests the potential superiority of combination therapy, prompting further investigations.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 2","pages":"183-185"},"PeriodicalIF":1.5000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rethinking Combination Therapy for S. aureus bacteremia: A Fading Paradigm.\",\"authors\":\"Sergio Venturini, Ingrid Reffo, Manuela Avolio, Giancarlo Basaglia, Giovanni Del Fabro, Astrid Callegari, Igor Bramuzzo, Maurizio Tonizzo, Riccardo Lucis, Elisa Pontoni, Laura De Santi, Massimo Crapis\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Staphylococcus aureus bacteremia presents clinical complexities, with prolonged duration associated with unfavorable outcomes. This research delves into unconventional treatments, such as combinations involving daptomycin, oxacillin, ceftaroline, and fosfomycin, with the aim of swiftly sterilizing bloodstream infection to reduce complications. Our examination of 30 MSSA bacteremia patients with infective endocarditis uncovers differing results between single-agent therapies (oxacillin or daptomycin) and combined treatment plans. Microbiologic clearance at the 72 hour mark demonstrates greater efficacy within the combination cohort (bacteremia persistence 29%) versus monotherapy (bacteremia persistence 78%). This limited case series suggests the potential superiority of combination therapy, prompting further investigations.\",\"PeriodicalId\":54723,\"journal\":{\"name\":\"New Microbiologica\",\"volume\":\"47 2\",\"pages\":\"183-185\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"New Microbiologica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"New Microbiologica","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

金黄色葡萄球菌菌血症临床表现复杂，持续时间长会导致不良后果。本研究深入探讨了一些非常规治疗方法，如达托霉素、氧西林、头孢他啶和磷霉素的组合，目的是迅速杀灭血流感染，减少并发症。我们对 30 名感染性心内膜炎的 MSSA 菌血症患者进行了研究，发现单药疗法（氧西林或达托霉素）和联合治疗方案的效果各不相同。在 72 小时内微生物清除率方面，联合疗法（菌血症持续率为 29%）比单一疗法（菌血症持续率为 78%）更有效。这一有限的病例系列表明，联合疗法可能更具优势，因此需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Rethinking Combination Therapy for S. aureus bacteremia: A Fading Paradigm.

Staphylococcus aureus bacteremia presents clinical complexities, with prolonged duration associated with unfavorable outcomes. This research delves into unconventional treatments, such as combinations involving daptomycin, oxacillin, ceftaroline, and fosfomycin, with the aim of swiftly sterilizing bloodstream infection to reduce complications. Our examination of 30 MSSA bacteremia patients with infective endocarditis uncovers differing results between single-agent therapies (oxacillin or daptomycin) and combined treatment plans. Microbiologic clearance at the 72 hour mark demonstrates greater efficacy within the combination cohort (bacteremia persistence 29%) versus monotherapy (bacteremia persistence 78%). This limited case series suggests the potential superiority of combination therapy, prompting further investigations.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

New Microbiologica 生物-微生物学

CiteScore

2.20

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： The publication, diffusion and furtherance of research and study on all aspects of basic and clinical Microbiology and related fields are the chief aims of the journal.