Hepatitis C Virus (HCV) genotypes distribution in South-Eastern Tuscany: a ten-year retrospective study.

IF 1.5 4区医学 Q4 MICROBIOLOGY

New Microbiologica Pub Date : 2024-07-01

Agostino Ognibene, Giulio Camarlinghi, Maria Lorubbio, Manuela Mafucci, Alessandro Saracini, Alessandro Pancrazzi, Silvana Gervino, Gianluca Viti, Augusto Maddalena, Danilo Tacconi, Eva Maria Parisio, Francesca Borgia, Giampiero Caldarelli, Simona Dei, Assunta De Luca, Antonio D'Urso

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引用次数: 0

Abstract

Italy is recognized as having the highest Hepatitis C virus (HCV) prevalence in Europe. The Tuscany region, where the prevalence of HCV infection is approximately 0.8%, implemented two programs for the control of chronic hepatitis C in Tuscany from 2018 to 2022. This retrospective study aims to investigate the incidence of HCV in a population screened in Southeastern Tuscany from 2013 to 2022. The study population included 246,137 patients from the provincial area of Arezzo and Grosseto, Tuscany, spanning from January 2013 to October 2022. Among the subjects included in the study, 3,190 (1.29%) tested positive for anti-HCV antibodies. Of this population, 2,119 patients (66.43%) also tested positive for HCV-RNA quantification, leading to their enrolment for subsequent viral genotyping. 1,106 patients had genotype (GT) 1 (52.2%), 484 had GT 3 (22.8%), 371 had GT 2 (17.5%), and 158 had GT 4 (7.5%). Our study underscores the prevalence of HCV GTs 1 and 3 as the most predominant GTs in the Southeast Tuscany region. We also observe a correlation between age, sex and HCV genotypic distribution.

本刊更多论文

托斯卡纳东南部的丙型肝炎病毒 (HCV) 基因型分布：一项为期十年的回顾性研究。

意大利是欧洲公认的丙型肝炎病毒（HCV）感染率最高的国家。托斯卡纳大区的 HCV 感染率约为 0.8%，从 2018 年到 2022 年，托斯卡纳大区实施了两项慢性丙型肝炎控制计划。这项回顾性研究旨在调查 2013 年至 2022 年期间托斯卡纳东南部筛查人群中的丙型肝炎病毒发病率。研究对象包括托斯卡纳阿雷佐和格罗塞托省区的 246137 名患者，时间跨度为 2013 年 1 月至 2022 年 10 月。在研究对象中，有3190人（1.29%）的抗-HCV抗体检测呈阳性。其中，2119 名患者（66.43%）的 HCV-RNA 定量检测结果也呈阳性，因此被纳入后续的病毒基因分型。1106名患者的基因型为1型（52.2%），484名患者的基因型为3型（22.8%），371名患者的基因型为2型（17.5%），158名患者的基因型为4型（7.5%）。我们的研究突出表明，HCV GT 1 和 3 是托斯卡纳东南部地区最主要的 GTs。我们还观察到年龄、性别和 HCV 基因型分布之间的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

New Microbiologica 生物-微生物学

CiteScore

2.20

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： The publication, diffusion and furtherance of research and study on all aspects of basic and clinical Microbiology and related fields are the chief aims of the journal.