New Microbiologica最新文献_第4页

Epidemiological characteristics and related risk factors of mixed infection in children with mycoplasma pneumoniae pneumonia. 肺炎支原体肺炎患儿混合感染的流行病学特征和相关风险因素。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-11-01

Wenli Lv, Chunyan Guo, Guofeng Lv, Xueqin Xi

{"title":"Epidemiological characteristics and related risk factors of mixed infection in children with mycoplasma pneumoniae pneumonia.","authors":"Wenli Lv, Chunyan Guo, Guofeng Lv, Xueqin Xi","doi":"","DOIUrl":"","url":null,"abstract":"Mycoplasma pneumoniae infection is a manifestation of pneumonia, which can be combined with multiple bacterial flora infection at the same time. This study explored the epidemiological characteristics and related risk factors of mixed infection in children with mycoplasma pneumonia (MP). 462 children with MP were enrolled and divided into simple infection and mixed infection groups. The mixed infection group was further divided into concurrent bacteria, virus, and chlamydia groups. Clinical data were collected to explore the epidemiological characteristics, and the related factors were analyzed by logistic regression. The co-infection rate was the highest in the mixed infection group (50.27%). Children under 1 year of age had the highest bacterial co-infection rate (40.95%). Children aged 1-5 years and >5 years had the highest viral co-infection rate (39.53%, 51.51%). Patients were more likely to be infected with virus from September to November (52.73%), and patients were more likely to be infected with bacteria from December to February (52.73%). The independent risk factors for concurrent viral, bacterial, and chlamydia infections were extrapulmonary complications, fever >10 days, high white blood cell count (WBC), and age, respectively. Conclusion: analysis of the epidemiological characteristics and risk factors of mixed infection in children with MP can provide guidance for clinicians to formulate a more reasonable diagnosis and treatment plan, reduce the occurrence of mixed infection, and improve the treatment effect.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 3","pages":"251-257"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PRESTIGIO RING: "A 28-year-old highly treatmentexperienced man with vertical HIV infection on ibalizumab therapy: ART simplification perspectives". prestigio ring："一名接受伊巴珠单抗治疗的 28 岁高度治疗经验男性艾滋病垂直感染者：简化抗逆转录病毒疗法的视角"。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-11-01

Rebecka Papaioannu Borjesson, Maurizio Zazzi, Francesco Saladini, Maria Mercedes Santoro, Daniele Armenia, Vincenzo Spagnuolo, Antonella Castagna

{"title":"PRESTIGIO RING: \"A 28-year-old highly treatmentexperienced man with vertical HIV infection on ibalizumab therapy: ART simplification perspectives\".","authors":"Rebecka Papaioannu Borjesson, Maurizio Zazzi, Francesco Saladini, Maria Mercedes Santoro, Daniele Armenia, Vincenzo Spagnuolo, Antonella Castagna","doi":"","DOIUrl":"","url":null,"abstract":"Due to a limited range of effective treatment options, highly treatment-experienced (HTE) people with HIV (PWH) still struggle to maintain virological suppression and obtain an adequate immunological recovery. To increase the likelihood of virologic success, HTE PWH require an individualized treatment regimen based on cumulative genotypic resistance testing (GRT) data, potential drug-drug interactions, and adherence. From the PRESTIGIO Registry, we present a case of a 28-year-old man with vertically transmitted HIV-1 infection, on therapy with an ibalizumab-including regimen and desiring a treatment simplification. In January 2024, the patient was started on a lenacapavir-containing regimen along with optimized background therapy in an attempt to maintain sustained virological suppression, simplify antiretroviral regimen, and potentially increase CD4+ T-cell count. At six months follow-up evaluation, virological suppression was confirmed, and an increase in CD4+ T-cell count of 60 cells/μL was observed. Close follow-up of this patient is ongoing.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 3","pages":"298-302"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and Pharmacokinetic Profiles of Subcutaneous Administration of Beta-Lactams: A Systematic Review. β-内酰胺类药物皮下注射的安全性和药代动力学特征：系统回顾

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-11-01

Chiara Moreal, Stefania Chiappinotto, George G Zhanel, Simone Lanini, Luca Montanari, Alvisa Palese, Carlo Tascini

{"title":"Safety and Pharmacokinetic Profiles of Subcutaneous Administration of Beta-Lactams: A Systematic Review.","authors":"Chiara Moreal, Stefania Chiappinotto, George G Zhanel, Simone Lanini, Luca Montanari, Alvisa Palese, Carlo Tascini","doi":"","DOIUrl":"","url":null,"abstract":"Beta-lactams are extensively used antibiotics known for their safety and effectiveness. The rise in patients who receive care in outpatient settings has increased the interest in subcutaneous administration (SA). The aim of the study is to assess the safety and pharmacokinetic (PK) profiles of SA of beta-lactams compared with other routes. The protocol was registered in the PROSPERO database and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed. Online databases were searched, and the quality of the eligible studies was assessed. The data extracted related to adverse events (AEs) and PK were summarised narratively. Sixteen studies were included. The reported AEs were generally mild, localised, and temporary. Although SA and intravenous administration had similar PK profiles, SA resulted in lower peak drug concentrations and slower absorption. Heterogeneity in the populations, medication delivery, outcome measures, and methodological quality emerged across the studies. The mild severity of AEs suggests that SA is a viable route. Additionally, SA appears to demonstrate effective PK profiles and delays drug release, with potential to reduce the dosing frequency and prolong the therapeutic effects. SA of beta-lactams is a promising viable alternative to intravenous administration, potentially enhancing treatment in the outpatient and long-term care settings.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 3","pages":"227-242"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Symbiotic Defence: Lung Microbiota and The Local Immune System. 共生防御：肺部微生物群与局部免疫系统。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-11-01

Ozel Yuruker, İskender Yılmaz, Meryem Güvenir

引用次数: 0

Analysis of infection indicators and risk factors for influenza A after the COVID-19 pandemic. COVID-19 大流行后甲型流感的感染指标和风险因素分析。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-11-01

Rui Ying Wang, Yu Wang, Xin Xin Wang, Bin Yan Wu, Hong Pei Wu, Hui Zheng Hu

{"title":"Analysis of infection indicators and risk factors for influenza A after the COVID-19 pandemic.","authors":"Rui Ying Wang, Yu Wang, Xin Xin Wang, Bin Yan Wu, Hong Pei Wu, Hui Zheng Hu","doi":"","DOIUrl":"","url":null,"abstract":"The flu outbreak after the coronavirus disease 2019 (COVID-19) pandemic has put a heavy burden on the medical system. We aimed to investigate the infection indicators and risk factors for influenza A virus, with the intention of offering valuable insights for clinical diagnosis and treatment. A total of 1590 throat swabs were collected from patients with influenza-like illness admitted to our hospital for treatment in March 2023. Influenza virus in infected patients was detected by the rapid antigen method and qPCR. We used statistical methods to compare clinical manifestations and laboratory tests between positive and negative patients. Among the 1590 influenza-like illness patients, 1004 (63.1%) were infected with influenza A, mainly children aged 0-9 years (52.8%); more males than females were infected, and the main clinical symptoms were fever, cough, diarrhea, nausea and vomiting, and muscle soreness. The leukocyte (WBC), lymphocyte (LYM), eosinophil (EOS), platelet (PLT), C-reactive protein (CRP) and lymphocyte/monocyte (LMR) levels in the positive group were lower than those in the negative group, while the neutrophil (NEU) and monocyte (MON) levels were higher than those in the negative group (P<0.05). Multivariate logistic regression analysis showed that age 0-9 years, cough, antiviral treatment time>48 h, and reduced PLT and LMR levels were independent risk factors for influenza A patients.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 3","pages":"269-274"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and genome characterization of a Klebsiella pneumoniae clinical strain carrying blaNDM-5 and blaOXA-48 isolated in Italy. 在意大利分离到的携带 blaNDM-5 和 blaOXA-48 的肺炎克雷伯氏菌临床菌株的分离和基因组特征。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-11-01

Stefano Amadesi, Erica Diani, Annarita Mazzariol, Davide Gibellini, Paolo Gaibani

引用次数: 0

Critical insights into the ocular surface microbiome: the need to standardize. 眼表微生物组的重要见解：标准化的必要性。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-11-01

Suzanne Bianca Clougher, Claudio Foschi, Antonio Moramarco, Luigi Fontana, Tiziana Lazzarotto, Antonella Marangoni, Piera Versura

{"title":"Critical insights into the ocular surface microbiome: the need to standardize.","authors":"Suzanne Bianca Clougher, Claudio Foschi, Antonio Moramarco, Luigi Fontana, Tiziana Lazzarotto, Antonella Marangoni, Piera Versura","doi":"","DOIUrl":"","url":null,"abstract":"Data from the literature indicates that the human ocular surface is inhabited by diverse commensal microbial communities, crucial for maintaining the homeostasis of healthy eyes. The ocular surface microbiome (OSM) plays a protective immunoregulatory role against pathogenic species, and any dysbiosis may contribute to disease onset. Traditional culture methods, employed in both clinical and research settings, have limitations. Certain pathogens are challenging to grow under routine conditions, leading to lower bacterial detection compared to next-generation sequencing (NGS). Despite the extensive use of NGS in published studies, variable results are observed. This variability may be attributed to factors such as limited sample size, differences in analytical procedures (from sampling to sequencing platforms), age and gender variations in included populations, diverse inclusion criteria, and geographical differences. These factors collectively impact the generated genomic data. Moreover, consistent reports on diversity indices are lacking in various published studies, whereas these indices could enhance the definition of OSM changes in disease states. Therefore, this review emphasizes the current imperative to standardize OSM sample collection, preparation, and analysis. This standardization is vital for accurately defining the composition of OSM in both healthy and pathogenic conditions and facilitating meaningful comparisons among studies.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 3","pages":"201-216"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-O1/non-O139 Vibrio cholerae bacteraemia and cholangitis: an unusual case in an oncological patient in Lecco Hospital, Italy. 非O1/非O139霍乱弧菌菌血症和胆管炎：意大利莱科医院一名肿瘤患者的罕见病例。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-11-01

Nicole Gemignani, Chiara Molteni, Federica Villa, Elena Briozzo, Silvia Pontiggia, Silvia Tonolo, Ilaria Mainardi, Giulia Carla Marchetti, Stefania Piconi

{"title":"Non-O1/non-O139 Vibrio cholerae bacteraemia and cholangitis: an unusual case in an oncological patient in Lecco Hospital, Italy.","authors":"Nicole Gemignani, Chiara Molteni, Federica Villa, Elena Briozzo, Silvia Pontiggia, Silvia Tonolo, Ilaria Mainardi, Giulia Carla Marchetti, Stefania Piconi","doi":"","DOIUrl":"","url":null,"abstract":"Only toxigenic serogroups O1 and O139 Vibrio cholerae have been associated with widespread cholera epidemics. Other serogroups (non-O1/non-O139 Vibrio cholerae or NOVC) most often cause sporadic gastrointestinal manifestations. Rarely, NOVC can result in severe extraintestinal manifestations in immunocompromised hosts. Although the presence of Vibrio cholerae is well documented in Mediterranean waters, it is not routinely tested in food sources in European countries. Here we report the case of a 46-year-old woman with a history of Von Hippel-Lindau syndrome who had previously undergone major hepatic and pancreatic surgeries and was on Everolimus, which caused neutropenia and mucositis. She was admitted to our emergency department with fever, chills, nausea, and abdominal pain, and was diagnosed with sepsis and acute cholangitis. Empiric piperacillin/ tazobactam was started, and blood cultures later identified non-O1/non-O139 Vibrio cholerae, linked to recent oyster consumption. The ongoing therapy resulted in initial clinical stabilization and microbiological clearance. However, fever persisted, along with the onset of diarrhoea (with negative stool cultures), leukopenia, thrombocytopenia, and elevated CRP levels. Ciprofloxacin was then added to the regimen, resulting in improved condition, fever resolution, normalization of bowel function, relief from abdominal pain, and radiological resolution of cholangitis. She was discharged in stable condition after 15 days of treatment. NOVC systemic infections are rising globally. Physicians should think of this pathogen in patients with risk factors, suggestive symptoms, and seafood ingestion. The literature shows significant heterogeneity in antimicrobial strategies, but association of beta-lactam antibiotic with ciprofloxacin proved to be an effective choice.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 3","pages":"289-291"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening of urinary and genital tracts of adult females for the Chlamydia-like bacterium Parachlamydia acanthamoebae. 筛查成年女性泌尿道和生殖道中的类衣原体 Parachlamydia acanthamoebae。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-11-01

Hesham M Al-Younes, Raneem A Abu-Saif, Sondos H Barghouthi, Ahmad Al-Younes, Nadia Mhaidat, Asma S Al-Basha

{"title":"Screening of urinary and genital tracts of adult females for the Chlamydia-like bacterium Parachlamydia acanthamoebae.","authors":"Hesham M Al-Younes, Raneem A Abu-Saif, Sondos H Barghouthi, Ahmad Al-Younes, Nadia Mhaidat, Asma S Al-Basha","doi":"","DOIUrl":"","url":null,"abstract":"Some members of the Chlamydiales order, particularly Chlamydia, Waddlia, and Parachlamydia, have been associated with adverse pregnancy outcomes in humans and animals. Recently, the existence of another Chlamydia-like bacterium, namely Simkania, has been confirmed in the genitalia of adult females, but its possible pathogenic role has not yet been examined. In comparison to other members of Chlamydiales, the presence of Parachlamydia in the urogenitalia of human females and its involvement in obstetrical complications is less convincingly investigated and still a matter of debate. This study aims to examine the existence of Parachlamydia and to assess its prevalence in the genital and urinary tracts of a population of women by using the polymerase chain reaction (PCR)-based methodology. Endocervical and vaginal specimens were collected from 103 married females, while only 60 females agreed to give urine samples. Among the examined population, 29 women (about 28%) had experienced miscarriage. Clinical samples were tested for Parachlamydia DNA by species-specific PCR assay. Nucleic acids of P. acanthamoebae were not detected in any endocervical, vaginal, and urine specimens tested. This investigation could not bring evidence for the existence of Parachlamydia in the urogenitalia of the female cohort tested. The role of Parachlamydia as a probable emerging obstetrical agent remains to be explained in future controlled studies targeting a larger number of females with prior unsuccessful pregnancies.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 3","pages":"258-264"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updating the relationship of Chlamydia pneumoniae with atherosclerotic cardiovascular diseases: a systematic review of reviews. 更新肺炎衣原体与动脉粥样硬化性心血管疾病的关系：系统性综述。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-11-01

Simone Filardo, Marisa Di Pietro, Silvio Romano, Rosa Sessa

{"title":"Updating the relationship of Chlamydia pneumoniae with atherosclerotic cardiovascular diseases: a systematic review of reviews.","authors":"Simone Filardo, Marisa Di Pietro, Silvio Romano, Rosa Sessa","doi":"","DOIUrl":"","url":null,"abstract":"Chlamydia pneumoniae is the etiologic agent of respiratory tract infections in humans, including community-acquired pneumonia, and has been associated with atherosclerotic cardiovascular diseases. The present systematic review of reviews aimed at answering important questions on the involvement of C. pneumoniae in the pathogenesis of atherosclerosis, its cellular and molecular mechanisms, and whether there is evidence of a causal relationship. The databases PubMed/Medline, Scopus, and Web of Science were searched for all review articles published from 2003 to the end of 2023. A total of 27 reviews, systematic reviews, and systematic reviews with metanalysis were included. Overall, current evidence suggests that C. pneumoniae is a biologically plausible candidate for the causation of atherosclerosis, albeit not all the 4 Koch postulates are fulfilled; oxidative stress and inflammation are the most likely pathogenic mechanisms mediated by C. pneumoniae. However, it is still unclear how the persistent form, responsible for chronic inflammation, fits into this etiopathogenetic scenario. In the future, the newly-designed transformation systems for the genomic manipulation of C. pneumoniae will surely help expand our knowledge on the role of this pathogen in atherogenesis.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 3","pages":"217-226"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0