New Microbiologica最新文献_第10页

Comparative transcriptome analysis of wild type and a pectate lyase mutant strain of Bacillus subtilis. 枯草芽孢杆菌野生型与果胶裂解酶突变株的转录组比较分析。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-02-01

Kongyang Wu, Jinqiu Wu, Xue Li, Tongxiang Yang, Xuedong Chen, Xueyi Yang

引用次数: 0

Pathogens distribution and antimicrobial resistance pattern of blood stream infections in Southern Italian hospital, 2016-2021 surveillance. 2016-2021年意大利南部医院血流感染病原菌分布及耐药模式监测

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-02-01

Maria Teresa Della Rocca, Vittorio Panetta, Adriana Durante, Lucio Bucci, Alfredo Matano, Angela Annecchiarico, Rita Greco

{"title":"Pathogens distribution and antimicrobial resistance pattern of blood stream infections in Southern Italian hospital, 2016-2021 surveillance.","authors":"Maria Teresa Della Rocca, Vittorio Panetta, Adriana Durante, Lucio Bucci, Alfredo Matano, Angela Annecchiarico, Rita Greco","doi":"","DOIUrl":"","url":null,"abstract":"Bloodstream infections (BSIs) monitoring and antibiotic susceptibility assumes a priority relevance to guide antibiotic treatment strategies and prevention programs. The study aims to identify the most common causative agents of BSIs, seasonal distribution and variation of antimicrobial susceptibility rates during a 6-year period in a in a Level II EAD Southern Italian Hospital. The study was conducted from 2016 to 2021 at Hospital of National Relevance (AORN) Sant'Anna and San Sebastiano, Caserta, Campania Region in Italy. BSIs Gram positive causative pathogens were S. aureus and Enterococci; Gram negative pathogens were E. coli, K. pneumoniae, P. aeruginosa and A. baumannii. Seasonal distribution showed the main incidence in April-June for Gram positive BSIs pathogens and in July-September months for Gram negative. Antimicrobial susceptibility fluctuations rates from 2016-2018 to 2019-2021 highlighted a significant decrease in S. aureus oxacillin resistance rates. Enterococci incremented resistance was reported for gentamicin. Gram negative pathogens antimicrobial susceptibility revealed decreased carbapenem-resistance rates for K. pneumoniae (-21.5%) and P. aeruginosa (-19.7%). A. baumannii colistin resistance had a significant increase in 2019-2021. K. pneumoniae and E. coli isolates showed decreased trend of extended-spectrum -lactamase-producing (ESBL) and carbapenem-resistant (CRE) resistance profiles. Our finding reflects the success of our Istitution regarding antimicrobial stewardship program and highlights the need to know the trend of antimicrobial resistance characterization focus on local pathogens' profile. In this way, in conjunction with infection control strategies, il could be possible to constantly reduce the spread of Multi Drug Resistant organisms.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"46 1","pages":"29-36"},"PeriodicalIF":1.8,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10818103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superior vena cava Candida krusei septic thrombophlebitis in an ARDS patient on ECMO, with an unusual late complication. 急性呼吸窘迫综合征患者上腔静脉克鲁氏念珠菌感染性血栓性静脉炎，伴有不寻常的晚期并发症。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-02-01

Elizabeth Iskandar, Caterina Cavanna, Eva Maria Giada Mollaschi, Ruben Mattia Trani, Francesco Mojoli, Alessandro Amatu

引用次数: 0

Cefditoren: a clinical overview. 头孢多伦:临床综述。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-02-01

Simone Giuliano, Angela Acquasanta, Luca Martini, Francesco Sbrana, Sarah Flammini, Carlo Tascini

{"title":"Cefditoren: a clinical overview.","authors":"Simone Giuliano, Angela Acquasanta, Luca Martini, Francesco Sbrana, Sarah Flammini, Carlo Tascini","doi":"","DOIUrl":"","url":null,"abstract":"Cefditoren is an oral third-generation cephalosporin with a large spectrum activity against Gram-negative and Gram-positive bacteria which are reported to be responsible for respiratory tract and skin and skin structure infections. In this work we reviewed the pharmacodynamics, pharmacokinetics, and the main clinical indications of cefditoren. Similarly to other beta-lactams, cefditoren is a time-dependent antibiotic, and its \"best\" PK/PD target is probably 40% dosing interval time > 4- 5-fold MIC and 40-70% dosing interval time > 4- 5-fold MIC for bacteriostatic and bactericidal effect, respectively. In fasting patients oral bioavailability is low and increases when the drug is taken with food. This cephalosporin has significant bactericidal activity against S. pneumoniae (both penicillin-susceptible and penicillin-resistant strains), S. pyogenes, H. Influenzae and M. catarrhalis, as well as methicillin-susceptible S. aureus (MSSA). Regarding Enterobacterales, cefditoren has very low MICs90 against K. pneumoniae andE. coli but is not active against AmpC-, ESBL- and carbapenemase-producer' strains. Licensed indications are treatment of exacerbations of chronic bronchitis,acute rhinosinusitis, otitis media, upper respiratory tract infections (pharyngitis/tonsillitis), lower community-acquired respiratory tract infections (LRTIs), and skin and skin-structure infections (SSTI). Cefditoren might have a role in switching from parenteral to oral therapy in acute pyelonephritis and LRTIs. with a reduction of adverse effects and hospital costs. Eventually, due to its supposed binding to enterococcal penicillin binding proteins (PBPs) cefditoren, in combination with other beta-lactams, might have a role in partial oral enterococcal endocarditis treatment..","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"46 1","pages":"9-17"},"PeriodicalIF":1.8,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10804178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A COVID-19 mystery: multisystem inflammatory syndrome in adults (MIS-A) associated with splenic rupture. COVID-19之谜:成人多系统炎症综合征(MIS-A)与脾破裂相关。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-02-01

Isil Isel, Istemi Serin, Beyza Kal Kolik, Hasan Goze, Tahir Alper Cinli, Gulben Erdem Huq, Mahmut Emin Cicek, Sermin Altindal, Osman Yokus

引用次数: 0

Strongyloides hyperinfection syndrome and cytomegalovirus infection in a patient with type II diabetes mellitus. 2型糖尿病患者的类圆线虫过度感染综合征和巨细胞病毒感染。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-02-01

Zhaoliang Wang, Jiaquan Guo, Jinlin Liu

{"title":"Strongyloides hyperinfection syndrome and cytomegalovirus infection in a patient with type II diabetes mellitus.","authors":"Zhaoliang Wang, Jiaquan Guo, Jinlin Liu","doi":"","DOIUrl":"","url":null,"abstract":"Strongyloidiasis is a gastrointestinal parasitic infection caused by percutaneous infection with Strongyloides stercoralis, which is mainly distributed in the tropics and subtropics worldwide. Digestive symptoms like diarrhea and abdominal pain are the main manifestation, but serious infections such as bacterial pneumonia, purulent meningitis and sepsis also occur in immunocompromised individuals. Herein, we present a rare case of a type II diabetes mellitus (T2DM) patient presented with gastrointestinal hemorrhage and sepsis caused by concomitant Strongyloides stercoralis and cytomegalovirus (CMV) infection. This 51-year-old male patient presented to the hospital with vomiting, diarrhea, dyspnea, palpitation and weakness. Examination revealed skin soft-tissue infection with T2DM, and upper endoscopy revealed gastric mucosal erosion and hemorrhage. Radiology revealed bilateral diffuse interstitial infiltrates and thickened walls of the colon. Importantly, stool and vomitus examination showed numerous larvae of Strongyloides stercoralis. Then the diagnosis of Strongyloides hyperinfection syndrome was made. But antibiotics and albendazole treatment did not improve the patient's symptoms of gastrointestinal bleeding and sepsis. Subsequently, other pathogens were screened by sequence and a positive CMV gene was found in the peripheral blood. Thus, antibiotics, albendazole and ganciclovir were all used which ultimately resolved the infection in this patient. Therefore, this case indicated CMV could also by co-infected with Strongyloides stercoralis in the immunocompromised patient, which remind us that an CMV test should also be performed when encountered in severe strongyloidiasis infection, which could improve the prognosis of the patient.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"46 1","pages":"86-89"},"PeriodicalIF":1.8,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9379078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic epidemiology and phylogenetics applied to the study of SARS-CoV-2 pandemic. 基因组流行病学和系统发育在SARS-CoV-2大流行研究中的应用。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-02-01

Alessia Lai, Annalisa Bergna, Carla Della Ventura, Gianguglielmo Zehender

引用次数: 0

Characterization of Gardnerella vaginalis isolates: correlations among clades, biofilm formation and cytokine stimulation. 阴道加德纳菌分离株的特征:分支、生物膜形成和细胞因子刺激之间的相关性。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-02-01

Sara Morselli, Melissa Salvo, Claudio Foschi, Tiziana Lazzarotto, Simone Ambretti, Antonella Marangoni

引用次数: 0

Severe Escherichia coli infections in critical adult patients: two case reports and genomic analysis. 危重成人患者的严重大肠杆菌感染:两例病例报告和基因组分析。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-02-01

Stefano Amadesi, Giulio Virgili, Elisa Marchionni, Alessandra Cascavilla, Tiziana Lazzarotto, Pierluigi Viale, Paolo Gaibani

{"title":"Severe Escherichia coli infections in critical adult patients: two case reports and genomic analysis.","authors":"Stefano Amadesi, Giulio Virgili, Elisa Marchionni, Alessandra Cascavilla, Tiziana Lazzarotto, Pierluigi Viale, Paolo Gaibani","doi":"","DOIUrl":"","url":null,"abstract":"Pathogenic Escherichia coli strains can infect a variety of body sites due to the expression of virulence factors necessary to overcome the host defenses. Here, we present two cases of E. coli infection in adults and discuss the associated genomic features. Whole-genome sequencing was performed using both Illumina iSeq 100 and Oxford Nanopore MinION systems. Assembly was carried out with Unicycler using a hybrid approach. The genomes were annotated with RASTtk and scanned for genes involved in antimicrobial resistance, virulence and stress response with AMRFinderPlus. Sequence analysis was conducted using tools from the Center for Genomic Epidemiology (CGE) website. The two strains, named SO80 and SO81, carried a genome of 5,229,956 and 5,437,935 base pairs, respectively. SO80 belonged to ST70 and carried 13 virulence factors, 6 of which were located on a 170 Kb plasmid, while SO81 belonged to ST69 and carried 29 virulence factors, 5 of which were located on a 113 Kb plasmid. Our work highlights key factors which may have contributed to the complicated clinical status of these patients, and provides new in-depth data on E. coli infections with few precedents in the literature.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"46 1","pages":"24-28"},"PeriodicalIF":1.8,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10818104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial resistance rates of Streptococcus pyogenes in a Greek tertiary care hospital: 6-year data and literature review. 希腊一家三级医院化脓性链球菌的抗菌素耐药率:6年数据和文献综述

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-02-01

Georgios Meletis, Alexandros Lazaros Soulopoulos Ketikidis, Nikoletta Floropoulou, Areti Tychala, Georgia Kagkalou, Olga Vasilaki, Paraskevi Mantzana, Lemonia Skoura, Efthymia Protonotariou

{"title":"Antimicrobial resistance rates of Streptococcus pyogenes in a Greek tertiary care hospital: 6-year data and literature review.","authors":"Georgios Meletis, Alexandros Lazaros Soulopoulos Ketikidis, Nikoletta Floropoulou, Areti Tychala, Georgia Kagkalou, Olga Vasilaki, Paraskevi Mantzana, Lemonia Skoura, Efthymia Protonotariou","doi":"","DOIUrl":"","url":null,"abstract":"Streptococcus pyogenes is responsible for various clinical manifestations in patients of all ages worldwide. Worryingly, an increase in antibiotic resistance rates of S. pyogenes has been observed in many countries. In the present study, 6-year data are presented regarding the antibiotic resistance rates of S. pyogenes in our hospital. During this period, a total of 52 S. pyogenes isolates were recovered from 52 patients and antimicrobial susceptibility testing was performed for 49 isolates. All were susceptible to penicillin, ampicillin, cefotaxime, ceftriaxone, linezolid, moxifloxacin, rifampicin, vancomycin, teicoplanin, and tigecycline. Erythromycin and clindamycin resistance rates were 20.4% and 18.8% respectively. Resistance rates to tetracycline were 40.8%, to chloramphenicol 6.9%, and to levofloxacin 2%. Since macrolides are recommended as an alternative treatment in case of allergy to β-lactams, the high macrolide resistance rates are causing concern. Because different phenotypic antimicrobial patterns for S. pyogenes have been observed in different geographic areas, epidemiological data is of considerable value for the appropriate treatment choices.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"46 1","pages":"37-42"},"PeriodicalIF":1.8,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10818108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0