Susceptibility of ceftolozane/tazobactam against multidrug-resistant and carbapenem-resistant Pseudomonas aeruginosa.

IF 1.5 4区医学 Q4 MICROBIOLOGY

New Microbiologica Pub Date : 2023-05-01

Ayaka Kakehi, Hideharu Hagiya, Koji Iio, Takumi Fujimori, Mami Okura, Hiroshi Minabe, Yukika Yokoyama, Fumio Otsuka, Akihito Higashikage

引用次数: 0

Abstract

Ceftolozane (CTLZ) is a novel cephalosporin antibiotic that exhibits broad-spectrum activity against gram-negative pathogens, including Pseudomonas aeruginosa, especially when combined with tazobactam (TAZ). We examined the minimum inhibitory concentration (MIC) of CTLZ/TAZ for 21 multidrug-resistant P. aeruginosa (MDRP) and eight carbapenem-resistant P. aeruginosa (CRPA) strains isolated at Okayama University Hospital, Japan. Consequently, 81% (17/21) of the MDRP strains and 25% (2/8) of the CRPA strains were resistant to CTLZ/TAZ (MIC >8 μg/mL). All 18 blaIMP-positive strains showed resistance to CTLZ/TAZ, whereas the drug retained in vitro susceptibility in 54.5% (6/11 strains) of blaIMP-negative strains.

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头孢唑烷/他唑巴坦对多重耐药和碳青霉烯耐药铜绿假单胞菌的敏感性。

Ceftolozane (CTLZ)是一种新型头孢菌素抗生素，对包括铜绿假单胞菌在内的革兰氏阴性病原体具有广谱活性，特别是与他唑巴坦(TAZ)合用时。研究了CTLZ/TAZ对21株耐多药铜绿假单胞菌(P. aeruginosa, MDRP)和8株耐碳青霉烯型铜绿假单胞菌(P. aeruginosa, CRPA)的最低抑菌浓度(MIC)。结果显示，81%(17/21)的MDRP菌株和25%(2/8)的CRPA菌株对CTLZ/TAZ耐药(MIC >8 μg/mL)。18株blaimp阳性菌株对CTLZ/TAZ均有耐药性，而blaimp阴性菌株对CTLZ/TAZ的体外敏感性为54.5%(6/11株)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

New Microbiologica 生物-微生物学

CiteScore

2.20

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： The publication, diffusion and furtherance of research and study on all aspects of basic and clinical Microbiology and related fields are the chief aims of the journal.