Retina-The Journal of Retinal and Vitreous Diseases最新文献_第3页

Direct posterior retinal injury caused by intravitreal injections: management and outcomes from a vitreoretinal perspective. 玻璃体内注射引起的直接后视网膜损伤：从玻璃体视网膜角度的处理和结果。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-10 DOI: 10.1097/IAE.0000000000004679

Evita Evangelia Christou, Yingjia Yang, Imran H Yusuf, Helen Mi, Amanda Ie, Katharina Eibenberger, Peter Charbel Issa, Robert E MacLaren, Jasmina Cehajic-Kapetanovic

{"title":"Direct posterior retinal injury caused by intravitreal injections: management and outcomes from a vitreoretinal perspective.","authors":"Evita Evangelia Christou, Yingjia Yang, Imran H Yusuf, Helen Mi, Amanda Ie, Katharina Eibenberger, Peter Charbel Issa, Robert E MacLaren, Jasmina Cehajic-Kapetanovic","doi":"10.1097/IAE.0000000000004679","DOIUrl":"10.1097/IAE.0000000000004679","url":null,"abstract":"Purpose: To report the clinical presentation, management, complications and outcomes after retinal injuries caused by intravitreal injections.Methods: Retrospective case series of twelve eyes presenting with visual deterioration due to vitreoretinal complications secondary to trauma caused by intravitreal injections. Detailed ocular history, clinical examination, vitreoretinal complications, management, final anatomical and visual outcomes are documented.Results: We observed 12 cases of direct retinal trauma by the needle tip of intravitreal injection. All retinal injuries were located in the temporal mid-periphery, usually near the inferior arcade. Of the twelve patients, four eyes developed a retinal detachment, all with proliferative vitreoretinopathy, six had vitreous hemorrhage, and two eyes presented with a focal chorioretinal atrophic lesion. The patients either underwent surgical procedure or were closely monitored after the injury. The surgical intervention was successful in terms of anatomical outcomes in all cases. Ten eyes had a final visual acuity similar to baseline while two eyes experienced visual deterioration during a follow up of at least 6 months.Conclusion: Direct retinal injury with the intravitreal injection needle is a rare but possibly underreported adverse event. Early detection of these complications, especially if associated with retinal detachment, is important for timely and appropriate management to avoid permanent loss of vision.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Incidence and Management of Ocular Hypertension Following Suprachoroidal Triamcinolone Acetonide Injection for Macular Edema in Noninfectious Uveitis. 脉络膜上曲安奈德注射治疗非感染性葡萄膜炎黄斑水肿后眼压升高的真实世界发生率和处理。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-10 DOI: 10.1097/IAE.0000000000004677

Saif A Hamdan, Sidra Zafar, Jamie A Nassur, Yoshihiro Yonekawa, Ajay E Kuriyan, James P Dunn, Michael N Cohen, Jason Hsu, Carl D Regillo, Sunir J Garg, David Xu, Michael Klufas, Jordan D Deaner

{"title":"Real-World Incidence and Management of Ocular Hypertension Following Suprachoroidal Triamcinolone Acetonide Injection for Macular Edema in Noninfectious Uveitis.","authors":"Saif A Hamdan, Sidra Zafar, Jamie A Nassur, Yoshihiro Yonekawa, Ajay E Kuriyan, James P Dunn, Michael N Cohen, Jason Hsu, Carl D Regillo, Sunir J Garg, David Xu, Michael Klufas, Jordan D Deaner","doi":"10.1097/IAE.0000000000004677","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004677","url":null,"abstract":"Purpose: To investigate the incidence of ocular hypertension (OHT) following suprachoroidal injection of triamcinolone acetonide (SCS-TA) for non-infectious uveitic macular edema.Methods: Retrospective review of eyes undergoing SCS-TA. The primary outcome was incidence of OHT (IOP > 24 mm Hg). Secondary outcomes included incidence of IOP > 30 mmHg, IOP rise ≥10 mm Hg above baseline, and treatment for OHT.Results: 76 eyes of 70 patients were treated with a mean of 1.71 (range 1-5) SCS-TA injections with an average follow-up of 7.6 (range 3.0-14.9) months. 9 eyes (11.8%) developed OHT, 4 eyes (5.3%) had IOP > 30 mmHg, and 9 eyes (11.8%) had an IOP elevation of ≥ 10 mmHg above baseline at any point after their first injection. Eyes that developed OHT were treated with topical therapy (7 eyes, mean 1.9 agents, range 1-4 agents) or close observation (2 eyes). No eyes required incisional glaucoma surgery. Eyes with history of glaucoma or OHT (7/34, 20.1%) were more likely to develop OHT versus eyes with no history (2/42, 4.8%, p = 0.03).Conclusion: In this real-world cohort, SCS-TA was associated with a low-incidence of OHT, consistent with clinical trial data. A prior history of glaucoma or OHT is a significant association for developing OHT following SCS-TA.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OCTA in the regression of macular choroidal neovascularization associated with Mac tel2: Three-year follow-up. OCTA在mactel2相关黄斑脉络膜新生血管消退中的作用：三年随访。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-10 DOI: 10.1097/IAE.0000000000004675

Gilda Cennamo, Michele Rinaldi, Ciro Costagliola

引用次数: 0

Frequency of misdiagnoses and associated risk factors in Macular Telangiectasia Type 2. 2型黄斑毛细血管扩张症的误诊频率及相关危险因素。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-10 DOI: 10.1097/IAE.0000000000004681

Kristin Raming, Jose Luis Rodriguez Garcia, Nele Steffens, Jennifer Nadal, Philipp Herrmann, Frank G Holz, Kristina Pfau, Lukas Goerdt

{"title":"Frequency of misdiagnoses and associated risk factors in Macular Telangiectasia Type 2.","authors":"Kristin Raming, Jose Luis Rodriguez Garcia, Nele Steffens, Jennifer Nadal, Philipp Herrmann, Frank G Holz, Kristina Pfau, Lukas Goerdt","doi":"10.1097/IAE.0000000000004681","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004681","url":null,"abstract":"Purpose: To analyze the frequency of misdiagnoses in Macular Telangiectasia Type 2 (MacTel) and to investigate factors influencing the probability of receiving an incorrect diagnosis.Methods: A retrospective analysis of 288 patients with confirmed diagnosis of MacTel from the Natural History Observation Registry at the University Eye Hospital Bonn was performed. Patients were grouped as follows: Correct diagnosis of MacTel, misdiagnosis, incidental finding. Clinical and demographic data, including best-corrected visual acuity, symptoms, prior treatments, were recorded. Misdiagnoses were categorized, and predictors were analyzed using mixed effect models.Results: Of 288 patients, 174 (60.4%) were correctly diagnosed, 103 (35.8%) were misdiagnosed, and 11 (3.8%) diagnosed incidentally. Misdiagnoses included macular hole (17.3%), maculopathy (12.5%), and AMD (12.5%). Mean age at symptom onset was 54.7 (± 9.8 years); mean time to correct diagnosis was 38.5 ± 50.3 months, decreasing from 115 months (2000-2005) to 5.9 months (after 2020). Younger age at symptom onset reduced the probability of misdiagnosis (odds-ratio 0.96, 95% CI: 0.94-0.98), subjective glare sensitivity increased misdiagnosis probability (OR 2.01, 95% CI: 1.14-3.55).Conclusions: Misdiagnoses of MacTel are common and may delay care. Improved awareness and imaging have shortened these delays. Early multimodal imaging and clinician education remain key to timely diagnosis and better management.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal Imaging and Long-Term Treatment Outcomes of Relentless Placoid Chorioretinitis. 无情的胎盘样脉络膜视网膜炎的多模式成像和长期治疗结果。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-10 DOI: 10.1097/IAE.0000000000004674

Viren K Govindaraju, Omar Moinuddin, Sarah Skender, Lisa J Faia

{"title":"Multimodal Imaging and Long-Term Treatment Outcomes of Relentless Placoid Chorioretinitis.","authors":"Viren K Govindaraju, Omar Moinuddin, Sarah Skender, Lisa J Faia","doi":"10.1097/IAE.0000000000004674","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004674","url":null,"abstract":"Purpose: Relentless placoid chorioretinitis (RPC) is a rare condition and although it may require long-term immunosuppressive therapy, there are no standardized treatment guidelines. Within this study, we discuss outcomes of the largest group of patients from a single institution with a diagnosis of RPC.Methods: This is a retrospective cohort study of patients diagnosed with RPC treated at the Associated Retinal Consultants in Royal Oak, Michigan from January 2015 to January 2024.Results: A total of eight patients (11 eyes) were included. Initial treatments included oral prednisone (10 of 11 eyes) and topical steroids (5 of 11 eyes). Four patients were treated with methotrexate as their initial IMT agent and achieved disease quiescence. One patient (2 eyes) was treated with cyclosporine followed by mycophenolate and successfully tapered off all therapy after remaining quiescent for more than ten years. All patients were able to achieve control of disease activity with no active lesions on final follow-up. Visual acuity either improved or remained stable in all eleven eyes with presenting and final mean logMAR visual acuities of 0.61 (20/80, Snellen) and 0.10 (20/25, Snellen), respectively (p=0.013) [A mean of 3.4 lines of improvement]. The four patients treated with methotrexate had presenting and final mean logMAR visual acuities of 1.13 (20/320, Snellen) and 0.27 (20/40, Snellen), respectively (p=0.047) [A mean of 6 lines of improvement].Conclusions: To our knowledge, this is the largest cohort of RPC patients in a single study. Care for these patients involves multimodal imaging as well as multidisciplinary care.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inner foveal irregularities after vitreomacular detachment: a morphologic risk factor for macular hole formation in the fellow eye. 玻璃体黄斑脱离后内中央凹不规则：在同侧眼形成黄斑孔的形态学危险因素。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-10 DOI: 10.1097/IAE.0000000000004682

Julian E Klaas, Jakob Siedlecki, Denise Vogt, Benedikt Schworm, Felix Hagenau, Leonie Keidel, Nathalie Bleidißel, Mathias Maier, Siegfried Priglinger

{"title":"Inner foveal irregularities after vitreomacular detachment: a morphologic risk factor for macular hole formation in the fellow eye.","authors":"Julian E Klaas, Jakob Siedlecki, Denise Vogt, Benedikt Schworm, Felix Hagenau, Leonie Keidel, Nathalie Bleidißel, Mathias Maier, Siegfried Priglinger","doi":"10.1097/IAE.0000000000004682","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004682","url":null,"abstract":"Purpose: To assess the morphologic risk of full thickness macular hole (FTMH) formation in the fellow eye based on posterior vitreous detachment (PVD) status and preceding vitreomacular interface changes using optical coherence tomography (OCT) data of the fellow eye.Methods: The natural history of fellow eyes of patients with unilateral FTMH was reviewed for tractional maculopathies, symmetry of the foveal contour, inner and outer retinal irregularities and PVD status on spectral domain OCT. PVD was classified as incomplete (iPVD= vitreomacular adhesion or traction) or macular (mPVD= vitreomacular detachment). Foveal contour changes were classified as inner foveal irregularity (IFI) if mPVD was present without evidence of other tractional maculopathies.Results: 72 eyes of 72 consecutive patients were included. 9 (12.5%) developed FTMH during a mean follow-up of 19.1 ± 23.8 (range: 3.0 - 133.0) months. iPVD at baseline was not associated with a higher incidence of FTMH at follow-up (10.5% mPVD vs. 14.7% iPVD, p=0.727). 9 of 38 eyes (23.7%) with mPVD had IFI at baseline. IFI was a risk factor for FTMH formation after mPVD (p=0.033, OR=14.0). The cumulative risk of IFI-FTMH conversion was 16.7% at 12 months and 44.4% at 24 months.Conclusion: IFI can be frequently documented in the fellow eyes of patients with FTMH and may be an early morphologic risk factor for FTMH formation after mPVD in the context of prior fellow eye involvement.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corkscrew Vessels and Hidden Clues: Retinal and Choroidal Manifestations of NF1. 螺旋状血管和隐藏的线索：NF1的视网膜和脉络膜表现。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-10 DOI: 10.1097/IAE.0000000000004680

Lucy Yang, Abdullah Al-Ani, Monique Munro

引用次数: 0

Excision of extensive subretinal fibrosis associated with rhegmatogenous retinal detachments in patients with familial exudative vitreoretinopathy. 家族性渗出性玻璃体视网膜病变患者与孔源性视网膜脱离相关的广泛视网膜下纤维化的切除。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-10 DOI: 10.1097/IAE.0000000000004686

Hiroyuki Kondo, Itsuka Matsushita, Mizuki Tsurusaki

{"title":"Excision of extensive subretinal fibrosis associated with rhegmatogenous retinal detachments in patients with familial exudative vitreoretinopathy.","authors":"Hiroyuki Kondo, Itsuka Matsushita, Mizuki Tsurusaki","doi":"10.1097/IAE.0000000000004686","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004686","url":null,"abstract":"Purpose: To determine the characteristics and treatment of the extensive subretinal fibrosis (ESF) in eyes with rhegmatogenous retinal detachment (RRD) but without a tractional retinal detachment in patients with familial exudative vitreoretinopathy (FEVR).Methods: Ten eyes of 9 men and 1 woman with ESF in patients with RRD-FEVR were studied. The characteristics, surgical procedures, and the outcomes after the removal of the ESF were determined. The ESF was excised by either stripping the ESF from small retinotomies or by en bloc excision through a >180° retinotomy or retinectomy at the ora serrata.Results: The median age of the patients was 12.5-years. All cases had a unilateral macula-off retinal detachment with a total detachment in 4 eyes and detachment over 2 quadrants in 6 eyes. The first case underwent ESF stripping through small retinotomies that required 7 additional surgeries with a final visual acuity (VA) of hand motion. The subsequent 9 cases underwent en bloc excision resulting in a retinal reattachment with silicone oil tamponade. The silicone oil was removed without a recurrence of the RD during a median follow-up period of 7 years. The median final VA was 20/66 with a range of 20/17 to 20/500.Conclusion: ESF can be found in FEVR eyes with a slowly progressive RRD. We conclude that the en bloc excision of the ESF is an effective and safe procedure to reattach the retina and thus improve the visual acuity.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperreflective Retinal Spots in Epiretinal Membranes: Evolving Significance Across Disease Stages. 视网膜上膜的高反射性视网膜斑点：疾病分期的演变意义。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-10 DOI: 10.1097/IAE.0000000000004672

Alberto Quarta, Maria Ludovica Ruggeri, Corina De Santis Ciacci, Ruggero Tartaro, Lisa Toto, Rodolfo Mastropasqua

{"title":"Hyperreflective Retinal Spots in Epiretinal Membranes: Evolving Significance Across Disease Stages.","authors":"Alberto Quarta, Maria Ludovica Ruggeri, Corina De Santis Ciacci, Ruggero Tartaro, Lisa Toto, Rodolfo Mastropasqua","doi":"10.1097/IAE.0000000000004672","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004672","url":null,"abstract":"Purpose: To investigate the hyperreflective spots (HRS) across different stages of epiretinal membrane (ERM) using optical coherence tomography (OCT) and their relationship with anatomical and functional parameters.Methods: This observational study included 111 patients with ERM, categorized into early (stages 1-2, n=43) and late (stages 3-4, n=68). Total Hyperreflective Spots (HRST), Visual Acuity (VA), central retinal thickness (CRT), and outer nuclear layer (ONL) thickness were measured using OCT. Statistical analyses included Mann-Whitney U test for group comparisons and Spearman's correlation to assess relationships between HRST and VA.Results: HRST increased significantly from early (27.67 ± 12.57) to late stages (35.15 ± 17.28, p=0.015). In early stages, HRST showed a moderate positive correlation with VA (ρ=0.48, p=0.001), while this correlation diminished in late stages (ρ=0.036, p=0.426). CRT also increased significantly from early to late stages (380.05 ± 94.51 μm vs. 523.54 ± 83.92 μm, p<0.001). ONL thickness showed no significant difference between stages (p=0.543). Linear regression model showed in early stages (1-2) that HRST and CRT were valuable VA predictors (Adjusted R2=0.284, p < 0.05).Conclusion: HRST progressively increases with ERM severity, correlating with visual function in early stages but losing this association in advanced stages. These findings suggest that HRST could be a prognostic marker for early disease progression and highlight the need for timely intervention to preserve visual function.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enucleation of an Eye with Potential High-Risk Retinoblastoma is Currently Important for Patient Survival. 有潜在的高风险视网膜母细胞瘤的眼睛摘除是目前重要的患者生存。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-10 DOI: 10.1097/IAE.0000000000004673

Carol L Shields, Sara E Lally, Amish C Shah

引用次数: 0