Retina-The Journal of Retinal and Vitreous Diseases最新文献_第3页

Baseline Superficial FAZ Disparity Is Associated With Recurrence in Branch Retinal Vein Occlusion-related Macular Edema. 基线浅表FAZ差异与视网膜分支静脉阻塞相关性黄斑水肿复发相关。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2026-09-21 DOI: 10.1097/IAE.0000000000005016

Taiichi Hikichi

{"title":"Baseline Superficial FAZ Disparity Is Associated With Recurrence in Branch Retinal Vein Occlusion-related Macular Edema.","authors":"Taiichi Hikichi","doi":"10.1097/IAE.0000000000005016","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005016","url":null,"abstract":"Purpose: To determine whether recurrence burden in branch retinal vein occlusion-related macular edema (BRVOME) reflects longitudinal foveal avascular zone (FAZ) enlargement or baseline inter-eye superficial microvascular disparity.Methods: This retrospective, paired-eye longitudinal study included consecutive treatment-naïve unilateral BRVOME eyes. Optical coherence tomography angiography (OCTA) was performed at the first visit after complete resolution of ME following anti-vascular endothelial growth factor (anti-VEGF) therapy (baseline) and at 1 year. FAZ areas in superficial and deep capillary plexuses (SCP and DCP) were quantified in both BRVO and fellow eyes. Inter-eye FAZ disparity (ΔFAZ = BRVO - fellow) was calculated. Recurrence burden was defined as the number of intravitreal anti-VEGF injections during 12 months.Results: Sixty-nine eyes were analyzed. SCP and DCP FAZ areas were significantly larger in BRVO than in fellow eyes at baseline and remained larger at 1 year (both p < 0.001). Longitudinal FAZ enlargement was not associated with recurrence burden. Baseline ΔSCP was independently associated with higher recurrence burden. Each 0.1-mm2 increase in baseline ΔSCP was associated with an 8% increase in recurrence burden [incidence rate ratio, 1.08; 95% confidence interval, 1.01 - 1.16; p = 0.022]. Baseline ΔDCP was not associated with recurrence frequency.Conclusion: Recurrence burden in BRVOME was associated with baseline superficial FAZ disparity rather than longitudinal FAZ progression. Baseline ΔSCP showed only modest discriminative ability and should be interpreted as one component of a broader microvascular risk profile rather than a standalone biomarker for recurrence prediction.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstructive Sleep Apnea as a Modifier of Systemic Thromboembolic Risk Following Retinal Vein Occlusion. 阻塞性睡眠呼吸暂停是视网膜静脉闭塞后系统性血栓栓塞风险的调节剂。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2026-09-21 DOI: 10.1097/IAE.0000000000005017

Neil Dogra, Aarthi Arun, Mark P Breazzano

{"title":"Obstructive Sleep Apnea as a Modifier of Systemic Thromboembolic Risk Following Retinal Vein Occlusion.","authors":"Neil Dogra, Aarthi Arun, Mark P Breazzano","doi":"10.1097/IAE.0000000000005017","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005017","url":null,"abstract":"Background: Systemic vascular risk stratification following retinal vein occlusion (RVO) remains limited. We evaluated whether comorbid obstructive sleep apnea (OSA) modifies thromboembolic risk following RVO.Methods: Retrospective cohort study using TriNetX Analytics Network. RVO patients with versus without prior OSA were matched 1:1 on demographics and comorbidities. Incident outcomes at 1, 3, and 5 years included hazard ratios (HR [95% confidence interval]) of anticoagulation initiation, composite venous thromboembolism (VTE; pulmonary embolism or deep vein thrombosis), myocardial infarction, composite arterial thromboembolism (ATE; cerebral infarction, transient ischemic attack, or arterial embolism), cerebral infarction, hemorrhagic stroke, carotid disease, and mortality. Secondary matched analysis compared central RVO (CRVO) versus branch RVO (BRVO) among OSA patients.Results: After matching, 10,728 patients remained per cohort. OSA was associated with increased anticoagulation initiation (1 year: HR 1.38 [1.18-1.61]; 3 years: HR 1.29 [1.16-1.44]; 5 years: HR 1.32 [1.19-1.45]), VTE (1 year: HR 1.48 [1.20-1.82]; 3 years: HR 1.46 [1.26-1.69]; 5 years: HR 1.44 [1.26-1.63]), and myocardial infarction (3 years: HR 1.21 [1.06-1.38]; 5 years: HR 1.17 [1.04-1.31]). ATE, cerebral infarction, hemorrhagic stroke, and carotid disease hazards were similar. All-cause mortality was lower among OSA patients at 3 years (HR 0.88 [0.80-0.96]) and 5 years (HR 0.90 [0.83-0.98]). Among OSA patients, CRVO showed higher mortality than BRVO (1 year: HR 1.50 [1.20-1.89]; 3 years: HR 1.29 [1.11-1.49]; 5 years: HR 1.33 [1.18-1.51]).Conclusions: Comorbid OSA identifies a subgroup of RVO patients at higher hazard for venous thromboembolism and myocardial infarction. Within this subgroup, CRVO may carry higher all-cause mortality hazard than BRVO.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between intravitreal anti-vascular endothelial growth factor therapy and adverse renal outcomes. 玻璃体内抗血管内皮生长因子治疗与不良肾结局之间的关系。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2026-09-21 DOI: 10.1097/IAE.0000000000005022

Shu-Han Chuang, Bing-Hua Lin, Yu-Pin Chen, Lien-Chen Wu, Yi-Jie Kuo, Cheng-Hsien Chang

{"title":"Associations between intravitreal anti-vascular endothelial growth factor therapy and adverse renal outcomes.","authors":"Shu-Han Chuang, Bing-Hua Lin, Yu-Pin Chen, Lien-Chen Wu, Yi-Jie Kuo, Cheng-Hsien Chang","doi":"10.1097/IAE.0000000000005022","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005022","url":null,"abstract":"Purpose: Intravitreal anti-vascular endothelial growth factor (VEGF) therapy is widely used for retinal vascular diseases, but its renal safety remains controversial. This study evaluated the risk of adverse renal outcomes following intravitreal anti-VEGF therapy.Methods: This retrospective cohort study used the TriNetX Global Network. Adults aged over 20 years with retinal vascular disorders who received intravitreal anti-VEGF injections were compared with those who did not. Propensity score matching (1:1) balanced baseline demographics, comorbidities, medication use, laboratory data, and healthcare utilization. The primary outcome was major adverse kidney events (MAKE), defined as end-stage renal disease, dialysis, or all-cause mortality. Risks of progression to chronic kidney disease (CKD) stage 3-5 and dialysis were also analyzed. Cox proportional hazards models estimated hazard ratios (HRs).Results: Among 7194 matched pairs (anti-VEGF cohort: mean age, 55.2±12.9 years, 55.2% male; control cohort: mean age, 55.7±11.6 years, 53.9% male), the anti-VEGF cohort showed a significantly higher risk of MAKE at 1 year (230 [3.20%] vs 146 [2.03%]; HR, 1.53 [1.25-1.89]), with similar findings at 3 and 5 years. The anti-VEGF cohort also showed higher risks of CKD stage 3-5 (769 [10.69%] vs 556 [7.73%]; HR, 1.37 [1.23-1.53]) and dialysis (70 [0.97%] vs 38 [0.53%]; HR, 1.79 [1.20-2.65]).Conclusion: In this real-world cohort, intravitreal anti-VEGF therapy was associated with higher risks of adverse renal outcomes. Given the observational design and small absolute risk differences, these findings warrant cautious interpretation, and renal function monitoring may be considered in these patients.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-Traumatic Choroidal Rupture: Characteristics, Management and Outcomes. 创伤后脉络膜破裂：特征、处理和结果。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2026-09-21 DOI: 10.1097/IAE.0000000000005013

Chayane Ziani, Thibaut Chapron, Ismael Chehaibou, Florence Metge, Georges Caputo, Youssef Abdelmassih

{"title":"Post-Traumatic Choroidal Rupture: Characteristics, Management and Outcomes.","authors":"Chayane Ziani, Thibaut Chapron, Ismael Chehaibou, Florence Metge, Georges Caputo, Youssef Abdelmassih","doi":"10.1097/IAE.0000000000005013","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005013","url":null,"abstract":"Purpose: To describe the clinical features, management, and outcomes of post-traumatic choroidal ruptures.Methods: This retrospective consecutive case series included patients with Bruch's membrane ruptures following ocular trauma. Clinical records, multimodal imaging, and treatment outcomes were reviewed.Results: A total of 26 patients (27 eyes) with post-traumatic choroidal rupture were included. Mean age at presentation was 27.4±16.3 years, with a male predominance (65%). Most ruptures were submacular (55%) and arc-shaped (52%), commonly associated with subretinal hemorrhage (74%) or commotio retinae (63%). Choroidal neovascularization (CNV) developed in 11 eyes (41%) at a median interval of 62 days after trauma and was effectively controlled in most cases with a limited number of intravitreal anti-VEGF injections, leading to significant functional and anatomical improvement. Seventy percent of eyes with CNV needed 5 injections or less to control CNV activity. Eyes without CNV also demonstrated significant visual gains. Final outcomes were similar between eyes with and without CNV. Additional complications included full-thickness macular hole (19%) and epiretinal membrane (15%).Conclusion: Trauma is a common cause for choroidal rupture. Post-traumatic choroidal rupture primarily affects young males and most often involves the submacular region. Choroidal neovascularization developed in nearly half of eyes within weeks of trauma but was generally well-controlled with anti-VEGF therapy, resulting in meaningful visual recovery. Despite frequent associated complications, most patients experienced improved vision over time, underscoring the importance of long-term monitoring and timely treatment.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraocular Mitomycin-C in the Management of Recurrent Retinal Detachment and Proliferative Vitreoretinopathy: A Comparative Study With a Control Group. 眼内丝裂霉素c治疗复发性视网膜脱离和增殖性玻璃体视网膜病变：与对照组的比较研究。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2026-09-21 DOI: 10.1097/IAE.0000000000005019

Emre Avcı, Ece Özal, Serhat Ermiş, Murat Karapapak, Sadık Altan Özal

{"title":"Intraocular Mitomycin-C in the Management of Recurrent Retinal Detachment and Proliferative Vitreoretinopathy: A Comparative Study With a Control Group.","authors":"Emre Avcı, Ece Özal, Serhat Ermiş, Murat Karapapak, Sadık Altan Özal","doi":"10.1097/IAE.0000000000005019","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005019","url":null,"abstract":"Purpose: This study aimed to evaluate the impact of intraoperative mitomycin-C (MMC) application during pars plana vitrectomy (PPV) on anatomical success, the need for additional surgery, and visual outcomes in patients with recurrent rhegmatogenous retinal detachment (RRD) associated with proliferative vitreoretinopathy (PVR) following previous retinal surgery.Methods: This retrospective comparative study included 60 patients who underwent surgery for recurrent RRD with PVR between 2022 and 2024. Patients were divided into an MMC-treated group (n=30) and a control group (n=30). All patients underwent PPV, and outcomes including anatomical and functional success, silicone oil removal, and additional surgical interventions were compared between groups.Results: Rates of retinal reattachment, PVR development, and functional improvement were comparable between groups. The primary anatomical success rate-defined as retinal reattachment with intraocular pressure above 6 mmHg at final postoperatively-was 83.3% in the MMC group and 70.0% in the control group. Secondary anatomical success-defined as successful silicone oil removal without redetachment or need for further intervention-was achieved in 50.0% and 46.7% of patients, respectively. Both groups showed statistically significant postoperative improvements in visual acuity; however, no significant difference was observed between them. Although the incidence of PVR was lower in the MMC group, the difference did not reach statistical significance.Conclusion: Although MMC use was associated with more favorable anatomical outcomes and complication profiles in recurrent RRD cases, the lack of statistical significance warrants cautious interpretation, and larger prospective studies are needed to confirm its potential benefit as an adjuvant therapy.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Associated With Single-Surgery Anatomical Success After Pars Plana Vitrectomy in Inferior Rhegmatogenous Retinal Detachment. 下孔源性视网膜脱离玻璃体切割术后单次手术解剖成功的相关因素。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2026-09-21 DOI: 10.1097/IAE.0000000000005020

Amine Habib, Nour Boungab, Karine Lagrené, Maxime Wack, Sarah Ayello-Scheer, Francine Behar-Cohen, Pierre-Olivier Barale, Stéphane Bertin, Aliénor Vienne-Jumeau

{"title":"Factors Associated With Single-Surgery Anatomical Success After Pars Plana Vitrectomy in Inferior Rhegmatogenous Retinal Detachment.","authors":"Amine Habib, Nour Boungab, Karine Lagrené, Maxime Wack, Sarah Ayello-Scheer, Francine Behar-Cohen, Pierre-Olivier Barale, Stéphane Bertin, Aliénor Vienne-Jumeau","doi":"10.1097/IAE.0000000000005020","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005020","url":null,"abstract":"Purpose: To evaluate associations between retinopexy modality, surgical and anatomical factors, and single-surgery anatomical success (SSAS) after pars plana vitrectomy (PPV) for primary inferior rhegmatogenous retinal detachment (RRD).Methods: This retrospective single-center cohort included consecutive eyes undergoing PPV for primary inferior RRD with at least 3 months of follow-up. The primary outcome was SSAS, defined as absence of redetachment during follow-up and at least 2 months after silicone oil removal when applicable.Results: Among 235 eyes, median follow-up was 8 months. SSAS was achieved in 175 eyes (74.5%), while 60 eyes (25.5%) redetached at a median of 35 days. SSAS was 83.3% with endolaser, 74.6% with combined retinopexy, and 64.6% with cryotherapy (p = 0.021). In multivariable analysis, endolaser was associated with lower odds of failure compared with cryotherapy (OR 0.21, 95% CI 0.09-0.48; p = 0.00037), while combined retinopexy was associated with intermediate odds of failure (OR 0.39, 95% CI 0.15-0.95; p = 0.043). Compared with PVR grade A, grade B (OR 5.19, 95% CI 2.30-12.37; p = 0.00011) and grade C (OR 10.60, 95% CI 4.15-28.84; p < 0.00001) were associated with higher odds of anatomical failure. A causative break at 6 o'clock was also associated with higher odds of failure (OR 4.61; p = 0.005).Conclusion: In PPV for inferior RRD, endolaser retinopexy was associated with significantly higher anatomical success than cryotherapy, with combined treatment yielding intermediate outcomes. No significant association was observed between anatomical outcome and tamponade choice or PFCL use.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ischemic Branch Retinal Vein Occlusion with Venous Overcrossing. 缺血性视网膜分支静脉闭塞伴静脉交叉。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2026-09-10 DOI: 10.1097/IAE.0000000000005011

Takahiro Kogo, Yuki Muraoka, Yuki Hama, Yuki Akiyama, Akitaka Tsujikawa

引用次数: 0

High Incidence of Sleep Apnea in Patients with Retinal Vein Occlusions. 视网膜静脉阻塞患者睡眠呼吸暂停的高发。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2026-09-10 DOI: 10.1097/IAE.0000000000005009

Patrick Higgins, Brennan Isaac, Shon B Shmushkevich, Patrick Higgins

{"title":"High Incidence of Sleep Apnea in Patients with Retinal Vein Occlusions.","authors":"Patrick Higgins, Brennan Isaac, Shon B Shmushkevich, Patrick Higgins","doi":"10.1097/IAE.0000000000005009","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005009","url":null,"abstract":"Purpose: To determine the prevalence of obstructive sleep apnea (OSA) using polysomnography (PSG) in previously undiagnosed OSA patients in our prospective cohort with newly diagnosed retinal vein occlusion (RVO) and compare the incidence of OSA identified in our previously diagnosed retrospective control group of RVO subjects by past medical history (PMH).Methods: This single-center retrospective and prospective cohort study included 321 patients with branch (BRVO), hemi-central (HCRVO), or central retinal vein occlusion (CRVO) at Retina Center of New Jersey between January 2016 and October 2025. A retrospective cohort of 272 patients was compared with a prospective cohort of 49 newly diagnosed RVO patients who underwent home or laboratory-based PSG testing. Demographics, BMI, and systemic comorbidities were recorded. Standardized OSA screening questionnaires were excluded to include all patients regardless of subjective screening assessments. Primary outcomes were PSG-confirmed OSA prevalence and comparison with PMH-based OSA prevalence.Results: Among 272 retrospective RVO patients, 14 (5.15%) reported a prior diagnosis of OSA. In the prospective cohort, 4 of 49 patients (8.16%) reported severe OSA. Excluding these patients, PSG identified undiagnosed OSA in 38 of 45 patients (84.44%). PSG identified OSA in 42 of 49 patients (85.71%), including moderate-to-severe OSA in 27 patients (55.10%). Patients undergoing PSG were significantly more likely to be diagnosed with OSA than by PMH alone (85.71% vs 8.16%; risk ratio 16.65, P<0.001).Conclusions: Patients with newly diagnosed RVO demonstrate a high prevalence of previously undiagnosed OSA, suggesting RVO may serve as an important clinical indicator warranting routine PSG evaluation.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macular Hole Surgery With ILM Flap, Viscoelastic, and Air Tamponade Without Positioning. 黄斑裂孔手术与ILM皮瓣，粘弹性，空气填塞无定位。

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2026-09-10 DOI: 10.1097/IAE.0000000000005010

Sevim Ayça Seyyar, Oğuzhan Saygılı, Burçak Balyemez

{"title":"Macular Hole Surgery With ILM Flap, Viscoelastic, and Air Tamponade Without Positioning.","authors":"Sevim Ayça Seyyar, Oğuzhan Saygılı, Burçak Balyemez","doi":"10.1097/IAE.0000000000005010","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005010","url":null,"abstract":"Purpose: To report the results of macular hole (MH) surgery performed using the viscoelastic-supported temporal inverted ILM flap technique with air tamponade alone, without gas endotamponade or postoperative head positioning.Methods: A temporal ILM flap was created in all patients and inverted over the MH with perfluorocarbon liquid (PFCL). After a fluid-air and PFCL-air exchange, a dispersive viscoelastic agent was injected over the inverted flap under air, covering an area of two-to-three-disc diameters. The sclerotomies were closed with the eye filled entirely with air, without any subsequent gas exchange. No head positioning was advised postoperatively. Data on preoperative MH size, best-corrected visual acuity (BCVA), MH closure rate, closure pattern, and postoperative complications were collected.Results: The study included 78 eyes of 71 patients. MH closure was achieved in all 78 eyes (100%) after a single surgical procedure. U-shaped closure occurred in 82.1%, V-shaped in 14.1%, and W-shaped in 3.8%. Significant BCVA improvement was observed (p<0.001), with no significant change in IOP (p=0.057).Conclusion: The viscoelastic-assisted temporal inverted ILM flap technique achieves successful MH closure using air as the sole tamponade agent, without gas endotamponade or postoperative head positioning, yielding favorable anatomical and functional outcomes with enhanced patient comfort.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and Management of Ocular Hypertension Following the 0.18 mg Fluocinolone Acetonide Implant for Non-infectious Uveitis affecting the Posterior Segment. 0.18 mg氟西诺酮植入治疗影响后段非感染性葡萄膜炎后高眼压的发生率和处理

IF 2.1 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2026-09-10 DOI: 10.1097/IAE.0000000000005012

Lily C Farrell, Isabella V Y Gomes, Sidra Zafar, Madison M Woods, Justin C Muste, Hemal Patel, Turner Wibbelsman, Samantha Massenzio, Julie S Kim, Sunir J Garg, James P Dunn, Jason Hsu, David Fell, Jordan D Deaner

{"title":"Incidence and Management of Ocular Hypertension Following the 0.18 mg Fluocinolone Acetonide Implant for Non-infectious Uveitis affecting the Posterior Segment.","authors":"Lily C Farrell, Isabella V Y Gomes, Sidra Zafar, Madison M Woods, Justin C Muste, Hemal Patel, Turner Wibbelsman, Samantha Massenzio, Julie S Kim, Sunir J Garg, James P Dunn, Jason Hsu, David Fell, Jordan D Deaner","doi":"10.1097/IAE.0000000000005012","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005012","url":null,"abstract":"Purpose: To investigate the real-world incidence and management of ocular hypertension (OHT) following intravitreal 0.18mg fluocinolone acetonide implant (FAi, Yutiq) for non-infectious uveitis affecting the posterior segment (NIU-PS).Methods: Retrospective review of eyes treated with 0.18 mg FAi (2019-2025) with ≥1 month follow-up. Primary outcome was OHT (IOP >24 mmHg). Secondary outcomes included IOP ≥30 mmHg, >12 mmHg IOP increase from baseline, and OHT treatment.Results: A total of 275 FAi-treated eyes (178 patients, mean age: 62.87 years) were included. Patients received an average of 1.05 FAi (range:1-2), with mean follow-up of 20.59 ± 0.72 months. Mean baseline IOP was 14.30 ± 3.90 mmHg. Glaucoma and OHT were present in 28.4% and 32.4% of eyes, respectively and 38.5% were on IOP-lowering therapy. Supplemental corticosteroid injections were required in 31.3%. The OHT rate after FAi was 10.5%. Elevated IOP ≥30 mmHg occurred in 5.82%. IOP >12 mmHg from baseline occurred in 7.3%. Among OHT eyes, 41.4% resolved with observation, 44.8% required topical therapy (mean 1.78 agents), and 10.3% required incisional surgery. Higher baseline IOP (adjusted OR 1.41 per 1 mmHg increase, 95% CI:1.19-1.67) and baseline IOP-lowering medication use (OR 8.56, 95% CI:2.61-28.11) were the strongest predictors of rise in IOP.Conclusion: FAi for the treatment of NIU-PS was associated with low rates of OHT, reinforcing its safety. Eyes with higher baseline IOP and those on prior IOP-lowering medications had a substantially increased risk of OHT, highlighting the need for closer IOP monitoring in this subgroup.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0