Damla Oncel, Samuel Minaker, E Annie Shepherd, Sam Rezaei, Nick Boucher, Nitika Aggarwal, Mathew MacCumber
{"title":"Risk Factors for Proliferative Vitreoretinopathy in a Large Clinical Database.","authors":"Damla Oncel, Samuel Minaker, E Annie Shepherd, Sam Rezaei, Nick Boucher, Nitika Aggarwal, Mathew MacCumber","doi":"10.1097/IAE.0000000000004391","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004391","url":null,"abstract":"<p><strong>Purpose: </strong>Proliferative vitreoretinopathy (PVR) is the leading cause of surgical failure following rhegmatogenous retinal detachment (RRD). In this study, we aimed to explore ocular and systemic risk factors for PVR due to RRD in a large patient database.</p><p><strong>Methods: </strong>Patients who have a diagnosis of RRD and PVR, and who have been seen in the last seven years prior to analysis (January 2015-February 2023) were identified in the Vestrum Health database. The variables selected for univariate and multivariate analysis in this study included age, gender, history of smoking, diabetes, hypertension, dyslipidemia, anemia, Wagner syndrome, Stickler syndrome, vitreous hemorrhage, high myopia, ocular trauma, choroidal detachment, uveitis, giant retinal tear, aphakia and endophthalmitis. Eyes with proliferative diabetic retinopathy and those that had a history of PVR before the RRD diagnosis date were excluded from the study. The incidence of PVR was determined within each subset of the patient population.</p><p><strong>Results: </strong>There were 57,264 eyes that underwent a post-operative examination within 1 month following RRD diagnosis. Systemic factors younger age, female gender, smoking history, and hypertension, and ocular factors poor baseline visual acuity, history of ocular trauma, choroidal detachment, history of uveitis, giant retinal tear, pseudophakia, aphakia, and endophthalmitis were significantly and independently associated with increased odds of PVR development.</p><p><strong>Conclusion: </strong>The findings of this study indicate that there are several systemic and ocular risk factors that increase PVR development. Ophthalmologists should keep these in mind when planning surgical and therapeutic interventions for PVR prevention and treatment in patients with RRD.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor.","authors":"Sampurna Bhattacharyya, Kumar Saurabh, Rupak Roy","doi":"10.1097/IAE.0000000000004386","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004386","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Campo-Gesto, Carmen Antía Rodríguez-Fernández, Sara T Baltazar, Ana Concheiro-Guisán
{"title":"Foveal Avascular Zone development by OCTA: weighing the influence of Gestational Age and neonatal early growth independently of Retinopathy of Prematurity.","authors":"Ana Campo-Gesto, Carmen Antía Rodríguez-Fernández, Sara T Baltazar, Ana Concheiro-Guisán","doi":"10.1097/IAE.0000000000004390","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004390","url":null,"abstract":"<p><strong>Purpose: </strong>Focusing the premature birth and its potential complications, this study analyzes Foveal Avascular Zone (FAZ) measured by Optical Coherence Tomography Angiography (OCTA) and its correlation with the severity of prematurity and neonatal growth.</p><p><strong>Methods: </strong>A cross-sectional comparative study was performed, involving 71 children school-age with history of prematurity and a full-term children control group. Several variables from the neonatal period were collected, such as Gestational Age (GA), Birth Weight (BW), initial Weight Gain (WG) and Retinopathy of Prematurity (ROP). OCTA scans determined FAZ perimeter, circularity, and area on both Superficial Capillary Plexus (SCP) and Deep Capillary Plexus (DCP).</p><p><strong>Results: </strong>A positive correlation between GA and FAZ area and perimeter was identified, with a smaller FAZ (p<0.001) in preterm children. Furthermore, scatter plots showed a rising trend for all FAZ values based on GA and BW. Thus, children with greater WG during the first 15 days of life had a larger FAZ (p<0.05). GA was also predictive (p<0.001) for FAZ area and perimeter, while the ROP stage was a better predictor (p<0.0232) for its circularity.</p><p><strong>Conclusions: </strong>OCTA finds discrepancies in FAZ between premature and full-term children, with GA and neonatal growth having a greater influence than ROP itself.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gizem Gürbostan Soysal, Sevim Ayca Seyyar, Murat Mercanlı, Yara Chiekhismailzadeh, Burçak Balyemez, Kübra Çetinkaya, Sabit Kimyon
{"title":"Evaluation of the effects of different mydriatic drops used on choroidal vascularity in healthy children.","authors":"Gizem Gürbostan Soysal, Sevim Ayca Seyyar, Murat Mercanlı, Yara Chiekhismailzadeh, Burçak Balyemez, Kübra Çetinkaya, Sabit Kimyon","doi":"10.1097/IAE.0000000000004380","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004380","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of mydriatics drops used primarily in routine eye examinations on the choroid tissue, which has a dense vascular network in the eye.</p><p><strong>Methods: </strong>This prospective observational study included 90 eyes of 90 healthy children. Optical coherence tomography (OCT) images were obtained for all children before dilation. They were randomly divided into two groups (46/44). The tropicamide group received 0.5% tropicamide and the phenylephrine group received 2.5% phenylephrine. After dilation, a second OCT image was obtained for all children.</p><p><strong>Results: </strong>Subfoveal choroidal thickness (SCFT) values decreased significantly after dilation in the phenylephrine and tropicamide drop groups compared to pre-dilation measurements (p=0.001 for both). No significant difference was observed in the choroidal vascularity index (CVI) values measured before and after dilation in either group (p=0.059, p=0.245).</p><p><strong>Conclusion: </strong>While 2.5% phenylephrine and 0.5% tropicamide caused a decrease in SCFT values after dilatation, there was no significant difference in CVI values. These results emphasize that when examining choroidal thickness and vascularity in individuals with chorioretinal disease, the selection of mydriatic agent should be taken into consideration, especially in choroidal thickness.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Giray Ersoz, Sibel Demirel, Claudio Iovino, Jay Chhablani, David Sarraf
{"title":"Reply to letter to editor: (Is Pachychoroid Serous Retinopathy a Better Name to Describe the Features of Central Serous Chorioretinopathy?).","authors":"M Giray Ersoz, Sibel Demirel, Claudio Iovino, Jay Chhablani, David Sarraf","doi":"10.1097/IAE.0000000000004387","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004387","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Niloufar Bineshfar, Faraz Changizi, Mina Farjam, Faezeh Sharafi, Basil K Williams
{"title":"Systematic Review and Meta-Analysis of OCT measurements in patients with chronic kidney disease.","authors":"Niloufar Bineshfar, Faraz Changizi, Mina Farjam, Faezeh Sharafi, Basil K Williams","doi":"10.1097/IAE.0000000000004377","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004377","url":null,"abstract":"<p><strong>Purpose: </strong>To assess neurodegeneration and chorioretinal thickness in subjects with and without chronic kidney disease (CKD).</p><p><strong>Methods: </strong>PubMed, Web of Science, Scopus and Embase were searched using proper keywords for articles published in the English language from their inception until January 2024. Publications were included if they reported optical coherence tomography (OCT) measurements of retinal or choroidal layers in patients with CKD compared to healthy or non-CKD controls. We used a random-effects model to calculate pooled standardized mean difference (SMD) estimates and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Twelve studies, with 29,340 patients, were included in quantitative synthesis. In comparison to controls, patients with CKD had a significantly lower value for average retinal thickness (SMD [CI]: -0.35 [-0.58; -0.12], P = 0.028), choroidal thickness (SMD [CI]: -1.84 [-4.17; 0.49], P = 0.122), macular ganglion cell-inner plexiform layer (GC-IPL) (SMD [CI]: -0.58 [-0.78; -0.38]], P < 0.001), and peripapillary retinal nerve fiber layer (RNFL) thickness (SMD [CI]: -0.32 [-0.44; -0.20], P < 0.001). Significant RNFL thinning was observed in both diabetic CKD excluded and not excluded subgroups.</p><p><strong>Conclusion: </strong>Compared to controls, the eyes of patients with CKD have significantly thinner retina, GC-IPL, and RNFL.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dimitrios Kalogeropoulos, Gabriella De Salvo, Farid Afshar, Serafeim Antonakis, Andrew John Lotery
{"title":"Diagnostic dilemmas in a patient with bilateral subretinal fluid and retinal leopard-spot pattern.","authors":"Dimitrios Kalogeropoulos, Gabriella De Salvo, Farid Afshar, Serafeim Antonakis, Andrew John Lotery","doi":"10.1097/IAE.0000000000004379","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004379","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Macular Hole with an Intact Bacillary Layer.","authors":"Yu-Teng Fu, Chung-May Yang, Tso-Ting Lai, Tzyy-Chang Ho, Chang-Hao Yang, Yi-Ting Hsieh","doi":"10.1097/IAE.0000000000004370","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004370","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the clinical characteristics of macular holes (MH) with an intact bacillary layer.</p><p><strong>Methods: </strong>This retrospective study analyzed the characteristics and surgical results of 23 eyes with MH and an intact bacillary layer, with or without rhegmatogenous retinal detachment (RRD).</p><p><strong>Results: </strong>Among the 23 eyes, 11 had only MH, and 12 had concurrent fovea-off RRD. Ten eyes (43.5%) were highly myopic. In the MH-only group, no bacillary layer detachment (BALAD) was observed before MH formation. Ten eyes underwent vitrectomy with internal limiting membrane (ILM) peeling and intravitreal injection of C3F8, and the other one received an intravitreal C3F8 only. The MH closure rate was 90.9% after one operation and 100% after two. In the RRD group, 66.7% had BALAD. ILM peeling was performed in 8 eyes (66.7%). The MH closure rate was 91.7% after one operation and 100% after two. Both groups showed significant visual improvement after surgery (P < 0.05).</p><p><strong>Conclusions: </strong>An intact bacillary layer can be observed in MH with or without concurrent fovea-off RRD. Surgical outcomes are similar to typical MH cases, and the intact bacillary layer may not facilitate MH sealing like the ILM. An ILM flap should be considered for large MHs or highly myopic eyes.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matteo Mario Carlà, Mattia Cusato, Lorenzo Hu, Stanislao Rizzo
{"title":"Pathogenesis, Prognosis and Surgical Outcomes of Full-Thickness Macular Holes in Macular Telangiectasia Type 2: A Literature Review.","authors":"Matteo Mario Carlà, Mattia Cusato, Lorenzo Hu, Stanislao Rizzo","doi":"10.1097/IAE.0000000000004375","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004375","url":null,"abstract":"<p><strong>Purpose: </strong>Macular Telangiectasia type 2 (MacTel2) is a rare disorder affecting retina's vascular structure and MacTel2-associated full-thickness macular holes (MHs) are extremely rare in general population. Since their management is still controversial, this literature review aims to gather evidences on the surgical management of MacTel2-associated MHs.</p><p><strong>Methods: </strong>A retrospective review on the Cochrane Central, PubMed, Web of Science, and ClinicalTrials.gov databases for papers regarding MacTel2 and MHs. The search period was set from January 2000 to February 2024, and any kind of article was taken into account.</p><p><strong>Results: </strong>We took into account 10 studies analyzing surgical outcomes of MacTel2-associated MHs, with a total number of 95 treated eyes. Different surgical techniques were used, with a better anatomical outcome after internal limiting membrane (ILM) inverted flap surgery but with very controversial functional outcomes. In a comparative report, ILM peeling alone (34 eyes) was associated with a 47% anatomical success rate, ILM inverted flap (22 eyes) with 90% successful closure and autologous retinal transplantation (5 eyes) with a 100% success rate, but without visual improvement.</p><p><strong>Conclusion: </strong>Since the exact pathophysiology of MacTel2 macular holes is not clear yet, even if the ILM inverted flap technique could be an effective treatment for these patients, visual outcomes are poor. This underlines the necessity of a deeper comprehension of the pathophysiology of the disease and the development of new surgical approaches.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}