Inner foveal irregularities after vitreomacular detachment: a morphologic risk factor for macular hole formation in the fellow eye.

IF 2.1 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-10 DOI:10.1097/IAE.0000000000004682

Julian E Klaas, Jakob Siedlecki, Denise Vogt, Benedikt Schworm, Felix Hagenau, Leonie Keidel, Nathalie Bleidißel, Mathias Maier, Siegfried Priglinger

{"title":"Inner foveal irregularities after vitreomacular detachment: a morphologic risk factor for macular hole formation in the fellow eye.","authors":"Julian E Klaas, Jakob Siedlecki, Denise Vogt, Benedikt Schworm, Felix Hagenau, Leonie Keidel, Nathalie Bleidißel, Mathias Maier, Siegfried Priglinger","doi":"10.1097/IAE.0000000000004682","DOIUrl":null,"url":null,"abstract":"Purpose: To assess the morphologic risk of full thickness macular hole (FTMH) formation in the fellow eye based on posterior vitreous detachment (PVD) status and preceding vitreomacular interface changes using optical coherence tomography (OCT) data of the fellow eye.Methods: The natural history of fellow eyes of patients with unilateral FTMH was reviewed for tractional maculopathies, symmetry of the foveal contour, inner and outer retinal irregularities and PVD status on spectral domain OCT. PVD was classified as incomplete (iPVD= vitreomacular adhesion or traction) or macular (mPVD= vitreomacular detachment). Foveal contour changes were classified as inner foveal irregularity (IFI) if mPVD was present without evidence of other tractional maculopathies.Results: 72 eyes of 72 consecutive patients were included. 9 (12.5%) developed FTMH during a mean follow-up of 19.1 ± 23.8 (range: 3.0 - 133.0) months. iPVD at baseline was not associated with a higher incidence of FTMH at follow-up (10.5% mPVD vs. 14.7% iPVD, p=0.727). 9 of 38 eyes (23.7%) with mPVD had IFI at baseline. IFI was a risk factor for FTMH formation after mPVD (p=0.033, OR=14.0). The cumulative risk of IFI-FTMH conversion was 16.7% at 12 months and 44.4% at 24 months.Conclusion: IFI can be frequently documented in the fellow eyes of patients with FTMH and may be an early morphologic risk factor for FTMH formation after mPVD in the context of prior fellow eye involvement.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Retina-The Journal of Retinal and Vitreous Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/IAE.0000000000004682","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To assess the morphologic risk of full thickness macular hole (FTMH) formation in the fellow eye based on posterior vitreous detachment (PVD) status and preceding vitreomacular interface changes using optical coherence tomography (OCT) data of the fellow eye.

Methods: The natural history of fellow eyes of patients with unilateral FTMH was reviewed for tractional maculopathies, symmetry of the foveal contour, inner and outer retinal irregularities and PVD status on spectral domain OCT. PVD was classified as incomplete (iPVD= vitreomacular adhesion or traction) or macular (mPVD= vitreomacular detachment). Foveal contour changes were classified as inner foveal irregularity (IFI) if mPVD was present without evidence of other tractional maculopathies.

Results: 72 eyes of 72 consecutive patients were included. 9 (12.5%) developed FTMH during a mean follow-up of 19.1 ± 23.8 (range: 3.0 - 133.0) months. iPVD at baseline was not associated with a higher incidence of FTMH at follow-up (10.5% mPVD vs. 14.7% iPVD, p=0.727). 9 of 38 eyes (23.7%) with mPVD had IFI at baseline. IFI was a risk factor for FTMH formation after mPVD (p=0.033, OR=14.0). The cumulative risk of IFI-FTMH conversion was 16.7% at 12 months and 44.4% at 24 months.

Conclusion: IFI can be frequently documented in the fellow eyes of patients with FTMH and may be an early morphologic risk factor for FTMH formation after mPVD in the context of prior fellow eye involvement.

查看原文本刊更多论文

玻璃体黄斑脱离后内中央凹不规则：在同侧眼形成黄斑孔的形态学危险因素。

目的：利用光学相干断层扫描（OCT）数据，基于玻璃体后脱离（PVD）状态和之前玻璃体黄斑界面的改变，评估同侧眼形成全层黄斑孔（FTMH）的形态学风险。方法：回顾单侧FTMH患者的自然病史，包括牵引性黄斑病变、中央凹轮廓的对称性、视网膜内外不规则性和PVD在光谱域oct上的状态，将PVD分为不完全性（iPVD=玻璃体黄斑粘连或牵拉）和黄斑（mPVD=玻璃体黄斑脱离）。如果mPVD没有其他牵引性黄斑病变的证据，则中央凹轮廓改变被归类为内中央凹不规则（IFI）。结果：连续纳入72例患者72只眼。9例（12.5%）在平均随访19.1±23.8（范围：3.0 - 133.0）个月期间发生FTMH。基线时的iPVD与随访时FTMH的高发生率无关（10.5% mPVD vs 14.7% iPVD, p=0.727）。38只mPVD眼中有9只（23.7%）在基线时有IFI。IFI是mPVD后FTMH形成的危险因素（p=0.033， OR=14.0）。IFI-FTMH转换的累积风险在12个月时为16.7%，在24个月时为44.4%。结论：IFI可以经常记录在FTMH患者的同侧眼睛中，并且可能是mPVD后FTMH形成的早期形态学危险因素，在先前的同侧眼睛受累的情况下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.