M Giray Ersoz, Sibel Demirel, Claudio Iovino, Jay Chhablani, David Sarraf
{"title":"Reply.","authors":"M Giray Ersoz, Sibel Demirel, Claudio Iovino, Jay Chhablani, David Sarraf","doi":"10.1097/IAE.0000000000004387","DOIUrl":"10.1097/IAE.0000000000004387","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"e28-e29"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dimitrios Kalogeropoulos, Gabriella De Salvo, Farid Afshar, Serafeim Antonakis, Andrew John Lotery, Mya Abousy, Nicholas A Yannuzzi
{"title":"DIAGNOSTIC AND THERAPEUTIC CHALLENGES.","authors":"Dimitrios Kalogeropoulos, Gabriella De Salvo, Farid Afshar, Serafeim Antonakis, Andrew John Lotery, Mya Abousy, Nicholas A Yannuzzi","doi":"10.1097/IAE.0000000000004379","DOIUrl":"10.1097/IAE.0000000000004379","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"801-806"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Changes of Cytokines in Aqueous Humor of Retinoblastoma with Intravitreal Melphalan.","authors":"Xiaoting Zhou, Fengxi Meng, Hui Ren, Binbin Xu, Xintong Lin, Jiang Qian, Kang Xue","doi":"10.1097/IAE.0000000000004471","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004471","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the levels of cytokines in the aqueous humor (AH) of patients diagnosed with retinoblastoma (RB) who received intravitreal melphalan (IVM).</p><p><strong>Methods: </strong>A total of 28 eyes from 27 patients diagnosed with RB who received IVM were enrolled, along with 14 eyes from 14 patients with congenital cataracts as controls. The clinical features of the patients were recorded before and after IVM. 27 cytokines concentrations in AH samples collected from these patients were measured by a suspension array system.</p><p><strong>Results: </strong>The levels of IL-8, IL-17A, Eotaxin, G-CSF, and PDGF-BB increased significantly following IVM administration in RB patients (p<0.05). Post IVM treatments, the levels of IL-5, IL-8, IL-9, IL-12p70, IL-15, IL-17A, G-CSF, IP-10, MIP-1α, PDGF-BB, TNF-α, and VEGF were higher in eyes that developed ocular toxicity than those eyes didn't (p<0.05). The ocular toxicity group received a higher cumulative dose and mean per dose of intravitreal melphalan. The elevated cytokines subsequent to IVM were associated with the number of treatments and cumulative dose of intravitreal melphalan.</p><p><strong>Conclusions: </strong>The results revealed a notable increase in cytokine levels subsequent to IVM interventions. Elevated cytokine concentrations in the eyes of RB patients post-IVM may be associated with ocular toxicities.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brian Mac Grory, Bruce Derrick, Nathan Tagg, Valerie Biousse, Sven Poli, Matthew Schrag
{"title":"Hyperbaric Oxygen Therapy for Retinal Artery Occlusion.","authors":"Brian Mac Grory, Bruce Derrick, Nathan Tagg, Valerie Biousse, Sven Poli, Matthew Schrag","doi":"10.1097/IAE.0000000000004470","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004470","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sebastian Nudleman, Ella R Feiner, Stella Affeldt, Jonathan L Prenner
{"title":"Office-Based 25-Gauge Needle Revision of Closed Peripheral Iridotomy in Aphakic Silicone Oil-Filled Eyes.","authors":"Sebastian Nudleman, Ella R Feiner, Stella Affeldt, Jonathan L Prenner","doi":"10.1097/IAE.0000000000004464","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004464","url":null,"abstract":"<p><strong>Purpose: </strong>We present a novel office-based technique using a 25-gauge needle to reopen closed peripheral iridotomies (PIs) in aphakic eyes filled with silicone oil.</p><p><strong>Methods: </strong>We use a 25-gauge needle to enter the clear cornea and reopen the closed PI, allowing for aqueous humor and silicone oil to escape and relieve elevated intraocular pressure (IOP).</p><p><strong>Results: </strong>This minimally invasive office-based approach provides immediate relief of elevated IOP due to silicone oil-induced pupillary block, avoiding the need for more invasive surgical intervention.</p><p><strong>Conclusion: </strong>Our technique is a simple, cost-effective, and accessible way to combat silicone-oil induced pupillary block in aphakic patients and may be a good first-line approach for a difficult-to-manage condition.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akhila Alapati, Saleema Kherani, Tedi Begaj, Timothy M Janetos, Kevin Zhang, Anjum Koreishi, Debra A Goldstein
{"title":"Re: Letter to Editor: Addressing Inter-eye Correlation in Retinal Image Analysis for Patients with Bilateral Data.","authors":"Akhila Alapati, Saleema Kherani, Tedi Begaj, Timothy M Janetos, Kevin Zhang, Anjum Koreishi, Debra A Goldstein","doi":"10.1097/IAE.0000000000004468","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004468","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel technique for macular hole-associated retinal detachment with inverted internal limiting membrane flap technique under perfluorocarbon liquid.","authors":"Jiro Kogo, Kazuhito Yoneda, Takeshi Iwase","doi":"10.1097/IAE.0000000000004465","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004465","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the technique and surgical outcomes of a modified inverted internal limiting membrane (ILM) flap technique, using perfluorocarbon liquid (PFCL) without creating iatrogenic retinal breaks in the management of macular hole-associated retinal detachment (MHRD).</p><p><strong>Methods: </strong>This retrospective study was approved by the Ethics Committee of Akita University Hospital. Eight patients with MHRD underwent pars plana vitrectomy (PPV) with the novel PFCL-assisted inverted ILM flap technique. Subretinal fluid was drained through the macular hole using a soft-tip needle, and ILM staining was performed after fluid-air exchange. PFCL was applied to stabilize the retina, and ILM peeling was completed under PFCL with improved visibility. The procedure concluded with air-fluid exchange and tamponade using silicone oil or gas. Patients maintained a face-down position postoperatively for one day.</p><p><strong>Results: </strong>All eight patients achieved initial retinal reattachment and macular hole closure without intraoperative or postoperative complications. After over 12 months of follow-up, macular hole closure and retinal reattachment were maintained in all cases.</p><p><strong>Discussion: </strong>Our novel technique avoids iatrogenic breaks, reducing ERM risk and secondary macular hole formation. The PFCL-assisted ILM manipulation ensures stability and minimizes retinal damage. The method is safe, effective, and promising for MHRD treatment in this small series.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}