Retina-The Journal of Retinal and Vitreous Diseases最新文献

DisCoVisc substituted for perfluorocarbon liquid stabilizing the detached retina during vitrectomy for rhegmatogenous retinal detachment. 在孔源性视网膜脱离玻璃体切除术中，用DisCoVisc代替全氟碳液体稳定脱离的视网膜。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-07-23 DOI: 10.1097/IAE.0000000000004617

Yanbo Bao, Huangyi Lei, Yinong Guo, Yajun Liu, Suyu Liu, Hui Chen, Zhenggao Xie

{"title":"DisCoVisc substituted for perfluorocarbon liquid stabilizing the detached retina during vitrectomy for rhegmatogenous retinal detachment.","authors":"Yanbo Bao, Huangyi Lei, Yinong Guo, Yajun Liu, Suyu Liu, Hui Chen, Zhenggao Xie","doi":"10.1097/IAE.0000000000004617","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004617","url":null,"abstract":"Purpose: To investigate the effectiveness of using DisCoVisc as an alternative to perfluorocarbon liquid (PFCL) in stabilizing the detached retina during rhegmatogenous retinal detachment (RRD) surgery.Methods: Thirty eyes of 30 patients with RRD underwent the DisCoVisc technique for stabilizing the detached retina. Following intraoperative air-fluid exchange and the aspiration of subretinal fluid, DisCoVisc was applied to seal retinal breaks, thereby stabilizing the detached retina. Subsequent removal of the peripheral and basal vitreous was then performed. Intraoperative vitrectomy duration, retinal reattachment rate, postoperative best-corrected visual acuity (BCVA), intraocular pressure (IOP), and intraoperative and postoperative complications were analyzed.Results: Retinal reattachment was achieved in 28 eyes (28/30, 93.3%). The base of the vitreous was removed with a mean time of 10.17±2.94 min, and the total vitrectomy time was 22.93±4.97 min. At the last follow-up, the BCVA was 0.74±0.70 LogMAR, showing a significant improvement over the preoperative value of 1.44±1.25 LogMAR (Z=2.700, P=0.007). On the first postoperative day, the IOP was measured at 25.71±12.41 mmHg, exhibiting a statistically significant elevation compared to the preoperative IOP of 13.94±5.23 mmHg (P=0.000). There was no statistical difference in IOP at the last follow-up 14.01±2.68 mmHg compared to the preoperative IOP of 13.94±5.23 mmHg (P = 0.923). One patient developed macular hole after the operation, and there were no obvious complications during the operation.Conclusions: DisCoVisc can effectively stabilize the detached retina during vitrectomy for RRD. Most significantly, it eliminated the risk of subfoveal PFCL residue-related complications.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the Dexamethasone Implant on Slowing Diabetic Retinopathy Progression: Post Hoc Analysis of the MEAD Study. 地塞米松植入物对减缓糖尿病视网膜病变进展的影响：MEAD研究的事后分析

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-07-23 DOI: 10.1097/IAE.0000000000004623

Kevin J Blinder, Charles C Wykoff, Joseph R Ferencz, Justis P Ehlers, Yixin Fang, Hongxin Lai, Miller Ogidigben, Francisco J López

{"title":"Impact of the Dexamethasone Implant on Slowing Diabetic Retinopathy Progression: Post Hoc Analysis of the MEAD Study.","authors":"Kevin J Blinder, Charles C Wykoff, Joseph R Ferencz, Justis P Ehlers, Yixin Fang, Hongxin Lai, Miller Ogidigben, Francisco J López","doi":"10.1097/IAE.0000000000004623","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004623","url":null,"abstract":"Purpose: To evaluate the effects of dexamethasone intravitreal implant (DEX) treatment on Diabetic Retinopathy Severity Scale (DRSS) scores and disease progression in patients with diabetic macular edema (DME).Methods: The 3-year, randomized, phase 3 MEAD study evaluated DEX 0.35 and 0.7 mg versus sham (treatment at ≥6-month intervals) in patients with DME. This post hoc analysis used data from the sham and pooled DEX arms.Results: The proportion of patients with ≥2-step DRSS score improvement was significantly higher after DEX treatment compared with sham at 24 months only (8.8% vs 4.2%, OR=2.1, P=0.016). Among those with ≥2-step DRSS score improvement, the time to first ≥2-step improvement was shorter with DEX (P<0.001; median 400 days with DEX versus 713 with sham). There were no significant differences between the DEX and sham groups in the proportion of patients who progressed from non-proliferative to proliferative DR, but among those who progressed, the time to progression was lengthened with DEX (P<0.001; median 531.1 days with DEX versus 191 with sham).Conclusion: This post hoc analysis of MEAD study data showed that DEX treatment may potentially have a positive impact on DR by reducing disease severity and slowing progression in DR patients with central DME.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re: Vitrectomy Combined With Inverted Internal Limiting Membrane Flap Insertion Or Single-Layered Flap Covering Technique For Highly Myopic Macular Holes With Macular Retinoschisis. 玻璃体切除联合内限定膜瓣置入或单层瓣覆盖技术治疗高度近视黄斑视网膜裂。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-07-23 DOI: 10.1097/IAE.0000000000004629

Matteo Mario Carlà, Carlos Mateo

引用次数: 0

Seasonal variation in the incidence of rhegmatogenous retinal detachment worldwide: a systematic review. 世界范围内孔源性视网膜脱离发病率的季节变化：一项系统综述。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-07-23 DOI: 10.1097/IAE.0000000000004627

Parsa Mehraban Far, Mariam Issa, Marko M Popovic, Charbel Wahab, Miguel Cruz-Pimentel, Yaping Jin, Peng Yan

{"title":"Seasonal variation in the incidence of rhegmatogenous retinal detachment worldwide: a systematic review.","authors":"Parsa Mehraban Far, Mariam Issa, Marko M Popovic, Charbel Wahab, Miguel Cruz-Pimentel, Yaping Jin, Peng Yan","doi":"10.1097/IAE.0000000000004627","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004627","url":null,"abstract":"Purpose: To assess the variability in the incidence of rhegmatogenous retinal detachment (RRD) across seasons.Methods: The study protocol was registered in PROSPERO (CRD42022378855) and the study was conducted in adherence to the Preferred Reporting Items for a Systematic Review and Meta-analysis (PRISMA) guidelines. A detailed search was conducted of Ovid MEDLINE, Ovid EMBASE, Cochrane Central Register of Controlled Trials and CINAHL. Two independent reviewers (PMF, MI) performed the study selection, data extraction, and quality assessment.Results: The 18 included studies identified 384,723 cases of RRD across North America, Europe, Asia, and Australia. 12/18 (66%) included studies including 366,219 cases (95%) observed a seasonal variation in the incidence of RRD, with higher numbers of cases in summer and spring. Of all meteorological variables, low atmospheric pressure and high solar radiation may be associated with higher RRD incidence.Conclusions: Epidemiological studies suggest a seasonal variation in RRD incidence, with more cases observed during spring and summer months. This observation may correlate with periods of elevated solar radiation and reduced atmospheric pressure. These associations do not imply causation. Large population-based studies are required to verify the associations identified in the present systematic review.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Detection of Neurovascular Alterations and the Impact of Medication Treatment on the Retina in Systemic Lupus Erythematosus Patients: A Retrospective Cohort Study and Mendelian Randomization Analysis. 系统性红斑狼疮患者神经血管改变的早期检测和药物治疗对视网膜的影响：回顾性队列研究和孟德尔随机化分析。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-07-23 DOI: 10.1097/IAE.0000000000004622

Qihang Zhou, Xin Wen, Zijing Li, Tingxiang Chen, Yunjiao Zhao, Yuqing Lan

{"title":"Early Detection of Neurovascular Alterations and the Impact of Medication Treatment on the Retina in Systemic Lupus Erythematosus Patients: A Retrospective Cohort Study and Mendelian Randomization Analysis.","authors":"Qihang Zhou, Xin Wen, Zijing Li, Tingxiang Chen, Yunjiao Zhao, Yuqing Lan","doi":"10.1097/IAE.0000000000004622","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004622","url":null,"abstract":"Purpose: This study aimed to evaluate early retinal structural and microvascular changes in patients with systemic lupus erythematosus (SLE) and to assess the impact of treatment on these alterations.Methods: This study used optical coherence tomography angiography (OCTA) to compare the retinal microstructure between patients with SLE and healthy controls. SLE patients were stratified into subgroups based on the treatment regimen they received: the hydroxychloroquine (HCQ)-glucocorticoid (GC) subgroup, the HCQ subgroup, and the GC subgroup. Mendelian randomization (MR) analysis was employed to explore the causal relationship between HCQ/GC use and retinal vascular disorders.Results: A retrospective analysis was conducted on data from 100 participants (59 SLE patients and 41 controls). SLE patients showed reduced vascular density (VD) in superficial/deep capillary plexuses (SCP/DCP), radial peripapillary capillaries (RPC), choriocapillaris flow areas (CCFAs), and foveal 300-µm wide vascular density (FD-300) (P < 0.05). Inner limiting membrane-retinal pigment epithelium (ILM-RPE) thickness in foveal/perifoveal regions was thinner in SLE patients (P < 0.05). HCQ or GC subgroups exhibited lower SCP-VD, DCP-VD, FD-300, and CCFAs versus controls and HCQ-GC subgroup (P < 0.05). The ILM-RPE thickness was thinnest in the HCQ monotherapy subgroup (P < 0.05). The MR analysis indicated that GC had an inhibitory effect on retinal vascular disorders (OR=0.733, P = 0.037), whereas HCQ was not significantly correlated with these disorders.Conclusion: OCTA can detect early retinal changes in asymptomatic patients with SLE. Compared with monotherapy, combination therapy with HCQ and GCs is associated with less retinal damage.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the letter commenting on the recently published article, "Vitrectomy Combined with Inverted Internal Limiting Membrane Flap Insertion or Single-Layered Flap Covering Technique for Highly Myopic Macular Holes with Macular Retinoschisis." 回复最近发表的文章“玻璃体切除术联合内限制性膜瓣插入或单层瓣覆盖技术治疗高度近视黄斑视网膜裂”的评论信。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-07-23 DOI: 10.1097/IAE.0000000000004630

Qinlang Jia, Ke Zhang, Biying Qi, Xiaohan Yang, Xiao Feng, Wu Liu

引用次数: 0

Optical coherence tomography angiography (OCTA) analysis of cohort with peripapillary choroidal neovascularization. 光学相干断层血管造影（OCTA）分析与乳突周围脉络膜新生血管队列。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-07-22 DOI: 10.1097/IAE.0000000000004626

Anna Heinke, Akshay Agnihotri, Ines D Nagel, Fritz Gerald P Kalaw, Nehal N Mehta, Mohamed Sherif Morsy, Lingyun Cheng, Dirk Uwe- Bartsch, William R Freeman

{"title":"Optical coherence tomography angiography (OCTA) analysis of cohort with peripapillary choroidal neovascularization.","authors":"Anna Heinke, Akshay Agnihotri, Ines D Nagel, Fritz Gerald P Kalaw, Nehal N Mehta, Mohamed Sherif Morsy, Lingyun Cheng, Dirk Uwe- Bartsch, William R Freeman","doi":"10.1097/IAE.0000000000004626","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004626","url":null,"abstract":"Purpose: While many studies have analyzed macular choroidal neovascularization (CNV) using OCTA, few have focused on peripapillary CNV, which comprises approximately 10% of CNV cases. This study examines OCTA vessel changes in treated and untreated peripapillary CNV patients to better understand disease progression.Methods: Nineteen eyes with peripapillary CNV secondary to neovascular age-related macular degeneration (nAMD) were retrospectively analyzed. Treated eyes (n=13) received anti-VEGF injections following a modified pro re nata (PRN) regimen, while untreated eyes (n=6) without macular involvement were closely observed. Median follow-up was 11.9 months (treated) and 8 months (untreated). High-quality OCTA scans centered on the CNV lesions were selected and analyzed using validated software (ImageJ and AngioTool).Results: Treated eyes showed significant reductions in CNV lesion size, vessel density, and lacunarity after anti-VEGF therapy (ImageJ: p<0.001; AngioTool: p=0.0004). Untreated eyes exhibited significant lesion enlargement (ImageJ: p=0.0356; AngioTool: p=0.0013). None of the patients in the untreated group developed macular exudation during the study.Conclusion: Peripapillary CNV without macular involvement may be considered for short-term observation in selected cases, as these lesions appeared indolent and stable over the limited follow-up period in our cohort. The vessels in OCTA in the treated group showed regression in size after anti-VEGF therapy. These findings will potentially help clinicians better understand this entity.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of GLP-1 receptor agonists for type 2 diabetes mellitus on the development and progression of age-related macular degeneration. 2型糖尿病GLP-1受体激动剂对年龄相关性黄斑变性发生发展的影响

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-07-22 DOI: 10.1097/IAE.0000000000004616

Samantha A McLaughlin, Natalia Davila, Chloe Shields, Niloufar Bineshfar, Touka Banaee, Basil K Williams

{"title":"Impact of GLP-1 receptor agonists for type 2 diabetes mellitus on the development and progression of age-related macular degeneration.","authors":"Samantha A McLaughlin, Natalia Davila, Chloe Shields, Niloufar Bineshfar, Touka Banaee, Basil K Williams","doi":"10.1097/IAE.0000000000004616","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004616","url":null,"abstract":"Purpose: To evaluate whether GLP-1 receptor agonist (GLP-1RA) therapy reduces the risk of age-related macular degeneration (AMD) in type 2 diabetes mellitus (T2DM) patients.Methods: A retrospective cohort study using a global health research network matched T2DM patients on GLP-1RA vs non-GLP-1RA therapy. AMD incidence was determined over the first 1 to 10 years of treatment. Patients with baseline early or intermediate nonexudative AMD were also matched and assessed for progression to advanced AMD. Measures of Association Analysis was used to calculate risk, risk difference, and risk ratio.Results: Among 600,816 matched patients without history of AMD, GLP-1RA users had a 15% relative risk reduction in incidence of nonexudative AMD (RR, 0.851; 95% CI, 0.801-0.905; p<0.0001) vs those who received alternative therapy. These patients also had a 20% relative risk reduction in incidence of exudative AMD (RR, 0.80; 95% CI, 0.808-0.989; p<0.0001). To assess progression, 4,450 patients with early or intermediate AMD were matched between the cohorts. GLP-1RA use was associated with 29% relative risk reduction in progression to advanced nonexudative AMD (RR, 0.715; 95% CI, 0.529-0.967; p=0.028) and a 27% relative risk reduction in progression to exudative AMD (RR, 0.729; 95% CI, 0.601-0.883; p=0.001).Conclusion: GLP-1RA use may reduce the both the risk and progression of AMD and progression of early and intermediate AMD to advanced AMD in adults with T2DM. GLP-1RAs have been shown to promote neuronal survival and reduce inflammation, which may provide a pathophysiological explanation of the potential beneficial role of GLP-1RAs.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trocar insertion into the pars plana using an intraocular endoscope-holding robot. 利用眼内内窥镜固定式机器人将套管针插入扁平部。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-07-22 DOI: 10.1097/IAE.0000000000004621

Kenta Ashikaga, Yoshihito Sakanishi, Toshiaki Hirakata, Kohei Ichikawa, Koh-Hei Sonoda, Shintaro Nakao

{"title":"Trocar insertion into the pars plana using an intraocular endoscope-holding robot.","authors":"Kenta Ashikaga, Yoshihito Sakanishi, Toshiaki Hirakata, Kohei Ichikawa, Koh-Hei Sonoda, Shintaro Nakao","doi":"10.1097/IAE.0000000000004621","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004621","url":null,"abstract":"Purpose: In vitrectomy for eyes with long axial lengths, trocar insertion distal to the limbus is beneficial for macular manipulation. We developed an intraocular endoscope-holding robot (OQrimo; Riverfield Inc, Tokyo, Japan), approved as a medical device in Japan. This study introduces a novel technique for trocar under direct visualization using OQrimo.Methods: This study included seven eyes of seven patients undergoing vitrectomy. All procedures were performed using the OQrimo (Riverfield Inc., Tokyo, Japan) and the OPMI Lumera 700 with Resight (Zeiss, Germany). Initially, two trocars were placed 3.5-4.0 mm from the limbus at the two and eight o'clock positions in the conjunctiva. The intraocular endoscope (25G: Machida, Japan), held by OQrimo, was inserted through the two o'clock trocar and positioned to visualize the contralateral pars plana. The surgeon used a light pipe to identify the pars plana closest to the ora serrata on the endoscopic screen. The trocar was then inserted at this location.Results: Surgeons successfully inserted the trocar while observing the pars plana under endoscopic guidance using OQrimo without any adverse events.Conclusions: Trocar insertion using the OQrimo is a promising technique that may improve surgical outcomes in vitrectomy for in eyes with axial lengths outside the normal range such as those with high myopia.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Internal limiting membrane (ILM) flap reposition facilitates preservation of the inner retina in surgically closed full-thickness macular holes. 内限制膜（ILM）瓣复位有利于手术封闭全层黄斑孔内视网膜的保存。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-07-21 DOI: 10.1097/IAE.0000000000004581

Warda Darwisch, Dominik Weber, Katarzyna Wieczorek, André Maurice Trouvain, Karl Boden, Philipp Ken Roberts, Peter Szurman, Boris Viktor Stanzel

{"title":"Internal limiting membrane (ILM) flap reposition facilitates preservation of the inner retina in surgically closed full-thickness macular holes.","authors":"Warda Darwisch, Dominik Weber, Katarzyna Wieczorek, André Maurice Trouvain, Karl Boden, Philipp Ken Roberts, Peter Szurman, Boris Viktor Stanzel","doi":"10.1097/IAE.0000000000004581","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004581","url":null,"abstract":"Purpose: To compare inner retinal thinning after an Internal Limiting Membrane (ILM) flap reposition technique to ILM peeling in full-thickness macular holes (FTMH).Methods: This retrospective study included a total of 78 eyes (71 consecutive patients) with primary FTMH undergoing vitrectomy between 10/2022 -12/2023. Exclusion criteria were secondary macular holes, high myopia, glaucoma and prior surgery except cataract-surgery. Eyes were separated by surgical technique into Group A (ILM flap repositioning; n = 30) and Group B (ILM peeling alone n = 48). We compared mean thickness/volume of parafoveal (3 mm) and perifoveal (6 mm Early Treatment Diabetic Retinopathy Study subfields) Retinal Nerve Fiber Layer (RNFL), Ganglion Cell Layer (GCL) and Inner Plexiform Layer (IPL) at six months after surgery (M6) to baseline (M0). Secondary, we assessed anatomical closure rate and visual acuity.Results: Anatomical type 1 closure was achieved in 90.00% (A) and 80.00% (B) without significant difference. For consistency in the subsequent analysis, only cases with successful closure were included. Preservation analysis at M6 showed thicker (P = .006) and more volume (P = .010) in parafoveal RNFL in Group A, whereas perifoveal GCL remained thicker (P = .001) and with more volume (P = .002) in Group A. IPL did not differ between the groups. Visual acuity improved by time (P < .001) without differing between the groups.Conclusions: Compared to ILM peeling, macular hole treatment with ILM flap repositioning results in better preserved RNFL and GCL, while maintaining a high closure rate and similar postoperative visual acuity.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0