Retina-The Journal of Retinal and Vitreous Diseases最新文献

{"title":"Clinical outcomes of epiretinal membrane surgery in patients with good baseline visual acuity.","authors":"Rebecca L Jones, Lubna Feroz, Roslyn Manrique Lipa, Fawzi Mahmoud, Roger Wong, Roxane Hillier, Giancarlo Dell'Aversana Orabona","doi":"10.1097/IAE.0000000000004976","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004976","url":null,"abstract":"<p><strong>Purpose: </strong>For patients with symptomatic epiretinal membrane (ERM), pars plana vitrectomy (PPV) with ERM peel is often performed to improve their distortion. However, there is no clear consensus on visual acuity threshold for performing surgery, nor evidence of potential likelihood of risk to allow patients to make informed decisions.</p><p><strong>Methods: </strong>A retrospective case notes review of visual outcomes and complications was performed at 4 UK surgical centres. All patients with symptomatic ERM and Snellen best corrected visual acuity (BCVA) of 20/40 or better (LogMAR 0.3 or better), were included. Outcome measures were BCVA at 1, 3, 6, and 12 months, as well as subjective improvement in symptoms, complications and further surgery.</p><p><strong>Results: </strong>163 eyes of 163 patients were included in analysis. For this cohort, the mean pre-operative BCVA was equivalent to the mean post-operative BCVA. 80% (n=133) maintained or improved from their baseline VA of ≤20/40, whereas 1.2% (n=2) suffered major harm with post-operative BCVA of worse than 20/200. 92% of patients reported symptomatic improvement following surgery.</p><p><strong>Conclusion: </strong>This study shows that for the vast majority of patients with symptomatic ERM but good visual acuity, pars plana vitrectomy and epiretinal membrane peel is a safe and successful surgery.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and Microvascular Alterations in Macular Telangiectasia Type 2: The Diagnostic Value of Vessel Tortuosity.","authors":"Mustafa Değer Bilgeç, Metehan Karaatlı, Onur Özalp, Eray Atalay","doi":"10.1097/IAE.0000000000005032","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005032","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate structural and microvascular changes in macular telangiectasia (MacTel) type 2 using optical coherence tomography (OCT) and OCT-angiography (OCTA) derived vascular parameters, and to examine their relationship in the macula.</p><p><strong>Methods: </strong>A retrospective cross-sectional study included 27 MacTel type 2 patients and 54 age-and-gender-matched healthy controls. Participants underwent OCT, and OCTA imaging. Images from the superficial (SCP) and deep capillary plexuses (DCP) analyzed with OCTA Vascular Analyzer (OCTAVA) software to obtain different vascular parameters. Statistical analysis involved Mann-Whitney U tests, Spearman's correlations, and multivariate logistic regression; p <0.05 was considered significant after adjusting using the false discovery rate.</p><p><strong>Results: </strong>MacTel type 2 patients exhibited significant reduction in macular thickness in all inner ETDRS subfields (p < 0.05). Mean vessel tortuosity (mTort) in the DCP was significantly decreased in MacTel type 2 (p = 0.025). Macular thickness showed significant negative correlations with SCP-VD in the inner nasal region (r = -0.426, p = 0.034), and DCP-VD in the inner temporal region (r = -0.572, p = 0.003). Logistic regression identified central, inner nasal, and outer superior macular thickness, along with reduced mTort, as independent predictors of MacTel type 2 (p < 0.05).</p><p><strong>Conclusion: </strong>This study highlights significant structural and microvascular changes in MacTel type 2, including macular thinning and reduced mean tortuosity. Additionally, the normal structural-vascular correlations were disrupted in MacTel Type 2, and different microvascular correlation patterns were observed in these patients. The identification of new vascular parameters may contribute to a better understanding of MacTel type 2.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macular holes and endogenous electric fields A Theoretical Model Of How Electrotaxis In Retinal Glial Cells Aids In Macular Hole Closure.","authors":"Aristomenis Thanos, Brad Fortune","doi":"10.1097/IAE.0000000000005036","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005036","url":null,"abstract":"<p><strong>Purpose: </strong>To introduce the concept of endogenous electric fields in macular hole closure and propose them as a plausible mechanism guiding retinal glial cell migration to facilitate closure.</p><p><strong>Methods: </strong>This theoretical model reviews the current literature on electrotaxis as a well-established mechanism of cell migration in wound healing, particularly in tissues such as cornea and skin. These principles are then applied to the unique bioelectric environment of the retina, with analysis focused on Müller cells and the retinal pigment epithelium (RPE) as critical ion regulators capable of generating endogenous fields.</p><p><strong>Results: </strong>The model proposes that ionic fluxes across the RPE and Müller cells can generate EEFs sufficient to direct electrotaxis, thereby providing a plausible biological explanation for the success of diverse surgical techniques. From ILM peeling to autologous or heterologous tissue transplantation, these interventions may restore or enhance the bioelectric environment necessary for glial-mediated closure.</p><p><strong>Conclusion: </strong>Endogenous electric fields may represent a previously unrecognized but potentially central mechanism in macular hole resolution. This unifying theory illuminates the cellular drivers underlying successful closure, explains existing surgical outcomes, and may inform novel, biology-driven therapeutic strategies to improve patient care.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Ang-1, sFLT-1, and sST2 Profiles Distinguish Anti-VEGF Responders in Diabetic Macular Edema.","authors":"Divya Ranga, Surya Prakash Sharma, Mohit Dogra, Naresh Sachdeva, Sanjay Bhadada, Ramandeep Singh, Nirbhai Singh","doi":"10.1097/IAE.0000000000005035","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005035","url":null,"abstract":"<p><strong>Purpose: </strong>Diabetic macular edema (DME) remains a significant cause of vision loss despite the widespread use of anti-VEGF therapy. Nearly half of patients experience suboptimal responses in both anatomical and functional outcomes. This study correlates molecular signatures with clinical outcomes to identify associative markers of early treatment response and optimize DME management.</p><p><strong>Methods: </strong>Serum samples from 44 DME patients, treated with ≥3 anti-VEGF injections and 6 months follow-up, classified as responders or non-responders. Multiplex bead-based assays were used to measure cytokines related to vascular integrity, inflammatory, and adhesion molecules. Statistical analysis was performed using GraphPad.</p><p><strong>Results: </strong>Responders demonstrated improvement in BCVA from 20/63 (0.5 logMAR) to 20/35 (0.25 logMAR) and CRT (443 µm to 270 µm) (p < 0.01), while non-responders worsened in both parameters. The macular fluid area was 5-fold lower in responders (p < 0.001). Responders had higher Ang-1, sFLT-1, sST2, TNF-a, MCP-1( p< 0.01). Ang-1 and sFLT-1 correlated strongly with CRT reduction and improvement in BCVA. ROC analysis identified Ang-1, CRT (AUC = 0.9), and the Ang-1 ratio having superior diagnostic accuracy. Ang-1/sFLT-1 and Ang-1/sST2 ratios enhanced discrimination (AUC=0.9; p < 0.001).</p><p><strong>Conclusion: </strong>Ang-1, sFLT-1, and sST2 are closely associated with treatment response to anti-VEGF therapy in DME patients, highlighting their roles in vascular integrity, endogenous VEGF blockade, and inflammation regulation. Both the cytokines individual levels and their ratios serve as early indicators of the success of anti-VEGF treatment in DME. Integrating these cytokines with BCVA and CRT measurements could enhance the efficiency of DME management.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silicone Oil Related Vision Loss in Macula On Retinal Detachment: A Narrative Review.","authors":"Peter Bracha, Shanzay Suhail","doi":"10.1097/IAE.0000000000005033","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005033","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LAMELLAR MACULAR HOLE AFTER ACQUIRED VITELLIFORM LESION COLLAPSE IN INTERMEDIATE AGE-RELATED MACULAR DEGENERATION.","authors":"Alessandro Feo, Anamika Patel, Marjan Afzali, Shahin Faghihi, David Sarraf","doi":"10.1097/IAE.0000000000005034","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005034","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Foveal Microvascular Alterations in Children With Hypoxic-Ischemic Encephalopathy: An OCT Angiography Study.","authors":"Zeynep Seymen, Evrim Polat, Onur Baş, Hayri Ferhat Budak, Hande Zeybek Aydoğan, Hülya Güngel","doi":"10.1097/IAE.0000000000004974","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004974","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the foveal microvascular structure in children with a history of hypoxic ischemic encephalopathy (HIE) compared with healthy controls.</p><p><strong>Methods: </strong>This prospective cross-sectional comparative study included 46 eyes of 23 children with HIE and 40 eyes of 20 age-matched healthy controls. The children were grouped as follows: Group 1: HIE Stage I (n=28 eyes); Group 2: HIE Stage II-III (n=18 eyes); Group 3: healthy age-matched controls (n=40 eyes). Patients were also subgrouped based on fundus appearance within the first week of life as follows: Group A: eyes without any retinal hemorrhages (RHs) (n=13 eyes); Group B: eyes with widespread peripheral RHs sparing the macula (n=28 eyes); Group C: eyes with widespread peripheral RHs with macular involvement (n=5 eyes); Group D: healthy controls (n=40 eyes). All children underwent optical coherence tomography angiography (OCTA)(Solix Visionix). FAZ area, foveal vessel densities and central foveal thickness (CFT) were compared.</p><p><strong>Results: </strong>Foveal vessel density of the superficial capillary plexus (VD-SCP) and CFT were significantly higher in Group 2 compared with Group 1 (all p<0.05). Significantly smaller FAZ area was noted in Group 2 (0.19±0.09 mm2) compared with Group 1 (0.28±0.10 mm2) and 3 (0.26±0.09 mm2)(all p<0.05).</p><p><strong>Conclusions: </strong>HIE may lead to persistent alterations in foveal microvasculature. OCTA may serve as a non-invasive biomarker for detecting long-term retinal microvascular sequelae in children with a history of perinatal asphyxia.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Retinal Artery Occlusion After Carotid Endarterectomy Versus Carotid Artery Stenting.","authors":"Zuhair Zaidi, Ahmed Alshaikhsalama, Brandon Winward, Faiza Sarwar, Mustafa Alrawi, Khalil Chamseddin, Noy Ashkenazy","doi":"10.1097/IAE.0000000000005029","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005029","url":null,"abstract":"<p><strong>Purpose: </strong>Retinal artery occlusion (RAO) is a rare but vision-threatening complication of carotid revascularization, yet its comparative incidence after carotid endarterectomy (CEA) versus carotid artery stenting (CAS) is poorly characterized. We compared the risk of RAO and associated neurologic outcomes after CEA and CAS.</p><p><strong>Methods: </strong>Retrospective multicenter cohort study using the TriNetX Research Network (January 1, 2004-March 15, 2026). Adults undergoing CEA or CAS with ≥6 months of follow-up and no prior diagnosis of any studied outcome condition (retinal artery or vein occlusion, glaucoma, legal blindness, or stroke were included. Propensity score matching on demographics, comorbidities, ophthalmic conditions, medications, and laboratory biomarkers (nearest-neighbor greedy algorithm; caliper 0.25 SD) yielded 17,851 patients per cohort. The primary outcome was the incidence of RAO at 90 days and 1 year after the index procedure. Secondary outcomes included central RAO (CRAO), branch RAO (BRAO), retinal vein occlusion, glaucoma, legal blindness, stroke (stratified by National Institutes of Health Stroke Scale [NIHSS] score), and mortality at the same intervals. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.</p><p><strong>Results: </strong>At 1 year, CAS was associated with higher risks of RAO (0.421% vs 0.257%; OR 1.64; 95% CI, 1.12-2.41), CRAO (OR 2.30; 1.10-4.84), BRAO (OR 3.21; 1.58-6.52), and legal blindness (OR 1.59; 1.26-2.92). CAS also conferred higher odds of stroke (6.20% vs 4.43%; OR 1.42; 1.25-1.62) and mortality (6.41% vs 3.87%; OR 1.70; 1.54-1.88). Most events occurred within 72 hours post-procedure.</p><p><strong>Conclusion: </strong>In this retrospective propensity-matched analysis, CAS was associated with greater risk of retinal and neurologic ischemic complications than CEA, although absolute event rates were low. These observational findings support consideration of heightened postoperative ophthalmic vigilance and interdisciplinary collaboration between ophthalmology and vascular surgery after CAS and suggest that targeted post-procedural ophthalmic evaluation may be reasonable in selected high-risk patients, pending prospective confirmation.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pooled Data Meta-Analysis of Pneumatic Vitreolysis for Treatment of Vitreomacular Traction Syndrome With, And Without Full Thickness Macular Holes.","authors":"Nathan A Brice, Madeline S Louie, Colin A McCannel","doi":"10.1097/IAE.0000000000005028","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005028","url":null,"abstract":"<p><strong>Purpose: </strong>To conduct a pooled data meta-analysis assessing the efficacy and complication rates of pneumatic vitreolysis as a first-line treatment for vitreomacular traction with and without full-thickness macular holes (FTMH).</p><p><strong>Methods: </strong>The National Library of Medicine PubMed interface, EMBASE, Scopus, and Cochrane Library were queried for articles published from May 1995 to March 2025 detailing the use of a gas injection for treatment of vitreomacular traction with or without FTMH. Efficacy and complication data were pooled and analyzed.</p><p><strong>Results: </strong>A total of 33 studies reporting on 637 eyes with VMT treated with PVL were included. Of these, 476 eyes had VMT alone and 161 had concurrent FTMH. VMT release occurred in 76% of all eyes with rates of 49%, 67%, 71%, and 83%, for filtered air, SF6, C2F6 and C3F8 respectively. Across eyes with VMT alone, the release rate was 71%, while eyes with VMT and macular holes (MH) it was 94%, and successful MH closure rate was 40%. VMT release was higher in phakic (84%) compared to pseudophakic eyes (76%). Adverse events included development of new FTMHs in 5% of VMT-only eyes, and across all studies, retinal tears and detachments developed in 8 (1%) and 13 (2%) eyes, respectively.</p><p><strong>Conclusion: </strong>Pneumatic vitreolysis appears to be a cost-effective treatment option for patients with vitreomacular traction without FTMH with modest to good success rates. Eyes with concurrent macular hole have a modest closure rate only. The risk of complications, including FTMH, retinal tear or detachment, must be considered.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence.","authors":"Phoebe C Lam, Sunny C L Au","doi":"10.1097/IAE.0000000000004889","DOIUrl":"10.1097/IAE.0000000000004889","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"e113"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148058277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}