Choroidal Vascularity Index, Retinal Vascularity and Hemoglobin Levels in Pediatric Sickle Cell Maculopathy.

IF 2.1 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-10-13 DOI:10.1097/IAE.0000000000004699

Celine Chaaya, Sandra Hoyek, Francisco Altamirano, Colin Lemire, Omar Halawa, Jonathan Yang, Kiran Kumar Vupparaboina, Nasiq Hasan, Efren Gonzalez, Jay Chhablani, Nimesh A Patel

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引用次数: 0

Abstract

Purpose: To evaluate the choroidal vascularity index (CVI) in pediatric patients with sickle cell disease (SCD) and its associations with retinal thickness and vasculature.

Methods: This is a retrospective case series of children with sickle cell disease (SCD) and healthy age matched controls. CVI was measured using an automated machine learning algorithm. Retinal assessments included total retinal thickness along with vessel density (VD).

Results: A total of 184 eyes from 92 pediatric SCD patients (55.4% male) were included. Eyes with low CVI had significantly lower median VD in the inferotemporal quadrant compared to eyes with higher CVI (14.8 vs 22.2; p = 0.009). Eyes with lower CVI had higher median retinal thickness in the nasal perifovea (322 μm vs 316 μm; p = 0.003) and the inferior perifovea (293 μm vs. 290 μm; p = 0.0028). Eyes with low CVI had significantly lower mean Hgb level (9.3 vs 10; p = 0.009). The mean CVI in the control group was 69%,which was significantly higher than the CVI in the studied population with a mean CVI of 54%, p < 0.001.

Conclusion: In pediatric SCD patients, there was a significant decrease in CVI when compared to healthy age matched controls. Decreased CVI was associated with a loss of retinal VD in the inferotemporal macular quadrant as well as lower Hgb levels. These findings suggest a role of choroidal ischemia in the pathogenesis of sickle cell maculopathy and a potential for CVI to serve as a biomarker for systemic disease activity.

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儿童镰状细胞黄斑病变的脉络膜血管指数、视网膜血管和血红蛋白水平。

目的：评价小儿镰状细胞病（SCD）患者脉络膜血管指数（CVI）及其与视网膜厚度和血管的关系。方法：这是一个回顾性的病例系列与儿童镰状细胞病（SCD）和健康年龄匹配的对照。使用自动机器学习算法测量CVI。视网膜评估包括视网膜总厚度和血管密度（VD）。结果：92例儿童SCD患者共184只眼，其中男性55.4%。与CVI较高的眼睛相比，低CVI的眼睛在颞下象限的中位VD明显较低（14.8 vs 22.2; p = 0.009）。CVI较低的眼在鼻隐窝周围（322 μm vs 316 μm, p = 0.003）和下隐窝周围（293 μm vs 290 μm, p = 0.0028）视网膜中位厚度较高。低CVI眼的平均Hgb水平显著降低（9.3 vs 10; p = 0.009）。对照组的平均CVI为69%，显著高于研究人群的平均CVI为54%，p < 0.001。结论：在儿童SCD患者中，与健康年龄匹配的对照组相比，CVI显著降低。CVI的降低与颞下黄斑象限视网膜VD的丧失以及Hgb水平的降低有关。这些发现提示脉络膜缺血在镰状细胞黄斑病发病机制中的作用，以及CVI作为全身性疾病活动性生物标志物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.