Retina-The Journal of Retinal and Vitreous Diseases最新文献

{"title":"Surgical Techniques for Optimal Lens Management of Posterior Segment Metallic Intraocular Foreign Body Removal: A Case Series.","authors":"Jade Y Moon, Tyler Looysen, Pedro Monsalve, Michael Simmons, Tahsin Khundkar, Ameay Naravane, Richard Sather, Richard Johnston, Hossein Nazari, Dara Koozekanani, Sandra R Montezuma","doi":"10.1097/IAE.0000000000004208","DOIUrl":"10.1097/IAE.0000000000004208","url":null,"abstract":"<p><strong>Purpose: </strong>We describe three different approaches for lens management in cases of metallic intraocular foreign bodies (IOFBs) involving the posterior segment.</p><p><strong>Methods: </strong>All consecutive posterior segment metallic IOFB cases from 2012 to 2023 at a single institution were included in this retrospective case series. Surgical outcomes and surgical videos are presented.</p><p><strong>Results: </strong>A total of 25 metallic IOFB cases were included. In 9 cases, there was no significant lens involvement, therefore, not requiring lens extraction at the time of IOFB removal. In 8 cases with traumatic cataract, lens extraction sparing the anterior lens capsule was performed with IOFB removal. In 8 cases, both lens extraction and lens capsule removal were required at the time of IOFB removal.</p><p><strong>Conclusion: </strong>We demonstrate our algorithm to capsular management in patients who present with IOFB with good visual outcomes in follow-up.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"790-797"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141725088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"M Giray Ersoz, Sibel Demirel, Claudio Iovino, Jay Chhablani, David Sarraf","doi":"10.1097/IAE.0000000000004387","DOIUrl":"10.1097/IAE.0000000000004387","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"e28-e29"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABSORBABLE GELATIN SPONGE AS AN INTRASCLERAL BUCKLE IN RABBITS: A Pilot Study.","authors":"Yan Zhou, Shiqun Lin, Xingyu Xiao, Youxin Chen, Zhe Chen, Rongping Dai","doi":"10.1097/IAE.0000000000004359","DOIUrl":"10.1097/IAE.0000000000004359","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the efficacy and safety of using an absorbable gelatin sponge as an intrascleral buckle in rabbit eyes; it also monitored degradation of the gelatin sponge over time.</p><p><strong>Methods: </strong>Ten, New Zealand, White rabbits underwent surgery to implant an absorbable gelatin sponge as an intrascleral buckle. Weekly ophthalmic examinations were conducted before and after the procedure until the implant was fully absorbed. Assessments included external eye and fundus examinations, color fundus imaging, and optical coherence tomography. Safety and efficacy were determined by comparing preoperative and postoperative conditions.</p><p><strong>Results: </strong>The surgery was successfully completed in 12 of 20 eyes, yielding favorable postoperative outcomes. Eight eyes were excluded due to issues with scleral tunneling, including accidental penetration, suprachoroidal implantation of the sponge, and choroidal excavation, resulting in a success rate of 60%. The indentation produced by the gelatin sponge implant progressively decreased, entirely disappearing within 2 weeks. No complications, such as retinal or choroidal hemorrhage or detachment, were observed.</p><p><strong>Conclusion: </strong>Intrascleral implantation of absorbable gelatin sponge was safe and effective for scleral buckling in rabbits, demonstrating favorable biodegradation characteristics.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"608-613"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SOCIAL DETERMINANTS OF HEALTH IN AGE-RELATED MACULAR DEGENERATION: A Nationally Representative Survey Study.","authors":"Ryan S Huang, Nikhil S Patil, Andrew Mihalache, Jim Xie, Marko M Popovic, Peter J Kertes, Rajeev H Muni, Radha P Kohly","doi":"10.1097/IAE.0000000000004356","DOIUrl":"10.1097/IAE.0000000000004356","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between social determinants of health and the prevalence of age-related macular degeneration (AMD).</p><p><strong>Methods: </strong>This analysis included adult respondents (≥50 years old) from the 2017 National Health Interview Survey. The primary outcomes were self-reported diagnosis of AMD and self-reported vision loss because of AMD. Univariable and multivariable logistic regression models were used for analysis.</p><p><strong>Results: </strong>A total of 14,267 National Health Interview Survey participants were included, of whom 668 (4.7%) reported an AMD diagnosis. In the multivariable analysis, respondents aged over 81 years had higher odds of AMD (odds ratio [OR] = 7.54, 95% confidence interval [CI], 4.76-11.96, P < 0.001) compared with those aged 50 to 60. Divorced, separated, or widowed participants (OR = 1.27, 95% CI, 1.01-1.61, P = 0.042) also had a higher odds of AMD compared with married participants. Conversely, Black/African-American (OR = 0.23, 95% CI, 0.14-0.39, P < 0.001), Asian (OR = 0.38, 95% CI, 0.16-0.88, P = 0.023), and gay, lesbian, or bisexual respondents (OR = 0.45, 95% CI, 0.22-0.93, P = 0.032) had lower odds of AMD compared with White and heterosexual respondents, respectively. Employment was also associated with lower odds of AMD (OR = 0.71, 95% CI, 0.53-0.96, P = 0.026) compared with unemployment.</p><p><strong>Conclusion: </strong>Several social determinants of health were associated with self-reported AMD diagnosis. These factors should be considered by policymakers and clinicians to effectively orchestrate public health initiatives aimed at promoting equitable care.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"703-713"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL COURSE AND PROGNOSTIC FACTORS IN NONNEOVASCULAR AGE-RELATED MACULAR DEGENERATION WITH SUBRETINAL FLUID.","authors":"Chang Hwan Lee, Kunho Bae, Chang Ki Yoon, Un Chul Park, Kyu Hyung Park, Eun Kyoung Lee","doi":"10.1097/IAE.0000000000004368","DOIUrl":"10.1097/IAE.0000000000004368","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical course and prognostic factors of age-related macular degeneration without macular neovascularization (MNV) in patients presenting with pigment epithelial detachment (PED) and the associated subretinal fluid (SRF).</p><p><strong>Methods: </strong>Morphological characteristics of spectral-domain optical coherence tomography images were analyzed to determine anatomic outcomes. Factors associated with the progression to late AMD, defined as complete retinal pigment epithelium and outer retinal atrophy (cRORA) or MNV, were investigated.</p><p><strong>Results: </strong>Fifty eyes of 41 patients were included in this study. The most common SRF location was the angle of the PED (56%), and there was a significant decrease in SRF thickness and PED height and width over the follow-up period. Eleven (22%) eyes developed cRORA, and seven (14%) eyes developed MNV during a mean period of 52.1 months. Multivariate analysis revealed that hyperreflective foci and MNV in the fellow eye were associated with the development of cRORA, and higher PED height was a significant factor associated with the development of MNV.</p><p><strong>Conclusion: </strong>In patients with AMD, SRF can be accompanied by PED in the absence of MNV. Notably, patients with this characteristic entity can progress to late AMD, including cRORA and MNV, in a significant proportion of cases.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"714-723"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BEYOND THE SURFACE: Investigating Silicone Oil's Impact on Macular Perfusion in Macula-Off Rhegmatogenous Retinal Detachment by Optical Coherence Tomography Angiography.","authors":"Ece Ozal, Muzaffer Said Guler, Murat Karapapak, Hakan Baybora, Serhat Ermis, Yusuf Cem Yilmaz, Serife Ciloglu Hayat, Sadık Altan Ozal","doi":"10.1097/IAE.0000000000004364","DOIUrl":"10.1097/IAE.0000000000004364","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to compare macular vessel density (VD) in eyes with macula-off rhegmatogenous retinal detachment after vitrectomy with gas or silicone oil (SO) tamponade.</p><p><strong>Methods: </strong>Patients with macula-off rhegmatogenous retinal detachment who underwent vitrectomy with either gas or SO tamponade were included. Best-corrected visual acuity (BCVA) and VD in superficial and deep retinal capillary plexuses (superficial capillary plexus and deep capillary plexus), choriocapillaris (choriocapillaris plexus), and foveal avascular zone were assessed using optical coherence tomography angiography. Comparisons were made with the unaffected fellow eye.</p><p><strong>Results: </strong>Fifty patients (average age: 57.9 ± 9.1 years) participated, with 26 eyes undergoing SO tamponade and 24 gas tamponade. No significant differences were found in baseline characteristics. Postoperative BCVA significantly improved in both groups. In the SO group, BCVA improved from 2.00 ± 0.77 logarithm of the minimum angle of resolution (20/2000 Snellen) to 0.95 ± 0.52 logarithm of the minimum angle of resolution (20/178 Snellen). In the gas tamponade group, BCVA improved from 2.12 ± 0.70 logarithm of the minimum angle of resolution (20/2636 Snellen) to 0.70 ± 0.55 logarithm of the minimum angle of resolution (20/100 Snellen) ( P < 0.001 for both groups). Moreover, the gas tamponade group achieved significantly better postoperative BCVA compared with the SO group ( P < 0.05). The silicone oil tamponade group exhibited significantly lower VD in superficial capillary plexus, deep capillary plexus, and choriocapillaris plexus quadrants ( P < 0.05), while gas tamponade showed no significant differences.</p><p><strong>Conclusion: </strong>This study reveals a decrease in VD in superficial capillary plexus, deep capillary plexus, and choriocapillaris plexus induced by SO tamponade, suggesting potential toxic effects on macular perfusion. Gas tamponade resulted in superior BCVA outcomes and preserved VD. Further investigation into SO's underlying mechanisms and careful patient selection is warranted. Gas tamponade may offer better outcomes for macula-off rhegmatogenous retinal detachment.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"621-629"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF FOVEAL HYPOPLASIA IN CHILDREN WITH A HISTORY OF RETINOPATHY OF PREMATURITY.","authors":"Gökhan Çelik, Bilge Batu Oto, Osman Kizilay, Murat Gunay","doi":"10.1097/IAE.0000000000004362","DOIUrl":"10.1097/IAE.0000000000004362","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the foveal development in patients diagnosed with retinopathy of prematurity (ROP) and to evaluate whether foveal development was affected by treatment in ROP patients.</p><p><strong>Methods: </strong>This cross-sectional study included patients with a history of ROP. Foveal development was compared between eyes with spontaneous regression and treated eyes. In addition, gestational age, birth weight, ROP zone and stage, and postmenstrual gestational age at the time of treatment were evaluated. The final visual acuity was analyzed according to the foveal hypoplasia (FH) severity.</p><p><strong>Results: </strong>This study included 166 eyes from 83 patients. Foveal development was significantly different among the treatment and spontaneous regression groups, and FH was more severe in the treatment group. The prevalence of normal foveal development was higher in the spontaneous regression group than in the treatment groups. This suggests that ROP treatment may induce morphological alterations during foveal development. Gestational age, postmenstrual age at the time of treatment, ROP stage, and ROP zone correlated with FH severity. Visual acuity was not affected by mild FH, and 88.5% of the patients had a visual acuity of logarithm of the minimum angle of resolution (logMAR) 0.</p><p><strong>Conclusion: </strong>Early stage foveal development is not significantly disrupted in patients with ROP, and patients with ROP show no significant visual disturbance associated with FH. However, eyes treated for ROP either with laser photocoagulation or intravitreal anti-vascular endothelial growth factor demonstrated more severe hypoplasia compared with that with spontaneous regression.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"660-666"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A COMPREHENSIVE REVIEW ON THE PERIFOVEAL EXUDATIVE VASCULAR ANOMALOUS COMPLEX.","authors":"Matteo Mario Carlà, Francesco Boselli, Federico Giannuzzi, Emanuele Crincoli, Mattia Cusato, Sofia Peschiaroli, Stanislao Rizzo","doi":"10.1097/IAE.0000000000004376","DOIUrl":"10.1097/IAE.0000000000004376","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this review was to summarize the most recent investigations on perifoveal exudative vascular anomalous complex (PEVAC) lesions and guide future research of this entity.</p><p><strong>Methods: </strong>Retrospective analysis of Cochrane Central, PubMed, Web of Science, and ClinicalTrials.gov databases for papers regarding PEVAC, looking for the following keywords: \"perifoveal exudative anomalous vascular complex,\" \"PEVAC,\" \"PVAC,\" \"nePVAC,\" \"ePVAC,\" \"deep retinal age-related microvascular anomalies,\" and \"DRAMA.\"</p><p><strong>Results: </strong>PEVACs are described as a single, massive, unilateral aneurysm that frequently present with intraretinal cystic edema surrounding the fovea, active exudation and hemorrhages, usually in healthy patients. Notwithstanding this, association with age-related macular degeneration, myopia, diabetes, lamellar hole, and pachychoroid pigment epitheliopathy are frequently reported. Currently, a multimodal imaging is warranted, especially the use of OCT and OCTA can rule out several other differential diagnoses. Because of the uncertainty of the pathophysiological mechanism, the right management of these lesions are yet to be clear. Overall, laser therapy has been effective in several reports, both with thermal and micropulse type. Anti-vascular endothelial growth factor injections and steroid injections demonstrated a nonconstant response.</p><p><strong>Conclusion: </strong>Several new findings are revolutionizing PEVAC management. Greater standardization could help understand the correct treatment of these lesions.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":"45 4","pages":"587-600"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EARLY RETINAL DETACHMENTS AFTER OPEN GLOBE REPAIR: Incidence and Risk Factors.","authors":"Neil Sheth, Arthur Y Chang, Arthi Bharadwaj, David Wu, Evguenia Ivakhnitskaia, William F Mieler","doi":"10.1097/IAE.0000000000004348","DOIUrl":"10.1097/IAE.0000000000004348","url":null,"abstract":"<p><strong>Purpose: </strong>Risk factors for the development of rhegmatogenous retinal detachments (RRDs) in the early postoperative period after open globe repair are not well understood. RRDs are often diagnosed late after open globe injuries, which can negatively affect visual prognosis. The authors assessed the incidence and risk factors that predict the development of this complication.</p><p><strong>Methods: </strong>The authors conducted a retrospective case-control study of all open globe injuries at a single ocular trauma center from January 2016 to September 2021 where at baseline the retina was attached. Cases were defined as postoperative RRDs that developed within 90 days of open globe repair.</p><p><strong>Results: </strong>Of 96 eyes included, 40 (41.7%) subsequently developed RRD. Univariate analysis revealed initial visual acuity of light perception or worse (odds ratio 7.64; 95% CI, 3.03-19.22; P < 0.01), Zone 3 injuries (odds ratio 7.54; 95% CI, 2.64-21.54; P < 0.01), no view of the lens (odds ratio 4.26; 95% CI, 1.77-10.26; P < 0.01), and the presence of injuries external to the globe (odds ratio 5.33; 95% CI, 2.09-13.63; P < 0.01) to be associated with early RRD development. On multivariate analysis, presenting visual acuity of light perception ( P < 0.001), the presence of external injuries ( P = 0.001), and Zone 3 injuries ( P = 0.037) remained significant. Of the 40 patients with early retinal detachment, 34 (85%) remained attached after repair, with variable visual outcomes.</p><p><strong>Conclusion: </strong>Presenting visual acuity of light perception, Zone 3 injuries, and external injuries to the globe confer increased risk of early postoperative RRD after open globe repair. The majority of RRDs can be successfully repaired.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":"45 4","pages":"614-620"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFICIENT ASSESSMENT OF PROGRESSION IN CLINICAL TRIALS IN RETINITIS PIGMENTOSA.","authors":"Ryo Asaoka, Manabu Miyata, Akio Oishi, Yuri Fujino, Hiroshi Murata, Shuichiro Aoki, Keiko Azuma, Ryo Obata, Tatsuya Inoue","doi":"10.1097/IAE.0000000000004360","DOIUrl":"10.1097/IAE.0000000000004360","url":null,"abstract":"<p><strong>Purpose: </strong>To conduct a simulation study to evaluate the effect of disease stage, frequency, and clustering of visual field tests, and inclusion of one or both eyes on sample size calculation in clinical trials on retinitis pigmentosa.</p><p><strong>Methods: </strong>A series of VFs were simulated on the basis of test-retest visual field data in the early, moderate, and advanced stages of retinitis pigmentosa. Visual field measurements were scheduled 8 times in approximately 2 years. The probability to detect significant difference between treatment and control groups was measured. The investigation was conducted for 50%, 40%, 30%, 20%, and 10% treatment effects.</p><p><strong>Results: </strong>When only one eye was used in each patient with a treatment effect of 50%, 80% probability of significance was observed in the moderate stage when sample size was 70 eyes in each arm (140 eyes in both arms). Early stage disease and inclusion of both eyes decreased this number to 30 eyes (60 eyes in both arms); these decreasing effects were larger than performing additional VFs at the beginning and at the end of the observation. A similar tendency was observed with 40%, 30%, 20%, and 10% treatment effects.</p><p><strong>Conclusion: </strong>When planning a clinical trial, it is important to consider disease stage, in addition to visual field schedule and inclusion of one or both eyes.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"765-773"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}