Retina-The Journal of Retinal and Vitreous Diseases最新文献

{"title":"Correspondence.","authors":"Raffaele Raimondi, Mario R Romano","doi":"10.1097/IAE.0000000000004908","DOIUrl":"10.1097/IAE.0000000000004908","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"e114-e116"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148284813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Eyes with Concurrent Suprachoroidal Hemorrhage and Retinal Detachment: A Multicenter Study.","authors":"Tianyu Liu, Jason Keil, Sahal Saleh, Revati Rashingkar, Yinxi Yu, Gui-Shuang Ying, George A Williams, Alexander J Brucker, Benjamin J Kim","doi":"10.1097/IAE.0000000000005026","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005026","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize eyes with concurrent suprachoroidal hemorrhage and retinal detachment (SCH-RD).</p><p><strong>Methods: </strong>Retrospective study of eyes with SCH-RD from two institutions between 1/1/2013 and 12/31/2022. The primary outcome was the 6-month change in visual acuity (VA).</p><p><strong>Results: </strong>Forty-four eyes of 44 patients (mean age 64.5 years, 40.9% female) were included. The RD was rhegmatogenous in 31 (70.5%) cases, exudative in 11 (25.0%) cases, and tractional in 2 (4.5%) cases. Proliferative vitreoretinopathy (PVR) was present in 22 (50.0%) cases. The mean (SD) presenting VA was 2.50 (0.46) logMAR (hand motion to light perception). Thirty-one (70.5%) cases underwent attempted surgical repair of RD at a median (IQR) 13.0 (6.0, 23.0) days after RD diagnosis. Of these 31 cases, 11 (35.5%) cases achieved single surgery success, defined as retinal attachment at 6 months with one surgery. At 6 months after presentation, the mean (SD) VA improved by 0.26 (0.78) logMAR [13.0 letters], with 19 (43.2%) cases achieving ≥ 3-line VA improvement and 4 (9.1%) cases achieving 20/200 VA or better. In multivariable analysis, greater VA improvement was associated with worse presenting VA and the absence of PVR. Twenty-seven (61.4%) cases achieved retinal attachment at 6 months. In multivariable analysis, greater odds of retinal attachment were associated with undergoing multiple surgeries for RD repair and the absence of PVR.</p><p><strong>Conclusion: </strong>Eyes with SCH-RD have guarded visual prognoses, especially when PVR is present. Undergoing multiple surgeries for RD repair and the absence of PVR were associated with greater odds of achieving retinal attachment.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure-Function Relationships in Retinitis Pigmentosa: Three-Year Changes in Visual Function and Outer Retinal Layers.","authors":"Min-Woo Lee, Yun-Sang Roh, Sung-Chul Lee","doi":"10.1097/IAE.0000000000005024","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005024","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize longitudinal changes in outer retinal layers in retinitis pigmentosa (RP) and to determine how these structural alterations relate to functional decline, including visual field parameters and visual acuity.</p><p><strong>Methods: </strong>In this retrospective cohort study, 57 eyes with RP were evaluated over a fixed 3-year follow-up. Annual measurements of ellipsoid zone width (EZW), outer nuclear layer (ONL) thickness, and outer segment (OS) thickness were obtained from horizontal foveal OCT scans. Functional assessments included best-corrected visual acuity (BCVA) and visual field index (VFI), mean deviation (MD), and pattern standard deviation (PSD). Linear mixed-effects models were used to estimate longitudinal rates of change and structure-function associations.</p><p><strong>Results: </strong>All visual field parameters significantly declined over time (VFI: -2.06%/year; MD and PSD both P < 0.050). Structural parameters also demonstrated progressive deterioration (EZW: -2.7%/year, P < 0.001; ONL: -1.82 µm/year, P = 0.038; OS: -1.25 µm/year, P = 0.006). Among structural measures, EZW demonstrated the strongest association with VFI (P < 0.001), while OS thickness showed the closest relationship with BCVA (P = 0.002). ONL thinning was significant but showed limited functional correlation.</p><p><strong>Conclusions: </strong>Distinct outer retinal biomarkers were differentially associated with functional measures in RP. Repeated EZW measurements were most strongly associated with VFI, whereas repeated OS thickness measurements were most closely associated with BCVA. ONL shows measurable structural loss but limited functional relevance. Multilayer structural assessment provides complementary information on RP progression and may help refine future clinical evaluation strategies.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multi-Institutional Study on West Nile Virus Uveitis: Treatment, Complications, and Long-Term Outcomes.","authors":"Tedi Begaj, Zujaja Tauqeer, Renee Liu, Meghan Smith, Ann-Marie Lobo-Chan, George A Williams, Jeremy D Wolfe, Dean Eliott, Lucia Sobrin, Lisa J Faia","doi":"10.1097/IAE.0000000000005025","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005025","url":null,"abstract":"<p><strong>Purpose: </strong>West Nile virus (WNV) can cause anterior/intermediate uveitis with characteristic multifocal chorioretinal lesions. Literature on acute manifestations is robust; however there is limited data describing the full spectrum of uveitic manifestations of WNV, treatments in the acute and chronic phase, as well as long-term sequelae.</p><p><strong>Methods: </strong>A retrospective observational study from three academic uveitis practices. Patients diagnosed with WNV based on serologic and imaging findings were selected; data collected included demographics, ocular and systemic co-morbidities, ophthalmic examination findings, and treatment.</p><p><strong>Results: </strong>Eleven patients were included between 2015 to 2023, with a mean follow-up of 128 weeks (∼ 2.5 years). The average patient was a 60-year-old Caucasian (64%) woman (55%); 27% of patients had diabetes. Fifty-five percent presented with 20/20-20/40 Snellen visual acuity. Importantly, 73% of patients in this cohort were hospitalized due to encephalitis or meningitis. Acute findings included anterior inflammation (8 [36.4%] eyes), vitreous inflammation (9 [40.9%] eyes), cystoid macular edema (CME) (6 [27.3%] eyes), non-occlusive retinal vasculitis (5 [22.7%]), and 1 (4.5%) eye with occlusive retinal vasculitis. Two (9.1%) eyes developed secondary peripheral retinal neovascularization requiring anti-vascular endothelial growth factor treatment or laser panretinal photocoagulation. Eight (36.4%) eyes were initially treated with systemic steroids, and 4 (18.2%) eyes required immunomodulatory therapy (IMT) for recurrent CME and retinal vasculitis.</p><p><strong>Conclusion: </strong>WNV uveitis often has a self-limited course but can be intractable in some patients, with long-term control needed for CME and retinal vasculitis with systemic IMT. Ophthalmologists must be aware of the rarer complications that may require intervention.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfusion Density Changes After Epiretinal Membrane Surgery Predominantly Reflect Topographic Redistribution of Macular Vasculature.","authors":"No Hae Park, Sung Min Lee, Sung Who Park, Iksoo Byon","doi":"10.1097/IAE.0000000000005027","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005027","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate changes in optical coherence tomography angiography (OCTA) flow parameters and its clinical aspects in idiopathic epiretinal membrane (iERM).</p><p><strong>Methods: </strong>Thirty-seven unilateral iERM patients who were followed up at least 6 months after iERM surgery were retrospectively reviewed. All eyes were imaged using a 6x6 mm volume scan of the swept source OCTA. The best corrected visual acuity, the foveal avascular zone (FAZ) area, perfusion density (PD) within 1-, 3-mm circle (PD1 and PD3), and the distance between the fovea and vascular arcades (FV) were assessed.</p><p><strong>Results: </strong>The FAZ areas increased and PD1s decreased in the superficial and deep capillary plexus (SCP and DCP) (P < 0.05 in all). In SCP, the FAZ area showed an inverse correlation with PD1. The association was observed between changes in FV and PD1 in SCP and DCP (r =0.364, 0.412, p =0.044, 0.021). The changes in the PD3s were not correlated with the changes in FV. The change in BCVA was significantly correlated with the changes in FAZ area (r = -0.514, p < 0.05), PD1 (r = 0.325, p < 0.05), and PD3 (r = 0.424, p < 0.05).</p><p><strong>Conclusions: </strong>In iERM, greater FAZ enlargement correlated with greater visual improvement despite a reduction in central PD. The significant relationship between changes in FV and PD suggests that changes in OCTA flow parameters after iERM surgery predominantly reflect topographic redistribution of macular vasculature rather than a true loss of perfusion, although a concurrent perfusion change cannot be entirely excluded.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-in-Human Implantation of an Add-On Dual Intraocular System Combining a Standard IOL and the SING-IMT™ Telescope: Optical Simulation, Preclinical Validation, and Clinical Feasibility.","authors":"Stanislao Rizzo, Paola Sasso, Irene Nepita, Giuseppe Francione, Carmela G Caputo, Mariantonia Ferrara, Alessandro Feo, Alfonso Savastano, Faustino Vidal-Aroca, Vladimir Belousov, Mario R Romano","doi":"10.1097/IAE.0000000000005023","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005023","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate a dual-implant system combining a capsular-bag monofocal intraocular lens with a sulcus-implanted small-incision new-generation implantable miniature telescope (SING-IMT).</p><p><strong>Methods: </strong>Optical simulations quantified retinal spot size, modulation transfer function (MTF), and tolerance to misalignment. Preclinical porcine experiments evaluated surgical feasibility, anatomical stability, and early safety. First-in-human (FiH) implantation assessed surgical outcomes, anterior segment behaviour using ultrasound biomicroscopy and optical coherence tomography, functional vision, and safety over 6 months.</p><p><strong>Results: </strong>Optical modelling demonstrated that the dual-implant configuration maintained retinal image quality within the rehabilitative regime for advanced AMD, with root-mean-square retinal spot radii of 18.7 µm (0°) and 20.4 µm (2.5°), below the estimated retinal sampling limit (∼49 µm), consistent with an expected visual acuity improvement of approximately 2 Snellen lines. Decentration up to 0.5 mm was optically well tolerated, whereas tilt produced rapid mid-frequency contrast loss. In vivo porcine studies confirmed stable sulcus seating without disruption of the capsular-bag IOL or anterior segment structures. FiH implantation was completed without intraoperative complications. At 6 months, distance visual acuity improved from 20/200 to 20/125, near acuity from 56 to 15 Colenbrander units, and reading speed from non-assessable preoperatively to 20 words/min, with no device-related adverse events.</p><p><strong>Conclusion: </strong>This integrated evaluation supports the feasibility and short-term safety of sulcus-based SING-IMT implantation as a minimally invasive intraocular magnification strategy for selected pseudophakic patients with advanced AMD.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss to Follow-Up and Subway Proximity in Proliferative Diabetic Retinopathy and Diabetic Macular Edema: CLEAR Study Report 2.","authors":"Ryan S Huang, Sumana C Naidu, Andrew Mihalache, Ali Benour, Marko M Popovic, Peter J Kertes, David Sarraf, SriniVas R Sadda, Rajeev H Muni, Radha P Kohly","doi":"10.1097/IAE.0000000000005018","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005018","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between home subway proximity and being lost to follow-up (LTFU) in patients with proliferative diabetic retinopathy (PDR) or diabetic macular edema (DME).</p><p><strong>Methods: </strong>This multi-center, retrospective cohort study included patients from the Greater Toronto Area with available residential address data who were treated with either intravitreal anti-vascular endothelial growth factor therapy or panretinal photocoagulation for PDR or DME between January 1st, 2012, and December 31st, 2021. LTFU was defined as the absence of an ophthalmic visit within one year of their most recent visit. Univariable and multivariable logistic regression models assessed associations between these transportation variables and LTFU status.</p><p><strong>Results: </strong>Among 2,755 patients with PDR or DME (mean age: 71 ± 13 years) who had available residential address data, 477 (17%) were LTFU over a mean follow-up period of 59 ± 19 months. In the multivariable analysis adjusting for total distance to the point of care and relevant confounding variables, patients residing farther from a subway station were more likely to be LTFU (>10 km: OR=2.04, 95%CI=[1.44-2.91], p<0.001). Patients requiring more subway stops (>10 stops: OR=1.51, 95%CI=[1.10-2.39], p=0.015) and line transfers (1 transfer: OR=1.63, 95%CI=[1.29-2.05], p<0.001) were more likely to be LTFU. Longer estimated travel times were also significantly associated with LTFU (>60 minutes: OR=2.07, 95%CI=[1.86-2.95], p<0.001).</p><p><strong>Conclusion: </strong>Limited subway proximity was associated with an increased odds of being LTFU, highlighting the importance of addressing transportation barriers and improving the accessibility of ophthalmic care in areas with limited public transit infrastructure to improve follow-up adherence.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACUTE NEUROSENSORY RETINAL THINNING AND SHORT-TERM VISUAL OUTCOMES IN MASSIVE SUBMACULAR HEMORRHAGE: A LONGITUDINAL ANALYSIS FROM PRE-ONSET TO POST-DISPLACEMENT WITH SUBRETINAL TISSUE PLASMINOGEN ACTIVATOR.","authors":"Lin Tsukui, Manabu Miyata, Masayuki Hata, Sotaro Ooto, Hiroshi Tamura, Ai Otsuka, Mai Shirakami, Naoko Ueda-Arakawa, Masahiro Miyake, Ayako Takahashi, Shin Kadomoto, Yuki Muraoka, Akitaka Tsujikawa","doi":"10.1097/IAE.0000000000005014","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005014","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate longitudinal visual and structural changes from pre-onset to 1 month postoperatively in eyes with massive submacular hemorrhage (SMH) secondary to neovascular age-related macular degeneration (nAMD) treated with subretinal tissue plasminogen activator (tPA) injection and to identify prognostic factors for visual outcomes.</p><p><strong>Methods: </strong>This retrospective observational study reviewed the medical records of consecutive eyes with massive SMH secondary to nAMD treated with pars plana vitrectomy with subretinal tPA injection and pneumatic displacement. We assessed best-corrected visual acuity (BCVA) and foveal sensory retinal thickness (FSRT) at pre-onset, preoperative, and 1-month postoperative time points.</p><p><strong>Results: </strong>Among 74 consecutive eyes treated with subretinal tPA injection for massive SMH, we analyzed 20 eyes with available pre-onset data. FSRT decreased significantly from 193.5 ± 101.4 μm at pre-onset to 107.0 ± 59.0 μm at 1 month postoperatively (P < 0.001). BCVA change negatively correlated with FSRT change (r = -0.56, P = 0.01). Univariable analysis showed that pre-onset BCVA significantly correlated with 1-month BCVA (r = 0.45, P = 0.049). At pre-onset, persistent fluid and pigment epithelial detachment were present in 65% and 15%, respectively.</p><p><strong>Conclusions: </strong>Massive SMH causes acute and profound neurosensory retinal thinning, and pre-onset neuronal integrity may be a key determinant of visual outcomes. Because surgery cannot reverse this immediate damage, preventing hemorrhage by maintaining a strictly fluid-free macula may be an important proactive strategy.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endophthalmitis Following Pars Plana Vitrectomy: An IRIS® Registry Study.","authors":"Mohamad Rani Hassoun, Kenny Y Wang, B Michelle Kim, Sophia Blumenfeld, Flora Lum, Matthew R Starr","doi":"10.1097/IAE.0000000000005015","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005015","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to characterize the clinical features, management strategies, and outcomes of endophthalmitis cases following pars plana vitrectomy using data from the American Academy of Ophthalmology (Academy) IRIS® Registry (Intelligent Research in Sight).</p><p><strong>Methods: </strong>This is a retrospective cohort study of eyes that developed endophthalmitis following pars plana vitrectomy between 2013 and 2022. Data was collected from the Academy IRIS Registry. This study analyzed differences in visual acuity, intraocular pressure, rates of evisceration and enucleation, and rates of rhegmatogenous retinal detachment following endophthalmitis diagnosis.</p><p><strong>Results: </strong>A total of 1,223,777 unique eyes underwent a PPV during the study period, with 1,275 eyes meeting the inclusion criteria. The median time from pars plana vitrectomy to endophthalmitis diagnosis was 10 days. The majority of eyes (80.9%) were managed with intravitreal antibiotics alone, without a repeat pars plana vitrectomy. Long-term visual acuity, intraocular pressure, cup-to-disc ratio, and rate of evisceration or enucleation did not differ significantly between treatment groups. However, eyes that underwent the initial pars plana vitrectomy for retinal detachment repair had poorer long-term vision and higher rates of retinal detachment following endophthalmitis. Overall, 16.1% of eyes required evisceration or enucleation in this cohort.</p><p><strong>Conclusions: </strong>Despite its rarity, post-pars plana vitrectomy endophthalmitis can cause significant morbidity and even globe loss. There were no significant differences observed between eyes that were treated with intravitreal tap and inject versus repeat pars plana vitrectomy.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LONG-TERM FUNCTIONAL AND ANATOMICAL OUTCOMES FOLLOWING LENS-SPARING VITRECTOMY FOR ADVANCED RETINOPATHY OF PREMATURITY.","authors":"Ilkay Kilic Muftuoglu, Kimberly A Drenser, Eric Nudleman, Antonio Capone","doi":"10.1097/IAE.0000000000005021","DOIUrl":"https://doi.org/10.1097/IAE.0000000000005021","url":null,"abstract":"<p><strong>Purpose: </strong>To report the long-term functional results following lens-sparing vitrectomy (LSV) in patients with advanced retinopathy of prematurity (ROP).</p><p><strong>Methods: </strong>We retrospectively reviewed the records of all patients at a single tertiary referral center who underwent LSV for advanced ROP and were followed for at least 5 years. Baseline demographics, retina status at final visit, need for additional retinal surgery, visual acuity (VA), and complications were recorded.</p><p><strong>Results: </strong>Of 456 eyes of 280 patients who underwent vitreoretinal surgery for advanced ROP, 107 eyes of 79 patients with a mean follow-up of 8.92 ± 3.05 years (range, 5.00-20.05 years) were included. Retinal attachment rates were higher in stage 4A (90.19%) and stage 4B ROP (89.13%) than in eyes with stage 5 ROP (60%). Visual acuity data were available in 52 eyes (48.59%), of which 25 eyes (48.07%) achieved letter-reading vision, whereas 27 eyes (51.93%) had counting fingers, light perception, or no light perception. Favorable VA (≥20/200) was achieved in 53.8% (14/26) of eyes with stage 4A ROP and 16.7% (4/24) of eyes with stage 4B ROP. Among eyes with letter-reading vision, the approximate Snellen VA was 20/100 in stage 4A ROP and 20/209 in stage 4B ROP. None of the eyes with stage 5 ROP achieved letter-reading vision. Glaucoma was the most common complication (26.16%), followed by clinically significant cataract formation (13.08%).</p><p><strong>Conclusions: </strong>LSV preserves letter-reading vision in about half of stage 4A eyes and in one of every six stage 4B eyes. A reattached retina does not guarantee measurable acuity, and no stage 5 eye in this series read letters.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}