Warda Darwisch, Dominik Weber, Katarzyna Wieczorek, André Maurice Trouvain, Karl Boden, Philipp Ken Roberts, Peter Szurman, Boris Viktor Stanzel
{"title":"Internal limiting membrane (ILM) flap reposition facilitates preservation of the inner retina in surgically closed full-thickness macular holes.","authors":"Warda Darwisch, Dominik Weber, Katarzyna Wieczorek, André Maurice Trouvain, Karl Boden, Philipp Ken Roberts, Peter Szurman, Boris Viktor Stanzel","doi":"10.1097/IAE.0000000000004581","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004581","url":null,"abstract":"<p><strong>Purpose: </strong>To compare inner retinal thinning after an Internal Limiting Membrane (ILM) flap reposition technique to ILM peeling in full-thickness macular holes (FTMH).</p><p><strong>Methods: </strong>This retrospective study included a total of 78 eyes (71 consecutive patients) with primary FTMH undergoing vitrectomy between 10/2022 -12/2023. Exclusion criteria were secondary macular holes, high myopia, glaucoma and prior surgery except cataract-surgery. Eyes were separated by surgical technique into Group A (ILM flap repositioning; n = 30) and Group B (ILM peeling alone n = 48). We compared mean thickness/volume of parafoveal (3 mm) and perifoveal (6 mm Early Treatment Diabetic Retinopathy Study subfields) Retinal Nerve Fiber Layer (RNFL), Ganglion Cell Layer (GCL) and Inner Plexiform Layer (IPL) at six months after surgery (M6) to baseline (M0). Secondary, we assessed anatomical closure rate and visual acuity.</p><p><strong>Results: </strong>Anatomical type 1 closure was achieved in 90.00% (A) and 80.00% (B) without significant difference. For consistency in the subsequent analysis, only cases with successful closure were included. Preservation analysis at M6 showed thicker (P = .006) and more volume (P = .010) in parafoveal RNFL in Group A, whereas perifoveal GCL remained thicker (P = .001) and with more volume (P = .002) in Group A. IPL did not differ between the groups. Visual acuity improved by time (P < .001) without differing between the groups.</p><p><strong>Conclusions: </strong>Compared to ILM peeling, macular hole treatment with ILM flap repositioning results in better preserved RNFL and GCL, while maintaining a high closure rate and similar postoperative visual acuity.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Outcomes of a Novel Technique That Does Not Require Head Position in Macular Hole Surgery: Application of Viscoelastic on an Inverted ILM Flap Under Air.","authors":"Sevim Ayça Seyyar, Oğuzhan Saygılı, Ayşegül Çömez, Erhan Kanat, Veysel Doğru","doi":"10.1097/IAE.0000000000004609","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004609","url":null,"abstract":"<p><strong>Purpose: </strong>To report outcomes of a novel technique involving the injection of a dispersive viscoelastic device on to inverted temporal internal limiting membrane (ILM) flap under air for macular hole (MH) closure, without requiring postoperative head positioning.</p><p><strong>Methods: </strong>A temporal ILM flap was created in all patients and inverted over the MH with perfluorocarbon liquid (PFCL). After a fluid-air exchange, a PFCL-air exchange was done. Afterwards, a dispersive viscoelastic agent was applied around the inverted flap under air, covering an area of two-to-three-disc diameters. An air-sulfur hexafluoride (SF6) exchange was then performed, and the sclerotomies were closed. No head positioning was adviced postoperatively. Data on preoperative MH size, best-corrected visual acuity (BCVA), MH closure rate, and closure pattern were collected.</p><p><strong>Results: </strong>The study included 114 eyes from 106 patients. Initial MH closure was achieved in 112 eyes (98.2%), with two cases closed after a second surgery. U-shaped closure occurred in 71.9%, V-shaped in 20.1%, and W-shaped in 8%. Significant BCVA improvement was observed (p<0.001), with no significant change in IOP (p=0.881).</p><p><strong>Conclusion: </strong>This technique enhances flap stabilization, facilitates MH closure, and eliminates the need for postoperative head positioning, leading to favorable anatomical and functional outcomes with improved patient comfort.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ioanna Ploumi, Xinyi Ding, Francesco Romano, Jenny Gan, Edward S Lu, Ying Cui, Krystal Phu, Ying Zhu, Kayla N Nodecker, Shivesh H Shah, Dimitrios P Ntentakis, Itika Garg, Filippos Vingopoulos, Demetrios G Vavvas, Deeba Husain, Leo A Kim, Nimesh A Patel, John B Miller
{"title":"Associations Between Predominant Peripheral Lesions and Systemic Complications of Diabetes Mellitus.","authors":"Ioanna Ploumi, Xinyi Ding, Francesco Romano, Jenny Gan, Edward S Lu, Ying Cui, Krystal Phu, Ying Zhu, Kayla N Nodecker, Shivesh H Shah, Dimitrios P Ntentakis, Itika Garg, Filippos Vingopoulos, Demetrios G Vavvas, Deeba Husain, Leo A Kim, Nimesh A Patel, John B Miller","doi":"10.1097/IAE.0000000000004620","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004620","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the association between predominant peripheral lesion (PPL) with systemic microvascular and macrovascular complications of diabetes mellitus (DM).</p><p><strong>Methods: </strong>Cross-sectional, retrospective study.182 eyes from 100 diabetic patients were imaged using ultra-widefield color fundus photographs (UWF-CFP). UWF-CFP were assessed by 2 graders for presence and extent of PPL. Comprehensive demographic and clinical data were collected from electronic medical records. Generalized estimating equations were used to determine the association between PPL and systemic complications of DM.</p><p><strong>Result: </strong>PPL were identified in 69 out of 182 eyes [37.9%]. Both presence and extent of PPL were significantly associated with peripheral arterial disease (presence: OR=11.36, p=0.033; extent: OR=1.63, p=0.036), coronary artery disease (OR=5.86, p<0.001; OR=1.82, p=0.001), and stroke (OR=10.11, p=0.003; OR=1.99, p=0.007). The presence of PPL was also significantly associated with diabetic nephropathy (OR=2.97, p=0.016) and decreased estimated glomerular filtration rate (β = -12.66, p = 0.037). No significant associations were found between PPL and diabetic neuropathy or diabetic foot complications.</p><p><strong>Conclusion: </strong>We highlight the strong link between PPL and diabetic vascular complications, suggesting their potential as an imaging biomarker of systemic vascular susceptibility. Early detection of PPL could facilitate risk stratification and proactive management of these severe complications, ultimately improving patient outcomes.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"BILATERAL MACULAR ATROPHY IN AN ADULT HEALTHY WOMAN.","authors":"Kemal Tekin, Mehmet Yasin Teke","doi":"10.1097/IAE.0000000000004615","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004615","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Choriocapillaris features in fellow eyes of thick and thin polypoidal choroidal vasculopathy.","authors":"Kwang-Eon Choi, Hyun Woo Chung, Cheolmin Yun","doi":"10.1097/IAE.0000000000004610","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004610","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze features of the choriocapillaris in fellow eyes with thick and thin polypoidal choroidal vasculopathy (PCV).</p><p><strong>Methods: </strong>We retrospectively reviewed optical coherence tomography (OCT) and OCT-angiography in the fellow eyes of patients with unilateral PCV. Patients were categorized into thick and thin PCV groups based on a subfoveal choroidal thickness of 250 μm. The choriocapillaris characteristics of the fellow eyes were compared with the controls.</p><p><strong>Results: </strong>We classified 59, 53, and 63 patients into thick PCV, thin PCV, and control groups, respectively. No difference was found in the total number of flow voids among the three groups. The total flow void (FV) density (%) differed among the thick PCV group (25.64±8.57), thin PCV group (29.72±7.61), and control group (30.35±6.78) (P < 0.001). The number and density of large-sized (>400 μm2) FVs also differed among the thick PCV group (2177.63±887.10, 20.49±11.31%), thin PCV group (2605.92±806.05, 25.58±10.48%), and control group (2807.14±789.49, 25.93±9.38%) (P < 0.001, 0.006).</p><p><strong>Conclusion: </strong>In PCV, the FV characteristics of the choriocapillaris in the fellow eyes differed between the thick and thin PCV groups. This finding suggests that the conditions of the choroid and choriocapillaris may vary between thick and thin PCV.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georges AbouKasm, Seyyedehfatemeh Ghalibafan, Ronaldo Nuesi, Flavius Beca, Michael Klufas, Nimesh A Patel, Ninel Z Gregori, Nicolas A Yannuzzi
{"title":"\"Feasibility of the BIONIKO 3D-Printed Eye Model as a Training Tool for Internal Limiting Membrane Peeling\".","authors":"Georges AbouKasm, Seyyedehfatemeh Ghalibafan, Ronaldo Nuesi, Flavius Beca, Michael Klufas, Nimesh A Patel, Ninel Z Gregori, Nicolas A Yannuzzi","doi":"10.1097/IAE.0000000000004612","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004612","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate ophthalmology trainees' experience with BIONIKO 3D-printed eye model in internal limiting membrane (ILM) peeling.</p><p><strong>Methods: </strong>Ophthalmology trainees were randomly assigned to two groups, BIONIKO-first and Eyesi-first, performing ILM peels on both models. Surgical performance was assessed via Eyesi score output, while an anonymous survey assessed model effectiveness.</p><p><strong>Results: </strong>Thirty-nine trainees participated (20 BIONIKO-first, 19 Eyesi-first). The BIONIKO-first group had a higher mean Eyesi score (50.63±31.68 vs. 37.53±30.30, p=0.497). The Eyesi-first group achieved a higher ILM peeling rate inside the macula (95.05%±4.58 vs. 92.66%±10.75, p=0.039). Completion time and forceps use were comparable. The BIONIKO-first group had fewer total spotted hemorrhages (2.4±2.1 vs. 4.4±3.6, p=0.035), while macular and retinal injuries were similar.Subgroup analysis by training level showed that in the junior group, BIONIKO-first resulted in fewer hemorrhages (p=0.012), while Eyesi-first had higher ILM peeling rate inside the macula (p=0.002). Among seniors, BIONIKO-first demonstrated a statistically lower area of macular injury (0.02 mm2±0.05 vs. 0.07 mm2±0.12, p=0.020).Survey results favored BIONIKO for tactile feedback (p=0.002) and surgical realism (p<0.001), while Eyesi was preferred for procedural feedback (p<0.001).</p><p><strong>Conclusion: </strong>BIONIKO and Eyesi models offer complementary advantages. A hybrid approach may optimize skill acquisition and patient safety in vitreoretinal surgery training.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aygun Orhan, Kadayifcilar Sibel, Karakaya Jale, Eldem Bora
{"title":"Assessment of Clinical Features and Prognosis in Behçet's Disease Patients with Ocular Manifestations: A Focus on Optical Coherence Tomography and Angiography.","authors":"Aygun Orhan, Kadayifcilar Sibel, Karakaya Jale, Eldem Bora","doi":"10.1097/IAE.0000000000004613","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004613","url":null,"abstract":"<p><strong>Purpose: </strong>To compare retinal microvascular structures in ocular (active/inactive) Behçet's disease (OBD) and non-ocular Behçet's disease (NOB) using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA).</p><p><strong>Methods: </strong>This cross-sectional study included patients with active/inactive OBD, NOB, and healthy controls. Disease activity was based on clinical findings and fluorescein angiography. OCT and OCTA assessed retinal, choroidal thicknesses, vascular density (VD) and perfusion density (PD), and optic nerve head flow, and foveal avascular zone (FAZ) characteristics. The primary aim was to identify retinal and choroidal microvascular alterations to assess their potential as biomarkers for disease activity and progression.</p><p><strong>Results: </strong>16 active OBD, 38 inactive OBD, 20 NOB, and 33 control eyes were analyzed. Most OBD patients were on stable immunosuppressive therapy. Central macular thickness was significantly lower in the inactive OBD eyes (239,9±42.1µm) than in active OBD (275,3±52,3 µm), NOB (263,3±22,6 µm), and controls (267,6±23,6 µm)(P=0.000). Inner retinal layer thicknesses were also reduced (p<0.05). The mean VD and PD were decreased in inactive OBD compared to NOB and controls (p<0.05). Active/inactive OBD patients demonstrated significantly higher FAZ areas and perimeters and significant deterioration in the circularity index at the deep capillary plexus, correlating with visual acuity loss (p<0.05). BCVA was 20/32 (0.63; 0.48 logMAR) in active OBD, 20/36 (0.55; 0.41 logMAR) in inactive OBD, and 20/20 (1.00; 0.00 logMAR) in NOB and controls.</p><p><strong>Conclusion: </strong>OCT and OCTA identify retinal thinning and vascular loss in OBD, with VD, PD, and FAZ metrics serving as markers of disease activity and visual function.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Near InfraRed Reflectance Imaging for the Assessment of Geographic Atrophy Using Deep Learning.","authors":"Aviv Fineberg, Alon Tiosano, Nili Golan, Bar Yacobi, Nadav Loebl, Inbar Smila Perchik, Assaf Dotan, Rita Ehrlich, Orly Gal-Or","doi":"10.1097/IAE.0000000000004614","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004614","url":null,"abstract":"<p><strong>Purpose: </strong>Near-infrared reflectance (NIR) imaging is a widely available but underutilized modality for assessing geographic atrophy (GA), a late-stage manifestation of dry age-related macular degeneration. This study aims to develop and evaluate a fully automated deep-learning-based approach for detecting GA on NIR imaging.</p><p><strong>Methods: </strong>NIR images of patients aged ≥ 50 years with GA, confirmed by two retinal specialists, were analyzed at Rabin Medical Center. The control group included NIR images of patients with healthy-appearing retinas. Models were trained and evaluated based on accuracy, precision, sensitivity, F1-Score, and DICE coefficient.</p><p><strong>Results: </strong>A total of 113 GA patients and 119 controls were included. The classification dataset contained 330 images, and the localization dataset included 659 images. Classification models performed well, with accuracy above 95%, while Vision Transformer B16 achieved the best results (precision=98.5%, sensitivity=98.4% and accuracy=98.5%). For GA localization, YOLOv8-Large achieved 91% sensitivity, 91% precision, an IoU of 84%, and a DICE coefficient of 88%.</p><p><strong>Conclusion: </strong>GA can be reliably identified using NIR images. Deep learning models can assist in evaluating GA on this routinely available imaging modality, aiding in the selection of patients who may benefit from emerging therapies.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of Characteristics and Treatment Outcomes of Type 1 and Type 2 Myopic Choroidal Neovascularization After Anti-Vascular Endothelial Growth Factor Therapy.","authors":"Teck Boon Tew, Yi-Ting Hsieh, Mei-Chi Tsui, Yun Hsia, Cheng-Yung Lee, Shih-Wen Wang, Chien-Jung Huang, I-Hsin Ma, Kuo-Chi Hung, Tso-Ting Lai, Chang-Hao Yang, Chung-May Yang, Tzyy-Chang Ho","doi":"10.1097/IAE.0000000000004611","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004611","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to compare baseline characteristics and treatment outcomes of type 1 and type 2 myopic choroidal neovascularization (CNV) after one year of anti-vascular endothelial growth factors (VEGF) therapy and identify clinical factors associated with visual outcomes, recurrence rates, and injection numbers.</p><p><strong>Methods: </strong>In this retrospective study, we reviewed 171 patients with active mCNV treated with anti-VEGF therapy and followed for at least one year. CNV types were classified using optical coherence tomography (OCT). Baseline characteristics, including best-corrected visual acuity (BCVA), myopic maculopathy grade, and OCT findings, were compared.</p><p><strong>Results: </strong>Type 1 CNVs (19.3% of cases) exhibited worse baseline BCVA and more advanced macular degeneration than type 2 CNVs. Both types showed significant visual improvement equivalent to 2.2 lines post-therapy, with no difference in recurrence rates or injection numbers. Multivariate analysis revealed that baseline BCVA, severity of myopic macular degeneration, and presence of subretinal hyperreflective exudation were significant predictors of final BCVA, while CNV type was not an independent predictor.</p><p><strong>Conclusion: </strong>Despite more severe macular degeneration in type 1 CNV, both types myopic CNVs benefit significantly from anti-VEGF therapy. These findings support extending treatment to type 1 CNVs and highlight the need for individualized management strategies.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Glenn J Jaffe, Gábor Deák, Kara Gibson, Rahul N Khurana, Eric Nudleman, Yuichiro Ogura, Ursula Schmidt-Erfurth, Tracey Wang, Peter D Westenskow, David Wong, Glenn Yiu, Jeffrey R Willis
{"title":"IMPACT OF FARICIMAB VERSUS AFLIBERCEPT ON EPIRETINAL MEMBRANE FORMATION OVER 2 YEARS IN PATIENTS WITH DIABETIC MACULAR EDEMA IN THE PHASE 3 YOSEMITE AND RHINE TRIALS.","authors":"Glenn J Jaffe, Gábor Deák, Kara Gibson, Rahul N Khurana, Eric Nudleman, Yuichiro Ogura, Ursula Schmidt-Erfurth, Tracey Wang, Peter D Westenskow, David Wong, Glenn Yiu, Jeffrey R Willis","doi":"10.1097/IAE.0000000000004572","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004572","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the effects of faricimab versus aflibercept on epiretinal membrane (ERM) formation in eyes with diabetic macular edema (DME).</p><p><strong>Methods: </strong>Post hoc analysis of phase 3 YOSEMITE/RHINE trial data in eyes with DME receiving faricimab Q8W, faricimab treat-and-extend (T&E; up to Q16W depending on central subfield thickness [CST] and best-corrected visual acuity [BCVA]), or aflibercept Q8W for 100 weeks.</p><p><strong>Results: </strong>ERMs developed in 3.8% (23/602) of eyes treated with faricimab Q8W, 5.1% (31/608) with faricimab T&E, and 7.6% (45/590) with aflibercept Q8W at 100 weeks. ERMs were less likely with faricimab Q8W versus aflibercept Q8W (odds ratio [OR] 0.48, 95% confidence interval [CI] 0.29-0.81, P = 0.0055). Mean (SD) BCVA at 100 weeks in eyes with and without ERMs were 69.2 (13.6) letters [20/40 Snellen] versus 73.8 (13.1) [20/40 Snellen], respectively; mean (SD) CSTs were 315.8 (99.2) vs. 274.6 (74.1) µm. Faricimab T&E dosing intervals were extended ≥ Q12W in 79.7% of eyes without ERMs versus 50.0% with ERMs.</p><p><strong>Conclusion: </strong>Risk of ERMs was 52% lower with faricimab Q8W versus aflibercept Q8W over 100 weeks in eyes with DME, suggesting a potential role for faricimab in reducing pre-retinal fibrotic proliferation. Results may help inform physician/patient decision-making when initiating intravitreal therapy.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}