{"title":"Correspondence.","authors":"Christoph R Clemens, Florian Alten, Nicole Eter","doi":"10.1097/IAE.0000000000004152","DOIUrl":"10.1097/IAE.0000000000004152","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Eye Transient Ischemia Attack Full Record.","authors":"Xuequan Sun, Qining Chen, Lei Gao","doi":"10.1097/IAE.0000000000004089","DOIUrl":"10.1097/IAE.0000000000004089","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Macular thickness fluctuations and visual acuity outcomes after intravitreal dexamethasone implant for diabetic macular edema.","authors":"Héloïse Torres-Villaros, Rhyme Timoumi, Franck Fajnkuchen, Arnaud Klokner, Audrey Giocanti-Aurégan","doi":"10.1097/IAE.0000000000004213","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004213","url":null,"abstract":"<p><strong>Purpose: </strong>To assess macular thickness fluctuations and their association with visual acuity (VA) outcomes in eyes with diabetic macular edema (DME) treated with intravitreal dexamethasone (DEX) implant.</p><p><strong>Methods: </strong>The standard deviation (SD) of all post-baseline central subfield thicknesses (CST) recorded over a 12-month period after the first injection of DEX implant was used to quantify CST fluctuations. Linear regression models were used to identify factors associated with the VA at 12 months (measured with the Early Treatment of Diabetic Retinopathy Study (ETDRS) score), and predictors of CST SD.</p><p><strong>Results: </strong>A retrospective review of 80 eyes of 80 patients treated with DEX implant for DME revealed a CST SD of 75.3 ± 50.3 μm. The CST SD was negatively associated with the VA at 12 months (-7.7 EDTRS letters for each 100-µm increase in CST SD, p=0.01), while changes in CST from baseline did not show any significant association. Eyes were stratified into quartiles based on the CST SD and a difference by -14.2 letters in VA at 12 months was observed between the first and fourth quartiles (p <0.001). Significant predictors of CST SD included the baseline VA (-12.0 μm for each 10-letter increase, p=0.02), and the number of DEX injections received (n=17.1, p=0.03).</p><p><strong>Conclusion: </strong>Greater fluctuations in retinal thickness were found to be associated with poorer visual outcomes in eyes with DME treated with DEX implant. Analyzing the CST SD could be a more predictive indicator of visual prognosis than individual measurements of the CST.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Sabatino, Sandra Banderas-García, Niall Patton, Felipe Dhawahir-Scala
{"title":"Intraoperative closure of large full thickness macular holes with perfluorocarbon liquid.","authors":"Francesco Sabatino, Sandra Banderas-García, Niall Patton, Felipe Dhawahir-Scala","doi":"10.1097/IAE.0000000000004219","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004219","url":null,"abstract":"<p><strong>Purpose: </strong>To report the role of perfluorocarbon liquid (PFCL) and passive extrusion for management of large full thickness macular holes (FTMHs).</p><p><strong>Methods: </strong>A standard pars plana vitrectomy with induction of posterior vitreous detachment was performed for all patients. After internal limiting membrane (ILM) peel, a bubble of perfluorocarbon liquid (PFCL) was injected over the posterior pole and passive extrusion of fluid was performed with a backflush instrument below the PFCL bubble, without touching the FTMH edges, until the FTMH centre was reached. Intraoperative optical coherence tomography (OCT) showed formation of an inner retina roof in all cases and confirmed intraoperative FTMH closure. Complete PFCL removal was performed after fluid-air exchange and gas tamponade was utilised in all cases.</p><p><strong>Results: </strong>Preoperative FTMH mean aperture size was 761um and standard deviation (SD) 100um (range 682-918um). FTMH closure was achieved in all eyes and visualised intraoperatively with OCT. After an average follow-up of 2 months, there was improvement in the mean BCVA and central scotoma.</p><p><strong>Conclusion: </strong>FTMH closure can be achieved intraoperatively with the use of PFCL and passive extrusion. The described surgical technique could be a valid alternative for repair of large FTMHs.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142086403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monica Lewis, Alex Brown, Monique Riemann, Luis F Goncalves, Aparna Ramasubramanian
{"title":"Doppler Ultrasound Twinkling Artifact in Retinoblastoma.","authors":"Monica Lewis, Alex Brown, Monique Riemann, Luis F Goncalves, Aparna Ramasubramanian","doi":"10.1097/IAE.0000000000004262","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004262","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sparing versus Removal of Epiretinal Proliferation in the Surgical Repair of Full-thickness Macular Holes.","authors":"Masaki Fukushima, Kotaro Tsuboi, Ryota Akai, Yuichiro Ishida, Shunji Kusaka, Motohiro Kamei, Atsushi Hayashi, Taku Wakabayashi","doi":"10.1097/IAE.0000000000004261","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004261","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of vitrectomy with epiretinal proliferation (EP) sparing for full-thickness macular hole (FTMH) accompanied by EP.</p><p><strong>Methods: </strong>A multicenter, retrospective study. Eyes were divided into two groups: the sparing group (Group S) included eyes in which the EP around the hole was peeled and preserved, whereas the removal group (Group R) included eyes in which the EP was partially or completely removed. The internal limiting membrane was peeling in all eyes.</p><p><strong>Results: </strong>Forty-six eyes were included. Twenty-five eyes were in Group S, and 21 eyes were in Group R, with no difference in preoperative best-corrected visual acuity (BCVA) (P = 0.96). After primary surgery, MHs were closed in all eyes, and there were no complications in either group. Postoperative 12-month BCVA significantly improved in both groups (both P < 0.01), while Group S had better 12-month BCVA than Group R (P = 0.016). In the multivariable analysis, EP sparing was associated with better BCVA at 12 months (P = 0.006) after accounting for the minimal macular hole size and preoperative BCVA.</p><p><strong>Conclusions: </strong>EP sparing and removal were both safe and effective techniques, while EP sparing may provide a favorable outcome for eyes with FTMH and EP.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fengjun Zhang, Qiong Zou, Qiuping Liu, Zhipeng You
{"title":"CHARACTERISTICS OF 'NOTCH' IN RETINOPATHY OF PREMATURITY FOLLOWING INTRAVITREAL RANIBIZUMAB MONOTHERAPY.","authors":"Fengjun Zhang, Qiong Zou, Qiuping Liu, Zhipeng You","doi":"10.1097/IAE.0000000000004231","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004231","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the clinical features and significance of \"notch\" in reactivation of retinopathy of prematurity (ROP) post-intravitreal ranibizumab (IVR) monotherapy.</p><p><strong>Methods: </strong>Ninety-six infants (173 eyes) with type 1 or aggressive ROP (A-ROP) post-IVR monotherapy were retrospectively analyzed; 51 eyes were notch (+) and 122 eyes were notch (-). General demographics and clinical outcomes were compared by notch status for type 1 and A-ROP.</p><p><strong>Results: </strong>The notch primarily appeared in stage 2 ROP (84.4 and 78.9%) at the junction of zones I and II (68.8 and 63.2%) on the temporal side in type 1 ROP and A-ROP. Notch was present in the type 1 ROP group before first IVR but post-treatment in the A-ROP group. A significantly higher reactivation rate, longer follow-up duration, and postmenstrual age at last follow-up were seen in the notch (+) versus the notch (-) group. In the notch (+) ROP group, the mean gestational age (28.34±0.93 vs. 29.94±1.48 weeks) was significantly lower in reactivated versus regressed eyes.</p><p><strong>Conclusion: </strong>Notches appeared at different times but similar locations in type 1 ROP and A-ROP. The reactivation rate after IVR was increased in ROP with notches. Notch may be a useful biomarker for reactivation after IVR in ROP.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Higher subfoveal choroidal thickness in choroidal melanomas than in choroidal nevi.","authors":"Abdelmajid Benlarbi, Denis Malaise, Juliana Estrada Walker, François Apéré, Livia Lumbroso-Le Rouic, Francine Behar-Cohen, Nathalie Cassoux, Alexandre Matet","doi":"10.1097/IAE.0000000000004254","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004254","url":null,"abstract":"<p><strong>Purpose: </strong>To compare subfoveal choroidal thickness (SFCT) between eyes with choroidal melanoma and choroidal nevi.</p><p><strong>Methods: </strong>Retrospective study of 126 consecutive patients in a tertiary ocular oncology center. Eyes with tumors located less than two disc-diameters from the fovea were excluded. In eyes with naevi, factors of potential transformation into melanoma were recorded (orange pigment, subretinal fluid, thickness >2 mm, diameter >5 mm, ultrasound hollowness). SFCT was assessed by 3 independent observers on horizontal spectral-domain OCT scans.</p><p><strong>Results: </strong>Sixty-seven eyes with choroidal melanoma and 59 eyes with choroidal nevi were included. The melanoma and nevi groups did not differ in gender (P=0.14) nor age (P=0.34). There was a very good agreement between the three independent observers for SFCT measurements (intraclass correlation coefficient=0.89). Mean SFCT was higher in melanomas (294.3±89.9 µm) than naevi (260.3±76.7 µm) (P=0.013), and the difference remained significant between melanomas and 28 naevi with ≥2 growth risk factors (256.3±77.0 µm) (P=0.027). In a multivariate model, the significant contributors to SFCT were presence of melanoma (P=0.004), younger age (P<0.0001) and shorter lesion distance to the fovea (P=0.016).</p><p><strong>Conclusion: </strong>SFCT may reflect the interplay between melanocytic tumors and their choroidal microenvironment. Its clinical utility should be explored in future studies.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The efficacy of intravitreal anti-VEGF for radiation maculopathy: a systematic review and meta-analysis.","authors":"Sheng-Chu Chi, Hsin-Ho Chang","doi":"10.1097/IAE.0000000000004255","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004255","url":null,"abstract":"<p><strong>Background: </strong>Anti-vascular endothelial growth factor (VEGF) therapy is the primary approach for managing radiation maculopathy. However, a noticeable gap exists in meta-analyses evaluating the efficacy of anti-VEGF therapy specifically in the context of radiation maculopathy.</p><p><strong>Methods: </strong>We conducted a review of comparative studies on anti-VEGF treatment up to October 2023. References were sourced from PubMed, EMBASE, and the Cochrane Library. The Cochrane Risk of Bias tool assessed the quality of randomized controlled trials (RCTs), while the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool evaluated non-RCTs.</p><p><strong>Results: </strong>Thirteen articles originating from eleven trials involving 2,525 eyes of 2408 patients were included. Four trials with 2226 eyes examined the effect of preventive anti-VEGF. Four trials with 189 eyes assessed the effect of anti-VEGF for preexisting maculopathy, and three trials with 110 eyes compared different anti-VEGF treatment modalities. In the preventive anti-VEGF treatment meta-analysis over a 24-month follow-up, the anti-VEGF group exhibited significantly fewer cases of radiation maculopathy (OR: 0.40; 95% CI: 0.25, 0.66, P= .0003, I2 =45%). For the meta-analysis of anti-VEGF treatment for pre-existing radiation maculopathy over a 6-month follow-up, the anti-VEGF group showed improved visual acuity (SMD: -1.13, 95% CI: -1.69 to -0.56, P < .0000, I2 = 47%) and decreased central macular thickness (SMD: -0.59, 95% CI: -1.13 to -0.05, P = 0.03, I2 = 62%).</p><p><strong>Conclusion: </strong>Prophylactic anti-VEGF effectively prevents radiation maculopathy and is also beneficial in treating pre-existing radiation maculopathy. Intensive treatment initially provides early benefits, but the efficacy diminishes after transitioning to a treat-and-extend regimen.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
William Foulsham, Luis Martinez-Velazquez, Kenneth Matthew McKay
{"title":"Unilateral scleral icterus due to spontaneous suprachoroidal hemorrhage.","authors":"William Foulsham, Luis Martinez-Velazquez, Kenneth Matthew McKay","doi":"10.1097/IAE.0000000000004260","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004260","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}