Mohamed Sherif Morsy, Nehal Nailesh Mehta, Amr L Ali, Anna Heinke, Dirk-Uwe Bartsch, Lingyun Cheng, William R Freeman
{"title":"COMPARISON OF ULTRAHIGH-SPEED 250 kHz OCTA WITH HIGH-SPEED 125 kHz MODE USING HEIDELBERG SPECTRALIS SHIFT: A Paired-Eye Analysis.","authors":"Mohamed Sherif Morsy, Nehal Nailesh Mehta, Amr L Ali, Anna Heinke, Dirk-Uwe Bartsch, Lingyun Cheng, William R Freeman","doi":"10.1097/IAE.0000000000004751","DOIUrl":"10.1097/IAE.0000000000004751","url":null,"abstract":"<p><strong>Purpose: </strong>Optical coherence tomography angiography is widely used to detect choroidal neovascularization in retinal diseases, but acquiring high-density raster scans can prolong acquisition time and increase motion artifacts due to patient fatigue. This study evaluates whether the 250 kHz ultrahigh-speed mode (3× faster than baseline) reduces scan time and motion artifacts while maintaining image quality compared with the FDA-approved 125 kHz mode.</p><p><strong>Methods: </strong>Fifty-eight eyes underwent 10°×10° fovea-centered optical coherence tomography angiography imaging using both modes. In 38 choroidal neovascularization eyes, AngioTool was used to analyze vascular metrics. In 20 nonchoroidal neovascularization eyes, superficial foveal avascular zone area was measured using ImageJ. Two masked retina specialists graded paired images for image quality, motion artifacts, and clinical diagnosis. Acquisition time was recorded.</p><p><strong>Results: </strong>The 250 kHz mode reduced acquisition time by 43% (17.5 ± 9.0 seconds vs. 33.6 ± 20.7 seconds, P < 0.00001). Image quality and motion artifacts favored the 250 kHz mode. Clinical diagnosis was rated similarly across modes. Quantitative metrics, including vessel area, junctions, lacunarity, and foveal avascular zone area, showed no significant differences (all P > 0.1).</p><p><strong>Conclusion: </strong>This is the first intraindividual comparison of Heidelberg's 250 kHz and 125 kHz optical coherence tomography angiography modes. The findings demonstrate that ultrahigh-speed scanning can enhance efficiency and image quality without compromising diagnostic or quantitative utility, highlighting its potential clinical impact pending Food and Drug Administration approval.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"829-835"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yehonatan Weinberger, Ori Mekiten, Ethan Priel, Edward Barayev, Amit Meshi, Rita Ehrlich, Assaf Dotan, Dov Weinberger, Orly Gal-Or
{"title":"IMAGING CHARACTERISTICS OF MACULAR NEOVASCULARIZATION IN PATIENTS WITH CHRONIC CENTRAL SEROUS CHORIORETINOPATHY.","authors":"Yehonatan Weinberger, Ori Mekiten, Ethan Priel, Edward Barayev, Amit Meshi, Rita Ehrlich, Assaf Dotan, Dov Weinberger, Orly Gal-Or","doi":"10.1097/IAE.0000000000004754","DOIUrl":"10.1097/IAE.0000000000004754","url":null,"abstract":"<p><strong>Purpose: </strong>To study the morphologic characteristics of Type1 macular neovascularization (MNV) in eyes with chronic central serous chorioretinopathy (CSCR) using optical coherence tomography (OCT) and OCT angiography (OCTA).</p><p><strong>Methods: </strong>Patients with chronic CSCR and secondary Type 1 MNV were included in the study. Macular OCT and OCTA images were acquired, and morphologic characteristics along with quantifiable features were analyzed.</p><p><strong>Results: </strong>Twenty eyes of 19 patients were included. All eyes exhibited neovascular flow signal on OCTA images. Nineteen eyes (95%) showed flat-irregular pigment epithelium detachment (flat irregular pigment epithelium detachment [FIPED]). Subretinal fluid (SRF) was detected in 90% of patients with no intraretinal fluid. Membranes were mostly located at the subfoveal area (65%). All membranes were identified in the location overlying choroidal pachyvessels. Mature membranes with a loose vascular configuration were identified in 75% of eyes. Morphologic biomarkers of \"indistinct\" (65%), \"tangled\" (30%), and \"sea-fan\" (5%) patterns were recorded. Feeder vessels was identified in 75% of membranes. The average vascular density was measured as 46% (±10%).</p><p><strong>Conclusion: </strong>Neovascular membranes of chronic CSCR sprout under the retinal pigment epithelium within the macular area (Type 1 MNV) inside an FIPED overlying pachyvessels. Morphologic characteristics assessed by OCTA of loose and indistinct pattern improve our understanding of vessel formation and maturation in patients with chronic CSCR and might be valuable to guide therapy.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"888-896"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TRANSMACULAR PACHYVESSELS BENEATH POLYPOIDAL CHOROIDAL VASCULOPATHY LESIONS PREDICT LATER RECURRENCE.","authors":"Hisashi Fukuyama, Tomomi Kawa, Yuki Yamamoto, Fumi Gomi","doi":"10.1097/IAE.0000000000004758","DOIUrl":"10.1097/IAE.0000000000004758","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between the spatial arrangement of pachyvessels and polypoidal choroidal vasculopathy (PCV) lesions in relation to recurrence.</p><p><strong>Methods: </strong>This retrospective study included 58 eyes of 58 patients with treatment-naive PCV who were followed for at least 1 year after receiving anti-vascular endothelial growth factor injections, with or without photodynamic therapy. Using en face optical coherence tomography, the eyes were categorized into 2 groups based on the presence or absence of transmacular pachyvessels passing beneath PCV lesions (polypoidal lesions or branching neovascular networks). The primary outcome was the recurrence rate of PCV within 1 year.</p><p><strong>Results: </strong>Of the 58 eyes, 35 (60.3%) had pachyvessels located beneath PCV lesions. The 1-year recurrence rate was significantly higher in eyes with pachyvessels than without (71.4% vs. 39.1%, P = 0.017). Univariable logistic regression analysis identified the presence of pachyvessels beneath lesions as a significant predictor (odds ratio, 3.89; 95% confidence interval, 1.28-11.84; P = 0.017). This remained the only significant predictor of recurrence within 1 year on multivariable logistic regression (odds ratio, 3.84; 95% confidence interval, 1.22-12.09; P = 0.022).</p><p><strong>Conclusion: </strong>The presence of transmacular pachyvessels may serve as a novel biomarker to predict prognosis and guide individualized treatment strategies for patients with PCV. These findings suggest that the anatomical relationship between pachyvessels and PCV lesions could be a critical factor in treatment response.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"927-933"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Omer Dor, May Cohen, Marganit Shahar-Gonen, Anat Loewenstein, Tunde Peto, David Wright, Reut Shor, Moshe Havilio, Gidi Benyamini, Qing Wen, Noam Shomron, Dinah Zur
{"title":"ANTI-VEGF THERAPY SWITCHING IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: Insights from Automated Volumetric Retinal Fluid Analysis.","authors":"Omer Dor, May Cohen, Marganit Shahar-Gonen, Anat Loewenstein, Tunde Peto, David Wright, Reut Shor, Moshe Havilio, Gidi Benyamini, Qing Wen, Noam Shomron, Dinah Zur","doi":"10.1097/IAE.0000000000004756","DOIUrl":"10.1097/IAE.0000000000004756","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of switching from bevacizumab to ranibizumab or aflibercept in neovascular age-related macular degeneration (nAMD) using automated volumetric retinal fluid analysis.</p><p><strong>Methods: </strong>This retrospective study included 186 eyes with nAMD showing inadequate response after ≥3 bevacizumab injections. Patients were switched to a second-line anti-VEGF agent and categorized as early (3-5 injections) or late (≥6 injections) switchers. Optical coherence tomography (OCT) scans were analyzed using the Notal-OCT Analyzer (NOA), an AI-based algorithm for retinal fluid quantification. Parameters included total retinal fluid (TRF), intraretinal fluid (IRF) volume, subretinal fluid (SRF) volume, pigment epithelial detachment (PED) volume, central subfield thickness (CST), and visual acuity (VA), assessed at baseline, after bevacizumab, and after three injections of the new agent.</p><p><strong>Results: </strong>Early switchers showed an increase in TRF from 105 nL to 158 nL after bevacizumab, then a reduction to 20 nL postswitch ( P < 0.001); PED volume decreased postswitch ( P = 0.010). Late switchers showed fluid reductions both after bevacizumab and postswitch (TRF: P < 0.001; PED: P = 0.007). CST significantly improved only in early switchers ( P = 0.004), while VA changes were not statistically significant.</p><p><strong>Conclusion: </strong>Automated fluid analysis reliably quantifies treatment response in nAMD. Early switchers showed worsening after bevacizumab, while late switchers had partial responses. These findings highlight the potential of automated analysis to support more individualized, data-driven treatment strategies. Prospective studies are required to confirm impact on patient outcomes.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"897-904"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ivo De Clerck, Maarten Schoovaerts, Martina Polidoro, Mouloud Ourak, Emmanuel Vander Poorten, Peter Stalmans
{"title":"IN-HUMAN FEASIBILITY AND SAFETY OF SUBRETINAL DRUG INJECTION THROUGH ATTACHED RETINA USING A ROBOTIC COMANIPULATION SYSTEM.","authors":"Ivo De Clerck, Maarten Schoovaerts, Martina Polidoro, Mouloud Ourak, Emmanuel Vander Poorten, Peter Stalmans","doi":"10.1097/IAE.0000000000004745","DOIUrl":"10.1097/IAE.0000000000004745","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate feasibility and safety of robot-assisted subretinal injections through attached retina using the comanipulated Mynutia system in patients with submacular hemorrhage.</p><p><strong>Methods: </strong>This prospective, single-center case series included 20 eyes undergoing vitrectomy with subretinal recombinant tissue plasminogen activator between June 2024 and August 2025. The EVA Inicio microinjection system with a 38-G needle was mounted on the Mynutia system. Injections were performed through attached retina when feasible. Primary outcomes were successful needle insertion, stable subretinal positioning for ≥3 minutes, safe withdrawal, and absence of device-associated adverse events (DAE). Secondary outcomes included injection parameters, hemorrhage displacement, visual outcomes, and complications.</p><p><strong>Results: </strong>Robot-assisted injection succeeded in all eyes; one required injection into the submacular hemorrhage because of anatomy. Mean injection duration was 178 ± 34 seconds (max 400), but the needle tip was maintained in the subretinal space ≥3 minutes in all cases. No DAE occurred. Retinotomies closed spontaneously without visible reflux. Mean bleb initiation and propagation pressures were 10.3 ± 3.2 and 3.0 [3.0-3.25] PSI, respectively; internal limiting membrane peeling reduced initiation pressure ( P < 0.05). Complete subfoveal displacement was achieved in 95%. Median BCVA improved from LogMAR 1.85 (counting fingers) to 0.66 (20/90) at 6 weeks ( P < 0.001). Adverse events included hyphema (5%), ocular hypertension (5%), vitreous hemorrhage (25%; 80% self-limited), RPE tear (20%), and recurrent submacular hemorrhage (5%).</p><p><strong>Conclusion: </strong>Robot-assisted subretinal injection with Mynutia is feasible and safe, enabling stable, prolonged low-pressure delivery through attached retina, and may enhance precision and tissue preservation in subretinal therapies.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"811-818"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optical Coherence Tomography-Angiography in the Regression of Macular Choroidal Neovascularization Associated With MacTel2: Three-Year Follow-up.","authors":"Gilda Cennamo, Michele Rinaldi, Ciro Costagliola","doi":"10.1097/IAE.0000000000004675","DOIUrl":"10.1097/IAE.0000000000004675","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"e36-e37"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETINAL AND PERIPAPILLARY MICROVASCULAR FEATURES IN PEDIATRIC HENOCH-SCHÖNLEIN PURPURA WITHOUT OCULAR INVOLVEMENT: An Optical Coherence Tomography Angiography Study.","authors":"Sevim A Seyyar, Gizem Gürbostan Soysal, Veysel DoĞru, OĞuzhan Saygılı, Serkan Coşkun","doi":"10.1097/IAE.0000000000004750","DOIUrl":"10.1097/IAE.0000000000004750","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate subclinical retinal and peripapillary microvascular alterations in pediatric patients with Henoch-Schönlein purpura (HSP) without ocular involvement using optical coherence tomography angiography.</p><p><strong>Methods: </strong>This prospective observational study included 95 right eyes of 95 children aged 5 years to 15 years, comprising 40 patients with HSP and 55 age- and sex-matched healthy controls. All participants underwent comprehensive ophthalmologic examination and optical coherence tomography angiography imaging. Quantitative parameters included superficial capillary plexus and deep capillary plexus vessel densities (VD) in foveal, parafoveal, and perifoveal regions; foveal avascular zone area; radial peripapillary capillary-VD; and peripapillary retinal nerve fiber layer thickness. Intergroup comparisons and correlation analyses between optical coherence tomography angiography metrics and disease duration, clinical finding score, and disease activity score were performed in the HSP group.</p><p><strong>Results: </strong>Baseline ocular parameters were comparable between the HSP and control groups, except for lower central corneal thickness ( P = 0.002). Optical coherence tomography angiography revealed significantly decreased foveal superficial capillary plexus-VD ( P = 0.003) and decreased deep capillary plexus-VD in the nasal perifoveal region ( P = 0.004) in patients with HSP. Correlation analysis revealed that foveal avascular zone area positively correlated with disease duration (r = 0.48, P = 0.001), whereas parafoveal superficial capillary plexus-VD negatively correlated with clinical finding score (r = -0.45, P = 0.004). In addition, nasal perifoveal deep capillary plexus-VD showed significant negative correlations with both clinical finding score (r = -0.52, P < 0.001) and disease duration (r = -0.44, P = 0.005).</p><p><strong>Conclusion: </strong>Pediatric patients with HSP without clinical ocular involvement demonstrate measurable macular microvascular impairment and foveal avascular zone enlargement on optical coherence tomography angiography. Optical coherence tomography angiography may serve as a sensitive, noninvasive tool for early detection of subclinical retinal vascular alterations, facilitating risk stratification and individualized ophthalmic monitoring.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"950-957"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meira Neudorfer, Miri M Fogel Levin, Ari Leshno, Noam Brakin, Adiel Barak, Dinah Zur, Anat Loewenstein, Iris Moroz, Shulamit Schwartz
{"title":"OPTICAL DENSITY RATIO AS A PROGNOSTIC BIOMARKER FOR CHRONICITY IN CENTRAL SEROUS CHORIORETINOPATHY.","authors":"Meira Neudorfer, Miri M Fogel Levin, Ari Leshno, Noam Brakin, Adiel Barak, Dinah Zur, Anat Loewenstein, Iris Moroz, Shulamit Schwartz","doi":"10.1097/IAE.0000000000004763","DOIUrl":"10.1097/IAE.0000000000004763","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the prognostic significance of baseline subretinal fluid (SRF) optical density ratio (ODR) in first-onset central serous chorioretinopathy.</p><p><strong>Methods: </strong>This retrospective study included patients with a new diagnosis of central serous chorioretinopathy, no prior retinal disease, and at least 3 months of follow-up. Eyes were categorized as resolved or nonresolved based on SRF resolution at 3 months. Optical density ratio was calculated as the ratio between SRF and vitreous optical densities on baseline optical coherence tomography scans.</p><p><strong>Results: </strong>Thirty-nine patients (33 men, 6 women; mean age 41.4 ± 9.1 years) met the inclusion criteria. At 3 months, SRF resolved in 19 eyes and persisted in 20 eyes. Baseline ODR was significantly higher in the nonresolved group compared with the resolved group (1.03 ± 0.32 vs. 0.80 ± 0.27; P = 0.018). Visual acuity at follow-up was significantly better in the resolved group (20/21.4 [logarithm of the minimum angle of resolution 0.03 ± 0.05] vs. 20/26.4 [logarithm of the minimum angle of resolution 0.12 ± 0.16]; P = 0.035). No significant differences were found between groups in age, sex, or choroidal thickness. In multivariate logistic regression, ODR remained the only independent predictor of SRF persistence at 3 months.</p><p><strong>Conclusion: </strong>Baseline ODR is associated with both fluid persistence and visual outcomes. As the only independent predictor of persistent SRF in this cohort, ODR shows promise as a potential prognostic biomarker requiring no additional cost to identify patients at higher risk for chronic disease at initial presentation.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"881-887"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meryem Feyza Cicek, Turker Oba, Fatma Feyza Nur Keskin Perk, Mesut Ayer, Feyza Onder
{"title":"NONINVASIVE EVALUATION OF CHORIORETINAL AND PERIPAPILLARY MICROVASCULAR ALTERATIONS IN ESSENTIAL THROMBOCYTHEMIA.","authors":"Meryem Feyza Cicek, Turker Oba, Fatma Feyza Nur Keskin Perk, Mesut Ayer, Feyza Onder","doi":"10.1097/IAE.0000000000004757","DOIUrl":"10.1097/IAE.0000000000004757","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the retinal, peripapillary, and choroidal microvascular structures in patients with essential thrombocythemia (ET), a myeloproliferative neoplasm characterized by sustained thrombocytosis and an increased risk of thrombotic events, using optical coherence tomography angiography (OCTA).</p><p><strong>Methods: </strong>This prospective, cross-sectional study included 20 ET patients and 20 age- and sex-matched healthy controls. All participants underwent spectral-domain OCTA to assess vessel density (VD) in the superficial and deep retinal capillary plexuses (SCP and DCP), radial peripapillary capillary (RPC) network, and choriocapillaris (CC). Structural parameters, including central macular thickness (CMT), macular ganglion cell complex (mGCC), retinal nerve fiber layer (RNFL), and foveal avascular zone (FAZ), were also evaluated. Statistical analyses included independent samples t-tests or Mann-Whitney U tests based on data distribution.</p><p><strong>Results: </strong>Patients with ET exhibited significantly increased CMT compared with controls ( P = 0.019), whereas RNFL and mGCC thicknesses showed no significant differences. Peripapillary whole image VD and RPC VD in the nasal-inferior quadrant were significantly reduced in the ET group ( P = 0.042 and P = 0.039, respectively). Most notably, DCP VD was significantly decreased in both parafoveal ( P = 0.004) and perifoveal ( P = 0.010) regions across all quadrants. No significant differences were observed in SCP VD, FAZ metrics, or CC flow parameters ( P > 0.05 for all).</p><p><strong>Conclusion: </strong>Patients with ET demonstrate subclinical retinal microvascular alterations predominantly affecting the DCP and peripapillary circulation, whereas superficial retinal and choroidal vasculature remains relatively preserved. OCTA may serve as a sensitive, noninvasive tool for detecting early retinal involvement in ET.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"958-966"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arnaldo F Bordon, Peter K Kaiser, Armin Wolf, Liyi Cen, Jens Heyn, Dragan Urosevic, Francis Dodeller, Lisa Allmannsberger, Rufino Silva
{"title":"EFFICACY AND SAFETY OF THE PROPOSED BIOSIMILAR AFLIBERCEPT, SDZ-AFL, IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: 52-Week Results From the Phase 3 Mylight Study: Erratum.","authors":"Arnaldo F Bordon, Peter K Kaiser, Armin Wolf, Liyi Cen, Jens Heyn, Dragan Urosevic, Francis Dodeller, Lisa Allmannsberger, Rufino Silva","doi":"10.1097/IAE.0000000000004832","DOIUrl":"10.1097/IAE.0000000000004832","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"e40"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}