Retina-The Journal of Retinal and Vitreous Diseases最新文献_第10页

The Role of Gliosis in Idiopathic Epiretinal Membranes: New Insights.

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-02-12 DOI: 10.1097/IAE.0000000000004429

Alberto Quarta, Lucio Zeppa, Maria Ludovica Ruggeri, Matteo Gironi, Agbeanda Aharrh-Gnama, Marta Di Nicola, Annamaria Porreca, Francesco Matarazzo, Lisa Toto, Rodolfo Mastropasqua

{"title":"The Role of Gliosis in Idiopathic Epiretinal Membranes: New Insights.","authors":"Alberto Quarta, Lucio Zeppa, Maria Ludovica Ruggeri, Matteo Gironi, Agbeanda Aharrh-Gnama, Marta Di Nicola, Annamaria Porreca, Francesco Matarazzo, Lisa Toto, Rodolfo Mastropasqua","doi":"10.1097/IAE.0000000000004429","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004429","url":null,"abstract":"Methods: Baseline and 6-months measurements included Snellen acuity (SA), central retinal thickness (CRT), the presence of microcystic macular edema (MME), outer retinal cysts (ORC), disruptions of the ellipsoid zone (EZ) and external limiting membrane (ELM) and quantitative analysis on MC-SLO were analyzed. The study primarily evaluated postoperative SA improvement, CRT reduction, and the prevalence of ERM remnants. Additionally, the relationship between gliotic components and postoperative outcomes was analyzed.Results: In stage 2 ERMs, clear ERMs had a higher incidence of ERM remnants after surgery (81.8% vs. 30.8%, p = 0.037). Both groups experienced visual acuity improvement (clear ERMs: +25 ETDRS letter score, cloudy ERMs: +15 ETDRS letter score p = 0.013). In stage 3 ERMs, no significant differences in SA or CRT changes were noted, but clear ERMs showed more inner retinal dimples (p = 0.015). Gliosis area and EIFL thickness showed significant correlation in cloudy stage 3 ERMs (p = 0.011).Conclusions: Clear and cloudy ERMs differ in postoperative recovery. Cloudy stage 2 ERMs have less functional recovery but fewer remnants than clear ERMs. In stage 3, gliosis correlates with EIFL severity, and clear ERMs exhibit more inner retinal dimples.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative Three-Dimensional Fluorescein Angiography-Guided Pars Plana Vitrectomy for the Treatment of Multiple Retinal Diseases.

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-02-12 DOI: 10.1097/IAE.0000000000004430

Xi Wang, Ruolan Ling, Hongzhuang Cheng, Yadan Shen, Li Chen, Xinru Ning, Chuyun Guo, Jie Li, Zhong Jie, You Wang

{"title":"Intraoperative Three-Dimensional Fluorescein Angiography-Guided Pars Plana Vitrectomy for the Treatment of Multiple Retinal Diseases.","authors":"Xi Wang, Ruolan Ling, Hongzhuang Cheng, Yadan Shen, Li Chen, Xinru Ning, Chuyun Guo, Jie Li, Zhong Jie, You Wang","doi":"10.1097/IAE.0000000000004430","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004430","url":null,"abstract":"Purpose: To explore the effectiveness and practicality of intraoperative fluorescein angiography (IOFA) in both common and rare retinal diseases.Methods: We conducted a case series study involving three patients with vascular abnormality from various causes. A custom-designed, single-photon ultra-wideband spectral light source and integrated filters were utilized to perform IOFA. The cases included one patient with diabetic retinopathy, one with Coat's disease, and one with familial exudative vitreoretinopathy (FEVR). IOFA was performed, and individualized treatment was conducted based on the angiographic findings.Results: All three patients had successful IOFA, and two of them also underwent pars plana vitrectomy (PPV) guided by the IOFA results. Postoperative outcomes were favorable, with controlled disease progression and improved or stable vision. The diabetic retinopathy patient's vision improved significantly post-surgery, the Coats disease patient's retinal detachment resolved without recurrence, and the FEVR patient showed no further bleeding on follow-up.Conclusion: The integration of an enhanced light source and filters reduced the transition time from standard surgical mode to angiography mode to just 10 seconds. Moreover, this study demonstrates that IOFA can effectively guide PPV surgeries and treatment for both common and rare retinal vascular diseases, offering a promising direction for personalized retinal disease management. In addition, further research and clinical trials are warranted to confirm the efficacy of IOFA-guided targeted retinal photocoagulation, particularly in diabetic retinopathy-induced vitreous hemorrhage.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serotonin Reuptake Inhibitors may reduce the risk of Retinal Vein Occlusion.

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-02-06 DOI: 10.1097/IAE.0000000000004426

Faye Thomas, Jonathan Lochhead

{"title":"Serotonin Reuptake Inhibitors may reduce the risk of Retinal Vein Occlusion.","authors":"Faye Thomas, Jonathan Lochhead","doi":"10.1097/IAE.0000000000004426","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004426","url":null,"abstract":"Purpose: To investigate any difference in the rate of serotonin reuptake inhibitor (SRI) use in patients with retinal vein occlusions (RVO), compared to an age matched control group.Methods: Retrospective data collection of risk factors and prescribed drugs from consecutive electronic patient records of all patients diagnosed with RVO over 5 years. Routine, age matched patients were identified for a control group. The two groups were compared with Chi2 test and multiple Logistic regression. Odds ratios (OR) were calculated.Results: In total, 775 patients were included in this study. 283 patients were in the RVO group and 492 in the control group. The rate of SRI and Statin use was significantly different in both groups for all ages (p<0.001). Logistic regression confirmed a significant reduction in RVO associated with SRI use (OR 0.39), Statins (OR 0.51) and combined drugs (OR 0.22) with all groups reaching statistical significance (p<0.001).Conclusion: This study has found lower rates of RVO in patients receiving an SRI or a Statin compared to controls. This data suggests that individuals taking an SRI are less likely to suffer a RVO and SRIs may have an additive effect when combined with Statins.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CORRESPONDENCE REGARDING THE ARTICLE "SUPRACHOROIDAL TRIAMCINOLONE ACETONIDE FOR REFRACTORY POSTOPERATIVE CYSTOID MACULAR EDEMA".

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-02-06 DOI: 10.1097/IAE.0000000000004422

Neha Joshi, Mihir Vaidya, Parth Mehta, Anand Subramanyam

引用次数: 0

Image Quality and Safety of 300 mg versus 100 mg Fluorescein in Ultra-widefield Fluorescein Angiography: A Randomized Clinical Trial.

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-02-06 DOI: 10.1097/IAE.0000000000004420

Seok Hyeon Song, Kwangsic Joo, Se Joon Woo, Min Seok Kim

{"title":"Image Quality and Safety of 300 mg versus 100 mg Fluorescein in Ultra-widefield Fluorescein Angiography: A Randomized Clinical Trial.","authors":"Seok Hyeon Song, Kwangsic Joo, Se Joon Woo, Min Seok Kim","doi":"10.1097/IAE.0000000000004420","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004420","url":null,"abstract":"Purpose: To compare the image quality and safety of ultra-widefield fluorescein angiography (UWFA) using 3 ml (300 mg) versus 1 ml (100 mg) of 10% fluorescein.Methods: In this prospective, randomized clinical trial, a total of 144 patients who required UWFA examination for various retinal diseases were randomized 1:1 to 300 mg or 100 mg of fluorescein. Images were qualitatively graded by three retinal specialists and quantitatively analyzed. The primary outcome measure was the assessment of image quality (scored in a five-point scale). Quantitative sub-analysis among normal UWFA images through pixel intensity in posterior and mid-peripheral zone was also performed.Results: A total of 67 participants in each group were included in the analysis. The mean difference of image quality between two dose groups was within the predefined non-inferiority margin of 0.5 (0.005; 95% confidence interval, -0.145 to 0.154). The mean pixel intensity showed no significant differences in both posterior and mid-peripheral zone (P = 0.988 and 0.726, respectively). In the safety analysis, significantly fewer adverse events were observed with the lower dose (300 mg, 10 of 67 [14.9%] vs. 100 mg, 3 of 67 [4.5%], P = 0.041).Conclusion: We demonstrated the non-inferiority of image quality of low-dose fluorescein (100 mg) compared to a 300 mg dose with a reduction in the rate of adverse events associated with fluorescein angiography.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

REPLY TO "CORRESPONDENCE REGARDING THE ARTICLE SUPRACHOROIDAL TRIAMCINOLONE ACETONIDE FOR REFRACTORY POSTOPERATIVE CYSTOID MACULAR EDEMA".

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-02-06 DOI: 10.1097/IAE.0000000000004423

Bita Momenaei, Saagar A Pandit, Kristine Y Wang, Taku Wakabayashi, Jason Hsu, Carl D Regillo, Michael A Klufas, David Xu, Michael N Cohen, Sunir J Garg, Ajay E Kuriyan, Yoshihiro Yonekawa

引用次数: 0

Quantitative Fluorescein Angiography Biomarkers in Diabetic Macular Edema.

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-02-05 DOI: 10.1097/IAE.0000000000004424

Ryan S Huang, Andrew Mihalache, Marko M Popovic, Colyn Munn, Isabela Martins Melo, Aurora Pecaku, Alon Friedman, Miguel Cruz Pimentel, Tina Tang, Peng Yan, David T Wong, Rajeev H Muni

{"title":"Quantitative Fluorescein Angiography Biomarkers in Diabetic Macular Edema.","authors":"Ryan S Huang, Andrew Mihalache, Marko M Popovic, Colyn Munn, Isabela Martins Melo, Aurora Pecaku, Alon Friedman, Miguel Cruz Pimentel, Tina Tang, Peng Yan, David T Wong, Rajeev H Muni","doi":"10.1097/IAE.0000000000004424","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004424","url":null,"abstract":"Purpose: To investigate the association between baseline clinical characteristics of patients with diabetic macular edema (DME) and quantitative intravenous fluorescein angiography (IVFA) parameters.Methods: Consecutive patients with DME presenting with a central macular thickness (CMT) >310 μm were recruited from 2017-2023. Ultra-widefield IVFA images were analyzed with the RETICAD algorithm to extract quantitative measures of blood-retinal barrier (BRB) permeability, retinal perfusion, and blood flow. Univariable and multivariable regression models were used to investigate associations between IVFA parameters and baseline best-corrected visual acuity (BCVA), CMT, and macular volume.Results: The study population consisted of 56 eyes with DME, and seven eyes from healthy controls. In our multivariable analysis, BRB permeability measured in the central and peripheral retina was significantly associated with BCVA (p=0.003 and 0.002, respectively) and macular volume (p=0.025 and 0.045, respectively). Both central and peripheral BRB permeability were significantly higher in DME eyes relative to healthy controls (p<0.001).Conclusion: Increased BRB permeability measured on IVFA in DME eyes was associated with a greater baseline macular volume and worse BCVA, suggesting its potential in providing an objective assessment of disease severity. Future research should explore the clinical utility of quantitative IVFA measurements in diverse patient populations.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Change in retinal perfusion with aflibercept for central retinal vein occlusion: the two-year prospective observational HERMES study.

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-02-05 DOI: 10.1097/IAE.0000000000004425

Agnès Glacet-Bernard, Jean-François Girmens, Florence Coscas, Sylvia Nghiem-Buffet, Christophe Morel, Ali Erginay, Michel Weber, Xavier Wang, Camille Jung, Salomon-Yves Cohen, Tristan Aubert, Rocio Blanco-Garavito, Eric H Souied, Alexandra Miere

{"title":"Change in retinal perfusion with aflibercept for central retinal vein occlusion: the two-year prospective observational HERMES study.","authors":"Agnès Glacet-Bernard, Jean-François Girmens, Florence Coscas, Sylvia Nghiem-Buffet, Christophe Morel, Ali Erginay, Michel Weber, Xavier Wang, Camille Jung, Salomon-Yves Cohen, Tristan Aubert, Rocio Blanco-Garavito, Eric H Souied, Alexandra Miere","doi":"10.1097/IAE.0000000000004425","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004425","url":null,"abstract":"Purpose: To analyze retinal perfusion (RP) using ultrawide-field fluorescein angiography (UWFA) and optical coherence tomography angiography (OCTA), in patients with central retinal vein occlusion (CRVO) treated by intravitreal injection of aflibercept.Methods: Single-arm, multicenter, prospective, observational study. Treatment-naive eyes with CRVO initiated therapy with aflibercept. UWFA with correction of projection distortion and OCTA were performed at baseline (M0), M3, M12, and M24.Results: Fifty-six eyes were included. Visual acuity improved by 16 ETDRS letters at M12 (p<0.001), while mean central subfield thickness decreased from 801µm at M0 to 352µm at M12 (p<0.001). The ischemic index on UWFA increased from 17% at M0 to 23% at M3, and to 36% at M24. Ischemic CRVO accounted for 18% at M0, 25% at M3, and 39% at M24 (p<0.05). Vascular leakage was only present in 21% of eyes at M12. The density of the superficial and deep capillary plexus remained stable, but the foveal avascular zone enlarged from 0.37 mm2 at M0 to 0.61 mm2 at M24 (p=0.02). No cases of reperfusion were observed. The mean number of injections at M12 was 7.0±3.6.Conclusion: Changes in RP were characterized by worsening perfusion in the periphery, while macular capillaries maintained a generally stable density at M24, even in ischemic CRVO. These findings support the need for regular monitoring of peripheral retinal perfusion in treated patients to detect silent progression of nonperfusion, which may lead to neovascular complications, while visual acuity is maintained over the long term, likely due to the preserved macular capillary density.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultra-widefield indocyanine green angiographic changes after photodynamic therapy in central serous chorioretinopathy. CERTAIN study report 3.

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-02-04 DOI: 10.1097/IAE.0000000000004414

Laurenz J B Pauleikhoff, Jennifer M Chang-Wolf, Roselie M H Diederen, Annette C Moll, Reinier O Schlingemann, Elon H C van Dijk, Camiel J F Boon

{"title":"Ultra-widefield indocyanine green angiographic changes after photodynamic therapy in central serous chorioretinopathy. CERTAIN study report 3.","authors":"Laurenz J B Pauleikhoff, Jennifer M Chang-Wolf, Roselie M H Diederen, Annette C Moll, Reinier O Schlingemann, Elon H C van Dijk, Camiel J F Boon","doi":"10.1097/IAE.0000000000004414","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004414","url":null,"abstract":"Purpose: Venous overload choroidopathy (VOC), showing pachyvessels, choroidal intervortex venous anastomoses (CVA), asymmetric venous drainage (AVD), choroidal vascular hyperpermeability (CVH) and increased choroidal thickness (CT), is observed in the vast majority of central serous chorioretinopathy (CSC) patients based on ultra-widefield indocyanine green angiography (UWF ICGA). This report investigates how photodynamic therapy (PDT) alters signs of VOC.Methods: The CERTAIN study is a monocentric, retrospective study on consecutive CSC patients who underwent UWF ICGA. For this report, patients who underwent UWF ICGA twice were included. Two independent graders assessed changes in pachyvessels, CVA, AVD, CT and CVH when comparing pre- and post-PDT images of treated and untreated eyes.Results: In total, 38 eyes (19 patients) were included. Of those, 19 eyes had undergone PDT and 19 had not. PDT had no significant effect on pachyvessels, CVA, and AVD (all p > 0.05). Only CT (-51 ± 48 µm vs. 1 ± 43 µm, p = 0.006) and CVH within the PDT treatment area (79% vs. 0% reduced CVH, p < 0.0001) were significantly decreased in treated vs. untreated eyes.Conclusion: PDT reduced CT and CVH within the treatment area while not significantly altering the overall choroidal vascular architecture associated with VOC.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prophylactic Laser Retinopexy and Scleral Buckle Placement for Retinal Detachment Prevention in Pierson Syndrome: A Retrospective, Case Series Study.

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-02-03 DOI: 10.1097/IAE.0000000000004421

Richard N Sather, George Jiao, Jade Y Moon, Polly Quiram

{"title":"Prophylactic Laser Retinopexy and Scleral Buckle Placement for Retinal Detachment Prevention in Pierson Syndrome: A Retrospective, Case Series Study.","authors":"Richard N Sather, George Jiao, Jade Y Moon, Polly Quiram","doi":"10.1097/IAE.0000000000004421","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004421","url":null,"abstract":"Purpose: To report the impact of prophylactic 360° laser retinopexy and scleral buckle placement for retinal detachment (RD) prophylaxis in patients affected by Pierson syndrome (PS).Method: This retrospective case series included 11 PS patients (2015-2024), analyzing demographic data, ophthalmological exams, and genetic testing. Prophylactic interventions were compared with post-RD surgical interventions based on RD occurrence and timing. A one-sample proportion test evaluated outcome differences.Results: This study of 11 PS patients evaluated the effectiveness of prophylactic 360° laser retinopexy and scleral buckle (SB) placement. Ten patients carried the LAMB2 c.440A>G mutation and had associated findings of thyroid and renal disease. All retinal detachments (RDs) were combined tractional retinal detachment (TRD) and rhegmatogenous retinal detachment (RRD) due to posterior tears. Eight eyes with TRD-RRD were actively treated with laser retinopexy and SB; six (75%) experienced re-detachments. In contrast, seven eyes with TRD-RRD were treated prophylactically, with 86.6% of eyes treated with laser retinopexy and 100% of those receiving additional SB placement maintaining retinal integrity over an average follow-up of 3.4 years. Prophylactically treated eyes had significantly fewer RD recurrences compared to those treated surgically after RD onset (p < 0.01), highlighting the benefits of early combined intervention in PS.Conclusion: This study's results suggest a potential role for prophylactic laser retinopexy and subsequent scleral buckle placement to prevent RD among patients with a confirmed diagnosis of Pierson syndrome.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0