Retina-The Journal of Retinal and Vitreous Diseases最新文献

{"title":"ASSESSING THE REPEATABILITY OF INNER CHOROID FLOW DEFICIT PERCENTAGE IN INTERMEDIATE AGE-RELATED MACULAR DEGENERATION AND CONTROLS: A Comparative Study Between Different Post-Processing Approaches.","authors":"Francesco Romano, Xinyi Ding, Mauricio Garcia, Yan Zhao, Filippos Vingopoulos, Itika Garg, Isabella Stettler, Cade Bennett, Katherine Overbey, Matthew J Finn, Ioanna Ploumi, Inês Laìns, Nimesh A Patel, David M Wu, Demetrios G Vavvas, Deeba Husain, Joan W Miller, John B Miller","doi":"10.1097/IAE.0000000000004345","DOIUrl":"10.1097/IAE.0000000000004345","url":null,"abstract":"<p><strong>Purpose: </strong>To assess repeatability of macular inner choroid flow deficit percentage in intermediate age-related macular degeneration and controls using various postprocessing approaches.</p><p><strong>Methods: </strong>Cross-sectional, observational study. The authors included 1) 22 intermediate age-related macular degeneration and 24 control eyes, with 2) age >50 years, 3) visual acuity >20/32, and 4) no additional ocular and systemic confounders. Participants underwent four consecutive 6 × 6-mm optical coherence tomography angiography scans (2 acquired at 100-kHz and 2 at 200-kHz speed; PLEX Elite 9000) for intrasession analysis. Same protocol was repeated after 30 minutes for intersession analysis. Three slabs of different thicknesses were generated underneath Bruch membrane (4-14, 4-19, 4-24 µ m). All slabs were processed with: 1) binarization-only using Phansalkar method (r = 4-15 pixels); 2) compensation + binarization; 3) averaging + binarization; 4) averaging + compensation + binarization. Inner choroid flow deficit percentage was measured within 3-mm and 5-mm circles, and measurements were repeated after excluding drusen areas. Repeatability was analyzed with generalized linear mixed-effects models, intraclass correlation coefficients, and Levene variance test.</p><p><strong>Results: </strong>Most postprocessing approaches demonstrated high repeatability (intraclass correlation coefficient >0.75) with no significant test-retest differences ( P > 0.05). Compensation + binarization of 15- µ m slabs at 200 kHz showed the highest repeatability (intraclass correlation coefficient: 0.96-0.98). Excluding drusen did not significantly affect inner choroid flow deficit percentage measurements ( P > 0.05), showing increased intraclass correlation coefficients for 10-µm-thick and binarized-only slabs.</p><p><strong>Conclusion: </strong>Strong repeatability can be achieved with various postprocessing methods for assessing inner choroid flow deficit percentage, especially with compensation + binarization of 15- µ m slabs acquired at 200 kHz. Drusen removal does not seem to affect repeatability in intermediate age-related macular degeneration when using a swept-source device, except for specific settings. These results contribute to refining choriocapillaris assessment, paving the way for future applications.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"454-463"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INCREASING THE VISIBILITY DURING INTERNAL LIMITING MEMBRANE PEELING IN VITRECTOMY SURGERY: Evaluation of Monochrome Mode with Brilliant Blue G Staining Using the NGENUITY 3D Visualization System.","authors":"Keiji Matsumoto, Yoshihito Sakanishi, Tatsuya Fujii, Ayumi Usui-Ouchi, Toshiro Sakuma, Nobuyuki Ebihara","doi":"10.1097/IAE.0000000000004330","DOIUrl":"10.1097/IAE.0000000000004330","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study is to explore the effectiveness of using monochrome mode with Brilliant Blue G during vitrectomy surgery with the NGENUITY 3D Visualization System.</p><p><strong>Methods: </strong>Vitrectomy cases involving BBG-stained internal limiting membrane peeling with the NGENUITY 3D Visualization System (Alcon Laboratories, Inc.) at Juntendo University Urayasu Hospital from October 2022 to February 2023 were selected. The contrast ratios between peeled and stained internal limiting membrane areas under three settings were assessed: normal, yellow, and monochrome. In the monochrome setting, a yellow hue was used with zero saturation, while the Friedman test compared these ratios.</p><p><strong>Results: </strong>Nineteen patients (19 eyes; 7 males, 12 females; average age 68.5 ± 10.3 years) with retinal conditions such as epiretinal membrane (n = 11), macular hole (n = 4), macular traction syndrome (n = 3), and retinoschisis (n = 1) were included. We obtained contrast ratios of 1.57 ± 0.21 (normal), 1.60 ± 0.21 (yellow), and 1.92 ± 0.29 (monochrome). The monochrome setting showed significantly higher contrast than that shown by the normal and yellow settings (P = 0.0001, P = 0.0005), with no difference between the normal and yellow settings (P = 0.903).</p><p><strong>Conclusion: </strong>Monochrome mode in NGENUITY with Brilliant Blue G potentially enhances contrast and increases visibility during internal limiting membrane peeling.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":"45 3","pages":"486-490"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHRONIC RETINAL DETACHMENT: Surgical vs. Observational Approach With Optical Coherence Tomography Monitoring.","authors":"Ioanna Dimakopoulou, Georgios Mylonas, Aliki Kanata, Gregor S Reiter, Markus Schranz, Marcus Lisy, Michael Georgopoulos","doi":"10.1097/IAE.0000000000004335","DOIUrl":"10.1097/IAE.0000000000004335","url":null,"abstract":"<p><strong>Purpose: </strong>To elucidate the management of individuals with chronic retinal detachment, considering both surgical intervention and observation. The authors specifically focus on the long-term anatomical and functional outcomes, with a particular emphasis on optical coherence tomography follow-up.</p><p><strong>Methods: </strong>Data from 24 consecutive patients presenting with a chronic retinal detachment between 2014 and 2023 at the Department of Ophthalmology and Optometry, Medical University of Vienna, Austria, were retrospectively analyzed. The study used optical coherence tomography scanning with the Heidelberg Spectralis optical coherence tomography device's integrated measurement tool to assess the stability of chronic retinal detachment, potentially introducing optical coherence tomography as a follow-up tool for these patients.</p><p><strong>Results: </strong>The study included 27 eyes of 24 patients with an average age of 41.8 ± 13 years, and the mean follow-up time was 34 ± 27 months. Among the cases, 11 (41%) progressed and required surgery. Of these surgeries, 4 (37%) were scleral buckling and 7 (63%) were pars plana vitrectomy. After surgery, 64% experienced improved or stable vision, whereas 36% experienced a decrease in visual acuity. In the subgroup that had pars plana vitrectomy, two eyes (29%) had a redetachment, necessitating a second surgery. Meanwhile, 94% of untreated patients maintained stable 20/20 best-corrected visual acuity throughout the entire follow-up period.</p><p><strong>Conclusion: </strong>A cautious observation strategy could lead to superior outcomes when contrasted with more invasive management approaches in patients with chronic retinal detachment. Furthermore, when surgical intervention becomes imperative, the study suggests a preference for the adoption of a scleral buckling procedure in phakic patients without posterior vitreous detachment.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":"45 3","pages":"402-409"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION BETWEEN OBESITY AND ALTERATIONS IN PHOTORECEPTOR-RETINAL PIGMENT EPITHELIUM-CHORIOCAPILLARIS COMPLEX IN HEALTHY EYES.","authors":"Hongling Cheng, Zhiyang Lin, Kuangching Lin, Hao Chen, Xi Zhang, Meixiao Shen, Suzhong Xu","doi":"10.1097/IAE.0000000000004338","DOIUrl":"10.1097/IAE.0000000000004338","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effect of obesity on alterations in the photoreceptor-retinal pigment epithelium (RPE)-choriocapillaris complex.</p><p><strong>Methods: </strong>Two hundred and twenty participants with varying body mass index were enrolled and categorized into three groups: normal weight, overweight, and obese. Retinal and choroidal images were obtained using swept-source optical coherence tomography. Automatic segmentation was used for image analysis, evaluating retina thickness parameters such as retinal nerve fiber layer, ganglion cell layer and inner plexiform layer, inner nuclear layer, outer plexiform layer, outer nuclear layer, myoid and ellipsoid zone, outer segment of photoreceptors, RPE, and choroidal parameters including choroidal thickness, luminal area, stromal area, total choroidal area, choroidal vascular index, and choriocapillaris flow void percentage. Differences in photoreceptor-RPE-choriocapillaris complex among the groups and their correlation with body mass index were explored.</p><p><strong>Results: </strong>Compared with the control subjects, participants with obesity exhibited thinner myoid and ellipsoid zone and outer segment of photoreceptors, increased choriocapillaris flow void percentage, and thicker RPE. Correlation analysis revealed a negative correlation between body mass index and myoid and ellipsoid zone (r = -0.17, P = 0.01) and outer segment of photoreceptors (r = -0.16, P = 0.02), whereas a positive correlation was observed with RPE (r = 0.15, P = 0.00).</p><p><strong>Conclusion: </strong>Individuals with obesity may present with a thinner myoid and ellipsoid zone and outer segment of photoreceptors, thicker RPE, and reduced choriocapillaris perfusion, suggesting potential damage to the photoreceptor-RPE-choriocapillaris complex. These alterations in the photoreceptor-RPE-choriocapillaris complex alterations could serve as potential biomarkers for monitoring early pathologic and physiologic changes associated with obesity.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":"45 3","pages":"555-564"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INHERITED RETINAL DISEASE GENE PANEL IN POSTERIOR OR PANUVEITIS WITH DYSTROPHIC FEATURES.","authors":"Stéphane Abramowicz, Audrey Meunier, Dafina Draganova, Laure Caspers, Marieke De Bruyne, Stijn Van de Sompele, Elfride De Baere, Bart P Leroy, Laurence Postelmans, François Willermain","doi":"10.1097/IAE.0000000000004329","DOIUrl":"10.1097/IAE.0000000000004329","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the presence of American College of Medical Genetics and Genomics class 3, 4, and 5 genetic variants in inherited retinal disease (IRD) genes in posterior or panuveitis with dystrophic features (PUD) in a Belgian cohort.</p><p><strong>Methods: </strong>Multicentric, retrospective study of PUD cases diagnosed between January 2012 and February 2022. Inherited retinal disease gene panels were analyzed in every patient. Three PUD categories were defined as follows: idiopathic posterior or panuveitis with retinitis pigmentosa-like features (PURPL), idiopathic posterior or panuveitis with other dystrophic features (PUOD), and posterior or panuveitis with established ophthalmological or systemic etiology and dystrophic features (POSED).</p><p><strong>Results: </strong>The authors included 12 patients (7 women, 5 men). The mean age at inclusion was 52.2 years (26-80 years). Three patients demonstrated class 4 or 5 variants in genes that led to a diagnostic reclassification. One patient had a class 3 variant in an X-linked IRD gene that possibly explained his phenotype. Seven patients had variants in IRD genes that could not explain their phenotype. One patient had a negative panel result.</p><p><strong>Conclusion: </strong>Inherited retinal disease gene panel analysis allowed diagnosis refinement in 3/12 (25%) patients in the PUD cohort, all belonging to the PURPL subgroup. The authors recommend that all patients with PURPL benefit from gene panel testing to avoid overlooking undiagnosed IRDs.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":"45 3","pages":"509-521"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A RETROSPECTIVE STUDY ON THE OUTCOMES OF PNEUMATIC VITREOLYSIS FOR THE TREATMENT OF VITREOMACULAR TRACTION.","authors":"Ivo De Clerck, Juliette Bivort, Joachim Van Calster, Peter Stalmans","doi":"10.1097/IAE.0000000000004319","DOIUrl":"10.1097/IAE.0000000000004319","url":null,"abstract":"<p><strong>Purpose: </strong>To study the effectiveness and safety of pneumatic vitreolysis (PVL) for the treatment of symptomatic vitreomacular traction (VMT) and macular holes (MHs) with VMT.</p><p><strong>Methods: </strong>This was a retrospective, monocentric analysis of 92 consecutive VMT (±MH) patients treated with pneumatic vitreolysis at University Hospitals Leuven between January 2022 and March 2024.</p><p><strong>Results: </strong>Release of VMT occurred in 60% of the patients who had VMT and in 86% of the patients who had MHs. MH closure occurred in 29% of the small MHs. Lens status was the only predictor of VMT release, with an odds ratio of 0.232 for pseudophakia ( P = 0.013). Successful pneumatic vitreolysis was associated with significant improvements in the best-corrected visual acuity in patients with VMT ( P = 0.007) and in patients with MHs ( P = 0.034). Two patients (2.2%) suffered a retinal tear, one of which led to retinal detachment. Two patients with VMT (3.17%) developed a MH.</p><p><strong>Conclusion: </strong>Pneumatic vitreolysis using the injection of 0.2 cc of C2F6 and subsequent posturing seems to be beneficial with limited complications for symptomatic focal VMT and for (very) small MHs with VMT, especially in phakic patients. The complication rate in this study was lower than that previously reported.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"420-425"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FACTORS PREDICTIVE OF PERSISTENT SUBRETINAL FLUID IN ACUTE CENTRAL SEROUS CHORIORETINOPATHY.","authors":"Chika Hatakeyama, Keiko Kataoka, Yuji Yoshikawa, Makiko Nakayama, Akiko Yamamoto, Annabelle A Okada","doi":"10.1097/IAE.0000000000004343","DOIUrl":"10.1097/IAE.0000000000004343","url":null,"abstract":"<p><strong>Purpose: </strong>To identify the clinical parameters predictive of persistent subretinal fluid in acute central serous chorioretinopathy (CSC).</p><p><strong>Methods: </strong>Clinical data of consecutive eyes diagnosed with first-time, acute, treatment-naïve CSC followed up for at least 6 months from symptom onset were evaluated retrospectively. Acute CSC was defined as CSC in which symptoms were noticed within 3 months of presentation. Subretinal fluid, central retinal thickness, subfoveal choroidal thickness, and fundus autofluorescence were examined.</p><p><strong>Results: </strong>Of the 48 eyes in 48 patients, 38% exhibited subretinal fluid persisting for at least 6 months after the symptom onset. Fundus autofluorescence alterations at baseline were observed in 52% and 36% of affected and fellow eyes, respectively. Multivariable analysis showed that persistent fluid was significantly associated with the presence of fundus autofluorescence alterations in fellow eyes (odds ratio = 23.5, P = 0.024), in addition to greater age (odds ratio = 1.16, P = 0.015) and thicker central retinal thickness (odds ratio = 1.01, P = 0.022).</p><p><strong>Conclusion: </strong>Fellow eye fundus autofluorescence alterations, in addition to older age and thicker central retinal thickness, were significant predictors of persistent subretinal fluid in patients with acute CSC. These findings underscore CSC's bilateral aspects and noninvasive markers' role in predicting persistent subretinal fluid.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"548-554"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF RETINAL ARTERIOLES IN RETINITIS PIGMENTOSA: Arterial Lumen Diameter Reduced With Retinal Degeneration and Wall Thickness Related to Systemic Condition.","authors":"Junya Ota, Taiga Inooka, Ryo Tomita, Taro Kominami, Yoshito Koyanagi, Yasuki Ito, Hiroko Terasaki, Koji M Nishiguchi, Shinji Ueno","doi":"10.1097/IAE.0000000000004333","DOIUrl":"10.1097/IAE.0000000000004333","url":null,"abstract":"<p><strong>Purpose: </strong>Retinal arterioles are attenuated in eyes with retinitis pigmentosa, but dimensions such as lumen diameter and wall thickness have not been thoroughly investigated. The aim of the study was to determine the dimensions of reduced retinal arterioles in eyes with retinitis pigmentosa.</p><p><strong>Methods: </strong>The study included 66 patients with retinitis pigmentosa (66 eyes) and 36 control participants (36 eyes) for whom adaptive optics recordings of the retinal arteries were available. Lumen diameter and wall thickness were measured on the adaptive optics images. The correlations between arteriole dimensions and clinical parameters were determined.</p><p><strong>Results: </strong>The mean lumen diameter was significantly smaller in patients with retinitis pigmentosa than in controls, while the mean wall thickness did not differ significantly. Lumen diameter was significantly and positively correlated with the mean deviation of the Humphrey 10-2 field analyzer and ellipsoid zone width. The wall thickness and wall-to-lumen ratio were significantly and positively correlated with age and systolic blood pressure but not with mean deviation and ellipsoid zone width.</p><p><strong>Conclusion: </strong>Retinal arteriole dimensions were significantly correlated with retinal degeneration and systemic factors.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":"45 3","pages":"532-540"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the inverted internal limiting membrane flap technique with internal limiting membrane insertion technique for treatment of large macular holes.","authors":"Miao Zeng, Chunyan Cai, Xiao Chen","doi":"10.1097/IAE.0000000000004443","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004443","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the anatomical and functional outcomes of the inverted internal limiting membrane(ILM) flap technique and ILM insertion technique for the treatment of large macular holes(MHs).</p><p><strong>Methods: </strong>Seventy-four consecutive eyes with large MHs(minimum diameter ≥400 µm) were included. All patients underwent 25-gauge pars plana vitrectomy(PPV) with either inverted ILM flap technique(n=40) or ILM insertion technique(n=34). Swept source optical coherence tomography (SS-OCT) was performed before surgery and 12 months postoperatively. The rate of MH closure, postoperative best corrected visual acuity(BCVA) and SS-OCT findings were evaluated at 12 months after surgery.</p><p><strong>Results: </strong>MH closure was achieved in 34 eyes(85%) of the inverted ILM flap group and in 30 eyes(88.2%) of the ILM insertion group.There was no significant difference in the rate of MH closure(P=0.685). The mean BCVA improved from 1.30±0.81 logMAR (Snellen: 20/400) at baseline to 0.64±0.67 logMAR (Snellen: 20/87) at 12 months in the inverted ILM flap group, which was significanlty better than that in the insertion ILM group(P=0.047). At 12 months, the mean external limiting membrane (ELM) defect sizes was 106.68±196.25 µm in the inverted ILM flap group and 234.12±296.06 µm in the ILM insertion group, whereas the mean ellipsoid zone (EZ) defect sizes were 167.08±223.08 µm and 261.58±290.92 µm, respectively. The mean ELM defect sizes were significantly smaller in the inverted ILM flap group than in the ILM insertion group(p=0.039). However, there was no significant difference in mean EZ defect sizes between the two groups(P=0.160).</p><p><strong>Conclusion: </strong>Both the inverted ILM flap and the insertion ILM techniques were associated with high rates of MH closure in large MHs. The inverted ILM flap technique seemed to be more effective surgery for large MHs compared with the ILM insertion techniques in improving visual outcomes.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can changes on OCTA predict exudative activity on OCT in eyes with neovascular age related macular degeneration? The ACTOR Study.","authors":"Eric H Souied, Francesca Amoroso, Stéphanie Baillif, François Devin, Michel Weber, Donato Colantuono, Rocio Blanco-Garavito, Alexandra Miere","doi":"10.1097/IAE.0000000000004444","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004444","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the predictability of changes in neovascularization morphology on optical coherence tomography angiography (OCTA) in relation to exudative activity on structural optical coherence tomography (OCT) in eyes with neovascular age-related macular degeneration (nAMD) treated with ranibizumab 0.5 mg.</p><p><strong>Methods: </strong>Eighty-five eyes of 85 patients with nAMD, diagnosed less than 1 year prior to study entry and treated with ranibizumab 0.5 mg, were included in this longitudinal, prospective study. Included eyes had no exudative activity feature at study inclusion and were treated with ranibizumab 0.5 mg in a PRN regimen for the following 9 months. At each study visit structural OCT and OCTA were performed. Qualitative and quantitative vascular characteristics of macular neovascularization (MNV) were extracted at each visit and correlated with the presence of exudative activity on OCT.</p><p><strong>Results: </strong>No significant correlation was found between OCTA (neo)vascular characteristics in the absence of exudation with the presence of exudative activity on structural OCT the following month. OCTA's positive predictive value (PPV) for the overall population was 38.87% (confidence interval [33.8%; 44.2%]). The negative predictive value (NPV) of OCTA on the overall population was 60.92%. Inter-observer reproducibility of OCTA assessments Cohen's kappa=0.82.</p><p><strong>Conclusion: </strong>While OCTA may not be predictive of imminent exudative activity in nAMD, it brings additional information on MNV flow and holds potential as a tool for understanding vascular remodeling. Neovascularization remodeling and exudation may be two separate findings in the disease process in nAMD without necessarily having a causal relationship.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}