Retina-The Journal of Retinal and Vitreous Diseases最新文献

{"title":"INCIDENCE AND PREVALENCE OF NONINFECTIOUS UVEITIS: A Systematic Review and Meta-Analysis.","authors":"Aswen Sriranganathan, Jacob Stasso, Rafael N Miranda, Tina Felfeli","doi":"10.1097/IAE.0000000000004812","DOIUrl":"10.1097/IAE.0000000000004812","url":null,"abstract":"<p><strong>Purpose: </strong>To estimate the incidence and prevalence of noninfectious uveitis (NIU).</p><p><strong>Methods: </strong>A systematic literature search was conducted of electronic databases including Ovid MEDLINE, Embase, and Scopus from 2020 to September 2025. A random-effects meta-analysis pooled incidence and prevalence data across various demographic and comorbid contexts.</p><p><strong>Results: </strong>From 15,172 initial studies, 106 were included. The pooled prevalence of NIU was 131.6 (95% CI 28.1-613.9) for adults and 27.4 (95% CI 6.3-118.3) for pediatrics per 100,000 persons. Pooled incidence of NIU was 204.4 (95% CI 0.0-438.9) for adults and 16.0 (95% CI 6.5-25.6) for pediatrics per 100,000 person-years. Increased incidence and prevalence of NIU were seen in populations of Juvenile idiopathic arthritis (JIA), undifferentiated spondyloarthritis (SpA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), and Behcet disease (BD). The prevalence of NIU in JIA was 129.2 (95% CI 94.2-174.7) per 1,000 persons and incidence was 22.4 (95% CI 2.5-42.4) per 1,000 person-years. The prevalence and incidence of NIU in SpA was 153.5 (95% CI 122.0-191.4) per 1,000 persons and 33.5 (95% CI 0.0-69.2) per 1,000 person-years, respectively. The prevalence and incidence of NIU in PsA was 27.3 (95% CI 18.1-41.2) per 1,000 persons and 13.1 (95% CI 0.0-32.5) per 1,000 person-years, respectively. The prevalence of NIU in AS and BD was 183.5 (95% CI 137.8-240.1) and 148.6 (95% CI 17.6-629.9) per 1,000 persons, respectively.</p><p><strong>Conclusion: </strong>NIU incidence and prevalence were higher in adults than in children, and in populations with specific conditions such as JIA and AS.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"1325-1336"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SURGICAL MANAGEMENT AND OUTCOMES OF LARGE HIGH MYOPIC MACULAR HOLES: Global Macular Hole Multicenter Study 3.","authors":"Tianyu Liu, Nassim A Abreu-Arbaje, Joana Andoh, J Fernando Arevalo, Remzi Avci, Bernardo Bach, Maria C Bohorquez, H Culver Boldt, Timothy M Boyce, Ana L Carauni, Matteo M Carla, Viet Q Chau, Hung-Da Chou, Adrienne Coche, Francesco M D'Alterio, Jason Fan, Tina Felfeli, Mariantonia Ferrara, Magno A Ferreira, Carolina Galvá Goriup, Stratos Gotzaridis, Ninel Z Gregori, Ahmed M Habib, Ian C Han, Yi-Ting Hsieh, Makoto Inoue, Kazuaki Kadonosono, Motohiro Kamei, Levent V Karabas, Jacob Keeley, Shohei Kitahata, Sandeep Kumar, Chi-Chun Lai, Bingqian Liu, Lin Lu, Mohamed M Mahgoub, Efrem Mandelcorn, Ahmed Mansour, Carlos Mateo, Ryo Matoba, Yuki Morizane, Christine Morozova, Zofia A Nawrocka, Jerzy Nawrocki, Marcio B Nehemy, Ronaldo Nuesi, Ogugua N Okonkwo, Ecem O Tokuc, Sengul Ozdek, Ece O Zeydanli, Jong G Park, Barbara Parolini, Fabio Patelli, Seemant Raizada, Revati Rashingkar, Eugen Reifschneider, Flavio A Rezende, Stanislao Rizzo, Mario R Romano, Stephen R Russell, Khalid A Sabti, Teresa Sandinha, Lydia Sauer, Alfonso Savastano, Daraius Shroff, Elliott H Sohn, David H Steel, Peter Szurman, Homayoun Tabandeh, Jonathan Than, Loka Thangamathesvaran, Kotaro Tsuboi, Mei-Chi Tsui, Ana R Viana, Hannah Walsh, George A Williams, Tom H Williamson, Chen Xi, Chung-May Yang, Aysegul M Yildiz, Tadashi Yokoi, Yoshihiro Yonekawa, Androniki Zampogianni, Tamer H Mahmoud","doi":"10.1097/IAE.0000000000004871","DOIUrl":"10.1097/IAE.0000000000004871","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the surgical management and outcomes of large high myopic macular holes (HMMHs).</p><p><strong>Methods: </strong>Global multicenter retrospective case series of HMMHs with minimum linear diameter ≥ 400 µ m undergoing surgery between 2013 and 2023 with follow-up ≥ 3 months. The main outcome measure was the HMMH closure rate at postoperative Month 3.</p><p><strong>Results: </strong>Four hundred and ninety-nine cases of 463 patients from 37 surgeons were included, with mean ± SD age 58.3 ± 12.2 years, 77.0% female, 77.4% primary, 22.6% refractory, and mean ± SD follow-up 18.8 ± 20.2 months. The mean ± SD (range) minimum linear diameter was 649 ± 280 (400, 2,759) µ m. Surgery techniques included 127 internal limiting membrane peels, 285 internal limiting membrane flaps, 19 amniotic membrane transplantations, 36 autologous retinal transplantations, and 32 others. The postoperative Month 3 closure rate for all cases was 72.4%. Closure rates significantly decreased with greater CLOSE Study Group size classification for HMMHs treated with internal limiting membrane peeling or internal limiting membrane flap ( P = 0.006) but not for HMMHs treated with amniotic membrane transplantations or autologous retinal transplantations ( P > 0.05). Visual acuity significantly increased from baseline to each follow-up time point among all eyes, with a final mean ± SD change in visual acuity of -0.29 (0.55) logMAR (+14.5 early treatment diabetic retinopathy study letters), which did not significantly differ by surgery type.</p><p><strong>Conclusion: </strong>High myopic macular hole closure rates are lower than those reported for macular holes in nonhighly myopic eyes, but most eyes can still achieve anatomical closure and meaningful visual acuity gains when treated with the appropriate technique.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"1345-1362"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CENTENARIAN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.","authors":"Vittorio Capuano, Serena Fragiotta, Jeremy Abadou, Riccardo Sacconi, Alexandra Miere, Francesca Amoroso, Eric H Souied, Giuseppe Querques","doi":"10.1097/IAE.0000000000004837","DOIUrl":"10.1097/IAE.0000000000004837","url":null,"abstract":"<p><strong>Purpose: </strong>To report clinical characteristics of exudative neovascular age-related macular degeneration in centenarian patients.</p><p><strong>Methods: </strong>A retrospective, longitudinal study conducted in two retinal referral centers in Europe. Clinical characteristics of patients with neovascular age-related macular degeneration having at last follow-up at least 100 years and older were reviewed.</p><p><strong>Results: </strong>Twenty-eight eyes from 14 patients (13 women), with a mean baseline age of 95.7 (SD 4.1) years and a mean follow-up duration of 89 months (39.9). The mean age at the last follow-up was 102.4 (1.7) years. Most eyes (86%) presented Type 1 macular neovascularization. At the last follow-up, best-corrected visual acuity was stable or improved in 57% of eyes, with a mean final best-corrected visual acuity of 53 letters (21.8), Snellen equivalent 20/100. Eyes with better visual outcomes (>50 letters) had significantly higher baseline best-corrected visual acuity ( P < 0.001) and thicker subfoveal choroidal thickness ( P = 0.03). Macular hemorrhage (25%) and macular atrophy (53.6%) were associated with poorer best-corrected visual acuity.</p><p><strong>Conclusion: </strong>Centenarian patients with neovascular age-related macular degeneration can maintain vision with long-term anti-VEGF therapy. These findings underscore the need for tailored management strategies for the challenges faced by centenarians with neovascular age-related macular degeneration.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"1415-1423"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE FLOW AND OPERATING EFFICIENCY OF TWO-DIMENSIONAL CUTTING VELOCE 27-GAUGE VITRECTOME.","authors":"Mitrofanis Pavlidis, David H Steel, Hideyasu Oh","doi":"10.1097/IAE.0000000000004870","DOIUrl":"10.1097/IAE.0000000000004870","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate comparative aspiration flow rates and core vitrectomy times of a reengineered 27-gauge (G) 20,000 cuts per minute (CPM) dual action cutting (two-dimensional cutting [TDC]) vitrectomy probe (TDC Veloce; DORC International B.V.) versus a standard 27-G 16,000 CPM TDC probe (DORC).</p><p><strong>Methods: </strong>In vitro investigations assessed comparative aspiration flow rates in Newtonian and non-Newtonian fluids using EVA Nexus system (DORC). In an accompanying single-surgeon randomized controlled clinical study, core vitrectomy duration in patients undergoing 27-G vitrectomy using either a TDC Veloce or regular TDC probe, both in combination with EVA Nexus (n = 42), was compared.</p><p><strong>Results: </strong>Significantly higher aspiration flow rates were achieved with the 27-G TDC Veloce probe compared with a 27-G TDC probe. The overall percentage increase in flow for TDC Veloce probe versus TDC probe was 31%, 69%, and 37% in water, artificial vitreous solution, and porcine vitreous, respectively ( P < 0.001). Higher flow rates stabilized at cut speeds greater than 16,000 CPM. The mean (SD) core vitrectomy time (seconds) was 59.5 (6.1), 58.2 (3.3), and 98.6 (7.9) for the TDC Veloce 20,000 CPM, TDC Veloce 16,000 CPM, and TDC 16,000 CPM groups, respectively. The mean difference between the TDC Veloce 20,000 CPM and TDC 16,000 CPM groups was -39.1 seconds (95% CI: -44.57 to -33.63, P < 0.0001).</p><p><strong>Conclusion: </strong>Increased flow with the 27-G TDC Veloce probe resulted in a significantly shorter core vitrectomy time compared with a standard 27-G TDC probe, suggesting greater procedural efficiency during vitrectomy with the modified vitrectome.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"1457-1464"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13390979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Silent Damage of Methamphetamine: Imaging-Based Findings in the Retina and Retinal Microcirculation.","authors":"Seray Sahin, Serhad Nalcaci, Musa Cicek, Hakan Coskunol, Filiz Afrashi","doi":"10.1097/IAE.0000000000004942","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004942","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate retinal structural parameters and layer-specific microvascular perfusion using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in patients with chronic methamphetamine use disorder.</p><p><strong>Methods: </strong>This prospective, cross-sectional study included 45 patients with methamphetamine use disorder and 45 age-and sex-matched healthy controls. All participants underwent comprehensive ophthalmologic examination and standardized OCT and OCTA imaging. Central macular thickness, peripapillary retinal nerve fiber layer (RNFL) thickness, and subfoveal choroidal thickness were assessed by OCT. OCTA was used to quantify foveal avascular zone (FAZ) area, vessel density of the superficial and deep capillary plexuses (SCP and DCP), and flow areas of the outer retina and choriocapillaris. Correlations with duration and cumulative methamphetamine exposure were analyzed.</p><p><strong>Results: </strong>Total and superior quadrant RNFL thicknesses were significantly higher in the methamphetamine group(p=0.039 and p=0.030, respectively). Although SCP-VD was lower in the methamphetamine group, this difference did not reach statistical significance(p>0.05). In contrast, DCP-VD was significantly reduced in the methamphetamine group across total, parafoveal, and perifoveal regions(all p<0.001). Choriocapillaris flow area was also significantly lower in methamphetamine users(p=0.001). No clinical signs of retinopathy were observed in the patient group. Total and superior RNFL thicknesses were positively correlated, and outer retinal flow was negatively correlated, with both duration and cumulative methamphetamine exposure(p<0.05).</p><p><strong>Conclusion: </strong>Chronic methamphetamine use was associated with reduced DCP vessel density and decreased choriocapillaris flow despite the absence of clinically apparent retinopathy. These findings suggest layer-specific subclinical microvascular alterations detectable by OCTA. Longitudinal studies are needed to determine their progression and clinical relevance.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Epiretinal Membrane-Induced Retinal Traction and the Natural Course of Lamellar Macular Hole.","authors":"Ryo Matoba, Yoshito Kakino, Akihiro Tsuji, Tetsuro Morita, Yuki Masuda, Junko Hayashi, Riku Akatsuka, Mio Morizane Hosokawa, Yuki Morizane","doi":"10.1097/IAE.0000000000004950","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004950","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of epiretinal membrane (ERM)-induced retinal traction on functional and anatomical changes of lamellar macular hole (LMH).</p><p><strong>Methods: </strong>This retrospective study included patients with LMH followed for at least 12 months without surgery. Best-corrected visual acuity (BCVA), M-CHARTS-assessed metamorphopsia, and optical coherence tomography (OCT) parameters were evaluated. ERM-induced retinal traction was assessed using B-scan and en face OCT images, with maximum depth of retinal folds (MDRF) quantified as an indicator of retinal traction strength. Annual rates of change in visual function and OCT parameters were compared between eyes with and without ERM-induced retinal traction.</p><p><strong>Results: </strong>Thirty-six eyes were analyzed. During a mean follow-up of 46.4 ± 28.4 months, BCVA and metamorphopsia worsened, accompanied by foveal cavity enlargement, increased epiretinal proliferation thickness and ellipsoid zone disruption length, and decreased minimum retinal thickness (all P < 0.05). Eyes with ERM-induced retinal traction demonstrated significantly faster functional and anatomical deterioration than those without traction. MDRF showed significant correlations with worsening rates of BCVA, metamorphopsia, foveal cavity enlargement, and retinal thinning.</p><p><strong>Conclusion: </strong>ERM-induced retinal traction was associated with accelerated functional and anatomical deterioration in LMH. Quantitative assessment of retinal traction may facilitate the identification of LMH at higher risk of progression.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-widefield optical coherence tomography characterization of Type 1 retinopathy of prematurity regression after treatment.","authors":"Duncan D Fuller, David A Sutter, John Jackson, Yakub Bayhaqi, Elizabeth Roti, Susan Ostmo, Shuibin Ni, Yifan Jian, John Peter Campbell, Benjamin K Young","doi":"10.1097/IAE.0000000000004944","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004944","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize early morphologic changes of the ridge and isolated retinal neovascularization (IRNV) after intravitreal bevacizumab (IVB) treatment for ROP using investigational ultra-widefield OCT (UWF-OCT).</p><p><strong>Methods: </strong>UWF-OCT were acquired weekly from the date of treatment through at least four weeks post treatment.</p><p><strong>Results: </strong>A total of 44 eyes from 23 infants were imaged. By one-week post-treatment, UWF-OCT demonstrated marked regression of neovascular tufts and flattening of the fibrovascular ridge. The ridge progressed anteriorly, but neovascularization did not change location throughout its course of regression. Through week four, residual ridge tissue exhibited segmental thinning and remodeling.</p><p><strong>Conclusion: </strong>IVB for ROP induces rapid regression of IRNV and ridge thickness in the initial weeks post-treatment with subsequent remodeling over the first month. UWF-OCT enables detailed characterization of these dynamic morphologic changes, providing potential biomarkers for monitoring treatment responses and identifying eyes at risk of reactivation.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical variations and outcomes of central serous chorioretinopathy in Black and White patients: MICRoN report-16.","authors":"Niroj Kumar Sahoo, Nasiq Hasan, Bita Momenaei, Roselind Ni, Sunir Garg, Giulia Gregori, Marco Lupidi, Jessica Cao, Charles C Wykoff, Priya Shah, Panisa Singhanetr, Elizabeth Rossin, Carol Villafuerte-Trisolini, Glenn Yiu, Halit Winter, Manjot K Gill, Andrea Coletto, Mohamed El Barkani, Elodie Bousquet, Lorenzo Ferro Desideri, Felicia Hertkorn, Marion R Munk, Jay Wang, Rahul N Khurana, Yusuf Ashfaq, Zachary Kroeger, Maurizio Battaglia Parodi, Gabriele Piccoli, Stela Vujosevic, Carmen Antía Rodríguez-Fernández, Luis Arias Barquet, Kent Small, Rufino Silva, Luiz H Lima, Adrian T Fung, Lihteh Wu, Jay Chhablani","doi":"10.1097/IAE.0000000000004949","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004949","url":null,"abstract":"<p><strong>Purpose: </strong>To compare baseline characteristics and outcomes of central serous chorioretinopathy (CSCR) between people who identify as Black and those who identify as White.</p><p><strong>Methods: </strong>This retrospective, multicenter study from the MICRoN study group, included Black and White patients with CSCR. Demographic information and multimodal imaging parameters were analyzed and compared in the two groups. Regression models were used to identify factors affecting visual outcomes, anatomical changes, and disease recurrence/persistence.</p><p><strong>Results: </strong>We included a total of 450 patients (312 males and 138 females), of whom 100 were Black patients, and 350 were White patients. Black patients were significantly older (51.9 versus 48.8 years, p=0.03) but had shorter symptom duration at presentation (1 versus 3 months, p=0.003). They demonstrated worse baseline visual acuity (0.3±0.3 versus 0.2±0.2 logMAR, p<0.001), greater retinal detachment height (157.9 versus 107.5 μm, p=0.002), and more frequent peripapillary retinal pigment epithelium changes (27% versus 9.4%, p<0.001). During a median follow-up of 24 months (IQR 10 to 60 months), White patients experienced significantly higher rates of disease recurrence (35.7% versus 19%, p=0.002), persistent subretinal fluid (13.1% versus 4%, p=0.01), and macular neovascularization development (21.1% versus 4%, p<0.001). Multivariable regression confirmed that Black patients were associated with reduced recurrence risk (OR 0.52, p=0.03).</p><p><strong>Conclusions: </strong>Despite presenting with more severe morphological changes and worse initial vision, Black patients demonstrate substantially lower rates of recurrences and sequelae, suggesting biological differences in disease pathophysiology.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dropless Pars Plana Vitrectomy Using Intravitreal Decanted Triamcinolone and Moxifloxacin: Safety and Efficacy.","authors":"Amr Lotfy Ali, Daniel Vail, Mohamed Sherif Morsy, Nehal Nailesh Mehta, Soumya Jena, Dirk-Uwe Bartsch, Lingyun Cheng, William R Freeman","doi":"10.1097/IAE.0000000000004947","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004947","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the safety and efficacy of a dropless regimen using intravitreal decanted triamcinolone acetonide and moxifloxacin at the conclusion of pars plana vitrectomy (PPV), compared with standard postoperative topical therapy.</p><p><strong>Methods: </strong>This retrospective study included consecutive patients undergoing PPV at a tertiary retina center. The dropless cohort (May-October 2025) received intravitreal decanted triamcinolone (5 mg) and moxifloxacin (500 μg). The control cohort, operated during the preceding 6 months, received topical moxifloxacin 0.5% and prednisolone acetate 1%. Outcomes included intraocular inflammation, intraocular pressure (IOP), central subfield thickness (CST), cystoid macular edema (CME), and best-corrected visual acuity (BCVA). A prespecified subgroup analysis was performed for epiretinal membrane (ERM).</p><p><strong>Results: </strong>172 eyes were included (87 dropless, 85 topical). The dropless group demonstrated significantly less anterior chamber inflammation at week 2 (P = 0.0008) and at month 3 (P = 0.0223). Mean CST was lower at week 2 (P = 0.001), month 3 (P = 0.0009), and month 6 (P = 0.012). CME incidence was reduced (P < 0.001). BCVA improvement was greater in the dropless group at week 2 (+15 vs -2.5 ETDRS letters; P = 0.0003), month 3 (+25 vs +9.5 letters; P = 0.002), and month 6 (+20 vs +8 letters; P = 0.01). IOP was similar between groups, and no endophthalmitis occurred. Findings were consistent in the ERM subgroup.</p><p><strong>Conclusion: </strong>A dropless intravitreal regimen at the conclusion of PPV can be a safe and effective alternative to topical therapy, with reduced postoperative inflammation and CME and improved visual outcomes.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volume of Opercular and Pseudopercular Tissue Is Associated With Outer Retinal Reconstitution After Full-Thickness Macular Hole Surgery.","authors":"Alberto Quarta, Ruggero Tartaro, Maria Ludovica Ruggeri, Corina De Santis Ciacci, Alessandro Avitabile, Giulia Gregori, Cesare Mariotti, Marco Lupidi, Rodolfo Mastropasqua","doi":"10.1097/IAE.0000000000004946","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004946","url":null,"abstract":"<p><strong>Purpose: </strong>To quantitatively evaluate the operculum-pseudoperculum volume (OPV) in full-thickness macular holes (MHs) and explore its relationship with anatomical and functional outcomes following surgery.</p><p><strong>Methods: </strong>This prospective study included patients with Stage 2 and Stage 3 MHs who underwent pars plana vitrectomy. OPV was measured using image processing software and its correlation with postoperative changes in visual acuity (VA), external limiting membrane (ELM), and ellipsoid zone (EZ) defect in each group, then a median split was applied to investigate the impact of OPV on baseline and final measures. Multivariable regression analysis was conducted to determine predictors of VA improvement.</p><p><strong>Results: </strong>In stage 2 MHs, OPV positively correlated with VA, minimum diameter (MD), basal diameter (BD), MH height (MHe) and changes in ELM at 3 and 6 months (p < 0.05). Only EZ changes at 6 months negatively correlated with OPV (p < 0.05). Patients with low OPV demonstrated greater EZ and ELM defect reduction at 6 months, whereas greater ΔVA was observed in the high-OPV group (p = 0.032). Multivariate analysis revealed that MD and OPV group were independent predictors of ΔVA at six months (Adjusted R2 = 0.266).</p><p><strong>Conclusions: </strong>OPV may represent a promising exploratory OCT-derived biomarker associated with postoperative structural and functional recovery in FTMH surgery. Larger longitudinal studies with external validation are warranted to confirm its prognostic utility.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}