Retina-The Journal of Retinal and Vitreous Diseases最新文献

{"title":"Letter to the Editor for Hebert M, Garneau J, Doukkali S, You E, Bourgault S, Caissie M, Tourville E, Dirani A (2024) Inferior Retinal Detachment Repair Using Vitrectomy with or without Scleral Buckling. Retina 44 (11):1899-1905. doi:10.1097/IAE.0000000000004216.","authors":"Maurizio Mete, Luigi Fontana, Antonio Moramarco","doi":"10.1097/IAE.0000000000004639","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004639","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of Yamane scleral intraocular lens fixation using extraocular docking of the trailing haptic.","authors":"Tadashiro Saeki, Sawako Koutari, Takahiko Hayashi, Harumasa Yokota, Satoru Yamagami, Richard Mackool","doi":"10.1097/IAE.0000000000004618","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004618","url":null,"abstract":"<p><strong>Purpose: </strong>To report results of a modified Yamane technique for scleral fixation of the intraocular lens (IOL).</p><p><strong>Methods: </strong>Data from all patients treated with scleral fixation using the Avansee AN6A at our hospital by a single surgeon were obtained and retrospectively analyzed from our database. In our technique, the trailing haptic was externally inserted into the lumen of the 30G needle. The preoperative measurements included three variables: best-corrected visual acuity (BCVA,Snellen), intraocular pressure (mmHg), and corneal endothelial cell count (cells/mm2). Postoperative measurements included: refractive error (D), aqueous depth (mm), tilt (°), decentration (mm), and the three preoperative variables.</p><p><strong>Results: </strong>This study included 20 eyes (mean age, 65.3±13.5 years). Preoperative conditions included lens subluxation (4 eyes), IOL dislocation (13 eyes), and aphakia (3 eyes). The BCVA improved from 20/32 preoperatively to20/20 postoperatively. The mean preoperative corneal endothelial cell density was 2,282 cells/mm2 and changed to 2,091 cells/mm2 at the last visit. Postoperative refractive error was slightly myopic (-0.13±1.4 D). Regarding the position of fixated IOLs, postoperative tilt was 5.57 ± 3.35°. and postoperative decentration was 0.50 ± 0.26 mm.</p><p><strong>Conclusion: </strong>The simplified Yamane technique showed good overall clinical outcomes and stability of refractive predictability when performed by a single surgeon, making it easier to master. Further studies are required to expand on this simplified procedure.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonvitrectomizing vitreous surgery in patients with macular holes.","authors":"Nan Chen, Xinying Li, Xiaonan Yao, Dong Chen, Xuewei Liu","doi":"10.1097/IAE.0000000000004628","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004628","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of internal limiting membrane (ILM) peeling combined with gas tamponade in nonvitrectomizing vitreous surgery (NVS) for macular holes (MHs).</p><p><strong>Methods: </strong>A total of 21 patients (21 eyes) with MHs who underwent NVS with ILM peeling and a small C3F8 gas bubble tamponade and completed at least 6 months of follow-up were included. The status of hole closure and visual acuity change were evaluated.</p><p><strong>Results: </strong>There were two secondary MHs and 19 idiopathic MHs with the mean minimal diameter of 309.47±165.71 µm at baseline. Hole closure was achieved in 19 (90.47%) eyes after the primary operation. The best-corrected visual acuity was improved from preoperative 20/400-20/28 (0.74±0.29 logMAR) to postoperative 20/166-20/22 (0.32±0.22 logMAR) (P < 0.001).</p><p><strong>Conclusions: </strong>The procedure of NVS with ILM peeling combined with short-term gas tamponade can promote closure of small to medium-sized MHs. This simplified surgical approach relieves the tangential force coming from the ILM and releases the vitreous adhesion from the macular surface while preserving the vitreous cortex.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using artificial intelligence to assess macular edema treatments in retinitis pigmentosa.","authors":"Jesse A Most, Evan H Walker, An D Le, Melanie D Tran, Gillian A Folk, Ines D Nagel, Shyamanga Borooah","doi":"10.1097/IAE.0000000000004636","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004636","url":null,"abstract":"<p><strong>Purpose: </strong>This study validates a deep learning-based artificial intelligence (AI) tool for quantifying macular edema (ME) intraretinal fluid (IRF) volumes in retinitis pigmentosa, and through longitudinal analysis of IRF, provides new insight into treatment efficacy and disease natural history.</p><p><strong>Methods: </strong>This retrospective, longitudinal study identified RP patients with ME. A commercially available retinal analysis tool quantified IRF, and was validated for segmentation of ME using spectral-domain optical coherence tomography volume scans. Baseline analysis of IRF versus traditional central subfield thickness (CST), and longitudinal analyses of IRF versus treatment and best-corrected visual acuity (BCVA) were performed.</p><p><strong>Results: </strong>Forty-four patients were identified. For treatment studies, 52 eyes were in the treated group and 14 eyes in the untreated ME group. Mean follow-up was 5.3 exams (3.7, 6.9) over 2.3 years (1.7, 3.0). Software validation compared automated and manual IRF segmentation of 490 image pairs, finding a Dice coefficient of 0.928 (95% CI: 0.92, 0.99). Cohort mean IRF volume was 230.85 nL (57.42, 403.91) at baseline. IRF change in eyes treated with topical carbonic anhydrase inhibitors (CAIs) was -2.1 nL/year (P=0.81). Oral acetazolamide (AZM)-treated eyes had significant IRF reduction (-33.6 nL/year, P=0.009), and significant improvements in BCVA (logMAR/yr; ETDRS letters equivalent) (-0.041; +2 letters) (P=0.025).</p><p><strong>Conclusion: </strong>A deep learning tool was able to rapidly and accurately quantify IRF in RP-associated ME. Using this analysis tool, we confirmed that treatment with AZM led to significant reduction in long-term IRF. Structural changes (IRF) only translated to significant functional improvements (BCVA) in eyes treated with AZM.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometric Changes In Macular Neovascularization Architecture After Faricimab Treatment In Neovascular Age-Related Macular Degeneration: Comparison Between Naïve And Switched Eyes.","authors":"Matteo Mario Carlà, Alessandra Scampoli, Giulia Grieco, Lorenzo Governatori, Roberta Catalani, Stanislao Rizzo, Tomaso Caporossi","doi":"10.1097/IAE.0000000000004635","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004635","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the morphometric changes in macular neovascularization (MNV) architecture after faricimab treatment in neovascular age-related macular degeneration (nAMD), comparing treatment-naïve and previously treated eyes.</p><p><strong>Methods: </strong>Prospective study analyzing 45 eyes (18 treatment-naïve, 27 switched) with nAMD undergoing faricimab treatment. Optical coherence tomography angiography (OCTA) images were exported and the quantification of changes in MNV area, vessel area, vessel density, number of junctions, branching index, total vessel length, endpoints, and lacunarity was performed using AngioTool v0.6a. Follow-ups at baseline (V0), end of the loading phase (V1) and at one-year (V2) were collected.</p><p><strong>Results: </strong>Baseline MNV characteristics differed significantly between treatment-naïve and switched eyes. Switched eyes exhibited greater MNV area (p<0.001), vessel area (p<0.001), junction count (p=0.004), vessel length (p<0.001), average vessel length (p=0.02), endpoint count (p=0.002), and lacunarity (p=0.04). Conversely, naïve eyes had higher vessel density (p<0.001) and branching index (p=0.007). Post-treatment, MNV area (p<0.001), vessel area (p<0.001), junction count (p=0.001) and total vessel length (p<0.001) decreased, while lacunarity increased (p=0.001). Greater changes were observed in naïve eyes, but the endpoint count only reduced in switched eyes (p=0.01), being stable in naïve eyes. At V2, switched eyes still had larger MNV area (p=0.007), vessel area (p=0.004), junction count (p=0.002), vessel length (p=0.004), and endpoints (p=0.007).</p><p><strong>Conclusion: </strong>Faricimab induces significant and sustained remodeling of the MNV network in nAMD, with more pronounced changes in treatment-naïve eyes. These changes were primarily driven by the loading phase, but then remained stable toward the one-year follow-up.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of age-related macular degeneration in late-onset atopic dermatitis: A multi-database cohort analysis.","authors":"Tai-Li Chen, Hou-Ren Tsai, Wei-Chuan Chang, Jing-Wun Lu, Yi-Ju Chen, Yuan-Chieh Lee, Chen-Yi Wu","doi":"10.1097/IAE.0000000000004634","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004634","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the relationship between atopic dermatitis (AD) and the risk of developing age-related macular degeneration (AMD).</p><p><strong>Methods: </strong>This retrospective cohort study utilized data from two large databases: the US-based TriNetX Research Network (46,018 patients with AD aged ≥ 50 years, spanning 2005-2021) and Taiwan's National Health Insurance Research Database (NHIRD; 9,513 patients with AD aged ≥ 50 years, spanning 2003-2017). The main outcome was the incidence of AMD. The Cox regression analysis was used to calculate hazard ratios (HRs) for AMD. Additional analyses examined the risk of dry and wet AMD, with stratified assessments based on age, sex, ethnicity, race, and AD activity.</p><p><strong>Results: </strong>Adults with AD exhibited a significantly elevated risk of developing AMD in both the TriNetX cohort (HR 1.97; 95% CI 1.78-2.19) and the NHIRD cohort (HR 1.25; 95% CI 1.11-1.41). Individual outcome analyses confirmed a heightened risk for both dry and wet AMD associated with AD. This increased risk was consistent across various groups stratified by demographic factors and AD activity.</p><p><strong>Conclusions: </strong>AD in adulthood is linked to a greater likelihood of developing AMD. These findings underscore the importance of regular funduscopic evaluations and proactive management of AMD in patients with AD.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proliferative vitreoretinopathy and outer retinal folds in rhegmatogenous retinal detachment. Insights into retinal remodeling.","authors":"Marzia Affatato, Angela Maria Castelluzzo, Giuseppe Rapino, Pasquale Cucciniello, Ciro Giugliano, Caterina Picotto, Giuseppe Campagna, Tommaso Rossi, Lucia Ziccardi, Roberto dell'Omo","doi":"10.1097/IAE.0000000000004631","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004631","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the relationship between proliferative vitreoretinopathy (PVR) and outer retinal folds (ORFs) in eyes with rhegmatogenous retinal detachment (RRD).</p><p><strong>Methods: </strong>Prospective cohort study. Patients with primary RRD operated with pars plana vitrectomy were studied postoperatively by using blue fundus autofluorescence and spectral-domain optical coherence tomography. Primary outcome was the influence of PVR severity on the incidence and height of ORFs at 1 month after surgery .</p><p><strong>Results: </strong>The study included 171 eyes. One month after operation, ORFs were identified in 22% of the eyes with PVR A, 26.6% with PVR B, and 44.4% with PVR C. The mean height (± SD) of ORFs was 99.8 ± 18.3 µm, 138.3 ± 50.3 µm and 199.25 ± 200.0 µm in PVR A, B and C, respectively (P = 0.008). Variables associated with the presence of ORFs included PVR grade C (p = 0.004), presence of ERM (P = 0.004), and gas tamponade (P = 0.02). PVR grade C correlated with ORFs height ( P = 0.006).</p><p><strong>Conclusion: </strong>PVR grade C is significantly associated with the incidence and height of ORFs at 1 month after surgery in eyes undergone PPV to repair RRD. Outer retinal folds may provide important insights about the process of retina remodeling occurring in eyes with RRD complicated by PVR C.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DisCoVisc substituted for perfluorocarbon liquid stabilizing the detached retina during vitrectomy for rhegmatogenous retinal detachment.","authors":"Yanbo Bao, Huangyi Lei, Yinong Guo, Yajun Liu, Suyu Liu, Hui Chen, Zhenggao Xie","doi":"10.1097/IAE.0000000000004617","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004617","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effectiveness of using DisCoVisc as an alternative to perfluorocarbon liquid (PFCL) in stabilizing the detached retina during rhegmatogenous retinal detachment (RRD) surgery.</p><p><strong>Methods: </strong>Thirty eyes of 30 patients with RRD underwent the DisCoVisc technique for stabilizing the detached retina. Following intraoperative air-fluid exchange and the aspiration of subretinal fluid, DisCoVisc was applied to seal retinal breaks, thereby stabilizing the detached retina. Subsequent removal of the peripheral and basal vitreous was then performed. Intraoperative vitrectomy duration, retinal reattachment rate, postoperative best-corrected visual acuity (BCVA), intraocular pressure (IOP), and intraoperative and postoperative complications were analyzed.</p><p><strong>Results: </strong>Retinal reattachment was achieved in 28 eyes (28/30, 93.3%). The base of the vitreous was removed with a mean time of 10.17±2.94 min, and the total vitrectomy time was 22.93±4.97 min. At the last follow-up, the BCVA was 0.74±0.70 LogMAR, showing a significant improvement over the preoperative value of 1.44±1.25 LogMAR (Z=2.700, P=0.007). On the first postoperative day, the IOP was measured at 25.71±12.41 mmHg, exhibiting a statistically significant elevation compared to the preoperative IOP of 13.94±5.23 mmHg (P=0.000). There was no statistical difference in IOP at the last follow-up 14.01±2.68 mmHg compared to the preoperative IOP of 13.94±5.23 mmHg (P = 0.923). One patient developed macular hole after the operation, and there were no obvious complications during the operation.</p><p><strong>Conclusions: </strong>DisCoVisc can effectively stabilize the detached retina during vitrectomy for RRD. Most significantly, it eliminated the risk of subfoveal PFCL residue-related complications.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the Dexamethasone Implant on Slowing Diabetic Retinopathy Progression: Post Hoc Analysis of the MEAD Study.","authors":"Kevin J Blinder, Charles C Wykoff, Joseph R Ferencz, Justis P Ehlers, Yixin Fang, Hongxin Lai, Miller Ogidigben, Francisco J López","doi":"10.1097/IAE.0000000000004623","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004623","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of dexamethasone intravitreal implant (DEX) treatment on Diabetic Retinopathy Severity Scale (DRSS) scores and disease progression in patients with diabetic macular edema (DME).</p><p><strong>Methods: </strong>The 3-year, randomized, phase 3 MEAD study evaluated DEX 0.35 and 0.7 mg versus sham (treatment at ≥6-month intervals) in patients with DME. This post hoc analysis used data from the sham and pooled DEX arms.</p><p><strong>Results: </strong>The proportion of patients with ≥2-step DRSS score improvement was significantly higher after DEX treatment compared with sham at 24 months only (8.8% vs 4.2%, OR=2.1, P=0.016). Among those with ≥2-step DRSS score improvement, the time to first ≥2-step improvement was shorter with DEX (P<0.001; median 400 days with DEX versus 713 with sham). There were no significant differences between the DEX and sham groups in the proportion of patients who progressed from non-proliferative to proliferative DR, but among those who progressed, the time to progression was lengthened with DEX (P<0.001; median 531.1 days with DEX versus 191 with sham).</p><p><strong>Conclusion: </strong>This post hoc analysis of MEAD study data showed that DEX treatment may potentially have a positive impact on DR by reducing disease severity and slowing progression in DR patients with central DME.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Vitrectomy Combined With Inverted Internal Limiting Membrane Flap Insertion Or Single-Layered Flap Covering Technique For Highly Myopic Macular Holes With Macular Retinoschisis.","authors":"Matteo Mario Carlà, Carlos Mateo","doi":"10.1097/IAE.0000000000004629","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004629","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}