Retina-The Journal of Retinal and Vitreous Diseases最新文献

{"title":"Biomarker-Guided Management in Vitreoretinal Diseases: Integrating Imaging, Pharmacotherapy, and Surgical Decision-Making-A Narrative Review.","authors":"Matias Iglicki, Dinah Zur, Javier Ignacio Melamud, Anat Loewenstein","doi":"10.1097/IAE.0000000000004984","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004984","url":null,"abstract":"<p><strong>Purpose: </strong>To synthesize current evidence on imaging biomarkers in vitreoretinal diseases and to review the potential for a biomarker-guided framework integrating imaging, pharmacotherapy, and surgical decision-making in contemporary clinical practice.</p><p><strong>Methods: </strong>This narrative review integrates published evidence and clinical insights on optical coherence tomography (OCT) and OCT angiography (OCTA)-derived biomarkers, focusing on their role in predicting disease behavior, therapeutic response, and surgical indications.</p><p><strong>Results: </strong>Key imaging biomarkers-including disorganization of the retinal inner layers (DRIL), hyperreflective foci (HRF), intraretinal and subretinal fluid patterns, and vascular perfusion changes-demonstrate significant value in stratifying disease phenotype and guiding management. Biomarker-based approaches enable differentiation between angiogenic and inflammatory patterns, supporting individualized therapeutic strategies. These include optimized use of anti-vascular endothelial growth factor therapy, corticosteroid-based treatments, and newer long-acting agents. In addition, imaging biomarkers play a central role in identifying surgical candidates and determining timing of intervention, particularly in tractional maculopathies and refractory disease.</p><p><strong>Conclusion: </strong>A biomarker-guided approach provides a clinically actionable framework for personalized vitreoretinal care. The integration of multimodal imaging with pharmacologic and surgical decision-making represents a critical step toward precision medicine, with the potential to improve outcomes and reduce treatment burden.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Outcomes of Transscleral Four-Point Fixation with Closed Continuous-Loop Suture and Yamane Technique for Intraocular Lens Fixation.","authors":"Jin Cho, Yong Joon Kim, Junwon Lee, Christopher Seungkyu Lee, Min Kim, Suk Ho Byeon, Sung Soo Kim, Jay Jiyong Kwak","doi":"10.1097/IAE.0000000000004961","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004961","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the outcomes of transscleral four-point fixation using a closed continuous-loop suture and transconjunctival intrascleral haptic fixation (Yamane technique) for intraocular lens (IOL) fixation.</p><p><strong>Methods: </strong>Patients who underwent scleral fixation of IOL using four-point fixation with a closed continuous-loop suture and the Yamane technique were reviewed. Demographics, pre- and postoperative data, including operation time, complications, and reoperation rates, were reviewed. The cumulative probability of remaining free from IOL redislocation was analyzed using Kaplan-Meier curves, and the factors associated with IOL redislocation were assessed using a Cox proportional hazards model.</p><p><strong>Results: </strong>A total of 179 eyes of 175 patients were included, comprising 120 eyes in the four-point fixation group and 59 eyes in the Yamane group. Visual and refractive outcomes were comparable 6 months postoperatively. Operative time was significantly shorter in the Yamane group (35.6 ± 10.9 vs. 49.5 ± 14.7 min; p < 0.001). Postoperative complication rates, including corneal decompensation, hypotony, and endophthalmitis, did not differ significantly between groups. Cox proportional hazards model showed that the Yamane technique was associated with a significantly higher hazard of IOL redislocation (hazard ratio, 8.68; 95% confidence interval, 1.38-54.46; p = 0.021).</p><p><strong>Conclusion: </strong>Both four-point fixation and the Yamane technique yielded comparable visual outcomes and safety profiles. The Yamane technique offered shorter operative time, whereas the four-point fixation was associated with a lower risk of IOL redislocation. These findings highlight the importance of preoperative structural assessments in guiding the selection of fixation methods.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical outcomes of retinal detachment due to giant retinal tear and utility of fellow eye prophylaxis: a multicenter study.","authors":"Sunir J Garg","doi":"10.1097/IAE.0000000000004967","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004967","url":null,"abstract":"<p><strong>Purpose: </strong>To compare 6-month single-surgery anatomic success (SSAS) in eyes with giant retinal tear (GRT)-related retinal detachment (RD) treated with pars plana vitrectomy (PPV) with or without scleral buckle (SB), and to assess whether prophylactic fellow eye treatment reduces long-term GRT or RD risk.</p><p><strong>Methods: </strong>Retrospective multi-center study of eyes with GRT-related RD with ≥6 months follow-up. The primary outcomes were 6-month SSAS after GRT repair and rates of fellow eye GRT and RD. Group differences were assessed with standard univariate tests and logistic regression models.</p><p><strong>Results: </strong>Among 379 eyes of 374 patients with GRT-related RD, PPV/SB was performed in 48.4% and PPV alone in 46.3%. In phakic eyes, higher 6-month SSAS was achieved in the PPV/SB vs PPV group (95.4% vs 83.1%, P=0.005), while in pseudophakic eyes, this PPV/SB benefit was not seen (85.7% vs 84.3%, P=0.82). Proliferative vitreoretinopathy (42.6%) and new retinal tears (22.2%) were the leading causes of re-detachment. Subsequent fellow eye GRT occurred in 5.5% and non-GRT RD in 9.2%. Most patients did not receive prophylactic fellow eye treatment: 7.7% underwent 360° laser and 20.0% received targeted laser. Over a mean follow-up period of 2.8 years, the rates of GRT and RD were similar among fellow eyes treated with circumferential, targeted, or no laser (P ≥ 0.11).</p><p><strong>Conclusions: </strong>Both PPV/SB and PPV achieved high rates of SSAS after GRT-related RD. PPV/SB should be considered particularly in phakic eyes. Prophylactic laser did not decrease the risk of fellow eye GRT or RD over this follow up period.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Sector Thickening of the Retinal Nerve Fiber Layer as a Structural Marker of Diabetic Retinopathy Severity in Chinese Adults with Type 2 Diabetes Mellitus.","authors":"Shimeng Wang, Yu Wang, Dong Li, Liang Wen, Binghua Guo, Chen Yang, Zhong Lin","doi":"10.1097/IAE.0000000000004969","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004969","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate alterations in peripapillary retinal nerve fiber layer (pRNFL) thickness in Chinese adults with type 2 diabetes mellitus and assess their association with the presence and severity of diabetic retinopathy (DR).</p><p><strong>Methods: </strong>This cross-sectional study was conducted within the Fushun Diabetic Retinopathy Cohort (FS-DIRECT). Participants underwent standardized ophthalmic examinations, six-field fundus photography, and Spectralis optical coherence tomography. Eyes were classified as no DR, non-proliferative DR (mild, moderate, or severe), or proliferative DR. Automated pRNFL measurements were pbtained for six sectors. Group differences were analyzed using t-tests and analysis of variance. Factors associated with pRNFL thickness were evaluated using univariate and multivariable linear regression.</p><p><strong>Results: </strong>A total of 833 right eyes were included, of whom 273 had DR and 560 did not. Global pRNFL thickness did not differ between groups (107.21 ± 17.59 µm vs. 105.91 ± 13.82 µm, P = 0.510). In contrast, the temporal sector was significantly thicker in eyes with DR (82.37 ± 20.72 µm vs. 76.22 ± 15.57 µm, P < 0.001) and showed progressive thickening with increasing DR severity (76.22 ± 15.57 µm in no DR vs. 94.53 ± 30.10 µm in severe/proliferative DR, P < 0.001). In multivariable analysis, DR severity remained the only independent predictor of temporal thickening (β = 3.70, P < 0.001).</p><p><strong>Conclusions: </strong>Temporal-but not global-pRNFL thickening was independently associated with DR severity. These findings support region-specific neuroaxonal alterations in DR and highlight temporal pRNFL thickening as a potential structural marker of diabetic retinal nerve damage.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plaque Radiotherapy for Posterior Uveal Melanoma (PUM) in 4000 Eyes in the Pre-Anti-VEGF Era: Impact of Radiation Dose to the Optic Disc and Foveola on ≥15-Letter Visual Acuity Loss.","authors":"Carol L Shields, Robert J Medina, Hidayet Sener, Naomi Warszawski, Evelyn G Miller, Antonio Bechara Ghobril, Sara E Lally, Jerry A Shields","doi":"10.1097/IAE.0000000000004966","DOIUrl":"10.1097/IAE.0000000000004966","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of radiation dose to the optic disc and foveola on ≥15-letter visual acuity loss following plaque radiotherapy of posterior uveal melanoma (PUM) in the pre-anti-vascular endothelial growth factor (anti-VEGF) era.</p><p><strong>Methods: </strong>We reviewed data on 4000 consecutive patients to assess radiation dose and dose rate to the optic disc and foveola on ≥15-letter visual acuity loss.</p><p><strong>Results: </strong>The (median) patient age was 60 years, tumor diameter was 11.0 mm and thickness 4.5 mm, and distance to the optic disc was 4.0 mm and foveola 3.0 mm. The (median) dose (centiGray (cGy)) (dose rate (cGy/hour)) to the tumor apex was 8079 cGy (85 cGy/hour (cGy/hr)), to the optic disc was 3346 cGy (34 cGy/hr), and the foveola was 4021 cGy (40 cGy/hr). By Kaplan-Meier analysis, eyes that received ≤4000 cGy to optic disc developed ≥15-letter vision loss at 3 years with foveal dose 0-2000 cGy in 41%, 2001-4000 cGy in 60%, and 4001-6000 cGy in 68% (p<0.01). For eyes that received >4000 cGy to optic disc, ≥15-letter vision loss at 3 years was poorer (p nonsignificant). For those with optic disc dose ≤4000 cGy, a comparison (foveal dose 0-2000 versus (vs.) 2001-4000 cGy) led to hazard ratio (HR) of 1.71 (p<0.01) and (foveal dose 2001-4000 vs. 4001-6000 cGy) showed HR of 1.21 (p<0.03) for ≥15-letter vision loss.</p><p><strong>Conclusions: </strong>In the pre-anti-VEGF days, following treatment of PUM with plaque radiotherapy, higher radiation doses to the optic disc and foveola demonstrated greater ≥15-letter vision loss.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond axial length: posterior segment curvature determining vitreoretinal traction.","authors":"João Heitor Marques, Ana Sofia Martins, Pedro Baptista, Bernardete Pessoa, João Melo Beirão","doi":"10.1097/IAE.0000000000004959","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004959","url":null,"abstract":"<p><strong>Purpose: </strong>To create an algorithm to calculate the posterior radius of curvature of Bruch´s membrane (rBM) on regular optical coherence tomography (OCT) and determine the association between posterior segment shape and vitreoretinal disease.</p><p><strong>Methods: </strong>Retrospective cross-sectional study that included patients with macular hole (MH) or rhegmatogenous retinal detachment (RRD). RRD eyes were matched with MH eyes based on age and axial length (AL), resulting in a final analysis of 43 eyes in each group. OCT B-scans were processed using a custom but open algorithm to calculate the rBM.</p><p><strong>Results: </strong>rBM was significantly higher in the RRD group (mean 56.1 mm, 95%CI 46.2 - 66.1 mm) whereas the MH group exhibited a steeper curvature (mean 41.6 mm, 95%CI 37.4 - 45.9 mm). No relationship was observed between AL and rBM. Multivariate logistic regression confirmed the independent effect of rBM.</p><p><strong>Conclusion: </strong>The geometry of the posterior segment differs substantially, independently of AL and age. A rounder posterior segment is associated with RRD, while a steeper curvature is associated with MH, suggesting that globe shape dictates whether vitreoretinal traction manifests peripherally or centrally. rBM on OCT is a simple and reproducible measure that may serve as a risk factor for vitreoretinal disease.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical Coherence Tomography Angiography Evaluation of Ocular Findings in Ankylosing Spondylitis Patients with and without Ocular Involvement.","authors":"Aynur Diracoglu, Ekin Ece Oskan, Tugba Sahbaz, Dilhan Karaca, Abdullah Ağın, Feyza Onder","doi":"10.1097/IAE.0000000000004954","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004954","url":null,"abstract":"<p><strong>Purpose: </strong>Ankylosing spondylitis (AS) is a chronic inflammatory disease frequently associated with anterior uveitis. While ocular involvement is typically considered anterior, recent evidence suggests subclinical posterior microvascular alterations. This study aimed to evaluate retinal and choroidal changes in AS patients with and without anterior uveitis using optical coherence tomography angiography (OCTA).</p><p><strong>Methods: </strong>This cross-sectional study included 77 participants: 22 AS patients with anterior uveitis (43 eyes), 22 AS patients without ocular involvement (44 eyes), and 33 healthy controls (66 eyes). All subjects underwent a comprehensive ophthalmologic examination and OCTA imaging. Quantitative OCTA parameters, including superficial and deep capillary plexus (SCP, DCP) vessel densities, foveal avascular zone (FAZ) metrics, and choriocapillaris flow area, were analyzed.</p><p><strong>Results: </strong>Both AS groups demonstrated significantly lower SCP vessel densities compared to controls (p<0.001), particularly in whole, parafoveal, and perifoveal regions. DCP vessel densities were markedly reduced in AS patients with anterior uveitis compared to both non-uveitis AS patients and controls (p<0.05). No significant differences were observed in FAZ area (p = 0.084), although FAZ perimeter was smaller in the uveitis group (p=0.045). Choriocapillaris and outer retinal flow areas also differed significantly among groups (p<0.01).</p><p><strong>Conclusion: </strong>AS patients, especially those with anterior uveitis, exhibit subclinical retinal and choroidal microvascular alterations detectable by OCTA. These findings suggest posterior segment involvement beyond clinically apparent anterior uveitis and indicate that OCTA may be a useful non-invasive tool for detecting microvascular alterations. Further longitudinal studies are warranted to assess the prognostic and therapeutic implications of these alterations.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dominant Eye Involvement and Thresholds for Binocular Metamorphopsia in Patients with Unilateral Epiretinal Membrane.","authors":"Noriko Kubota, Hideki Tanaka, Ryuta Koike, Tatsuho Tomiyama, Tomoyuki Kunishige, Yuji Nakano, Fumiki Okamoto","doi":"10.1097/IAE.0000000000004953","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004953","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of dominant eye involvement on binocular visual function and vision-related quality of life (VR-QoL), and to determine the monocular metamorphopsia threshold associated with binocular symptom perception in patients with unilateral epiretinal membrane (ERM).</p><p><strong>Methods: </strong>This prospective single-center study included patients with unilateral ERM. Ocular dominance was determined using the hole-in-card test. Best-corrected visual acuity (BCVA), monocular and binocular metamorphopsia measured with M-CHARTS, aniseikonia, stereopsis, and VR-QoL using VFQ-25 were evaluated. Patients were classified according to whether ERM involved the dominant or non-dominant eye.</p><p><strong>Results: </strong>Sixty-eight patients were enrolled, including 35 patients in the non-dominant eye group and 33 in the dominant eye group. Horizontal binocular metamorphopsia scores were significantly higher in the dominant eye group than in the non-dominant eye group (p < 0.05). No significant differences were observed in BCVA, stereopsis, or VFQ-25 composite scores between the groups. Binocular metamorphopsia scores significantly correlated with VFQ-25 composite scores only in the dominant eye group. Receiver operating characteristic (ROC) analysis demonstrated that a mean monocular metamorphopsia score of 0.55 was the optimal threshold for binocular symptom perception in eyes with dominant eye involvement (AUC = 0.66; 95% CI, 0.48-0.85).</p><p><strong>Conclusion: </strong>Dominant eye involvement was associated with greater binocular metamorphopsia and a stronger association between metamorphopsia and VR-QoL in unilateral ERM. A mean monocular metamorphopsia score of ≥ 0.55 may represent a preliminary threshold associated with binocular symptom perception and may help guide future clinical assessment.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression of choriocapillaris flow deficit in eyes with drusenoid pigment epithelial detachment.","authors":"Mirinae Kim, Young-Hoon Park","doi":"10.1097/IAE.0000000000004955","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004955","url":null,"abstract":"<p><strong>Purpose: </strong>To quantitatively evaluate choriocapillaris flow deficits (CCFD) in eyes with drusenoid pigment epithelial detachment (PED) and examine their associations with disease progression and visual outcomes.</p><p><strong>Methods: </strong>This retrospective longitudinal cohort study included 42 eyes with drusenoid PED. Choriocapillaris flow deficit percentage (CCFD%) was quantified using compensation-corrected OCTA imaging with standardized thresholding algorithms. Longitudinal changes in CCFD%, risk factors for geographic atrophy (GA) progression, and predictors of final best-corrected visual acuity (BCVA) were analyzed.</p><p><strong>Results: </strong>Mean baseline CCFD% was 36.26 ± 5.06%, with gradual worsening over 4 years to 38.47 ± 5.34% (0.60 ± 2.06%/year, P = .012). Eyes progressing to GA demonstrated significantly higher baseline CCFD% than stable eyes (37.94 ± 2.31% vs. 35.12 ± 6.07%, P < .001). During follow-up, 17 eyes (40.5%) developed GA, 23 (54.8%) remained stable, and 2 (4.8%) progressed to neovascular AMD. Multivariate Cox regression identified baseline CCFD (HR, 1.804; P = 0.006) and annual CCFD change rate (HR, 2.262; P = .024) as independent risk factors for GA progression. Multiple linear regression demonstrated that baseline CCFD and CCFD change rate independently predicted final BCVA (adjusted R2 = 0.961, P < .001).</p><p><strong>Conclusions: </strong>Both baseline CCFD and progressive CCFD deterioration serve as independent predictors of anatomical and functional outcomes in drusenoid PED, emphasizing the pathophysiological role of choroidal hemodynamic dysfunction in AMD progression.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ULTRA-WIDEFIELD EXAMINATION OF THE PERIPHERAL RETINA IN BEST1 -RELATED RETINOPATHY.","authors":"Maurizio Battaglia Parodi, Ahmad Mansour, Andrea Saladino, Alessandro Arrigo, Maria Vittoria Cicinelli, Manuel Vilela, Francesc March de Ribot, Rebecca Toscani, Lorenzo Bianco, Sebastiano Del Fabbro, Francesco Bandello, Alessio Antropoli","doi":"10.1097/IAE.0000000000004846","DOIUrl":"10.1097/IAE.0000000000004846","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate peripheral retinal findings in BEST1 -related retinopathies by means of ultra-widefield (UWF) imaging.</p><p><strong>Methods: </strong>Observational, case-control study. All subjects underwent comprehensive ophthalmologic evaluation, including ultrawide-field fundus photography (UWF-FP) and UWF fundus autofluorescence, and selected cases also received UWF optical coherence tomography. Peripheral retinal changes, including white or dark without pressure and vascular abnormalities, were assessed, and their prevalence was compared with a control group.</p><p><strong>Results: </strong>Seventy-two eyes from 36 patients with BEST1 -related retinopathy (58 eyes from 29 patients with autosomal dominant Best vitelliform macular dystrophy [BVMD]), 14 eyes from seven patients with autosomal recessive bestrophinopathy (ARB), and 78 eyes from 39 control subjects were enrolled. Compared with controls, patients had significantly higher odds of exhibiting peripheral alterations. White without pressure (WWP) and dark without pressure (DWP) were the most frequent findings, especially in ARB, where WWP and DWP were present in 86% of eyes. OCT imaging confirmed EZ reflectivity attenuation in areas of DWP, without signs of vitreous traction. Vascular abnormalities were detected in nearly half of all eyes, with intraretinal microvascular abnormalities (IRMAs) and vessel tortuosity more common in BVMD, and focal narrowing more frequent in ARB. Overall, peripheral changes were evenly distributed across Gass stages in BVMD.</p><p><strong>Conclusion: </strong>BEST1 -related retinopathies are associated with a spectrum of peripheral retinal changes, particularly retinal reflectance alterations.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"1424-1430"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147583075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}