Retina-The Journal of Retinal and Vitreous Diseases最新文献_第6页

Prevalence and associated factors of choroidal caverns in patients with type 2 diabetes mellitus. 2型糖尿病患者脉络膜腔的患病率及相关因素分析。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-12-03 DOI: 10.1097/IAE.0000000000004365

Lourdes Vidal-Oliver, Sabrina Spissinger, Elisa Herzig-de Almeida, Davide Garzone, Argyrios Chronopoulos, Robert P Finger

{"title":"Prevalence and associated factors of choroidal caverns in patients with type 2 diabetes mellitus.","authors":"Lourdes Vidal-Oliver, Sabrina Spissinger, Elisa Herzig-de Almeida, Davide Garzone, Argyrios Chronopoulos, Robert P Finger","doi":"10.1097/IAE.0000000000004365","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004365","url":null,"abstract":"Purpose: To study the prevalence of choroidal caverns (CCs) in patients with type 2 diabetes (T2DM) and their association with demographic and clinical data.Methods: We included patients with T2DM and nondiabetic controls in a cross-sectional, monocenter study. The main outcome measure was the presence of CCs. Exploratory variables included age, sex, diabetic retinopathy (DR) status, duration of T2DM, visual acuity, arterial hypertension (aHT), hyperlipidemia, HbA1c, choroidal thickness (CT) and choroidal vascularity index (CVI). Group differences between eyes with and without CCs and associations with demographic and clinical variables were assessed.Results: After including a total of 205 eyes of 116 patients, the prevalence of CCs was 25% in the control, 28% in the T2DM without DR and 9.5% in the DR groups. The locations of the caverns were: choriocapillaris (N=2, 4.2%), Sattler's (N=29, 60.4%) and Haller's layer (N=17, 35.4%). 34.3% of patients had caverns in both eyes. We found no significant differences in systemic conditions (including aHT, hyperlipidemia, HbA1c or T2DM disease duration). CVI was the only parameter independently associated with the presence of choroidal caverns (OR 1.37).Conclusions: We found choroidal caverns in almost a quarter of patients with and without T2DM. CCs were mainly located in the Sattler's layer. CVI was independently associated with the presence of CCs. These findings suggest that the presence of CCs may be a sign of a higher metabolic activity within the choroidal microenvironment, irrespective of T2DM status.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social Determinants of Health in Age-Related Macular Degeneration: A Nationally Representative Survey Study. 年龄相关性黄斑变性健康的社会决定因素：一项全国代表性调查研究

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-12-03 DOI: 10.1097/IAE.0000000000004356

Ryan S Huang, Nikhil S Patil, Andrew Mihalache, Jim Xie, Marko M Popovic, Peter J Kertes, Rajeev H Muni, Radha P Kohly

{"title":"Social Determinants of Health in Age-Related Macular Degeneration: A Nationally Representative Survey Study.","authors":"Ryan S Huang, Nikhil S Patil, Andrew Mihalache, Jim Xie, Marko M Popovic, Peter J Kertes, Rajeev H Muni, Radha P Kohly","doi":"10.1097/IAE.0000000000004356","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004356","url":null,"abstract":"Purpose: To investigate the relationship between social determinants of health (SDoH) and the prevalence of age-related macular degeneration (AMD).Methods: This analysis included adult respondents (>50 years old) from the 2017 National Health Interview Survey (NHIS). The primary outcomes were self-reported diagnosis of AMD and self-reported vision loss due to AMD. Univariable and multivariable logistic regression models were employed for analysis.Results: A total of 14,267 NHIS participants were included, of whom 668 (4.7%) reported an AMD diagnosis. In the multivariable analysis, respondents aged over 81 years had higher odds of AMD (OR=7.54, 95%CI=[4.76, 11.96], p<0.001) compared to those aged 51-60. Divorced, separated, or widowed participants (OR=1.27, 95%CI=[1.01, 1.61], p=0.042) were also associated with higher odds of AMD compared to married participants. Conversely, Black/African-American (OR=0.23, 95%CI=[0.14, 0.39], p<0.001), Asian (OR=0.38, 95%CI=[0.16, 0.88], p=0.023), and gay, lesbian, or bisexual respondents (OR=0.45, 95%CI=[0.22, 0.93], p=0.032) had lower odds of AMD compared to White and heterosexual respondents, respectively. Employment was also associated with lower odds of AMD (OR=0.71, 95%CI=[0.53, 0.96], p=0.026) compared to unemployment.Conclusion: Several SDoH were associated with self-reported AMD diagnosis. These factors should be considered by policymakers and clinicians to effectively orchestrate public health initiatives aimed at promoting equitable care.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient Assessment of Progression in Clinical Trials in Retinitis Pigmentosa. 色素性视网膜炎临床试验进展的有效评估。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-12-03 DOI: 10.1097/IAE.0000000000004360

Ryo Asaoka, Manabu Miyata, Akio Oishi, Yuri Fujino, Hiroshi Murata, Shuichiro Aoki, Keiko Azuma, Ryo Obata, Tatsuya Inoue

{"title":"Efficient Assessment of Progression in Clinical Trials in Retinitis Pigmentosa.","authors":"Ryo Asaoka, Manabu Miyata, Akio Oishi, Yuri Fujino, Hiroshi Murata, Shuichiro Aoki, Keiko Azuma, Ryo Obata, Tatsuya Inoue","doi":"10.1097/IAE.0000000000004360","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004360","url":null,"abstract":"Purpose: To conduct a simulation study to evaluate the effect of disease stage, frequency, and clustering of visual field (VF) tests, and inclusion of one or both eyes on sample size calculation in clinical trials on retinitis pigmentosa.Methods: A series of VFs were simulated on the basis of test-retest VF data in the early, moderate, and advanced stages of retinitis pigmentosa. VF measurements were scheduled 8 times in approximately 2 years. The probability to detect significant difference between treatment and control groups was measured. The investigation was conducted for 50%, 40%, 30%, 20% and 10% treatment effects.Results: When only one eye was used in each patient with a treatment effect of 50%, 80% probability of significance was observed in the moderate stage when sample size was 70 eyes in each arm (140 eyes in both arms). Early stage disease and inclusion of both eyes decreased this number to 30 eyes (60 eyes in both arms); these decreasing effects were larger than performing additional VFs at the beginning and end of the observation. A similar tendency was observed with 40%, 30%, 20% and 10% treatment effects.Conclusions: When planning a clinical trial, it is important to consider disease stage, in addition to VF schedule and inclusion of one or both eyes.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncovering Hidden Patterns: Macrophage-like Cell Distribution Across Different Stages of Posterior Vitreous Detachment. 揭示隐藏模式：巨噬细胞样细胞分布在玻璃体后脱离的不同阶段。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-12-03 DOI: 10.1097/IAE.0000000000004358

Gongpeng Sun, Amin Xu, Xueying Yang, Lu Zhang, Wenyu Wang, Abdulla Sawut, Weichen Xu, Xiaoling Wang, Zuohuizi Yi, Hongmei Zheng, Changzheng Chen

{"title":"Uncovering Hidden Patterns: Macrophage-like Cell Distribution Across Different Stages of Posterior Vitreous Detachment.","authors":"Gongpeng Sun, Amin Xu, Xueying Yang, Lu Zhang, Wenyu Wang, Abdulla Sawut, Weichen Xu, Xiaoling Wang, Zuohuizi Yi, Hongmei Zheng, Changzheng Chen","doi":"10.1097/IAE.0000000000004358","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004358","url":null,"abstract":"Purpose: To investigate the distribution of macrophage-like cells (MLCs) across different stages of posterior vitreous detachment (PVD).Methods: A total of 168 eyes from 168 subjects were included. MLCs were imaged by acquiring en face OCT images at depths of 5 to 10 µm on the inner limiting membrane, as well as using B-scan OCT. Participants were categorized into three groups according to the degree of PVD: Group A for stage 1a PVD, Group B for stages 1b and 2 PVD, and Group C for stages 3 and 4 PVD. Localized vitreoretinal relationships were categorized into vitreoretinal adhesions, type 1a PVD, where the vitreous and retina are not clearly separated, and type 1b PVD, where there is clear separation.Results: MLC density was sequentially lower in Groups A, B, and C. Multiple linear regression analysis revealed that MLC density was correlated with both the PVD group and age (both P < 0.001). In Group A, MLC density was significantly higher in type 1a PVD than in the vitreoretinal adhesion area. In Group B, the distribution of MLCs in the vitreoretinal adhesion region was significantly less than in type 1a PVD and type 1b PVD. MLCs were more sparsely distributed in Group C.Conclusions: MLCs exhibit distinct distribution patterns in various stages of PVD.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Characteristics and Surgical Outcomes of the Full-thickness Macular Hole Without Focal Vitreomacular Traction: A Multicenter Retrospective Study. 无局灶性玻璃体黄斑牵引的全层黄斑裂孔的临床特征和手术结果：一项多中心回顾性研究。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-12-02 DOI: 10.1097/IAE.0000000000004357

Ryota Akai, Rikuto Inoue, Jiro Kogo, Masaki Fukushima, Tsuyoshi Kato, Atsushi Hayashi, Takeshi Iwase

{"title":"Clinical Characteristics and Surgical Outcomes of the Full-thickness Macular Hole Without Focal Vitreomacular Traction: A Multicenter Retrospective Study.","authors":"Ryota Akai, Rikuto Inoue, Jiro Kogo, Masaki Fukushima, Tsuyoshi Kato, Atsushi Hayashi, Takeshi Iwase","doi":"10.1097/IAE.0000000000004357","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004357","url":null,"abstract":"Purpose: This study investigated the clinical features and surgical outcomes of full-thickness macular holes (FTMHs) without focal vitreomacular traction (VMT) and discusses possible underlying mechanisms.Methods: This was a retrospective observational study included patients aged 18 years or older with stage 2 FTMHs who underwent pars plana vitrectomy at three hospitals between December 2016 and March 2024. Patients diagnosed without focal VMT in the macula were classified as VMT- and those with focal VMT were classified as VMT+. Medical records and comprehensive ophthalmologic examinations, including best-corrected visual acuity (BCVA) and optical coherence tomography assessments, were reviewed.Results: This study analyzed 94 eyes that underwent surgery for stage 2 MHs. Patients in the VMT- were younger (VMT- vs VMT+: 63.6 vs 69.1 years, P = 0.008), had a longer axial length (AL) (25.2 vs 24.0 mm, P = 0.004), and had better preoperative BCVA [0.41 (20/43) vs 0.66 (20/74) logMAR, P = 0.002 ] compared with the VMT+. The VMT- had a higher prevalence of epiretinal proliferation (EP) compared with the VMT+ (76 vs 5 %, P<0.001). Postoperatively, no significant difference in visual outcomes was found between the two groups . VMT- showed significantly thicker central retinal thickness at 1 month (244 vs 201 μm, P = 0.021) and poorer external limiting membrane status at 1 month compared with the VMT+.Conclusions: FTMHs without focal VMT were associated with younger age, longer AL, better baseline visual acuity, and a higher incidence of EP compared with FTMHs with VMT.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absorbable gelatin sponge as an intrascleral buckle in rabbits: a pilot study. 可吸收明胶海绵作为兔巩膜内扣环的初步研究。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-12-02 DOI: 10.1097/IAE.0000000000004359

Yan Zhou, Shiqun Lin, Xingyu Xiao, Youxin Chen, Zhe Chen, Rongping Dai

{"title":"Absorbable gelatin sponge as an intrascleral buckle in rabbits: a pilot study.","authors":"Yan Zhou, Shiqun Lin, Xingyu Xiao, Youxin Chen, Zhe Chen, Rongping Dai","doi":"10.1097/IAE.0000000000004359","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004359","url":null,"abstract":"Purpose: This study aimed to evaluate the efficacy and safety of using an absorbable gelatin sponge as an intrascleral buckle in rabbit eyes; it also monitored degradation of the gelatin sponge over time.Methods: Ten New Zealand white rabbits underwent surgery to implant an absorbable gelatin sponge as an intrascleral buckle. Weekly ophthalmic examinations were conducted before and after the procedure until the implant was fully absorbed. Assessments included external eye and fundus examinations, color fundus imaging, and optical coherence tomography. Safety and efficacy were determined by comparing pre-operative and post-operative conditions.Results: The surgery was successfully completed in 12 of 20 eyes, yielding favorable postoperative outcomes. Eight eyes were excluded due to issues with scleral tunneling, including accidental penetration, suprachoroidal implantation of the sponge, and choroidal excavation, resulting in a success rate of 60%. The indentation produced by the gelatin sponge implant progressively decreased, entirely disappearing within 2 weeks. No complications, such as retinal or choroidal hemorrhage or detachment, were observed.Conclusion: Intrascleral implantation of absorbable gelatin sponge was safe and effective for scleral buckling in rabbits, demonstrating favorable biodegradation characteristics.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the Surface: Investigating Silicone Oil's Impact on Macular Perfusion in Macula-off Rhegmatogenous Retinal Detachment via OCTA. 表面之外：通过OCTA研究硅油对黄斑脱落孔源性视网膜脱离的黄斑灌注的影响。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-12-02 DOI: 10.1097/IAE.0000000000004364

Ece Ozal, Muzaffer Said Guler, Murat Karapapak, Hakan Baybora, Serhat Ermıs, Yusuf Cem Yılmaz, Serife Ciloglu Hayat, Sadık Altan Ozal

{"title":"Beyond the Surface: Investigating Silicone Oil's Impact on Macular Perfusion in Macula-off Rhegmatogenous Retinal Detachment via OCTA.","authors":"Ece Ozal, Muzaffer Said Guler, Murat Karapapak, Hakan Baybora, Serhat Ermıs, Yusuf Cem Yılmaz, Serife Ciloglu Hayat, Sadık Altan Ozal","doi":"10.1097/IAE.0000000000004364","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004364","url":null,"abstract":"Purpose: This study aims to compare macular vessel density (VD) in eyes with macula-off rhegmatogenous retinal detachment (RRD) after vitrectomy with gas or silicone oil (SO) tamponade.Methods: Patients with macula-off RRD who underwent vitrectomy with either gas or SO tamponade were included. Best-corrected visual acuity (BCVA) and VD in superficial and deep retinal capillary plexuses (SCP and DCP), choriocapillaris (CCP), and foveal avascular zone (FAZ) were assessed using optical coherence tomography angiography (OCTA). Comparisons were made with the unaffected fellow eye.Results: Fifty patients (average age: 57.9±9.1 years) participated, with 26 eyes undergoing SO tamponade and 24 gas tamponade. No significant differences were found in baseline characteristics. Postoperative BCVA significantly improved in both groups. In the SO group, BCVA improved from 2.00±0.77 logMAR (20/2000 Snellen) to 0.95±0.52 logMAR (20/178 Snellen). In the gas tamponade group, BCVA improved from 2.12±0.70 logMAR (20/2636 Snellen) to 0.70±0.55 logMAR (20/100 Snellen) (p<0.001 for both groups). Moreover, the gas tamponade group achieved significantly better postoperative BCVA compared to the silicone oil group (p<0.05). SO tamponade group exhibited significantly lower VD in SCP, DCP, and CCP quadrants (p<0.05), while gas tamponade showed no significant differences.Conclusion: This study reveals a decrease in VD in SCP, DCP, and CCP induced by SO tamponade, suggesting potential toxic effects on macular perfusion. Gas tamponade resulted in superior BCVA outcomes and preserved VD. Further investigation into SO's underlying mechanisms and careful patient selection is warranted. Gas tamponade may offer better outcomes for macula-off RRD.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Foveal Hypoplasia in Children with a History of Retinopathy of Prematurity. 有早产儿视网膜病变史的儿童中央窝发育不全的评价。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-12-02 DOI: 10.1097/IAE.0000000000004362

Gökhan Çelik, Bilge Batu Oto, Osman Kızılay, Murat Gunay

{"title":"Evaluation of Foveal Hypoplasia in Children with a History of Retinopathy of Prematurity.","authors":"Gökhan Çelik, Bilge Batu Oto, Osman Kızılay, Murat Gunay","doi":"10.1097/IAE.0000000000004362","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004362","url":null,"abstract":"Purpose: To evaluate the foveal development in patients diagnosed with retinopathy of prematurity (ROP) and to evaluate whether foveal development was affected by treatment in ROP patients.Methods: This cross-sectional study included patients with a history of ROP. Foveal development was compared between eyes with spontaneous regression and treated eyes. Additionally, gestational age, birth weight, ROP zone and stage, and postmenstrual gestational age at the time of treatment, were evaluated. The final visual acuity was analyzed according to the foveal hypoplasia (FH) severity.Results: This study included 166 eyes from 83 patients. Foveal development was significantly different among the treatment and spontaneous regression groups, and FH was more severe in the treatment group. The prevalence of normal foveal development was higher in the spontaneous regression group than in the treatment groups. This suggests that ROP treatment may induce morphological alterations during foveal development. Gestational age, postmenstrual age at the time of treatment, ROP stage, and ROP zone were correlated with FH severity. Visual acuity was not affected by mild FH, and 88.5% of the patients had a visual acuity of LogMAR 0.Conclusion: Early stage foveal development is not significantly disrupted in patients with ROP, and patients with ROP show no significant visual disturbance associated with FH. However,eyes treated for ROP either with laser photocoagulation or intravitreal anti-vascular endothelial growth factor demonstrated more severe hypoplasia compared to that with spontaneous regression.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BILATERAL MULTIPLE RETINAL SEROUS DETACHMENTS ASSOCIATED WITH FGFR INHIBITOR THERAPY. 与FGFR抑制剂治疗相关的双侧多发性视网膜浆液性脱离。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-12-02 DOI: 10.1097/IAE.0000000000004363

Rita Rodrigues, Manuel Falcão

引用次数: 0

Tissue Glue-Assisted Plaque Radiotherapy for Choroidal Tumors with Scleral Thinning. 组织胶辅助斑块放疗治疗伴有巩膜变薄的脉络膜肿瘤。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-11-27 DOI: 10.1097/IAE.0000000000004355

Carol L Shields, Rhea Suribhatla, Mark Romero, Christin Ealer, Rolika Bansal, Jacqueline Emrich, Lydia Komarnicky-Kocher, Sara E Lally

{"title":"Tissue Glue-Assisted Plaque Radiotherapy for Choroidal Tumors with Scleral Thinning.","authors":"Carol L Shields, Rhea Suribhatla, Mark Romero, Christin Ealer, Rolika Bansal, Jacqueline Emrich, Lydia Komarnicky-Kocher, Sara E Lally","doi":"10.1097/IAE.0000000000004355","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004355","url":null,"abstract":"Purpose: To evaluate tissue glue-assisted plaque placement regarding accuracy, stability, and longer-term outcomes for choroidal tumors with scleral thinning.Methods: All patients with tissue glue-assisted plaque radiotherapy at a single ocular oncology center were evaluated for patient demographics, tumor features, surgical details, tumor response, and glue-related complications.Results: There were 13 patients (mean age 72 years) treated with tissue glue-assisted plaque radiotherapy for choroidal melanoma (n=12) or choroidal metastasis (n=1). At presentation, the tumor was mean 4.3 mm to the optic disc and 2.0 mm to the foveola with mean basal diameter of 9.5 mm and thickness of 4.2 mm. In all cases, the tissue glue-assistance was employed due to extreme scleral thinning in the bed of proposed radiation. The plaque size was 15 mm (n=5), 18 mm (n=7), or 20 mm (n=1). At application, there was no immediate glue hypersensitivity, ultrasonography confirmed accuracy of placement, and the glue remained adherent for the entire treatment duration (mean 113 hours) with stable plaque location at removal. At removal, the plaque-glue composite was peeled off the globe without need for glue dissolvent and without scleral disruption. At 12 months mean melanoma thickness (2.7 mm, regression 36%). There were no conjunctival, corneal, or scleral complications.Conclusion: Tissue glue-assisted plaque radiotherapy is safe and effective for treatment of choroidal tumors with thin sclera.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0