Kyeung Min Kim, Se Joon Woo, Sang Jun Park, Kwangsic Joo, Min Seok Kim
{"title":"Natural history of tractional lamellar macular hole.","authors":"Kyeung Min Kim, Se Joon Woo, Sang Jun Park, Kwangsic Joo, Min Seok Kim","doi":"10.1097/IAE.0000000000004659","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004659","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the long-term functional and anatomical outcomes in patients with tractional lamellar macular holes who were managed without surgical intervention.</p><p><strong>Methods: </strong>63 eyes previously diagnosed with tractional lamellar macular hole between July 1, 2009 and January 30, 2024 without any surgical interventions were enrolled. The change in best-corrected visual acuity (BCVA), lamellar hole diameter, central retinal thickness (CRT) on Optical coherence tomography (OCT), foveal avascular zone (FAZ) areas on OCT angiography, and M-chart scores between initial and final visit were assessed.</p><p><strong>Results: </strong>The mean follow-up was 3.7±3.0 years. BCVA remained stable (0.07±0.07 to 0.08±0.09 logMAR; ≈20/23 to 20/24 Snellen equivalent; P=0.464). Lamellar hole diameter increased significantly (1586±610 to 1786±603 µm, P<0.001), while CRT remained unchanged (374±60 to 372±62 µm, P=0.564). FAZ area in the deep capillary plexus significantly increased (1.01±0.49 to 1.19±0.62 mm2, P=0.009), whereas FAZ in the superficial capillary plexus showed no significant change (0.48±0.19 to 0.49±0.18 mm2, P=0.624). M-chart scores remained stable in both horizontal and vertical axis (0.12±0.27 to 0.16±0.33 degree, P=0.534; 0.17±0.31 to 0.15±0.28 degree, P=0.640, respectively).</p><p><strong>Conclusions: </strong>Patients with tractional lamellar macular holes maintained stable visual function over long-term follow-up without surgical intervention.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maurizio Battaglia Parodi, Lorenzo Bianco, Alessio Antropoli, Annamaria Nunziata, Sebastiano Del Fabbro, Alessandro Arrigo, Francesco Bandello
{"title":"ACQUIRED TORPEDO-LIKE MACULOPATHY ASSOCIATED WITH MACULAR NEOVASCULARIZATION IN BEST VITELLIFORM MACULAR DYSTROPHY.","authors":"Maurizio Battaglia Parodi, Lorenzo Bianco, Alessio Antropoli, Annamaria Nunziata, Sebastiano Del Fabbro, Alessandro Arrigo, Francesco Bandello","doi":"10.1097/IAE.0000000000004666","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004666","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Classifying Subretinal Lucency: A Matter of Terminology and Resolution.","authors":"Ryoh Funatsu, Hiroto Terasaki","doi":"10.1097/IAE.0000000000004655","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004655","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katherine L Jung, Aurora Pecaku, Suellen Demian, Miguel Cruz Pimentel, Isabela Martins Melo, Rajeev H Muni
{"title":"Reply: Letter to the Editor.","authors":"Katherine L Jung, Aurora Pecaku, Suellen Demian, Miguel Cruz Pimentel, Isabela Martins Melo, Rajeev H Muni","doi":"10.1097/IAE.0000000000004657","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004657","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer I Lim, Ogugua N Okonkwo, Sally S Ong, Carl D Regillo, Adrienne W Scott, Charles C Wykoff, Jessica Cao, Alicia Chen, Bernadette A Miao, Bita Momenaei, Jianyou Liu
{"title":"Anti-Vascular Endothelial Growth Factor Therapy for Stages 3 and 4 Proliferative Sickle Cell Retinopathy Results in Improved Anatomic and Visual Outcomes.","authors":"Jennifer I Lim, Ogugua N Okonkwo, Sally S Ong, Carl D Regillo, Adrienne W Scott, Charles C Wykoff, Jessica Cao, Alicia Chen, Bernadette A Miao, Bita Momenaei, Jianyou Liu","doi":"10.1097/IAE.0000000000004658","DOIUrl":"10.1097/IAE.0000000000004658","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the potential utility of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy for stages 3 and 4 proliferative sickle cell retinopathy (PSR).</p><p><strong>Methods: </strong>Retrospective review of anatomic and visual acuity outcomes after intravitreal anti-VEGF therapy for stages 3 and 4 PSR eyes.</p><p><strong>Results: </strong>There were 45 PSR eyes (17 stage 3 and 28 stage 4) treated with anti-VEGF agents (bevacizumab (37 eyes), aflibercept (6 eyes), ranibizumab (3 eyes), one eye received 2 both bevacizumab and aflibercept). Follow-up ranged from 1 to 120 months (mean= 21 months). Within 1 month after anti-VEGF treatment, VA improved > 2 lines in 17/45 eyes, remained stable in 27/45 eyes and worsened in 1/45 eyes. Median visual acuity remained 20/20 for stage 3 and improved from 20/200 to 20/30 for stage 4 PSR eyes. More stage 4 PSR eyes had VA improvement post-treatment than stage 3 PSR eyes (P=0.003). There were no cases of endophthalmitis. Visual acuity outcomes were similar for anti-VEGF with and without laser treatment. Control of PSR was achieved in 42/45 (93%) of eyes without the need for pars plana vitrectomy.</p><p><strong>Conclusion: </strong>Within one month of treatment, administration of anti-VEGF therapy of PSR eyes resulted in seafan regression, clearing of vitreous hemorrhage, and stable or improved vision in most eyes.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12529713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leonardo Nunes Bezerra Souza, Felipe de Queiroz Tavares Ferreira
{"title":"HYPORREFLECTIVE LUCENCY, SUBRETINAL PSEUDOCYST AND VACUOLE SIGN: DISCUSSION ON TERMINOLOGY AND TOPOGRAPHIC CORRELATION WITH LEAKAGE SITES IN CSC.","authors":"Leonardo Nunes Bezerra Souza, Felipe de Queiroz Tavares Ferreira","doi":"10.1097/IAE.0000000000004654","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004654","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristine Y Wang, Sidra Zafar, Julia Yu, Adina S Kazan, Lara Cheslow, Taku Wakabayashi, Robert Abishek, Meera Sivalingam, Raziyeh Mahmoudzadeh, Jason Hsu
{"title":"Rate and Severity of Epiretinal Membrane Formation Following Scleral Buckling Surgery.","authors":"Kristine Y Wang, Sidra Zafar, Julia Yu, Adina S Kazan, Lara Cheslow, Taku Wakabayashi, Robert Abishek, Meera Sivalingam, Raziyeh Mahmoudzadeh, Jason Hsu","doi":"10.1097/IAE.0000000000004652","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004652","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the rate and progression of epiretinal membrane (ERM) formation following scleral buckling (SB) for rhegmatogenous retinal detachment (RRD).</p><p><strong>Methods: </strong>A retrospective review of eyes undergoing SB for RRD repair between January 2015 and June 2022 that developed ERM. ERM grading and structural analysis were performed using spectral domain optical coherence tomography (SD-OCT) based on a standardized scheme.</p><p><strong>Results: </strong>Among 1064 eyes undergoing SB, 143 eyes (13.4%) developed ERM. Over a mean (SD, standard deviation) follow-up of 5.3 (2.6) years, most eyes (122/143, 85.3%) were observed, while 21 (14.7%) underwent membrane peeling (MP) at a mean (SD) of 13.2 (13.8) months post-SB. There was no statistically significant ERM stage predilection observed in the eyes that underwent MP. The observed eyes had mean (SD) logMAR VA [Snellen equivalent] of 0.51 (0.63) [20/65] at ERM diagnosis, 0.34 (0.39) [20/44] at 12 months post-ERM diagnosis (p=0.03), and 0.36 (0.43) [20/46] at final visit (p=0.03). In eyes that underwent MP, mean (SD) logMAR VA [Snellen] improved from 1.25 (0.69) [20/356] pre-peel to 0.63 (0.71) [20/85] at final visit (p<0.001).</p><p><strong>Conclusion: </strong>ERM commonly develops after SB for RRD repair. Most cases were mild stage and managed conservatively with vision improving over 5.3 years.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sidra Zafar, Aaron T Zhao, Rebecca R Soares, Martin Calotti, Elliott Sina, Turner D Wibbelsman, Bita Momenaei, Roselind L Ni, Luis Acaba-Berrocal, Samir N Patel, David Xu, Yoshihiro Yonekawa
{"title":"Sociodemographic factors affecting presentation in pediatric rhegmatogenous retinal detachment.","authors":"Sidra Zafar, Aaron T Zhao, Rebecca R Soares, Martin Calotti, Elliott Sina, Turner D Wibbelsman, Bita Momenaei, Roselind L Ni, Luis Acaba-Berrocal, Samir N Patel, David Xu, Yoshihiro Yonekawa","doi":"10.1097/IAE.0000000000004650","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004650","url":null,"abstract":"<p><strong>Purpose: </strong>Evaluate impact of sociodemographic factors with visual acuity (VA) and macula status at presentation in pediatric rhegmatogenous retinal detachment (RRD) and with single surgery anatomic success (SSAS), postoperative VA and 1-year lost to follow-up (LTFU).</p><p><strong>Methods: </strong>Retrospective review of patients <18 years who presented with RRD between 2015-2024. Data on demographics (age, gender, race, ethnicity), area deprivation index (ADI), insurance status, rurality of residence and travel time to clinic were recorded. VA was recorded at presentation and 12-month postoperative visit. Regression analysis was used to evaluate the relationship of sociodemographic factors with macula status at presentation, presenting VA, SSAS, 12-month postoperative VA and LTFU.</p><p><strong>Results: </strong>Of the 229 pediatric patients who presented with RRD, 33.6% (N=77/229) were macula-on at presentation. The mean (± standard deviation) patient age was 12.9 (± 4.1) years and 58% were male. On multivariable analysis, older age (OR 1.17, 95% confidence interval: 1.07-1.28, p<0.001) was the only factor predictive of macula-on status at presentation. Females (OR 2.31, 95% CI: 1.18-4.56, p=0.02) versus males were more likely to have better vision (VA 20/40 or better) at presentation. The SSAS was 85.9%, and macula-off status at presentation (OR 4.47, 95% CI: 1.21-16.46; p=0.02) was associated with increased likelihood of needing reoperation. The 1-year LTFU rate was 46%, with insured status associated with decreased odds of LTFU.</p><p><strong>Conclusions: </strong>Older age and female gender were associated with more favorable presentation among pediatric RRDs and insurance status influenced LTFU. ADI and travel time did not influence presentation or postoperative outcomes in pediatric RRDs.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Changes in widefield choroidal thickness after anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration.","authors":"Sorako Wakugawa, Naoya Imanaga, Nobuhiro Terao, Choyu Kuroshima, Yasunori Miyara, Marina Maehira, Hideki Koizumi","doi":"10.1097/IAE.0000000000004651","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004651","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate changes in choroidal thickness using widefield optical coherence tomography following anti-vascular endothelial growth factor (VEGF) therapy for neovascular age-related macular degeneration (AMD).</p><p><strong>Methods: </strong>We examined 69 patients with unilateral neovascular AMD. All patients underwent three monthly intravitreal injections of anti-VEGF agents. Widefield choroidal thickness within an 18-mm circular glid centered on the fovea, subdivided into nine areas, was evaluated at baseline and at 3 months.</p><p><strong>Results: </strong>Forty-two and 27 patients were classified into the AMD and pachychoroid neovasculopathy (PNV) groups, respectively. At 3 months, the treated eyes in both groups showed significantly and extensively reduced choroidal thickness (P < 0.01 for all areas). The untreated fellow eyes in the PNV group also showed decreased choroidal thickness at 3 months (P < 0.05 for all areas). Complete retinal fluid resolution was significantly associated with a greater decrease ratio of choroidal thickness in the PNV group (P < 0.05 for all areas).</p><p><strong>Conclusion: </strong>Anti-VEGF therapy for neovascular AMD led to extensively decreased choroidal thickness. In patients with PNV, a greater decrease in overall choroidal thickness appeared to be associated with more effective resolution of retinal fluid. Observation of widefield choroidal thickness may be important for the management of neovascular AMD.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}