Retina-The Journal of Retinal and Vitreous Diseases最新文献

{"title":"Pores in the retinal inner limiting membrane formed by Müller cell protrusions.","authors":"Denise Vogt, Ross Laws, Ricarda G Schumann, Yulia Zaytseva, Armin Wolf, David H Steel","doi":"10.1097/IAE.0000000000004671","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004671","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the ultrastructure of inner limiting membrane (ILM) pores in whole-retina specimens, and to compare with surgically excised specimens from eyes with vitreo-maculopathies.</p><p><strong>Methods: </strong>Ultrastructural analysis included (1) three-dimensional serial block-face scanning electron microscopy (3D SBF-SEM) of inner retinal layers from macular area of two human donor eyes, and (2) transmission electron microscopy (TEM) of ILM specimens obtained from 25 eyes with tractional vitreo-maculopathies that tested positive for the presence of ILM pores.</p><p><strong>Results: </strong>SBF-SEM analysis revealed circumscribed areas of ILM thinning and multiple retinal cell processes protruding into the ILM with or without ILM breakthrough. In the peri-pore regions the ILM was thin and bulged towards the vitreous. Müller cells had finger-like extensions through the ILM forming small individual breakthrough points. Surgically removed ILM specimens also showed regions with ILM thinning and protruding retinal cell fragments in the ILM but with no pre-existing ILM breakthroughs. Epiretinal cells were found on the vitreal side of the ILM pore regions.</p><p><strong>Conclusion: </strong>There is evidence that ILM pores are newly formed by retinal Müller cells, growing their processes through the ILM towards its vitreal side in health and disease. These pore regions may contribute to the formation of epiretinal membranes.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy Versus Standard Silicone Oil Tamponade in Primary Retinal Detachment Surgery: a Systematic Review and Meta-Analysis.","authors":"Matteo Mario Carlà, Carlos Mateo, Tomaso Caporossi, Federico Giannuzzi, Francesco Boselli, Emanuele Crincoli, Stanislao Rizzo","doi":"10.1097/IAE.0000000000004660","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004660","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the anatomical and functional outcomes of heavy and standard silicone oil (HSO and SSO) in primary rhegmatogenous retinal detachment (RRD), along with post-operative complications.</p><p><strong>Methods: </strong>Meta-analysis conducted in accordance with PRISMA guidelines and registered on PROSPERO (CRD42024507061). We retrieved randomized trials, prospective and retrospective studies comparing HSO and SSO to manage primary inferior/posterior or complex RRDs published from 2000 to nowadays in PubMed/Medline-Embase-Cochrane-Scholar-Web of Science. This meta-analysis focused on primary success rates, best-corrected visual acuity (BCVA) improvement and postoperative complications.</p><p><strong>Results: </strong>A total of 6 studies on 984 eyes (615 in SSO and 369 in HSO group) were included. In a fixed-effect model (p=0.112, I2 = 43.99%), HSO and SSO tamponades showed comparable primary anatomic success rates (OR 1.461, 95% CI: 0.890 to 2.399, p=0.134). Average BCVA improvement was similar between the 2 groups (I2 = 79.21%, WMD -0.071 LogMAR; 95% CI:-0.524 to 0.382, p=0.61). Conversely, HSO tamponade was associated with higher rates of IOP elevation (I2 = 37.42%, OR 2.073, 95% CI: 1.182 to 3.634, p=0.011) and emulsification (I2 = 16.43%, OR 2.953, 95% CI: 1.109 to 7.862, p=0.030). Finally, inflammation rates did not differ between HSO and SSO (I2 = 66.46%, OR 2.015, 95% CI: 0.234 to 17.323, p=0.523).</p><p><strong>Conclusion: </strong>HSOs showed similar rates of primary anatomic success when compared to SSOs in complex primary RRDs. Although hindered by poor baseline values, visual outcomes were generally comparable among the two groups. In contrast, HSO group showed higher rates of post-operative IOP elevation and emulsification.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicenter Study of Factors Associated with Visual and Anatomic Outcomes of Suprachoroidal Hemorrhage.","authors":"Tianyu Liu, Sahal Saleh, Jason Keil, Revati Rashingkar, Yinxi Yu, Gui-Shuang Ying, George A Williams, Alexander J Brucker, Benjamin J Kim","doi":"10.1097/IAE.0000000000004670","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004670","url":null,"abstract":"<p><strong>Purpose: </strong>To report outcomes of suprachoroidal hemorrhage (SCH).</p><p><strong>Methods: </strong>Retrospective non-randomized study of eyes with SCH from two sites (1/1/2013-12/31/2022). The primary outcome was the 6-month change in visual acuity (VA). Multivariable analysis was performed, as well as a comparison of matched eyes with and without systemic steroids.</p><p><strong>Results: </strong>143 eyes of 143 patients (mean age 70.8 years, 52.4% male) were included, with 72 perioperative, 24 traumatic, and 47 spontaneous SCH cases. The mean (SD) presenting VA was 2.07 (0.92) logMAR. 87 (60.8%) were managed non-surgically, 24 (16.8%) underwent drainage, and 32 (22.4%) underwent drainage and vitrectomy; 36 (25.2%) received systemic steroids. At 6 months, the mean (SD) change in VA from presentation was -0.41 (0.84) logMAR. 102 (71.3%) eyes achieved anatomic success (complete retinal attachment). Concurrent RD was associated with worse VA change and anatomic success in multivariable analysis (P < 0.05). In the matching analysis, eyes receiving systemic steroids were more likely to achieve ≥ 3-line gain in VA than matched eyes without systemic steroids (77.8% vs 55.3%, P = 0.047).</p><p><strong>Conclusion: </strong>The visual prognosis of eyes with SCH remains guarded. Systemic steroids may be associated with a modest benefit for visual outcomes. Concurrent RD portends worse outcomes.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pars Plana Vitrectomy- Suprachoroidal Viscopexy for Rhegmatogenous Retinal Detachment Repair.","authors":"Rajeev H Muni, Isabela Martins Melo, Shiva Sabour, Tomas Minelli, Hatim Batawi, Aurora Pecaku","doi":"10.1097/IAE.0000000000004642","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004642","url":null,"abstract":"<p><strong>Purpose: </strong>To report reattachment rate (RR) of pars plana vitrectomy-suprachoroidal viscopexy (VIT-SCVEXY) for rhegmatogenous retinal detachment (RRD) repair. Additionally, this study compares the anatomic reattachment rate and functional outcomes of VIT-SCVEXY vs pars plana vitrectomy with traditional scleral buckle (PPV-SB) at postoperative month 3 and final follow-up.</p><p><strong>Methods: </strong>A retrospective cohort study conducted at St. Michael's Hospital, Toronto, Canada, between 2023 and 2024. Consecutive cases of RRD with inferior breaks were included, comparing outcomes between those who underwent VIT-SCVEXY (n = 12) vs PPV-SB (n = 12). Cases were matched for age, gender, lens status, retinal detachment characteristics, preoperative visual acuity, and follow-up duration.</p><p><strong>Results: </strong>A suprachoroidal viscoelastic buckle was successfully created under the break(s) in 75.0% (9/12) of PPV-SCVEXY cases. The reattachment rate at 3 months in those with a successful suprachoroidal buckle was 100% (9/9), with a mean LogMAR BCVA of 0.75 ± 0.25 (Snellen 20/100). The reattachment rate for VIT-SCVEXY and PPV-SB cohorts at 3 months was 100% (12/12). At final follow-up, 88.8% (8/9) of patients who had PPV-SCVEXY remained attached, with an overall retinal reattachment rate of 91.6% (11/12) vs 100% (12/12) in the PPV-SB cohort, p=1.0. Mean LogMAR VA was 0.7±0.5 vs 0.7±0.3 (Snellen 20/100), p=0.9. Chemosis was observed in 25.0% (3/12) of VIT-SCVEXY cases, whereas no adverse events were recorded in PPV-SB cases.</p><p><strong>Conclusions: </strong>VIT-SCVEXY may be a less invasive alternative to PPV-SB with comparable anatomic and functional outcomes. However, further investigations are warranted.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Posterior Vitreous Detachment Annotation Consistency on OCT Scans in Patients with Disease of the Vitreomacular Interface.","authors":"Lorenzo Ferro Desideri, Nina Eldridge, Nicola Sagurski, Jonathan Brenneisen, Florian Heussen, Raphael Sznitman, Sebastian Wolf, Martin Zinkernagel, Rodrigo Anguita","doi":"10.1097/IAE.0000000000004668","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004668","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate inter-grader variability in posterior vitreous detachment (PVD) classification in patients with epiretinal membrane (ERM) and macular hole (MH) on spectral-domain optical coherence tomography (SD-OCT) and identify challenges in defining a reliable ground truth for artificial intelligence (AI)-based tools.</p><p><strong>Methods: </strong>A total of 437 horizontal SD-OCT B-scans were retrospectively selected and independently annotated by six experienced ophthalmologists adopting four categories: 'full PVD', 'partial PVD', 'no PVD', and 'ungradable'. Inter-grader agreement was assessed using pairwise Cohen's kappa scores. Consensus levels, accuracy, recall, specificity, and grading time were also analyzed using the majority vote as reference.</p><p><strong>Results: </strong>The overall average Cohen's kappa was 0.57. Agreement was highest for 'partial PVD' (Cohen's kappa = 0.70), followed by 'full PVD' (Cohen's kappa = 0.65), and lowest for 'no PVD' (Cohen's kappa = 0.14), indicating substantial diagnostic variability. Full consensus was achieved in only 31.1% of OCT scans, while 11.4% required adjudication. The sensitivity for 'no PVD' was notably low (0.35 ± 0.32), and misclassified OCT scans took significantly longer to grade (p < 0.001).</p><p><strong>Conclusion: </strong>Our results underscore challenges associated with reliable OCT-based classification of PVD in patients with diseases of the vitreomacular interface, especially for cases with completely attached vitreous. Improving inter-grader agreement through consensus grading and advanced imaging modalities will be critical for establishing a solid ground truth to support reliable, AI-driven PVD detection systems.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swept Source Optical Coherence Tomography Imaging of the Optic Pit Complex.","authors":"Richard F Spaide","doi":"10.1097/IAE.0000000000004662","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004662","url":null,"abstract":"<p><strong>Purpose: </strong>To reassess the anatomic basis of optic disc pit maculopathy (OPM) using swept-source optical coherence tomography (SS-OCT) and to characterize the broader structural abnormalities comprising the optic pit complex.</p><p><strong>Methods: </strong>Sixteen patients with OPM were imaged using a high-resolution SS-OCT system (DREAM OCT). Cross-sectional and volume-rendered scans were analyzed for lamina cribrosa defects, intraneural cavitations, and pathways for fluid entry into or beneath the retina.</p><p><strong>Results: </strong>All eyes demonstrated lamina cribrosa defects with associated cavitations extending a mean of 1855 ± 492 µm posterior to a modified Bruch's membrane opening. Four distinct patterns by which fluid entered the retina were observed: (1) direct channels from cavitations into the retina, (2) perivascular hyporeflective spaces, (3) intraneural channels extending toward cystoid spaces, and (4) isolated retinal cysts without a visible interconnection. Vitreous remnants, trabecular structures, or disorganized connective tissue were found within the optic nerve pit in several eyes. In 13% of cases, the pit was not visible by ophthalmoscopy due to overlying tissue. These structural variations frequently coexisted, and associated abnormalities extended beyond the optic disc margins.</p><p><strong>Conclusions: </strong>OPM is associated with a spectrum of deep optic nerve abnormalities, collectively termed the optic pit complex. The combination of laminar disruption, cavitations, and multiple anatomic conduits for fluid ingress broadens the morphologic understanding of this condition. SS-OCT enables visualization of structures not accessible by ophthalmoscopy and may improve diagnostic precision, guide treatment decisions, and clarify the diverse mechanisms contributing to fluid accumulation in OPM.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney Injury During Treatment with Aflibercept versus Ranibizumab: a Population-based Study.","authors":"Robert J Campbell, Sherif R El-Defrawy, Sudeep S Gill, Jonas Shellenberger, Marlo Whitehead, Chaim M Bell, Susan E Bronskill, J Michael Paterson, Michael A McIsaac","doi":"10.1097/IAE.0000000000004653","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004653","url":null,"abstract":"<p><strong>Purpose: </strong>Systemically administered anti-cancer VEGF inhibiting therapies can cause severe kidney injury. Intravitreal aflibercept has a greater impact on renal VEGF levels than ranibizumab. We compared the risk of kidney injury among patients receiving intravitreal aflibercept vs. ranibizumab.</p><p><strong>Methods: </strong>This population-based new-user active-comparator cohort study in Ontario, Canada, evaluated 44,571 patients aged 66 years and older, newly treated with intravitreal aflibercept or ranibizumab between August 1, 2015, and July 31, 2019. The risk of adverse renal outcomes was compared while controlling for baseline and time-varying covariates.</p><p><strong>Results: </strong>The composite renal outcome occurred in 12.0% (1,778/14,863) of aflibercept recipients versus 10.0% (1,327/13,289) of ranibizumab recipients (Relative risk: 1.00, 95% CI: 0.93-1.06 at 5 years follow up). No significant differences were observed across retinal disease subgroups.</p><p><strong>Conclusion: </strong>Intravitreal aflibercept and ranibizumab carry comparable risks of renal adverse events despite their distinct systemic pharmacodynamics.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 4 Macular Neovascularization (NV): A New Member of the Optical Coherence Tomography (OCT) Classification of NV Age-Related Macular Degeneration (AMD).","authors":"Hiok Hong Chan, Alessandro Feo, Diogo Cabral, Elodie Bousquet, Marko M Popovic, Alejandro Itzam Marin, Alberto Quarta, Wael M El-Haig, Kelvin Yi Chong Teo, Anna C S Tan, Chui Ming Gemmy Cheung, Giuseppe Querques, Andrea Govetto, Mario R Romano, Rodolfo Mastropasqua, Srinivas R Sadda, David Sarraf","doi":"10.1097/IAE.0000000000004664","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004664","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the clinical and multimodal imaging features of a novel form of macular neovascularization (MNV), designated Type 4 MNV, defined by mixed Type 1 and Type 2 neovascularization (NV), extensive intraretinal anastomotic NV, and central posterior hyaloid fibrosis (CPHF).</p><p><strong>Methods: </strong>This multicenter retrospective observational case series included patients with neovascular age-related macular degeneration (AMD) exhibiting both Type 1 and 2 MNV and an overlying anastomotic intraretinal NV network. This was confirmed with OCT and OCT angiography (OCTA). Demographics, baseline visual acuity (VA), and OCT imaging biomarkers including the hyperreflective oblique band (HOB) sign, CPHF, epiretinal membrane (ERM), and OCTA NV subtype were assessed.</p><p><strong>Results: </strong>Eleven eyes from eleven patients (mean age: 76.9 years; 36.4% female) met inclusion criteria. Baseline VA was logMAR 1.56 ± 0.45 (≈20/630) and 90.9% of subjects presented with severe visual loss. All eyes showed the HOB sign. CPHF was observed in 81.8% (9/11 subjects). ERM with radial traction was present in 81.8%. OCTA illustrated mixed Type 1 and 2 MNV with a prominent overlying intraretinal anastomotic network extending into the preretinal space.</p><p><strong>Conclusion: </strong>Type 4 MNV represents a distinct AMD phenotype with aggressive anatomical features including mixed Type 1 and 2 MNV, inner retinal and preretinal proliferation and anastomosis and retinal disorganization. The visual prognosis is invariably poor with recalcitrance to anti-VEGF therapy. The recognition of this signature NV lesion subtype further refines the MNV classification system and can impact therapeutic strategies for neovascular AMD.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LARGE RETINAL CAPILLARY ANEURYSM: CLINICAL FEATURES, MULTIMODAL IMAGING CHARACTERISTICS AND TREATMENT OUTCOMES OF PRIMARY AND SECONDARY LESIONS.","authors":"Kemal Tekin, Mehmet Ali Sekeroglu, Sibel Doguizi, Cemile Ucgul Atilgan, Merve Inanc, Mehmet Fatih Kagan Degirmenci, Hilal Kılınc Hekimsoy, Mehmet Yasin Teke","doi":"10.1097/IAE.0000000000004665","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004665","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the clinical features, multimodal imaging characteristics, and treatment outcomes of primary and secondary large retinal capillary aneurysms (LRCA).</p><p><strong>Methods: </strong>A total of 34 eyes were included: seven with primary LRCA and 27 with secondary LRCA. All patients underwent fundus photography, optical coherence tomography (OCT), and fundus fluorescein angiography. Indocyanine green angiography and OCT-angiography were performed in selected cases. Various clinical, morphological, and vascular features and treatment outcomes were evaluated and compared between the primary and secondary LRCA groups.</p><p><strong>Results: </strong>All lesions in the primary LRCA group were unilateral, and five of seven were unifocal. However, in the secondary LRCA group, 19% of patients had bilateral involvement and lesions were multifocal in 48% of eyes. OCT characteristics, including the horizontal and vertical diameters of aneurysmal lesions and mean subfoveal choroidal thickness, were similar for the groups (p>0.05). During follow-up, neither visual acuity nor central macular thickness changed significantly in the primary LRCA group and no cases responded to treatment, whereas these improved significantly in the secondary LRCA group.</p><p><strong>Conclusion: </strong>Clinical and imaging characteristics of primary and secondary LRCA lesions were similar, although treatment outcomes were more favorable in secondary LRCA lesions due to the differing pathophysiology and etiology.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanded field OCTA Biomarkers Associated with the Development of Tractional Retinal Detachment in Proliferative Diabetic Retinopathy.","authors":"Edward S Lu, Yifan Lu, Ying Cui, Rebecca Zeng, Ying Zhu, Xinyi Ding, Raviv Katz, Rongrong Le, Itika Garg, Jay C Wang, Demetrios G Vavvas, Deeba Husain, Joan W Miller, David M Wu, John B Miller","doi":"10.1097/IAE.0000000000004661","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004661","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate associations among expanded field swept-source optical coherence tomography angiography (SS-OCTA) biomarkers and the development of tractional retinal detachment (TRD) in patients with proliferative diabetic retinopathy (PDR).</p><p><strong>Methods: </strong>Patients with PDR without TRD at baseline were imaged with SS-OCTA. Quantitative and qualitative OCTA metrics were independently evaluated by two trained graders. A logistic regression model was utilized to identify OCTA biomarkers associated with TRD development.</p><p><strong>Results: </strong>Forty-nine PDR eyes from 38 participants were included. Seven of 49 eyes (14%) developed TRD over a median of 576 (range 35-805) days. Biomarkers associated with TRD were: large retinal non-perfusion area (NPA) (odds ratio [OR], 7.84; 95% confidence interval [CI], 2.61 - 16.3; p = 0.04), presence of neovascularization (NV) with total area > 4 disc diameters, (OR, 2.30; 95% [CI], 1.09 - 4.51; p = 0.04), and presence of tabletop NV (OR, 2.64; 95% [CI], 1.42 - 4.86; p = 0.02), defined as NV displaced anteriorly by vitreous traction but tethered to the retina by vascular membranes.</p><p><strong>Conclusion: </strong>Presence of large retinal NPA, extensive NV, and NV with features of anterior displacement by vitreous traction were associated with increased risk of TRD occurrence. SS-OCTA may be useful for predicting diabetic TRD development.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}