Retina-The Journal of Retinal and Vitreous Diseases最新文献_第4页

Novel Agents in the Management of Diabetes and Risk of Worsening Diabetic Retinopathy. 治疗糖尿病和糖尿病视网膜病变恶化风险的新型药物。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-08-14 DOI: 10.1097/IAE.0000000000004252

Rithwick Rajagopal, Janet B McGill

{"title":"Novel Agents in the Management of Diabetes and Risk of Worsening Diabetic Retinopathy.","authors":"Rithwick Rajagopal, Janet B McGill","doi":"10.1097/IAE.0000000000004252","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004252","url":null,"abstract":"Purpose: Novel therapies for diabetes have potent effects on glycemic control, obesity and cardiovascular risk reduction but some, including the popular drug semaglutide, have also been implicated in worsening of diabetic retinopathy (DR). Given the ubiquity of these new agents, understanding the risks to vision is important. Here we review the data for several newly available agents in terms of systemic efficacy and retinal safety.Methods: Literature review.Results: Novel antihyperglycemic treatments include incretin mimetics and enhancers, sodium-glucose cotransporter inhibitors, long-acting insulins, and insulin delivery systems. All improve glycemic control and some have been shown to reduce major cardiovascular outcomes. In a pivotal trial, semaglutide was associated with ∼75% increased risk of DR worsening. The novel long-acting insulin icodec, formulated for once-weekly dosing, showed increased risk of DR worsening over a once-daily insulin. No other recent antihyperglycemic agent was associated with DR worsening, though following the semaglutide trials, nearly all studies excluded patients with pre-existing DR. Cases of DR worsening were rare in all instances. Dedicated safety studies for semaglutide in DR are currently underway.Conclusion: For most patients being considered for treatment with a novel anti-hyperglycemic agent, benefits on systemic metabolic and cardiovascular health are very likely to outweigh potential retinal harms. Although the true risks of the new agents on DR are unclear since their safety data come from secondary endpoints, the most vulnerable patients are those with pre-existing high-risk DR, poor baseline glycemic control and using insulin.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141992502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macular neurodegenerative and vascular changes on OCTA in sickle cell disease are not related to its ocular and systemic complications. 镰状细胞病 OCTA 显示的黄斑神经变性和血管变化与眼部和全身并发症无关。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-08-13 DOI: 10.1097/IAE.0000000000004247

Rajani P Brandsen, Bart J Biemond, Gulsum Z Nasim, Erfan Nur, Reinier O Schlingemann, Roselie M H Diederen

{"title":"Macular neurodegenerative and vascular changes on OCTA in sickle cell disease are not related to its ocular and systemic complications.","authors":"Rajani P Brandsen, Bart J Biemond, Gulsum Z Nasim, Erfan Nur, Reinier O Schlingemann, Roselie M H Diederen","doi":"10.1097/IAE.0000000000004247","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004247","url":null,"abstract":"Purpose: To evaluate macular abnormalities in sickle cell disease (SCD) with OCT-Angiography (OCTA) and to determine associations with sickle cell retinopathy (SCR) and clinical and laboratory characteristics.Methods: Complete ophthalmic examination was performed in consecutive SCD patients (HbSS, HbSC, HbSβ0 or HbSβ+ genotype), including fundoscopy and macular SD-OCT/OCTA scans. SCR stage was based on fundoscopic examination (without fluorescein angiography) instead of the Goldberg classification, since fluorescein angiography was only used in case of tentative diagnosis. Medical/ophthalmological history and hematologic characteristics were retrieved from medical records.Results: 249 eyes of 137 patients were analyzed. The mean age was 33.3 ± 12.4 years (range 15-70). Non-proliferative SCR was present in 57 eyes (22.9%) and proliferative SCR in 36 eyes (14.5%). Macular thinning was present in 100 eyes (40.2%) and was associated with lower foveal vessel density (VD) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) and with enlargement of the foveal avascular zone (FAZ) area, perimeter and acircularity index (AI). Age and female sex were associated with lower (para)foveal VD in the SCP and DCP. No associations were found between SCR presence/severity and macular thinning or VD.Conclusion: Macular abnormalities were common, but did not result in visual impairment. No relation with SCR presence/severity was found. While OCTA-imaging is suitable for detecting maculopathy, it appears to have no diagnostic value in identifying patients at risk for SCR.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Mini-Steamroll: An Abbreviated Variation of the Steamroller Maneuver Following Pneumatic Retinopexy for Rhegmatogenous Retinal Detachment. 迷你蒸汽卷：治疗风湿性视网膜脱离的气动视网膜剥离术后的蒸气滚筒操作简易版。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-08-09 DOI: 10.1097/IAE.0000000000004221

Aurora Pecaku, Ahmed El-Sehemy, Isabela Martins Melo, Sue Ellen Demian, Michael Andreoli, Arun Ramachandran, Rajeev H Muni

{"title":"The Mini-Steamroll: An Abbreviated Variation of the Steamroller Maneuver Following Pneumatic Retinopexy for Rhegmatogenous Retinal Detachment.","authors":"Aurora Pecaku, Ahmed El-Sehemy, Isabela Martins Melo, Sue Ellen Demian, Michael Andreoli, Arun Ramachandran, Rajeev H Muni","doi":"10.1097/IAE.0000000000004221","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004221","url":null,"abstract":"Purpose: To describe a novel positioning maneuver for patients with rhegmatogenous retinal detachment (RRD) following pneumatic retinopexy(PnR).Methods: Single-center prospective case series of primary RRDs referred to St. Michael's Hospital, Toronto, Canada, between 2021 and 2023. All patients underwent PnR. Baseline ultra-widefield fundus imaging and repeat imaging 10 minutes after the gas injection was performed. After PnR, patients were instructed to perform the mini-steamroll maneuver which consists of a face-down position for ten minutes followed by positioning to the retinal break. The reduction of subretinal fluid (SRF) volume after the initial face-down position was evaluated with clinical examination and ultra-widefield imaging.Results: Six patients who presented with primary bullous RRD and a sizable superior break were enrolled. The mini-steamroll maneuver resulted in a rapid and significant reduction of SRF in all patients with bullous RRD and large superior breaks, allowing subretinal fluid to be expressed into the vitreous cavity with 10 minutes of face-down positioning. One patient required a sequential PnR. Primary retinal reattachment was achieved in all cases .This approach was well-tolerated by patients.Conclusion: This case series demonstrates that the mini-steamroll maneuver may be a suitable alternative for patient positioning following PnR in certain cases. The mini-steamroll is a simpler positioning regimen with the potential benefits of direct-to-break and full steamroller maneuver.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141910129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Good Initial Visual Acuity in Patients with Macular Edema due to Retinal Vein Occlusion - Management and Outcomes. 视网膜静脉闭塞导致黄斑水肿患者的良好初始视力--管理与疗效。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-08-09 DOI: 10.1097/IAE.0000000000004244

Nir Gomel, Rossella D'Aloisio, Aya Wattad, Rodolfo Mastropasqua, Federico Formenti, Anat Loewenstein, Matias Iglicki, Dinah Zur

{"title":"Good Initial Visual Acuity in Patients with Macular Edema due to Retinal Vein Occlusion - Management and Outcomes.","authors":"Nir Gomel, Rossella D'Aloisio, Aya Wattad, Rodolfo Mastropasqua, Federico Formenti, Anat Loewenstein, Matias Iglicki, Dinah Zur","doi":"10.1097/IAE.0000000000004244","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004244","url":null,"abstract":"Purpose: The approach to managing patients with retinal vein occlusion (RVO) and cystoid macular edema (CME) with good initial visual acuity (VA) better than 6/12 has not been investigated. This study aimed to evaluate functional and anatomical outcomes of intravitreal treatment and observation in patients with CME due to RVO, who presented with good initial VA. Methods: Multicenter retrospective cohort study. Seventy-nine eyes of 79 patients with CME secondary to RVO and initial VA better than 6/12, either treated with anti-VEGF therapy or observed. Clinical parameters and OCT measures were recorded. Main Outcome Measure: Proportion of patients losing ≥1 line of VA at 12 months. Secondary outcomes: Visual and anatomical results at 12 and 24 months, and correlation between number of injections and VA outcomes.Results: Fifty-three percent of patients maintained VA at month 12. VA of 6/6 - 6/7.5 was maintained in 59% and 57% at 12 and 24 months, respectively. At 24 months, the number of anti-VEGF injections was strongly correlated with VA among patients with BRVO and CRVO.Conclusion: This study marks the first exploration of patients with RVO and initial VA better than 6/12, indicating that most patients sustained good VA, and anti-VEGF treatment maintained and improved VA.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141910121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human amniotic membrane patches dislocated in the anterior chamber. 前房脱位的人类羊膜贴片。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-08-09 DOI: 10.1097/IAE.0000000000004246

Rita Serra, Yasmine Serrar, Thibaud Mathis, Antonio Pinna, Laurent Kodjikian

引用次数: 0

Pars-plana vitrectomy for the treatment of vitreous amyloid in patients with hereditary transthyretin amyloidosis. 为治疗遗传性转甲状腺素淀粉样变性患者的玻璃体淀粉样变性而进行的玻璃体旁切除术。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-08-09 DOI: 10.1097/IAE.0000000000004243

João Heitor Marques, Inês Morais, João Coelho, Milton Severo, Maria João Menéres, João Melo Beirão

{"title":"Pars-plana vitrectomy for the treatment of vitreous amyloid in patients with hereditary transthyretin amyloidosis.","authors":"João Heitor Marques, Inês Morais, João Coelho, Milton Severo, Maria João Menéres, João Melo Beirão","doi":"10.1097/IAE.0000000000004243","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004243","url":null,"abstract":"Purpose: To describe a series of patients with hereditary transthyretin amyloidosis (ATTRv) with vitreous amyloid and to study the efficacy and safety of pars plana vitrectomy (PPV) for its treatment.Methods: Retrospective study of 266 patients with ATTRv due to Val30Met mutation submitted to PPV for vitreous amyloid, with a minimum 3-month follow-up. Indications for surgery were disabling myodesopsia or 2 lines loss in visual acuity. Only the first operated eye was considered for analysis.Results: Male patients were operated at younger age (51.0 vs 53.6, p<0.001). Best-corrected visual acuity improved from 0.38 to 0.89 (decimal scale, p<0.001). Preoperative glaucoma was associated with lower gain in visual acuity (p<0.001). During the follow-up, 69%, 22% and 1% developed new onset glaucoma, retinal angiopathy or retinal detachment, respectively, and 36% required cataract surgery. PPV was also required in the fellow eye in 57%. ATTRv-related death occurred in 27%, 9.3 95%CI 8.0-10.7 years after PPV.Conclusion: Vitreous opacities are frequently the first symptomatic manifestation of ocular amyloidosis. Moreover, they may be a marker of mortality. Vitrectomy is a safe and effective treatment, but these patients require long-term follow-up to monitor the development or worsening of glaucoma or retinal angiopathy.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141910125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Automated Aspiration of Subretinal Fluid Method During Scleral Buckling For Rhegmatogenous Retinal Detachment. 巩膜屈曲术治疗风湿性视网膜脱离时自动抽吸视网膜下积液的新方法

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-08-09 DOI: 10.1097/IAE.0000000000004238

Kai Zhu, Yonghao Gu, Xiaojun Li, Enliang Zhou, Qin He, Qihong Gu

{"title":"A Novel Automated Aspiration of Subretinal Fluid Method During Scleral Buckling For Rhegmatogenous Retinal Detachment.","authors":"Kai Zhu, Yonghao Gu, Xiaojun Li, Enliang Zhou, Qin He, Qihong Gu","doi":"10.1097/IAE.0000000000004238","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004238","url":null,"abstract":"Purpose: The goal of the study is to introduce a modified technique for the removal of subretinal fluid during scntleral buckling (SB) to treat rhegmatogenous retinal detachment (RRD).Methods: This case series study was comprised of 18 cases of RRD patients suffering from a novel automated aspiration of subretinal fluid method during SB. The cases took place from July 2023 to November 2023 at the First Affiliated Hospital of USTC. Preoperative and intraoperative situations were evaluated, and spectral-domain optical coherence (SDOCT) and scanning laser ophthalmoscopy were used to observe the absorption of SRF in the early postoperative period.Results: The SRF method's automated aspiration primarily eliminated the SRF of all 18 RRD cases during SB surgery, leading to retinal reattachment, as showed by SLO. The method did not cause extensive intraoperative hemorrhage and had no risk of retinal incarceration or other complications. The SDOCT showed that the height of SRF in the macular area decreased in 10 cases (66.67%), leaving just a thin layer; was completely cleared in two cases (13.33%); had just a macular single bleb in one case (6.67%); and had several blebs left in two cases (13.33%).Conclusions: These findings suggest that the automated aspiration of the SRF method is effective, controllable, and beneficial for retinal reattachment, especially in the early postoperative period. Complications with this method were rare.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outer Retinal Holes in Degenerative Retinoschisis Photo Essay. 退行性视网膜裂孔症中的视网膜外孔图片说明。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-08-09 DOI: 10.1097/IAE.0000000000004241

Alessandro Feo, David Sarraf

引用次数: 0

The Image Warping Test: A Novel Method to Quantify and Qualify Metamorphopsia. 图像扭曲测试：量化和鉴定变形症的新方法

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-08-09 DOI: 10.1097/IAE.0000000000004240

Clara Valor Suárez, Jonathan Than, Ye Ling, Jean-Yves Guillemaut, David M Frohlich, Tom H Williamson

{"title":"The Image Warping Test: A Novel Method to Quantify and Qualify Metamorphopsia.","authors":"Clara Valor Suárez, Jonathan Than, Ye Ling, Jean-Yves Guillemaut, David M Frohlich, Tom H Williamson","doi":"10.1097/IAE.0000000000004240","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004240","url":null,"abstract":"Purpose: To determine the validity, accuracy and acceptability of the Image Warping Test (IWT), a novel test for the measurement of visual distortion in the central visual field.Methods: 25 volunteers with metamorphopsia secondary to vitreoretinal pathology were recruited at a tertiary referral center. All subjects underwent ophthalmological examination and measurement of metamorphopsia via Amsler grid, Morphision, M-CHARTS and the IWT. Construct validity was determined through assessment of the association between symptoms, pathology, visual acuity, established metamorphopsia test results and IWT results.Results: There was close association between subjective estimation of metamorphopsia severity and IWT score (p=0.005), between Morphision result and IWT score (p=0.015), and between the nature of vitreoretinal pathology and IWT score (p=0.007). There was no statistically significant correlation between best corrected distance visual acuity and IWT score, and between M-CHARTS score and IWT score.Conclusion: The IWT allows the creation of a digital map of subjective metamorphopsia which effectively measures its severity and nature, and opens the possibility to its non-invasive correction in future through inverse mapping of the distortion map onto live images.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141910128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Technique of Sterile Polyethylene Instrument Cover as Temporary Corneal Patch to Reconstruct Anterior Chamber in Penetrating Keratoplasty Combined with Intraocular Surgery. 在穿透性角膜移植术联合眼内手术中使用无菌聚乙烯器械盖作为临时角膜贴片重建前房的新技术。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-08-08 DOI: 10.1097/IAE.0000000000004229

Jianfeng Long, Haoyu Li, Liwei Zhang, Xinyue Sun, Shaohua Liu, Hanhan Peng, Baihua Chen

{"title":"A New Technique of Sterile Polyethylene Instrument Cover as Temporary Corneal Patch to Reconstruct Anterior Chamber in Penetrating Keratoplasty Combined with Intraocular Surgery.","authors":"Jianfeng Long, Haoyu Li, Liwei Zhang, Xinyue Sun, Shaohua Liu, Hanhan Peng, Baihua Chen","doi":"10.1097/IAE.0000000000004229","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004229","url":null,"abstract":"Purpose: Complications such as explosive choroidal hemorrhage, residual cortex, and capsule rupture often occur during intraocular surgery combined with penetrating keratoplasty (PKP) due to poor maintenance of the anterior chamber. To address these challenges, we have innovatively utilized a sterile polyethylene instrument cover to temporarily reconstruct the anterior chamber.Methods: In this report, we describe a technique where a 'temporary corneal patch' was created from a sterile instrument cover, using a trephine to ensure a diameter approximately 1-2 mm wider than the corneal bed or perforation. This patch was then sutured into the host corneal bed or the perforation with 10-0 nylon sutures during intraocular surgery combined with PKP. Each case was evaluated for surgical efficacy and complications.Results: We successfully applied this technique in three cases of combined corneal transplantation surgery. In two cases, PKP, phacoemulsification, and intraocular lens implantation were successfully performed. In the third case, PKP, vitrectomy, and other intraocular procedures were performed. No intraoperative or postoperative complications were observed.Conclusion: The use of a sterile polyethylene material as a temporary corneal patch for anterior chamber reconstruction represents a safe, effective, and cost-efficient approach for intraocular surgery combined with PKP or posterior segment surgery as a keratoprosthesis.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141910119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0