Hongan Chen, Anne Strong Caldwell, Jennifer L Patnaik, Eric G Feinstein, Maryam Ghiassi, Marc T Mathias, Scott C N Oliver
{"title":"Long-Term Functional and Clinical Outcomes in Familial Exudative Vitreoretinopathy.","authors":"Hongan Chen, Anne Strong Caldwell, Jennifer L Patnaik, Eric G Feinstein, Maryam Ghiassi, Marc T Mathias, Scott C N Oliver","doi":"10.1097/IAE.0000000000004372","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004372","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize long-term functional and anatomical outcomes in patients with familial exudative vitreoretinopathy (FEVR).</p><p><strong>Methods: </strong>A retrospective chart review was conducted of all patients with a diagnosis of FEVR at a tertiary academic institution and its affiliated children's hospital treated from January 2003 through January 2024. Demographic and clinical data were collected. Functional vision was defined as at least one eye with Snellen visual acuity (SVA) ≥20/40 and ambulatory vision defined as at least one eye with SVA ≥20/200.</p><p><strong>Results: </strong>A total of 186 eyes from 96 patients comprised the FEVR cohort, of which 90 eyes from 46 patients were included for analysis. Average age at presentation was 6.4 years (SD 8.6) and average duration of follow-up was 9.1 years (SD 7.3, range 0-40).At most recent exam, 77.3% of patients had functional vision and 88.6% had ambulatory vision. Globe salvage was achieved in 98.4% of eyes. Of the exam findings studied, only retinal detachment at presentation was significantly associated with worse vision in multivariable analysis.</p><p><strong>Conclusions: </strong>Patients in our FEVR cohort show promising long-term functional and ambulatory vision outcomes. More than 75% of patients were 20/40 or better, and 89% of patients avoided legal blindness.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tommaso Mori, Vincenzo Barone, Sebastiano Nunziata, Pier Luigi Surico, Simone Stefanini, Valentina Mastrofilippo, Antonio Di Zazzo, Marco Coassin
{"title":"Epiretinal Membrane and Senile Cataract: Combined vs Sequential Surgery.","authors":"Tommaso Mori, Vincenzo Barone, Sebastiano Nunziata, Pier Luigi Surico, Simone Stefanini, Valentina Mastrofilippo, Antonio Di Zazzo, Marco Coassin","doi":"10.1097/IAE.0000000000004371","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004371","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the outcomes of combined phacovitrectomy versus sequential phacoemulsification and vitrectomy in patients with both senile cataract and epiretinal membrane (ERM).</p><p><strong>Methods: </strong>A retrospective multicenter study was conducted between 2014 and 2022 at two hospitals in Italy. Patients with idiopathic ERM and senile cataract in the same eye were enrolled and underwent either combined (n=38) or sequential surgery (n=38), performed by a single surgeon. Best corrected visual acuity (BCVA) and central macular thickness (CMT) were measured at 1, 3, and 6 months after surgery.</p><p><strong>Results: </strong>Both surgical approaches significantly improved BCVA and reduced CMT after 6 months. However, sequential surgery showed faster visual recovery, with significant improvements in BCVA (P=0.008) and CMT (P<0.0001) observed as early as 1-month post-surgery, compared to the combined group.</p><p><strong>Conclusion: </strong>Although both surgical approaches yielded significant improvements in visual acuity and central macular thickness at 6 months, the sequential approach offered a faster recovery in the early postoperative period. According to the literature, the sequential approach also allows some patients to be satisfied after cataract surgery alone, potentially avoiding unnecessary vitrectomy and reducing the risk of overtreatment.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paulo Eduardo Stanga, Dan Z Reinstein, Francisco Javier Valentin Bravo, Andrea Saladino, Sebastian Francis Eduardo Stanga, Ursula Inge Reinstein, Yvonne O'Neill, Timothy J Archer, Stuart W Harmer, J Sebag, John Marshall
{"title":"THERAPEUTIC REFRACTIVE VITRECTOMY (TRV) FOR THE MANAGEMENT OF VITREOUS FLOATERS AND OPACITIES (VFO) ASSESSED BY THE STANDARDIZED AND KINETIC ANATOMICAL AND FUNCTIONAL TESTING OF VITREOUS FLOATERS AND OPACITIES (SK VFO TEST).","authors":"Paulo Eduardo Stanga, Dan Z Reinstein, Francisco Javier Valentin Bravo, Andrea Saladino, Sebastian Francis Eduardo Stanga, Ursula Inge Reinstein, Yvonne O'Neill, Timothy J Archer, Stuart W Harmer, J Sebag, John Marshall","doi":"10.1097/IAE.0000000000004373","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004373","url":null,"abstract":"<p><strong>Purpose: </strong>Propose new terminology and evaluate the effectiveness of Therapeutic Refractive Vitrectomy (TRV) for selective removal of vitreous floaters and opacities (VFO) utilizing Standardized Kinetic Anatomical Functional Testing of VFO (SK VFO Test) and new ultra widefield (UWF) OCT imaging techniques.</p><p><strong>Methods: </strong>Retrospective analysis. Twenty eyes underwent TRV for symptomatic VFO. Pre-/post-TRV assessments: SK-VFO Test, including straylight measurements (HD Analyzer, Light Disturbance Analyzer, C-Quant) alongside non-contact imaging including a new UWF OCT to evaluate changes in vitreous anatomical and optical properties.</p><p><strong>Results: </strong>Post-TRV evaluations indicated objective changes in vitreous optical properties and subjective measures. Reduced straylight measurements: HDA 22%, LDA 54.4% (p=0.013), and C-Quant 7.8% (p=0.034). Patient reported outcomes statistically significantly improved (p=0.022). Corrected distance visual acuity (CDVA) changes were marginal. New UWF 26 mm with a 12 mm imaging window OCT facilitated detailed vitreous imaging, confirming status of posterior vitreous detachment (PVD) (100%). Post-TRV UWF and OCT imaging demonstrated restoration of vitreous clarity, confirmed presence of residual cortical vitreous and absence of new PVDs.</p><p><strong>Conclusion: </strong>TRV is a significant contribution for therapeutic refractive surgery as a safe and effective approach to enhancing visual quality, correcting refractive and opaque vitreous anomalies. Improvement in CDVA was minimal representing limited effectiveness as a measure of comprehensive visual function. Improvements in objective straylight measures and imaging are in alignment with subjective symptom improvements post-TRV. This underscores the utility and value of new holistic evaluation methods beyond traditional metrics to assess the impact of TRV on visual function and quality of life.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"VITRECTOMY AND COMPLETE DRAINAGE OF SUPRACHOROIDAL FLUID WITHOUT PERIOPERATIVE STEROIDS FOR RHEGMATOGENOUS RETINAL DETACHMENT COMBINED WITH CHOROIDAL DETACHMENT: A RANDOMIZED CLINICAL TRIAL.","authors":"Wei Lin, Hao Chen, Minxue Ren, Xiaoyan Lin, Yongping Tang, Yong Wei","doi":"10.1097/IAE.0000000000004374","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004374","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the surgical effect of complete drainage of suprachoroidal fluid (SCF) before vitrectomy to avoid perioperative steroids in rhegmatogenous retinal detachment combined with choroidal detachment (RRD-CD) eyes.</p><p><strong>Methods: </strong>It was a prospective, randomized controlled trial. 58 eyes were randomly divided into the no steroids (NS) group and local steroids (LS) group, 29 eyes each, respectively. Patients in the LS group received a single preoperative periocular injection of methylprednisolone, while SCF drainage was performed before vitrectomy in eyes of the NS group. Follow-up assessments were performed at 1 week, 1 month, 3 months, 6 months postoperatively.</p><p><strong>Results: </strong>The postoperative retinal reattachment rate was similar in the NS and LS groups (96.6% vs 93.1%, p = 1.00). Best-corrected visual acuity was improved in 72.4% and 75.9% in the NS and LS groups, respectively. Inflammation occurred in 5 eyes (17.2%) in the NS group and 6 eyes (20.7%) in the LS group (p = 0.74). Hypotony occurred in 11 (37.9%) and 14 (48.3%) eyes in the LS and NS groups (p = 0.43), respectively. Macular chorioretinal folds were found in 21 (72.4%) and 22 (75.9%) eyes in the LS and NS groups (p = 0.76), respectively. Hypotony and chorioretinal folds disappeared after 1 week postoperatively.</p><p><strong>Conclusions: </strong>Preoperative steroids may not be necessary for RRD-CD patients if the SCF is completely drained before vitrectomy. Postoperative retinal reattachment does not depend on the use of preoperative steroids; instead, surgeons should focus on improving surgical techniques in RRD-CD to improve the retinal reattachment rate.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chang Hwan Lee, Kunho Bae, Chang Ki Yoon, Un Chul Park, Kyu Hyung Park, Eun Kyoung Lee
{"title":"Clinical Course and Prognostic Factors in Non-Neovascular Age-Related Macular Degeneration with Subretinal Fluid.","authors":"Chang Hwan Lee, Kunho Bae, Chang Ki Yoon, Un Chul Park, Kyu Hyung Park, Eun Kyoung Lee","doi":"10.1097/IAE.0000000000004368","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004368","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical course and prognostic factors of age-related macular degeneration (AMD) without macular neovascularization (MNV) in patients presenting with pigment epithelial detachment (PED) and the associated subretinal fluid (SRF).</p><p><strong>Methods: </strong>Morphological characteristics of spectral-domain optical coherence tomography images were analyzed to determine anatomic outcomes. Factors associated with the progression to late AMD, defined as complete retinal pigment epithelium and outer retinal atrophy (cRORA) or MNV, were investigated.</p><p><strong>Results: </strong>Fifty eyes of 41 patients were included in this study. The most common SRF location was the angle of the PED (56%), and there was a significant decrease in SRF thickness and PED height and width over the follow-up period. Eleven (22%) eyes developed cRORA, and seven (14%) eyes developed MNV during a mean period of 52.1 months. Multivariate analysis revealed that hyperreflective foci and MNV in the fellow eye were associated with the development of cRORA, and higher PED height was a significant factor associated with the development of MNV.</p><p><strong>Conclusions: </strong>In patients with AMD, SRF can be accompanied by PED in the absence of MNV. Notably, patients with this characteristic entity can progress to late AMD, including cRORA and MNV, in a significant proportion of cases.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matteo Mario Carlà, Emanuele Crincoli, Stanislao Rizzo
{"title":"Retinal Imaging Analysis Performed By ChatGPT-4o And Gemini Advanced: The Turning Point Of The Revolution?","authors":"Matteo Mario Carlà, Emanuele Crincoli, Stanislao Rizzo","doi":"10.1097/IAE.0000000000004351","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004351","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the diagnostic capabilities of the most recent chatbots releases, GPT-4o and Gemini Advanced, facing different retinal diseases.</p><p><strong>Methods: </strong>Exploratory analysis on 50 cases with different surgical (n=27) and medical (n=23) retinal pathologies, whose optical coherence tomography/angiography (OCT/OCTA) scans were dragged into ChatGPT and Gemini's interfaces. Then, we asked \"Please describe this image\" and classified the diagnosis as: 1) Correct; 2) Partially correct; 3) Wrong; 4) Unable to assess exam type and 5) Diagnosis not given.</p><p><strong>Results: </strong>ChatGPT indicated the correct diagnosis in 31/50 cases (62%), significantly higher than Gemini Advanced 16/50 cases (p=0.0048). In 24% of cases, Gemini Advanced was not able to produce any answer, stating \"That's not something I'm able to do yet\". For both, primary misdiagnosis was macular edema, given erroneously in 16% and 14% of cases, respectively. ChatGPT-4o showed higher rates of correct diagnoses either in surgical (52% vs 30%) and medical retina (78% vs 43%). Notably, when presented without the corresponding structural image, in any case Gemini was able to recognize OCTA scans, confusing images for artworks.</p><p><strong>Conclusion: </strong>ChatGPT-4o outperformed Gemini Advanced in terms of diagnostic accuracy facing OCT/OCTA images, even if the range of diagnoses is still limited.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Romano, Xinyi Ding, Mauricio Garcia, Yan Zhao, Filippos Vingopoulos, Itika Garg, Isabella Stettler, Cade Bennett, Katherine Overbey, Matthew Finn, Ioanna Ploumi, Inês Laìns, Nimesh A Patel, David M Wu, Demetrios G Vavvas, Deeba Husain, Joan W Miller, John B Miller
{"title":"Assessing the Repeatability of Inner Choroid Flow Deficit Percentage in Intermediate AMD and Controls: A Comparative Study between Different Post-processing Approaches.","authors":"Francesco Romano, Xinyi Ding, Mauricio Garcia, Yan Zhao, Filippos Vingopoulos, Itika Garg, Isabella Stettler, Cade Bennett, Katherine Overbey, Matthew Finn, Ioanna Ploumi, Inês Laìns, Nimesh A Patel, David M Wu, Demetrios G Vavvas, Deeba Husain, Joan W Miller, John B Miller","doi":"10.1097/IAE.0000000000004345","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004345","url":null,"abstract":"<p><strong>Purpose: </strong>To assess repeatability of macular inner choroid flow deficit percentage (ICFD%) in intermediate age-related macular degeneration (iAMD) and controls employing various post-processing approaches.</p><p><strong>Methods: </strong>Cross-sectional, observational study. We included (1) 22 iAMD and 24 control eyes, with (2) age >50 years, (3) visual acuity >20/32, and (4) no additional ocular and systemic confounders.</p><p><strong>Participants: </strong>underwent four consecutive 6x6-mm OCTA scans (2 acquired at 100-kHz and 2 at 200-kHz speed; PLEX® Elite 9000) for intra-session analysis. Same protocol was repeated after 30 minutes for inter-session analysis. Three slabs of different thicknesses were generated underneath Bruch's membrane (4-14, 4-19, 4-24 µm). All slabs were processed with: (1) binarization-only using Phansalkar method (r=4-15 pixels); (2) compensation+binarization; (3) averaging+binarization; (4) averaging+compensation+binarization. ICFD% was measured within 3- and 5-mm circles, and measurements were repeated after excluding drusen areas.Repeatability was analyzed with generalized linear mixed-effects models, intraclass correlation coefficients (ICC) and Levene's variance test.</p><p><strong>Results: </strong>Most post-processing approaches demonstrated high repeatability (ICC>0.75) with no significant test-retest differences (p>0.05). Compensation+binarization of 15-µm slabs at 200 kHz showed the highest repeatability (ICC: 0.96-0.98). Excluding drusen did not significantly impact ICFD% measurements (p>0.05), showing increased ICCs for 10 µm-thick and binarized-only slabs.</p><p><strong>Conclusions: </strong>Strong repeatability can be achieved with various post-processing methods for assessing ICFD%, especially with compensation+binarization of 15-µm slabs acquired at 200 kHz. Drusen removal does not seem to impact repeatability in iAMD when using a swept-source device, except for specific settings.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intravitreal bevacizumab for the treatment of choroidal haemangiomas.","authors":"Hassan E Elkayal, Mandeep S Sagoo, Guy S Negretti","doi":"10.1097/IAE.0000000000004323","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004323","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the use of intravitreal bevacizumab for the treatment of subretinal (SRF) and intraretinal fluid associated with circumscribed choroidal haemangiomas (CCH).</p><p><strong>Methods: </strong>This was a retrospective review of all patients treated with at least 3 bevacizumab injections for CCH-associated SRF between May 2020 and August 2023 in Moorfields eye hospital. Outcome measures included change in best corrected visual acuity (BCVA), change in patient reported symptoms, change in SRF and change in central subfield thickness (CSFT). Data on further management following cessation of injections was analysed.</p><p><strong>Results: </strong>The study included 9 patients. Median BCVA was 6/19 before and 6/24 after injections (p = 0.41). CSFT decreased from a median of 466 μm to 447 μm (p = 0.11). Two thirds of (n=6) patients did not show any reduction in foveal SRF, one third (n=3) showed a partial reduction and no patients had a complete resolution of SRF. Eight patients received rescue-photodynamic therapy and one received external beam radiotherapy. BCVA changed from a median of 6/60 to a median of 6/12 after rescue treatment (p = 0.63). The median CSFT decreased significantly from 470 μm to 249 μm (p = 0.01).</p><p><strong>Conclusions: </strong>Intravitreal bevacizumab is unlikely to be an effective treatment for exudative CCH.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew Mihalache, Nikhil S Patil, Ryan S Huang, Eli Kisilevsky, Jason Kwok, Marko M Popovic, Georges Nassrallah, Clara C Chan, Ashwin Mallipatna, Peter J Kertes, Rajeev H Muni
{"title":"Reply: Artificial intelligence chatbots ChatGPT and Google Bard to accurately convey preoperative information for patients undergoing ophthalmological surgeries.","authors":"Andrew Mihalache, Nikhil S Patil, Ryan S Huang, Eli Kisilevsky, Jason Kwok, Marko M Popovic, Georges Nassrallah, Clara C Chan, Ashwin Mallipatna, Peter J Kertes, Rajeev H Muni","doi":"10.1097/IAE.0000000000004366","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004366","url":null,"abstract":"","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jovi C Y Wong, Meera D Sivalingam, Matthew Griffin, John Magagna, Bita Momenaei, Taku Wakabayashi, Roselind L Ni, Kristine Y Wang, Michael J Ammar, Jason Hsu, Yoshihiro Yonekawa
{"title":"Sickle Cell Retinopathy Lost to Follow-up Study.","authors":"Jovi C Y Wong, Meera D Sivalingam, Matthew Griffin, John Magagna, Bita Momenaei, Taku Wakabayashi, Roselind L Ni, Kristine Y Wang, Michael J Ammar, Jason Hsu, Yoshihiro Yonekawa","doi":"10.1097/IAE.0000000000004369","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004369","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the outcomes of sickle cell retinopathy (SCR) patients who experienced at least one episode of being lost to follow-up (LTFU) compared to those who attended all appointments.</p><p><strong>Methods: </strong>Adult SCR patients who visited Wills Eye Hospital Retina service (January 2012-December 2021) with >2 visits were reviewed for LTFU events, defined as failure to return for a follow-up appointment within 6 months of the scheduled date.</p><p><strong>Results: </strong>One hundred and eighty-one eyes of 94 patients were included. Fifty-one patients (99 eyes) attended all appointments (\"attended group\") whilst 43 patients (82 eyes), or 46%, had at least one LTFU event (\"LTFU group\"). The mean (standard deviation, SD) LTFU duration was 470 (329) days. In the LTFU group, mean (SD) VA was significantly worse at the final visit (logMAR 0.45 (0.63), Snellen 20/56) and at the post-LTFU visit (0.36 (0.59), 20/46) compared to the pre-LTFU visit (0.3 (0.47), 20/40, p = 0.001). In the attended group, mean (SD) VA was significantly better at the final visit (0.41 (0.63), 20/51) compared to the initial visit (0.52 (0.78), 20/66, p = 0.038).</p><p><strong>Conclusion: </strong>Patients with SCR with an LTFU event have worse visual outcomes compared to patients who attend all appointments.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}