Retina-The Journal of Retinal and Vitreous Diseases最新文献_第4页

CHOROIDAL HYPERREFLECTIVE FOCI AS BIOMARKERS OF SEVERITY IN STARGARDT DISEASE. 脉络膜高反射灶作为Stargardt病严重程度的生物标志物。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-04-01 DOI: 10.1097/IAE.0000000000004367

Seo Yoon Lee, Chang Ki Yoon, Un Chul Park, Kyu Hyung Park, Eun Kyoung Lee

{"title":"CHOROIDAL HYPERREFLECTIVE FOCI AS BIOMARKERS OF SEVERITY IN STARGARDT DISEASE.","authors":"Seo Yoon Lee, Chang Ki Yoon, Un Chul Park, Kyu Hyung Park, Eun Kyoung Lee","doi":"10.1097/IAE.0000000000004367","DOIUrl":"10.1097/IAE.0000000000004367","url":null,"abstract":"Purpose: To investigate the clinical implications of choroidal hyperreflective foci (HF) as biomarkers of disease severity in Stargardt disease.Methods: One hundred and twenty-nine eyes from 66 patients with Stargardt disease were included. The primary outcome was the correlation between the number of foveal choroidal HF and indicators of disease severity. Secondary outcome included a comparison of choroidal HF between the pathologic and healthy borders of atrophy, and the 2-year longitudinal change of foveal choroidal HF.Results: Long disease duration, thin central macular thickness, large definitely decreased autofluorescence area, atrophic foveal retinal pigment epithelium, high Fishman stage, and low visual acuity were associated with a higher number of foveal choroidal HF. Foveal retinal pigment epithelium involvement (β = 0.522, P < 0.001) was the most strongly correlated factor in multivariate analysis. Genotype-phenotype relationships between the number of severe ABCA4 variants and choroidal HF could not be determined. The pathologic border had significantly more choroidal HF than the healthy border ( P < 0.001), and the number of foveal choroidal HF increased over 2 years ( P = 0.003).Conclusion: Choroidal HF could serve as a biomarker of disease severity in Stargardt disease, correlating with various severity indicators and especially reflecting the presence of retinal pigment epithelium atrophy.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"774-784"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unilateral Idiopathic Progressive Subretinal Fibrosis: Imaging Characteristics. 单侧特发性进行性视网膜下纤维化：影像学特征。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-04-01 DOI: 10.1097/IAE.0000000000004277

Anamika Patel, Anup Kelgaonkar, Avinash Pathengay

引用次数: 0

DIAGNOSTIC AND THERAPEUTIC CHALLENGES. 诊断困境患者双侧视网膜下液和视网膜豹斑模式。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-04-01 DOI: 10.1097/IAE.0000000000004379

Dimitrios Kalogeropoulos, Gabriella De Salvo, Farid Afshar, Serafeim Antonakis, Andrew John Lotery, Mya Abousy, Nicholas A Yannuzzi

引用次数: 0

TISSUE GLUE-ASSISTED PLAQUE RADIOTHERAPY FOR CHOROIDAL TUMORS WITH SCLERAL THINNING. 组织胶辅助斑块放疗治疗伴有巩膜变薄的脉络膜肿瘤。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-04-01 DOI: 10.1097/IAE.0000000000004355

Carol L Shields, Rhea Suribhatla, Mark Romero, Christin Ealer, Rolika Bansal, Jacqueline Emrich, Lydia Komarnicky-Kocher, Sara E Lally

{"title":"TISSUE GLUE-ASSISTED PLAQUE RADIOTHERAPY FOR CHOROIDAL TUMORS WITH SCLERAL THINNING.","authors":"Carol L Shields, Rhea Suribhatla, Mark Romero, Christin Ealer, Rolika Bansal, Jacqueline Emrich, Lydia Komarnicky-Kocher, Sara E Lally","doi":"10.1097/IAE.0000000000004355","DOIUrl":"10.1097/IAE.0000000000004355","url":null,"abstract":"Purpose: To evaluate tissue glue-assisted plaque placement regarding accuracy, stability, and longer-term outcomes for choroidal tumors with scleral thinning.Methods: All patients with tissue glue-assisted plaque radiotherapy at a single ocular oncology center were evaluated for patient demographics, tumor features, surgical details, tumor response, and glue-related complications.Results: There were 13 patients (mean age 72 years) treated with tissue glue-assisted plaque radiotherapy for choroidal melanoma (n = 12) or choroidal metastasis (n = 1). At presentation, the tumor was mean 4.3 mm to the optic disk and 2.0 mm to the foveola with a mean basal diameter of 9.5 mm and a thickness of 4.2 mm. In all cases, the tissue glue-assistance was used due to extreme scleral thinning in the bed of proposed radiation. The plaque size was 15 mm (n = 5), 18 mm (n = 7), or 20 mm (n = 1). At application, there was no immediate glue hypersensitivity, ultrasonography confirmed accuracy of placement, and the glue remained adherent for the entire treatment duration (mean 113 hours) with stable plaque location at removal. At removal, the plaque-glue composite was peeled off the globe without need for glue dissolvent and without scleral disruption. At 12 months, mean melanoma thickness was 2.7 mm (regression 36%). There were no conjunctival, corneal, or scleral complications.Conclusion: Tissue glue-assisted plaque radiotherapy is safe and effective for treatment of choroidal tumors with thin sclera.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"675-682"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UNCOVERING HIDDEN PATTERNS: Macrophage-Like Cell Distribution Across Different Stages of Posterior Vitreous Detachment. 揭示隐藏模式：巨噬细胞样细胞分布在玻璃体后脱离的不同阶段。

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-04-01 DOI: 10.1097/IAE.0000000000004358

Gongpeng Sun, Amin Xu, Xueying Yang, Lu Zhang, Wenyu Wang, Abdulla Sawut, Weichen Xu, Xiaoling Wang, Zuohuizi Yi, Hongmei Zheng, Changzheng Chen

{"title":"UNCOVERING HIDDEN PATTERNS: Macrophage-Like Cell Distribution Across Different Stages of Posterior Vitreous Detachment.","authors":"Gongpeng Sun, Amin Xu, Xueying Yang, Lu Zhang, Wenyu Wang, Abdulla Sawut, Weichen Xu, Xiaoling Wang, Zuohuizi Yi, Hongmei Zheng, Changzheng Chen","doi":"10.1097/IAE.0000000000004358","DOIUrl":"10.1097/IAE.0000000000004358","url":null,"abstract":"Purpose: To investigate the distribution of macrophage-like cells (MLCs) across different stages of posterior vitreous detachment (PVD).Methods: A total of 168 eyes from 168 subjects were included. MLCs were imaged by acquiring en face OCT images at depths of 5 µ m to 10 µ m on the inner limiting membrane, and using B-scan OCT. Participants were categorized into three groups according to the degree of PVD: Group A for Stage 1a PVD, Group B for Stages 1b and 2 PVD, and Group C for Stages 3 and 4 PVD. Localized vitreoretinal relationships were categorized into vitreoretinal adhesions, Type 1a PVD, where the vitreous and retina are not clearly separated, and Type 1b PVD, where there is clear separation.Results: MLC density was sequentially lower in Groups A, B, and C. Multiple linear regression analysis revealed that MLC density was correlated with both the PVD group and age (both P < 0.001). In Group A, MLC density was significantly higher in Type 1a PVD than in the vitreoretinal adhesion area. In Group B, the distribution of MLCs in the vitreoretinal adhesion region was significantly less than in Type 1a PVD and Type 1b PVD. MLCs were more sparsely distributed in Group C.Conclusion: MLCs exhibit distinct distribution patterns in various stages of PVD.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":"639-648"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cautious Use of Gas Anesthesia in Vitrectomy Surgery.

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-03-28 DOI: 10.1097/IAE.0000000000004473

Haishuang Lin, Suqing Gou, Jieling Chen

引用次数: 0

Clinical Features and Outcomes of Late Recurrent Rhegmatogenous Retinal Detachment.

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-03-28 DOI: 10.1097/IAE.0000000000004472

Seyyedehfatemeh Ghalibafan, Vincent Angelo Santiago Volante, Colin Kim, Landon J Rohowetz, Harry W Flynn, Nicolas A Yannuzzi

{"title":"Clinical Features and Outcomes of Late Recurrent Rhegmatogenous Retinal Detachment.","authors":"Seyyedehfatemeh Ghalibafan, Vincent Angelo Santiago Volante, Colin Kim, Landon J Rohowetz, Harry W Flynn, Nicolas A Yannuzzi","doi":"10.1097/IAE.0000000000004472","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004472","url":null,"abstract":"Purpose: To evaluate clinical features and outcomes in patients with late recurrent primary non-complex rhegmatogenous retinal detachment (LRRD).Method: A retrospective review was conducted for LRRD cases, defined as redetachment occurring ≥3 months after complete primary reattachment, excluding eyes with silicone oil tamponade at initial surgery.Results: Among 1,879 eyes undergoing primary retinal detachment surgery, 69 eyes (4%) experienced LRRD. Mean age was 59.6 ± 15.8 years, with 58% male. Initial surgeries included scleral buckle (SB) alone (22%), pars plana vitrectomy (PPV) alone (29%), and combined SB/PPV (49%). Recurrence occurred at a mean of 7.9 ± 9.1 months. The mean interval between initial retinal detachment surgery and LRRD was 7.9 ± 9.1 months, with a median of 4.9 months (range: 3 months to 4 years).At recurrence, 45% of eyes were phakic, 55% pseudophakic, and 45% had proliferative vitreoretinopathy (PVR) grade C or higher. Macula involvement was observed in 54%, and new or undiagnosed breaks in 64%. Surgical repair included PPV alone (74%) and combined SB/PPV (26%), with silicone oil used in 75%. Reattachment was achieved in 93%. At the final follow-up, silicone oil tamponade remained in 5 eyes (7%) and BCVA was ≥20/40 in 16%, 20/40-20/200 in 38%, and ≤20/200 in 46%. A comparative analysis of LRRDs after 3 or 6 months showed no significant differences in surgical traits or final reattachment rates.Conclusion: Late recurrence of retinal detachment presents considerable management challenges and often has guarded visual outcomes despite successful anatomic reattachment.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to "Cautious Use of Gas Anesthesia in Vitrectomy Surgery".

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-03-28 DOI: 10.1097/IAE.0000000000004474

Santaro Noguchi, Shunsuke Nakakura, Asuka Noguchi, Hitoshi Tabuchi

引用次数: 0

Changes of Cytokines in Aqueous Humor of Retinoblastoma with Intravitreal Melphalan.

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-03-26 DOI: 10.1097/IAE.0000000000004471

Xiaoting Zhou, Fengxi Meng, Hui Ren, Binbin Xu, Xintong Lin, Jiang Qian, Kang Xue

{"title":"Changes of Cytokines in Aqueous Humor of Retinoblastoma with Intravitreal Melphalan.","authors":"Xiaoting Zhou, Fengxi Meng, Hui Ren, Binbin Xu, Xintong Lin, Jiang Qian, Kang Xue","doi":"10.1097/IAE.0000000000004471","DOIUrl":"https://doi.org/10.1097/IAE.0000000000004471","url":null,"abstract":"Purpose: To explore the levels of cytokines in the aqueous humor (AH) of patients diagnosed with retinoblastoma (RB) who received intravitreal melphalan (IVM).Methods: A total of 28 eyes from 27 patients diagnosed with RB who received IVM were enrolled, along with 14 eyes from 14 patients with congenital cataracts as controls. The clinical features of the patients were recorded before and after IVM. 27 cytokines concentrations in AH samples collected from these patients were measured by a suspension array system.Results: The levels of IL-8, IL-17A, Eotaxin, G-CSF, and PDGF-BB increased significantly following IVM administration in RB patients (p<0.05). Post IVM treatments, the levels of IL-5, IL-8, IL-9, IL-12p70, IL-15, IL-17A, G-CSF, IP-10, MIP-1α, PDGF-BB, TNF-α, and VEGF were higher in eyes that developed ocular toxicity than those eyes didn't (p<0.05). The ocular toxicity group received a higher cumulative dose and mean per dose of intravitreal melphalan. The elevated cytokines subsequent to IVM were associated with the number of treatments and cumulative dose of intravitreal melphalan.Conclusions: The results revealed a notable increase in cytokine levels subsequent to IVM interventions. Elevated cytokine concentrations in the eyes of RB patients post-IVM may be associated with ocular toxicities.","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperbaric Oxygen Therapy for Retinal Artery Occlusion.

IF 2.3 2区医学

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-03-26 DOI: 10.1097/IAE.0000000000004470

Brian Mac Grory, Bruce Derrick, Nathan Tagg, Valerie Biousse, Sven Poli, Matthew Schrag

引用次数: 0