Expanded Field OCTA Biomarkers Associated with Future Cardiovascular Disease and Mortality in Patients with Diabetic Retinopathy.

IF 2.1 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-29 DOI:10.1097/IAE.0000000000004695

Edward S Lu, Ying Cui, Krystal K Phu, Xinyi Ding, Kayla N Nodecker, Rongrong Le, Ying Zhu, Itika Garg, Grace Baldwin, Jocelyn Rodriguez, Matthew J Finn, Peyman Razavi, Inês Laíns, David M Wu, Deeba Husain, Leo A Kim, Nimesh A Patel, Demetrios G Vavvas, John B Miller

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引用次数: 0

Abstract

Purpose: To explore associations among expanded field swept-source optical coherence tomography angiography (SS-OCTA) metrics and the development of myocardial infarction (MI), congestive heart failure (CHF), and all-cause mortality in diabetic patients with and without diabetic retinopathy (DR).

Methods: Baseline SS-OCTA images (6×6mm, Montage 15×15mm ) were assessed for quantitative and qualitative metrics to identify parameters associated with MI, CHF, and all-cause mortality.

Results: 178 eyes from 119 adults with diabetes without DR or with NPDR or PDR were included (median 44 months, range 3-57). 11 participants (9.2%) had a cardiovascular event (6 MI, 5 CHF), and 7 (5.9%) died. Neovascularization vessel density (HR=44.0, 95% CI: 1.0-1,861.2, P=0.048) and vitreous hemorrhage (HR=39.7, 95% CI: 4.0-392.8, P=0.002) were associated with CHF. Vitreous hemorrhage (HR=13.5, 95% CI: 3.0-61.2, P=0.001) and prior treatment with anti-VEGF injections and panretinal photocoagulation (HR=11.4, 95% CI: 2.0-66.3, P=0.007) were associated with cardiovascular disease (CHF or MI). Increased skeletonized vessel density of the deep capillary plexus (DCP) (HR=1.2, 95% CI: 1.0-1.5, P=0.026) was associated with mortality.

Conclusion: Neovascularization vessel density and skeletonized vessel density of the DCP on SS-OCTA are associated with cardiovascular disease and mortality in patients with DR. These exploratory findings suggest SS-OCTA may be a useful non-invasive tool to identify diabetic patients at increased risk of cardiovascular disease and death.

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与糖尿病视网膜病变患者未来心血管疾病和死亡率相关的扩展域OCTA生物标志物

目的：探讨伴有或不伴有糖尿病视网膜病变（DR）的糖尿病患者扩展场扫描源光学相干断层血管造影（SS-OCTA）指标与心肌梗死（MI）、充血性心力衰竭（CHF）和全因死亡率之间的关系。方法：评估基线SS-OCTA图像（6×6mm, Montage 15×15mm）的定量和定性指标，以确定与心肌梗死、心力衰竭和全因死亡率相关的参数。结果：纳入了119例无DR或NPDR或PDR的成人糖尿病患者的178只眼睛（中位44个月，范围3-57）。11名参与者（9.2%）发生心血管事件（6名MI， 5名CHF）， 7名（5.9%）死亡。新生血管密度（HR=44.0, 95% CI: 1.0 ~ 1861.2， P=0.048）和玻璃体出血（HR=39.7, 95% CI: 4.0 ~ 392.8， P=0.002）与CHF相关。玻璃体出血（HR=13.5, 95% CI: 3.0-61.2， P=0.001）和之前接受抗vegf注射和全视网膜光凝治疗（HR=11.4, 95% CI: 2.0-66.3， P=0.007）与心血管疾病（CHF或MI）相关。深毛细血管丛（DCP）骨化血管密度增加（HR=1.2, 95% CI: 1.0-1.5， P=0.026）与死亡率相关。结论：SS-OCTA显示的DCP新生血管密度和骨化血管密度与dr患者的心血管疾病和死亡率相关，这些探索性发现表明SS-OCTA可能是一种有用的无创工具，可用于识别心血管疾病和死亡风险增加的糖尿病患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.