Hyperreflective Retinal Spots in Epiretinal Membranes: Evolving Significance Across Disease Stages.

IF 2.1 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-10 DOI:10.1097/IAE.0000000000004672

Alberto Quarta, Maria Ludovica Ruggeri, Corina De Santis Ciacci, Ruggero Tartaro, Lisa Toto, Rodolfo Mastropasqua

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引用次数: 0

Abstract

Purpose: To investigate the hyperreflective spots (HRS) across different stages of epiretinal membrane (ERM) using optical coherence tomography (OCT) and their relationship with anatomical and functional parameters.

Methods: This observational study included 111 patients with ERM, categorized into early (stages 1-2, n=43) and late (stages 3-4, n=68). Total Hyperreflective Spots (HRST), Visual Acuity (VA), central retinal thickness (CRT), and outer nuclear layer (ONL) thickness were measured using OCT. Statistical analyses included Mann-Whitney U test for group comparisons and Spearman's correlation to assess relationships between HRST and VA.

Results: HRST increased significantly from early (27.67 ± 12.57) to late stages (35.15 ± 17.28, p=0.015). In early stages, HRST showed a moderate positive correlation with VA (ρ=0.48, p=0.001), while this correlation diminished in late stages (ρ=0.036, p=0.426). CRT also increased significantly from early to late stages (380.05 ± 94.51 μm vs. 523.54 ± 83.92 μm, p<0.001). ONL thickness showed no significant difference between stages (p=0.543). Linear regression model showed in early stages (1-2) that HRST and CRT were valuable VA predictors (Adjusted R2=0.284, p < 0.05).

Conclusion: HRST progressively increases with ERM severity, correlating with visual function in early stages but losing this association in advanced stages. These findings suggest that HRST could be a prognostic marker for early disease progression and highlight the need for timely intervention to preserve visual function.

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视网膜上膜的高反射性视网膜斑点：疾病分期的演变意义。

目的：利用光学相干断层扫描（OCT）研究视网膜前膜（ERM）不同阶段的高反射斑（HRS）及其与解剖和功能参数的关系。方法：本观察性研究纳入了111例ERM患者，分为早期（1-2期，n=43）和晚期（3-4期，n=68）。采用oct测量患者的总高反射斑（HRST）、视敏度（VA）、视网膜中央厚度（CRT）、外核层厚度（ONL）。统计学分析采用Mann-Whitney U检验进行组间比较，Spearman相关分析HRST与VA的关系。结果：HRST从早期（27.67±12.57）到晚期（35.15±17.28,p=0.015）显著升高。在早期，HRST与VA呈中度正相关（ρ=0.48, p=0.001），而在晚期，这种相关性减弱（ρ=0.036, p=0.426）。HRST随ERM严重程度的增加而逐渐升高（380.05±94.51 μm vs. 523.54±83.92 μm）。结论：HRST随ERM严重程度的增加而逐渐升高，早期HRST与视功能相关，晚期HRST与视功能相关消失。这些发现表明，HRST可能是早期疾病进展的预后标志，并强调了及时干预以保持视觉功能的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.