Romanian Journal of Morphology and Embryology最新文献_第5页

Humps and bumps of head: review of meningiomas of the scalp. 头部的凹凸不平：头皮脑膜瘤回顾。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2023-10-01 DOI: 10.47162/RJME.64.4.02

Elena Porumb-Andrese, Claudia Florida Costea, Georgiana Macovei, Gabriela Florenţa Dumitrescu, Laurenţiu Andrei Blaj, Iulian Prutianu, Andrei Ionuţ Cucu

引用次数: 0

Time to redefine hyperuricemia? The serum uric acid cut-off level for precipitation might be lower: a pilot study. 是时候重新定义高尿酸血症了吗？沉淀的血清尿酸临界值可能更低：一项试点研究。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2023-10-01 DOI: 10.47162/RJME.64.4.11

Ananu Florentin Vreju, Cristina Dorina Pârvănescu, Adina Turcu-Ştiolică, Ştefan Cristian Dinescu, Sineta Cristina Firulescu, Andreea Lili Bărbulescu, Andreea Beatrice Chisălău, Răzvan Adrian Ionescu, Horaţiu Valeriu Popoviciu, Cristina Elena Gofiţă, Roxana Mihaela Dumitraşcu, Cristina Gabriela Ene, Florin Liviu Gherghina, Paulina Lucia Ciurea, Claudiu Avram

{"title":"Time to redefine hyperuricemia? The serum uric acid cut-off level for precipitation might be lower: a pilot study.","authors":"Ananu Florentin Vreju, Cristina Dorina Pârvănescu, Adina Turcu-Ştiolică, Ştefan Cristian Dinescu, Sineta Cristina Firulescu, Andreea Lili Bărbulescu, Andreea Beatrice Chisălău, Răzvan Adrian Ionescu, Horaţiu Valeriu Popoviciu, Cristina Elena Gofiţă, Roxana Mihaela Dumitraşcu, Cristina Gabriela Ene, Florin Liviu Gherghina, Paulina Lucia Ciurea, Claudiu Avram","doi":"10.47162/RJME.64.4.11","DOIUrl":"10.47162/RJME.64.4.11","url":null,"abstract":"Background: Hyperuricemia is classically defined as serum uric acid (SUA) value higher than 6.8 mg∕dL; between hyperuricemic patients, only 15-20% will develop gout. Our first goal was to find if there is a specificity of the \"snowstorm\" feature on ultrasound (US) for hyperuricemia. Moreover, we aimed to determine if there is a level of SUA from which the urates tend to appear in the synovial fluid, without generating a typical clinical gouty flare.Patients, materials and methods: We conducted a cross-sectional, transverse study, including 108 consecutive patients that displayed a set of clinical and imaging features, such as swollen knee and US proof for knee joint effusion.Results: Performing binary logistic regression, the relation between the explanatory variable (hyperechogenic spots) and the response variable (SUA) was demonstrated to be a significant one (p=0.005). The value of 0.397 for the statistical phi coefficient suggests a medium intensity association between the diagnosis of gout or asymptomatic hyperuricemia and whether the patients have hyperechogenic spots or not. We found the cut-off value for SUA equal to 4.815 mg∕dL, regardless of gender, from which, the urate starts to precipitate. Values for men tend to be higher in comparison to the ones found for women (4.95 mg∕dL vs. 3.9 mg∕dL).Conclusions: The \"snowstorm\" aspect of the fluid might be the result of an increased level of SUA and more than this, the cut-off level for SUA to precipitate might be lower than the fore used values.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant exophytic gastrointestinal stromal tumor (GIST) causing gastric outlet obstruction: case report and review of literature. 巨大外生性胃肠道间质瘤（GIST）导致胃出口梗阻：病例报告和文献综述。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2023-10-01 DOI: 10.47162/RJME.64.4.17

Victor Mihai Sacerdoţianu, Cecil Sorin Mirea, Petrică Popa, Dan Ionuţ Gheonea, Maria Camelia Foarfă, Marius Matei, Daniela Larisa Săndulescu, Cristian Virgil Lungulescu, Tudorel Ciurea, Bogdan Silviu Ungureanu

引用次数: 0

Symptomatic pericardial cysts and dilemmas in their diagnosis. 有症状的心包囊肿及其诊断难题。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2023-10-01 DOI: 10.47162/RJME.64.4.08

Adriana Grigoraş, Cornelia Amălinei, Irina Draga Căruntu, Constantin Cristian Grigoraş, Irina Rodica Chiseliţă, Radu Adrian Crişan-Dabija

{"title":"Symptomatic pericardial cysts and dilemmas in their diagnosis.","authors":"Adriana Grigoraş, Cornelia Amălinei, Irina Draga Căruntu, Constantin Cristian Grigoraş, Irina Rodica Chiseliţă, Radu Adrian Crişan-Dabija","doi":"10.47162/RJME.64.4.08","DOIUrl":"10.47162/RJME.64.4.08","url":null,"abstract":"Pericardial cysts (PCs) or pleuropericardial cysts are rare congenital mediastinal lesions with an approximate incidence of one in 100 000 persons. Usually, they are asymptomatic, being incidentally discovered during a routine chest imaging examination or an autopsy exam. The study involved a retrospective evaluation of clinicopathological findings in a 6-year series of PCs, treated in the Clinic of Pulmonary Diseases, Iaşi, Romania. A group of five cases of PCs, four females and one male, were evaluated. All patients displayed different symptoms, such as dyspnea, chest pain, chronic cough, fatigue, palpitation, and epigastric pain. The cystic lesions were located in the right and left cardiophrenic angle, in four cases, and in the central mediastinum in a single case. The lesions had a fluid content and a maximum diameter that ranged between 35 and 95 mm. The microscopic examination of the surgical resection tissues revealed a thin connective tissue wall without any associated smooth muscle cells. The loose connective tissue band was lined by a layer of mesothelial cells with no cellular atypia, which displayed discrete papillary projections, in one case. Although PCs are rare incidental findings, they should be considered in differential diagnoses of mediastinal cysts, especially as they are associated with non-specific symptoms. Furthermore, considering the possibility of development of severe complications, PCs should be thoroughly explored for suitable patients' management.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zinc-Boron-PLGA biocomposite material: preparation, structural characterization, and in vitro assessment. 锌-硼-PLGA 生物复合材料：制备、结构表征和体外评估。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2023-10-01 DOI: 10.47162/RJME.64.4.14

Maria Viorica Ciocîlteu, Ion Romulus Scorei, Gabriela Rău, Claudiu Nicolicescu, Andrei Biţă, Vladimir Lucian Ene, Andreea Simionescu, Adina Turcu-Ştiolică, Venera Cristina Dinescu, Johny Neamţu, Laurenţiu Mogoantă, George Dan Mogoşanu

{"title":"Zinc-Boron-PLGA biocomposite material: preparation, structural characterization, and in vitro assessment.","authors":"Maria Viorica Ciocîlteu, Ion Romulus Scorei, Gabriela Rău, Claudiu Nicolicescu, Andrei Biţă, Vladimir Lucian Ene, Andreea Simionescu, Adina Turcu-Ştiolică, Venera Cristina Dinescu, Johny Neamţu, Laurenţiu Mogoantă, George Dan Mogoşanu","doi":"10.47162/RJME.64.4.14","DOIUrl":"10.47162/RJME.64.4.14","url":null,"abstract":"Nowadays, the state-of-the-art discoveries in the field of delivery systems for therapeutic purposes have redefined the importance of biocompatible and biodegradable poly(lactic-co-glycolic acid (PLGA) nanocomposites. The study aimed to obtain a biocomposite material, with improved properties of its constituents [zinc-boron (Zn-B) complex and PLGA], by a simple, cost-effective method. The water∕oil∕water double emulsion technique allowed the adjustment of the synthesis parameters, to maximize the degree of Zn-B complex encapsulation. The morphological aspects of the samples were established by scanning electron microscopy (SEM). Particle size distribution was determined by dynamic light scattering (DLS). Morphology was typical for PLGA, spherical one. Depending on the synthesis conditions, the obtained particles have diameters between 10-450 nm. Zeta potential (ZP) showed that the particles have electronegative surface charge, offering a favorable perspective on aggregation, flocculation, and dispersion phenomena. It was observed, applying the design of experiments, that the particles size increased with increasing amounts of PLGA and polyvinyl alcohol (PVA), while ZP increased with higher PLGA and smaller PVA amounts in the formulation. The encapsulation efficiency was determined by ultra-high performance liquid chromatography∕mass spectrometry (UHPLC∕MS). The in vitro assessment was performed using Vero CCL-81 epithelial cell line and the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test. Zn-B-PLGA biocomposite has promising characteristics and can be used for future biomedical applications.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obliterative foam-cell arteriopathy. A unifying concept embracing several entities previously described as radiation, decidual, transplant, and intratumoral-associated arteriopathy. 闭塞性泡沫细胞动脉病变。这是一个统一的概念，包含了之前被描述为辐射、蜕膜、移植和瘤内相关动脉病变的几种实体。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2023-10-01 DOI: 10.47162/RJME.64.4.01

José Fernando Val-Bernal, Marta María Mayorga, Carlos Bercebal, María Luisa Cagigal

{"title":"Obliterative foam-cell arteriopathy. A unifying concept embracing several entities previously described as radiation, decidual, transplant, and intratumoral-associated arteriopathy.","authors":"José Fernando Val-Bernal, Marta María Mayorga, Carlos Bercebal, María Luisa Cagigal","doi":"10.47162/RJME.64.4.01","DOIUrl":"10.47162/RJME.64.4.01","url":null,"abstract":"This review article aimed to postulate the existence of a specific arterial injury having as its histological hallmark a collection of macrophages loaded with lipids in the intima of small-sized and medium-sized arteries causing narrowing or complete obstruction. The proposal is made that a series of previously described entities, such as ionizing radiation arteriopathy, acute atherosis (foam-cell decidual arteriopathy), transplant chronic arteriopathy of solid organ allografts, and intratumoral-associated foam-cell arteriopathy constitute different manifestations of the same basic morphological process identified as obliterative foam-cell arteriopathy (OFCA). OFCA is a local (single-organ) lesion in the aforementioned diverse processes with variable etiopathogenesis but converges in a single morphological marker. This arteriopathy is essentially an intimal disease. The processes in which the OFCA appears are known under a variety of names partly dependent on the location of the lesion. The basic unifying mechanism of the different entities is endothelial activation and dysfunction (local arterial endotheliopathy), preferably in small-sized or medium-sized arteries (100 to 500 μm in external diameter).","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-COVID-19 enterocolitis - a cause of rebellious diarrhea, acute abdomen and liver failure. COVID-19 后小肠结肠炎--导致反常腹泻、急性腹部和肝功能衰竭。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2023-10-01 DOI: 10.47162/RJME.64.4.09

Cosmin Vasile Obleagă, Rukie Ana Maria Ahmet, Dan Nicolae Florescu, Dragoş Marian Popescu, Cristian Meşină, Liliana Streba, Cristin Constantin Vere, Cristian Constantin

{"title":"Post-COVID-19 enterocolitis - a cause of rebellious diarrhea, acute abdomen and liver failure.","authors":"Cosmin Vasile Obleagă, Rukie Ana Maria Ahmet, Dan Nicolae Florescu, Dragoş Marian Popescu, Cristian Meşină, Liliana Streba, Cristin Constantin Vere, Cristian Constantin","doi":"10.47162/RJME.64.4.09","DOIUrl":"10.47162/RJME.64.4.09","url":null,"abstract":"Currently, worldwide, the coronavirus disease 2019 (COVID-19) pandemic, which first appeared in Wuhan, China, in December 2019, is capsizing the medical system and turning the attention of the entire healthcare system through the many aspects it presents, both from a pathophysiological and from a semiological view, insufficiently studied aspects. With a high rate of morbidity and mortality, the COVID-19 pandemic was initially observed as a pathology leading to a severe acute respiratory syndrome, but over time gastrointestinal and hepatic manifestations have been reported. The study includes an analysis of 21 patients in the stage of the clinical disease of COVID-19 or in the stage of recovery, hospitalized in the Departments of General Surgery II or Gastroenterology, Emergency Clinical County Hospital of Craiova, Romania, with predominantly digestive symptoms, with the clinical expression of infectious enterocolitis, although stool culture was negative for pathogenic bacteria. The evolution of patients was influenced by the appearance of peritonitis through colonic necrosis or remission of clinical symptoms under empirical therapy.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro effects of heparin-binding epidermal growth factor on adhesion stage of implantation. 肝素结合表皮生长因子对植入粘附阶段的体外影响。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2023-10-01 DOI: 10.47162/RJME.64.4.05

Burcu Biltekin, Ayhan Bilir, Ismail Seckin, Gozde Erkanli Senturk

{"title":"In vitro effects of heparin-binding epidermal growth factor on adhesion stage of implantation.","authors":"Burcu Biltekin, Ayhan Bilir, Ismail Seckin, Gozde Erkanli Senturk","doi":"10.47162/RJME.64.4.05","DOIUrl":"10.47162/RJME.64.4.05","url":null,"abstract":"A member of the epidermal growth factor (EGF) family, the heparin-binding EGF (HB-EGF) is expressed in the uteri of both humans and mice during the implantation process. To study the effects of HB-EGF on adhesion stage, we developed an in vitro implantation model employing Ishikawa cell line and JAR cell line, which may attach to Ishikawa cells. For 1, 6, 12, and 24 hours, co-cultures of JAR spheroids grown on Ishikawa monolayers were treated with 1, 10, and 100 ng∕mL doses of HB-EGF. Using immunocytochemistry and Western blot analysis, the effects of HB-EGF on the protein expressions of E-cadherin, Erb-B2 receptor tyrosine kinase 4 (ErbB4), and integrin ανβ3 in Ishikawa and JAR cells were examined semi-quantitatively and quantitatively. Ultrastructural changes of in vitro implantation model were investigated by transmission electron microscopy. We revealed that HB-EGF influenced trophoblast cell adhesion to endometrial cells by upregulating the expression of the proteins ErbB4 and trophoblastic integrin ανβ3. Decrease in trophoblastic E-cadherin expression and increase in endometrial E-cadherin expression were demonstrated accompanying morphological variations in cells required for the invasion. We discovered ultrastructurally that Ishikawa cells acquired uterodome-like appearance, including the organelles, when 10 and 100 ng∕mL dosages of HB-EGF were administered for 12 and 24 hours. However, following additional hours of adhesion and invasion, their intercellular spaces enlarged. The trafficking of vesicular transport was enhanced by JAR spheroids. We therefore discovered that in this implantation paradigm, HB-EGF may enhance the receptivity of Ishikawa cells and the adherence of JAR cells.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental carcinoma of the prostate in cystoprostatectomy specimens - is it always a toothless lion? 前列腺膀胱切除术标本中的前列腺偶发癌--总是无牙狮子吗？

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2023-10-01 DOI: 10.47162/RJME.64.4.06

Vlad Dema, Alexei Croitor, Andreea Floruncuţ, Sorin Dema, Tiberiu Răzvan Bardan, Sorina Maria Tăban, Robert Alexandru Barna, Bianca Roxana Natarâş, Alin Adrian Cumpănaş

{"title":"Incidental carcinoma of the prostate in cystoprostatectomy specimens - is it always a toothless lion?","authors":"Vlad Dema, Alexei Croitor, Andreea Floruncuţ, Sorin Dema, Tiberiu Răzvan Bardan, Sorina Maria Tăban, Robert Alexandru Barna, Bianca Roxana Natarâş, Alin Adrian Cumpănaş","doi":"10.47162/RJME.64.4.06","DOIUrl":"10.47162/RJME.64.4.06","url":null,"abstract":"Incidental prostate carcinoma (iPC) is a subject of debate concerning its definition, incidence, biology, diagnosis, staging, and treatment. The present study aimed to assess the incidence and main clinical-morphological characteristics of iPC identified in radical cystoprostatectomy (RCP) specimens over a 5-year period. Using the database of the Urology and Pathology Departments, we identified all patients with bladder carcinomas (BCs) who underwent RCP within a 5-year frame time. We selected only those patients with synchronous BC and prostate carcinoma (PC). The following parameters were analyzed for these patients: age, type of bladder and prostate tumor, degree of differentiation, pathological stage, and other prognostic parameters. We identified 91 men with bladder tumors treated by RCP among whom 43, aged between 53 and 84 years (mean age: 69.2 years), presented synchronous PC. iPC was more prevalent in older individuals (>65 years: 30 patients, 69.8%), with only six out of the 43 (12.8%) patients with iPC being aged ≤60 years. All iPC cases were conventional adenocarcinoma. Well-differentiated prostate adenocarcinomas (grade group 1) predominated (65.1%). Among the 43 iPCs, 16 (37.2%) were clinically significant PCs. iPC is frequently identified in patients with BC when inclusion and evaluation of all or most of the prostate tissue are performed. Although more than half of iPCs were well-differentiated tumors confined to the prostate, a significant number of cases met the criteria of clinically significant PC. All men over the age of 50 who are candidates for RCP, should undergo evaluation through serum prostate specific antigen determination.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kaposi's sarcoma of the larynx: case series. 喉部卡波西肉瘤：病例系列。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2023-10-01 DOI: 10.47162/RJME.64.4.13

Mircea Sorin Ciolofan, Florin Anghelina, Carmen Aurelia Mogoantă, Alexandru Nicolae Vlăescu, Mihaela Roxana Mitroi, Alina Nicoleta Căpitănescu, Charoula Florou, Anca Maria Istrate-Ofiţeru, Gheorghe Iovănescu

引用次数: 0