Romanian Journal of Morphology and Embryology最新文献_第4页

MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis - key points in understanding the mechanisms and celerity of tumor dissemination. 黑色素瘤及其转移中的 MMP1、MMP9、MMP11 和 MMP13--了解肿瘤扩散机制和速度的关键点。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2024-01-01 DOI: 10.47162/RJME.65.1.06

Bogdan Stelian Mastalier Manolescu, Angela Mădălina Lazar, George Sorin Ţiplica, Sabina Andrada Zurac, Adrian Reboşapcă, Bogdan Andreescu, Cristiana Gabriela Popp

{"title":"MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis - key points in understanding the mechanisms and celerity of tumor dissemination.","authors":"Bogdan Stelian Mastalier Manolescu, Angela Mădălina Lazar, George Sorin Ţiplica, Sabina Andrada Zurac, Adrian Reboşapcă, Bogdan Andreescu, Cristiana Gabriela Popp","doi":"10.47162/RJME.65.1.06","DOIUrl":"10.47162/RJME.65.1.06","url":null,"abstract":"Background: Matrix metalloproteinase (MMP)1, MMP9, MMP11, and MMP13 are overexpressed in malignant melanoma (MM), being associated with tumor invasive phase, metastases, and more aggressive neoplastic phenotypes.Aim: The main objective of the current study was to correlate the expression of the MMPs with the evolution of MM toward distant metastasis.Patients, materials and methods: We designed a retrospective cohort study, including 13 patients with metastatic MM. Data concerning age, sex, localization of the primary lesion and metastasis, and histological and immunohistochemical features (intensity of expression and percent of positive cells for MMPs) were statistically processed.Results: The time between the diagnosis of primitive melanoma and the diagnosis of metastasis ranged between 0 and 73 months, with a mean value of 18.3 months. The metastases rich in MMP1- and MMP9-positive cells occurred earlier than the metastases with low levels of positive cells. The mean period until metastasis was shorter for the MMP1-expressing tumors than the ones without MMP1 expression. MMP13 expression in the tumor and its metastasis was significantly linked with the time until the metastasis occurrence.Conclusions: This study emphasizes the roles of MMP1, MMP9, and MMP13 in the process of metastasis in melanoma and the opportunity to use them as therapeutic targets and surveillance molecules.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primitive neuroectodermal tumors of the ovary: a multidecade review of the scientific literature. 卵巢原始神经外胚层肿瘤：多年科学文献回顾。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2024-01-01 DOI: 10.47162/RJME.65.1.01

Tiberiu Augustin Georgescu, Antonia Carmen Georgescu, Andrei Dennis Voichiţoiu, Dragoş Creţoiu, Nicolae Suciu, Adriana Irina Ciuvică

{"title":"Primitive neuroectodermal tumors of the ovary: a multidecade review of the scientific literature.","authors":"Tiberiu Augustin Georgescu, Antonia Carmen Georgescu, Andrei Dennis Voichiţoiu, Dragoş Creţoiu, Nicolae Suciu, Adriana Irina Ciuvică","doi":"10.47162/RJME.65.1.01","DOIUrl":"10.47162/RJME.65.1.01","url":null,"abstract":"Primitive neuroectodermal tumor (PNET) is a general term used in scientific literature for a heterogeneous group of small round-cell malignant tumors primarily arising from neural crest cells. These are extremely aggressive neoplasms which usually occur within soft tissue or bone of young adults. Ovarian tumors composed of primitive neuroectodermal elements are extremely rare, with only few case reports in scientific literature. Due to being so exceedingly rare, PNETs are frequently misdiagnosed and there are no standard therapeutic guidelines. Young patients seem to have better prognoses and individualized strategy is recommended. Limited data suggests that various gene deletions as well as amplifications may be crucial factors for tumorigenesis and the aggressive behavior of PNET. In this paper, we performed a brief review of all cases of primary ovarian PNETs published in the scientific literature to date, in regard to their clinical, histopathological, and therapeutic aspects, with the aim to provide a more comprehensive understanding of this exceedingly rare pathology.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial cell proliferation and vascular patterns in urothelial carcinoma. 尿路上皮细胞癌的内皮细胞增殖和血管形态。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2024-01-01 DOI: 10.47162/RJME.65.1.08

Tiberiu Gabriel Adelmann, Amalia Raluca Ceauşu, Nela Puşa Gaje, Marius Raica

{"title":"Endothelial cell proliferation and vascular patterns in urothelial carcinoma.","authors":"Tiberiu Gabriel Adelmann, Amalia Raluca Ceauşu, Nela Puşa Gaje, Marius Raica","doi":"10.47162/RJME.65.1.08","DOIUrl":"10.47162/RJME.65.1.08","url":null,"abstract":"Introduction: The bladder cancer has some characteristics: the sixth most incident neoplasm in the United States, the majority of diagnosed cases in those 55 years of age and older, four times more common in man than women, a reduced five-year survival rate in case of metastatic disease. Despite the beneficial effects of the combination therapy and immunotherapy, the low response rate and drug resistance were reported. The main goal of this work was evaluation of the endothelial cell proliferation from urothelial carcinomas.Patients, materials and methods: Fifty-two cases of T2-T4 infiltrative bladder tumors, aged between 46 and 78 years, were investigated. Morphological, simple and cluster of differentiation 31 (CD31)∕Ki67, CD31∕smooth muscle actin (SMA) double immunostaining were performed.Results: In all the analyzed infiltrative bladder tumors, three types of vessels were noticed: immature, intermediate and mature. In the central part of the tumor area, the following distribution of vessel types was noticed: immature (62.25%), intermediate (35.1%), and mature vessels (2.65%). In the peripheral tumor area, the intermediate vessels increase numerically, up to 54% and the mature ones, up to 18.6%. The peritumoral area was characterized by the absence of immature vessels and the presence of intermediate and mature ones only. It was found the presence of endothelial cell nuclei stained for Ki67 only for immature and intermediate vessels, and never for mature ones.Conclusions: The vascular patterns may contribute to a better stratification of the patient subgroups and antiangiogenic treatment algorithms.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of sepsis on erythrocytes morphology: case report and literature review. 败血症对红细胞形态的影响：病例报告和文献综述。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2024-01-01 DOI: 10.47162/RJME.65.1.15

Cristian Mircea Nicolescu, Silviu Daniel Moldovan

引用次数: 0

Cyclophosphamide stimulates endoplasmic reticulum stress and induces apoptotic cell death in human glioblastoma cell lines. 环磷酰胺刺激内质网应激，诱导人类胶质母细胞瘤细胞株的细胞凋亡。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2024-01-01 DOI: 10.47162/RJME.65.1.04

Mustafa Oztatlici, Hulya Oztatlici, Suna Karadeniz Saygili, Ismail Kaya, Ilker Deniz Cingoz

{"title":"Cyclophosphamide stimulates endoplasmic reticulum stress and induces apoptotic cell death in human glioblastoma cell lines.","authors":"Mustafa Oztatlici, Hulya Oztatlici, Suna Karadeniz Saygili, Ismail Kaya, Ilker Deniz Cingoz","doi":"10.47162/RJME.65.1.04","DOIUrl":"10.47162/RJME.65.1.04","url":null,"abstract":"Cyclophosphamide (CP) is an alkylating chemotherapeutic agent commonly used in cancer treatments. In this study, we aimed to investigate the effects of 4-Hydroperoxy cyclophosphamide (4-HC), which is active form of CP, on glucose-regulated protein 78 (GRP78), activating transcription factor 6 (ATF6), phospho-protein kinase R (PKR)-like endoplasmic reticulum (ER) kinase (p-PERK), phospho-inositol-requiring enzyme 1 alpha (p-IRE1α), eukaryotic translation initiation factor 2 alpha (eIF2α), and caspase-3 messenger ribonucleic acids (mRNAs) and proteins that play roles in the ER stress pathway and apoptosis in U87 and T98 human glioblastoma cell lines. U87 and T98 human glioblastoma cell lines were divided into control and 4-HC-treated groups. Cell viability assay was used to detect the half maximal inhibitory concentration (IC50) for 24 hours of 4-HC. Immunocytochemistry and quantitative polymerase chain reaction (qPCR) methods were used to evaluate the levels of proteins and their mRNAs. The IC50 values of U87 and T98 cells were calculated as 15.67±0.58 μM and 19.92±1 μM, respectively. The levels of GRP78, ATF6, p-PERK, p-IRE1α, eIF2α, and caspase-3 protein expressions in the 4-HC-treated group compared to that in the control group. These increased protein expressions also were correlated with the mRNA levels. The ER stress signal pathway could be active in 4-HC-induced cell death. Further studies of ER-related stress mechanisms in anticancer treatment would be important for effective therapeutic strategies.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fetal acrania diagnosed at 17 weeks of gestation by 2D∕3D ultrasound: a case report and literature review. 通过二维∕三维超声波检查在妊娠 17 周时诊断出胎儿acrania：病例报告和文献综述。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2024-01-01 DOI: 10.47162/RJME.65.1.16

Bogdan Ioan Ştefănescu, Tiberiu Ioan Mihalache, Georgiana Bianca Constantin, George Ţocu, Miruna Maria Ştefănescu, Roxana Elena Bogdan Goroftei

引用次数: 0

Ultrastructural changes of lung tissue under conditions of experimental obesity and smoking. 实验性肥胖和吸烟条件下肺组织的超微结构变化

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2024-01-01 DOI: 10.47162/RJME.65.1.07

Yuliia Kuzyk, Olena Mazur, Yuryj Bisyarin

{"title":"Ultrastructural changes of lung tissue under conditions of experimental obesity and smoking.","authors":"Yuliia Kuzyk, Olena Mazur, Yuryj Bisyarin","doi":"10.47162/RJME.65.1.07","DOIUrl":"10.47162/RJME.65.1.07","url":null,"abstract":"Obesity can cause respiratory disorders inflicted by adipose tissue accumulation and the numerous cytokines adipocytes produce. Smoking is, first of all, associated with a wide range of lung diseases characterized by diffuse changes in the lung tissue and a decrease in the respiratory volume of the lungs. The study aimed to investigate the ultrastructural changes in the lungs of sexually mature male rats under conditions of experimental obesity and smoking. The total sample of experimental animals consisted of 120 rats, divided into four groups: the control group (n=30) - conditionally healthy rats fed on a standard diet; a group of rats subjected to isolated exposure to tobacco smoke (n=30); a group of experimentally obese rats (n=30) and a group of experimentally obese rats simultaneously exposed to tobacco smoke (n=30) - feeding using a high-fat diet with exposure to a chamber with tobacco smoke. The revealed ultrastructural features of the lungs in the group of rats with experimental obesity and the group of rats with experimental obesity that were simultaneously exposed to tobacco smoke did not differ qualitatively, which indicates that pathological changes in the ultrastructure of the lung tissue developed regardless of the presence or absence of a direct damaging effect on the lung tissue of passive smoking.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoexpression of Ki67, P16 and Beta-catenin in precursor lesions of cutaneous squamous cell carcinoma. 皮肤鳞状细胞癌前驱病变中 Ki67、P16 和 Beta-catenin 的免疫表达。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2024-01-01 DOI: 10.47162/RJME.65.1.03

Alina Maria Vîlcea, Loredana Elena Stoica, Bianca Cătălina Andreiana, Cecil Sorin Mirea, Tiberiu Ştefăniţă Ţenea Cojan, Ioana Cristina Vîlcea, Claudiu Mărgăritescu

{"title":"Immunoexpression of Ki67, P16 and Beta-catenin in precursor lesions of cutaneous squamous cell carcinoma.","authors":"Alina Maria Vîlcea, Loredana Elena Stoica, Bianca Cătălina Andreiana, Cecil Sorin Mirea, Tiberiu Ştefăniţă Ţenea Cojan, Ioana Cristina Vîlcea, Claudiu Mărgăritescu","doi":"10.47162/RJME.65.1.03","DOIUrl":"10.47162/RJME.65.1.03","url":null,"abstract":"Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer, after basal cell carcinoma, representing about 10-20% of all malignant skin tumors. The mortality rates of CSCC approach those of renal and oropharyngeal carcinomas, as well as melanoma, with the increasing of the risk once metastases and perineural invasion occur. Both actinic keratosis (AK) and Bowen's disease (BD) are direct precursors with the potential for progression to CSCC. In this study, we analyzed the expression of Ki67, P16 and Beta-catenin in the precursor lesions of CSCC in relation to histological prognostic parameters, respectively between them, with the aim of identifying possible correlations with a role in prognosis. Ki67 and P16 presented higher scores in advanced precancerous lesions, such as keratinocyte intraepithelial neoplasia (KIN) III and BD and low scores in seborrheic keratosis (SK). The immunoreactivity to the investigated markers confirms the multistage skin carcinogenesis, and their involvement starting from the initiation phase of the cancer process. The importance of the studied markers in the evolution and prognosis of precancerous lesions of CSCC is also supported by the linear correlations revealed between the immunoexpressions of P16, Ki67 and the membranous immunoexpression of Beta-catenin in AK.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic resonance imaging combined with histological evaluation of repair process using the microfracture technique in an association of osteocartilaginous and meniscal surgically induced lesions of the knee. In vivo experiment on a rabbit model. 利用微骨折技术对膝关节骨软骨和半月板手术引起的损伤的修复过程进行磁共振成像和组织学评估。兔子模型的活体实验。

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2024-01-01 DOI: 10.47162/RJME.65.1.11

Jenel Marian Pătraşcu, Sorin Florescu, Silviu Brad, Bogdan Corneliu Andor, Iosif Ilia, Ştefan Iulian Stănciugelu, Romeo Teodor Cristina

{"title":"Magnetic resonance imaging combined with histological evaluation of repair process using the microfracture technique in an association of osteocartilaginous and meniscal surgically induced lesions of the knee. In vivo experiment on a rabbit model.","authors":"Jenel Marian Pătraşcu, Sorin Florescu, Silviu Brad, Bogdan Corneliu Andor, Iosif Ilia, Ştefan Iulian Stănciugelu, Romeo Teodor Cristina","doi":"10.47162/RJME.65.1.11","DOIUrl":"10.47162/RJME.65.1.11","url":null,"abstract":"The present research study aimed to assess magnetic resonance imaging (MRI) changes and histological findings in the therapeutic effects of microfractures in the treatment of complex animal knee lesions resulting from osteochondral and meniscal defects resulting from non-total meniscectomies. The anterior cruciate ligament lesions are also proven to facilitate the development of osteoarthritis in the knee and worsen the prognosis. Surgery was performed on the right knee joint of 22 male rabbits in order to partially remove the anterior horn of the internal meniscus and to induce an osteochondral defect at the level of the internal femoral condyle. The induced lesion complex was aimed to simulate a clinical situation that occurs frequently in orthopedic practice when young adults undergo partial meniscectomy and at the time of surgery, an osteochondral defect is diagnosed. Rabbits were separated into two study groups: the control (C1) group and the microfractures (MF2) group. After the induced cartilage defect and partial meniscectomy, both groups were followed-up for six months using detailed MRI. Also, anatomical specimens were histologically analyzed to show modifications and signs of healing process, along with complications, in the study group. The results showed that the microfracture group had better results concerning articular surface defect healing in comparison to the control group. Our results suggest that microfractures do improve results concerning surface contact healing and serial MRI studies can be useful in observing the remodeling process in dynamics.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of quercetin on gentamicin-induced experimental testicular injury in rats. 槲皮素对庆大霉素诱导的大鼠实验性睾丸损伤的影响

IF 1 4区医学

Romanian Journal of Morphology and Embryology Pub Date : 2024-01-01 DOI: 10.47162/RJME.65.1.09

Ayse Firuze Biyik, Esin Yulug, Engin Yenilmez, Abdulkadir Kutlu, Ahmet Alver, Seniz Erdem

{"title":"Effects of quercetin on gentamicin-induced experimental testicular injury in rats.","authors":"Ayse Firuze Biyik, Esin Yulug, Engin Yenilmez, Abdulkadir Kutlu, Ahmet Alver, Seniz Erdem","doi":"10.47162/RJME.65.1.09","DOIUrl":"10.47162/RJME.65.1.09","url":null,"abstract":"The purpose of this study was to investigate the effects of gentamicin (GEN) on the testis and whether quercetin (QUE) has any protective effect. Twenty-four adult male Sprague-Dawley rats were divided into equal four groups: control (0.9% saline solution), GEN (80 mg∕kg GEN), QUE (50 mg∕kg QUE) and GEN+QUE (80 mg∕kg GEN + 50 mg∕kg QUE). Histopathological (HP) evaluation of testis was performed, epididymal sperm parameters were analyzed and oxidative status was evaluated. The use of QUE improved the HP findings, such as decrease in the germinal epithelial thickness in the testicular tissue of the GEN group, decrease in the Johnsen's tubular biopsy score (JTBS), increase in the rate of immature cell shedding tubules, and the apoptotic index (AI). In the GEN group, sperm count, and abnormal morphology increased compared to the control group; the viability and motility decreased according to the sperm analysis results. In the GEN+QUE group, QUE was found to improve sperm viability and morphology. In the GEN group, tissue malondialdehyde (MDA) levels increased while superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels decreased. Compared with the GEN+QUE group, it was found that the tissue MDA level decreased, while the levels of SOD, CAT and GPx increased. The results demonstrate that GEN impairs testicular structure and function, and QUE treatment can prevent this adverse effect.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0