A 10-year retrospective study of the risks and peculiarities in pediatric patients with (para)gonadal tumors and cysts.

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Usiwoma Okeroghene Ataikiru, Emil Radu Iacob, Elena Rodica Heredea, Maria Corina Stănciulescu, Mihai Codrin Galinescu, Călin Marius Popoiu, Eugen Sorin Boia
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引用次数: 0

Abstract

Introduction: Gonadal pediatric tumors are rare, ranking fourth (6%) among pediatric tumors, by Surveillance, Epidemiology, and End Results Program (https:∕∕seer.cancer.gov∕). They have vague symptoms, leading to late discovery, but early detection and identifying its risk factors result in favorable prognosis and reduction of its incidence respectively.

Patients, material and methods: A 10-year retrospective study identified peculiarities and risk factors in 210 children till age 17 with (para)gonadal tumors.

Results: Stress, pollution (agricultural chemicals, insecticides and metal mine), obesity, breastfeeding ≤5 months, malformations [mainly non-genetic related 67∕87 (77%), especially eye malformation - 64%], hormone, smoking, positive heredo-genetic history, rural residence area, abnormal birth weight, and menstruation disorders showed an increased gonadal malignancy risk; relative risk ratio (RR): 1.33, 1.30, 1.34, 1.11, 1.65, 1.16, 1.36, 1.10, 1.00, 1.08 and 1.15 folds, respectively. RR for histopathological subtypes: immature teratoma (IT) (pollution - 1.75, Rhesus positive - 3.41), dysgerminoma (menstruation disorders - 2.80), granulosa cell tumor (stress - 2.10, menstruation disorders - 2.80), mucinous cystadenomas (obesity - 2.84, no postnatal vaccine - 3.71), mature teratomas (stress - 2.35, malformations - 2.18) and serous cystadenomas (breastfeeding ≤5 months - 2.53), dependent variables being mixed germ cell tumors (GCTs) and cysts. Children presenting with bleeding (73%), abdominal distention (62%), elevated tumor markers (91%), (multilocular) solid tumor (88% and 100%), tumor size >10 cm (65%), GCTs (74%), death (100%), metastases (100%), viruses (77%), loss of appetite (68%), and weight (85%), had gonadal malignant tumors, especially mixed GCTs and IT.

Conclusions: Avoiding these risk factors will prevent and reduce gonadal pediatric tumors. Investigating children presenting with the listed peculiarities, especially if exposed to the mentioned risk factors, will enable early gonadal tumor identification, successful patient management, and favorable prognosis.

对患有(副)性腺肿瘤和囊肿的儿科患者的风险和特殊性的 10 年回顾性研究。
导言:根据监测、流行病学和最终结果计划(https:∕∕seer.cancer.gov∕),儿童性腺肿瘤在儿童肿瘤中排名第四(6%),非常罕见。它们的症状模糊,导致发现较晚,但早期发现并确定其风险因素可分别获得良好的预后和降低其发病率:一项为期10年的回顾性研究确定了210名17岁以下患有(副)性腺肿瘤的儿童的特殊性和危险因素:结果:压力、污染(农业化学品、杀虫剂和金属矿)、肥胖、母乳喂养不足 5 个月、畸形[主要是非遗传相关的 67∕87 (77%),尤其是眼部畸形 - 64%]、激素、吸烟、阳性遗传病史、居住在农村地区、出生体重异常和月经失调都增加了性腺恶性肿瘤的风险;相对风险比 (RR):分别为 1.33、1.30、1.34、1.11、1.65、1.16、1.36、1.10、1.00、1.08 和 1.15 倍。组织病理学亚型的 RR:未成熟畸胎瘤(IT)(污染 - 1.75,恒河猴阳性 - 3.41)、畸形生殖细胞瘤(月经失调 - 2.80)、颗粒细胞瘤(压力 - 2.10,月经失调 - 2.80)、粘液性囊腺瘤(肥胖 - 2.84、产后未接种疫苗-3.71)、成熟畸胎瘤(压力-2.35、畸形-2.18)和浆液性囊腺瘤(母乳喂养≤5 个月-2.53),因变量为混合生殖细胞瘤(GCTs)和囊肿。出现出血(73%)、腹胀(62%)、肿瘤标志物升高(91%)、(多形性)实体瘤(88%和100%)、肿瘤大小>10厘米(65%)、生殖细胞瘤(74%)、死亡(100%)、转移(100%)、病毒(77%)、食欲不振(68%)和体重减轻(85%)的儿童患有性腺恶性肿瘤,尤其是混合型生殖细胞瘤和IT:避免这些危险因素将预防和减少儿童性腺肿瘤。对出现上述特殊情况的儿童进行调查,尤其是在暴露于上述危险因素的情况下,将有助于早期发现性腺肿瘤,成功治疗患者,并获得良好的预后。
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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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