Fatty infiltration and ventricular premature beats originating from right ventricular outflow tract: association or causality?

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Raluca Vasilica Sîrbu Prisecaru, Leila Riahi, Mădălina Abagiu, Oana Elena Purcar, Mircea Corvin Claudiu Vlădoianu, Cristina Gabriela Leaţu, Alexandru Dan Sîrbu, Ioan Maniţiu
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Abstract

Background: Anatomical evidence reveals heterogeneous fat distribution in both atrial and ventricular myocardium that are considered normal, but at the same time arrhythmogenic, and numerous cardiac pathophysiological conditions are associated with myocardial fat deposits. The relationship between fatty infiltration, especially in the epicardial layer and its pathophysiological implication is not completely understood.

Aim: The aim of this study was to establish a positive or negative relationship between the ventricular burden and several parameters related to right ventricle (RV) adipose tissue - the RV thickness, RV indexed mass, body mass index (BMI), age, gender.

Patients, materials and methods: Twenty-three patients with documented premature ventricular contractions (PVCs) originating from right ventricular outflow tract based on electrocardiography (ECG) evaluation were hospitalized between January 2018-November 2022 for electrophysiological study and PVCs ablation. Data obtained after collecting the clinical characteristics, ECG, RV measurements from transthoracic echocardiography (TTE), cardiac computed tomography (CT) and magnetic resonance imaging (MRI) were analyzed.

Results: A weak positive relationship between the ventricular burden and BMI (r=0.14, p=0.49), tricuspid annular plane systolic excursion (TAPSE) (r=0.07, p=0.7), the RV thickness (r=0.03, p=0.8), epicardial adipose tissue (r=0.13, p=0.55), RV mass indexed (r=0.05, p=0.82) was observed. No clear cut-off of the PVCs burden could be established in terms related to the increase in BMI, RV thickness, epicardial adipose tissue, RV mass indexed.

Conclusions: No significant positive or negative relationship between the ventricular burden and the RV thickness, RV indexed mass were found in individuals with a high PVCs originating from right ventricular outflow tract (RVOT) burden.

脂肪浸润与右室流出道源性室性早搏:关联还是因果关系?
背景:解剖学证据显示,心房和心室心肌中存在异质性脂肪分布,这被认为是正常的,但同时也是导致心律失常的原因,许多心脏病理生理状况都与心肌脂肪沉积有关。目的:本研究旨在确定心室负荷与右心室(RV)脂肪组织相关参数(RV 厚度、RV 指数质量、体重指数(BMI)、年龄、性别)之间的正负关系:2018年1月至2022年11月期间,23名根据心电图(ECG)评估记录的源于右室流出道的室性早搏(PVCs)患者住院接受电生理研究和PVCs消融术。在收集了临床特征、心电图、经胸超声心动图(TTE)、心脏计算机断层扫描(CT)和磁共振成像(MRI)的 RV 测量数据后,对数据进行了分析:观察到心室负荷与体重指数(r=0.14,p=0.49)、三尖瓣环平面收缩期偏移(TAPSE)(r=0.07,p=0.7)、RV厚度(r=0.03,p=0.8)、心外膜脂肪组织(r=0.13,p=0.55)、RV质量指数(r=0.05,p=0.82)之间存在微弱的正相关关系。与体重指数、RV 厚度、心外膜脂肪组织和 RV 质量指数的增加相关的 PVCs 负担没有明确的分界线:结论:在右心室流出道(RVOT)负荷引起的高PVC患者中,未发现心室负荷与RV厚度、RV指数质量之间存在明显的正相关或负相关。
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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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