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Using TCR-CAR dual signaling for precise cancer targeting. 利用TCR-CAR双信号精确靶向癌症。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-05-13 DOI: 10.1016/j.it.2025.04.007
Mohammad Shahbazy, Isabelle Rose Leo, Pouya Faridi, Etienne Caron
{"title":"Using TCR-CAR dual signaling for precise cancer targeting.","authors":"Mohammad Shahbazy, Isabelle Rose Leo, Pouya Faridi, Etienne Caron","doi":"10.1016/j.it.2025.04.007","DOIUrl":"https://doi.org/10.1016/j.it.2025.04.007","url":null,"abstract":"<p><p>Recently, Kondo et al. engineered the coexpression of a T cell receptor (TCR) and a chimeric antigen receptor (CAR) and developed an antagonism-enforced braking system where TCR signals both enhance and inhibit CAR activation. This work may enable rational design of CAR-T agents that limit toxicity to healthy tissue.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The microglial lineage: present and beyond. 小胶质细胞谱系：现在和将来。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-05-13 DOI: 10.1016/j.it.2025.04.001
Wei-Wei Chen, Zhisheng Wu, Hanjie Li
{"title":"The microglial lineage: present and beyond.","authors":"Wei-Wei Chen, Zhisheng Wu, Hanjie Li","doi":"10.1016/j.it.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.it.2025.04.001","url":null,"abstract":"<p><p>Emerging studies demonstrate the presence of cells with microglial features in peripheral tissues. Here, we propose using the term 'microglial lineage' to categorize both these cells and classical microglia. Microglial lineage cells are resident immune cells with a microglial molecular phenotype and ontogeny that exhibit diverse tissue distribution and functions.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poxvirus structural biology for application to vaccine design. 痘病毒结构生物学在疫苗设计中的应用。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-05-07 DOI: 10.1016/j.it.2025.04.002
Huibin Yu, Wolfgang Resch, Bernard Moss
{"title":"Poxvirus structural biology for application to vaccine design.","authors":"Huibin Yu, Wolfgang Resch, Bernard Moss","doi":"10.1016/j.it.2025.04.002","DOIUrl":"https://doi.org/10.1016/j.it.2025.04.002","url":null,"abstract":"<p><p>The upsurge of mpox (formerly known as monkeypox) in Africa and its global spread highlight the need for improved vaccines. The development of new recombinant vaccines, including mRNA and protein nanoparticles, depends on understanding the biology of poxviruses and selecting the most protective immunogens. Animal studies demonstrate that vaccines need to target the antigens of both infectious forms - the mature virion and the enveloped virion - which display surface proteins responsible for cell entry and cell-to-cell spread, respectively. Although some of these proteins have been shown to induce protective antibodies, others including most of those that are essential for membrane fusion remain to be tested. We review the structures of orthopoxvirus surface proteins as a guide to the selection of optimal antigens for recombinant vaccines.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epstein-Barr virus-mediated immune evasion in tumor promotion. eb病毒介导的免疫逃避在肿瘤促进中的作用。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-05-01 Epub Date: 2025-04-15 DOI: 10.1016/j.it.2025.03.007
Lie Yuan, Ling Zhong, Claude Krummenacher, Qinjian Zhao, Xiao Zhang
{"title":"Epstein-Barr virus-mediated immune evasion in tumor promotion.","authors":"Lie Yuan, Ling Zhong, Claude Krummenacher, Qinjian Zhao, Xiao Zhang","doi":"10.1016/j.it.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.it.2025.03.007","url":null,"abstract":"<p><p>Epstein-Barr virus (EBV) was the first DNA virus identified to be tightly associated with multiple human tumors. It promotes malignant progression of tumors - including related lymphomas, nasopharyngeal carcinoma, and gastric adenocarcinoma - in part by evading surveillance and attack by the host immune system. In this article we review the main molecular mechanisms by which EBV-encoded proteins and RNAs interact with key molecules of the host immune system to inhibit Toll-like receptor (TLR)-nuclear factor κB (NF-κB), retinoic acid-inducible gene I (RIG-I), and interferon (IFN) signaling pathways, affect antigen presentation, prevent the cytotoxic effects of CD8<sup>+</sup> effector cells, regulate the tumor microenvironment (TME) and cell metastasis and invasion, and inhibit cell apoptosis. These interactions not only contribute to the persistence of the virus but also provide potential targets for developing new immunotherapy strategies.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"46 5","pages":"386-402"},"PeriodicalIF":13.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammasomopathies: mechanisms and disease signatures. 炎性肌病：机制和疾病特征。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-05-01 Epub Date: 2025-04-21 DOI: 10.1016/j.it.2025.03.008
Sara Cahill, Fiachra Humphries
{"title":"Inflammasomopathies: mechanisms and disease signatures.","authors":"Sara Cahill, Fiachra Humphries","doi":"10.1016/j.it.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.it.2025.03.008","url":null,"abstract":"<p><p>Inflammasomes form in response to infection, cellular stress, or damage. Gain-of-function (GOF) mutations in inflammasome receptors have been identified as the underlying cause of severe inflammatory diseases, termed 'inflammasomopathies'. Recently, molecular interrogation of these diseases revealed several distinctions at the level of the tissue affected, the inflammatory mediators that drive disease progression, and the contribution of programmed cell death. In this review we discuss key emerging differences across inflammasomopathies and the distinct inflammatory patterns seen in patients. We discuss how programmed cell death influences the progression of inflammasomopathies and the role of plasma membrane rupture. Understanding the molecular disease signatures across inflammasomopathies provides crucial insights into identifying and treating the underlying disease and opens new avenues for therapeutic interventions.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"46 5","pages":"372-385"},"PeriodicalIF":13.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-1β+ macrophages and the control of pathogenic inflammation in cancer. IL-1β+巨噬细胞与肿瘤致病性炎症的控制。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI: 10.1016/j.it.2025.03.001
Nicoletta Caronni, Federica La Terza, Luca Frosio, Renato Ostuni
{"title":"IL-1β<sup>+</sup> macrophages and the control of pathogenic inflammation in cancer.","authors":"Nicoletta Caronni, Federica La Terza, Luca Frosio, Renato Ostuni","doi":"10.1016/j.it.2025.03.001","DOIUrl":"10.1016/j.it.2025.03.001","url":null,"abstract":"<p><p>While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated macrophages (TAMs). Among these, interleukin (IL)-1β<sup>+</sup> TAMs - cells with high levels of expression of inflammatory response and tissue repair genes, but with limited capacity to stimulate cytotoxic immunity - are emerging as key drivers of pathogenic inflammation in cancer. In this review we discuss recent literature defining the phenotypical, molecular, and functional properties of IL-1β<sup>+</sup> TAMs, as well as their temporal dynamics and spatial organization. Elucidating the biology of these cells across tumor initiation, progression, metastasis, and therapy could inform the design and interpretation of clinical trials targeting IL-1β and/or other inflammatory factors in cancer immunotherapy.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"403-415"},"PeriodicalIF":13.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
mRNA vaccines: miRNA-based controlled biodistribution and directed adjuvantation. mRNA疫苗：基于mirna的可控生物分布和定向佐剂。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1016/j.it.2025.03.004
Byron Brook, Morgan Goetz, Valerie Duval, Romain Micol, David J Dowling
{"title":"mRNA vaccines: miRNA-based controlled biodistribution and directed adjuvantation.","authors":"Byron Brook, Morgan Goetz, Valerie Duval, Romain Micol, David J Dowling","doi":"10.1016/j.it.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.it.2025.03.004","url":null,"abstract":"<p><p>The development of ionizable mRNA-lipid nanoparticle (mRNA-LNP) nucleic acid carriers facilitated the clinical translation of the Coronavirus 2019 (COVID-19) mRNA vaccines BNT162b2 and mRNA-1273. Here, we discuss insights into rational improvements to mRNA vaccines, focusing on LNP modifications for mRNA-LNP biodistribution control, miRNA-based biodistribution control of encoded transcripts, and precision adjuvantation strategies.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"46 5","pages":"357-360"},"PeriodicalIF":13.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An era of immunological discoveries heralded by molecular biology. 分子生物学预示着免疫学新发现的时代。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-05-01 Epub Date: 2025-04-15 DOI: 10.1016/j.it.2025.03.003
Amy Kenter, Harinder Singh
{"title":"An era of immunological discoveries heralded by molecular biology.","authors":"Amy Kenter, Harinder Singh","doi":"10.1016/j.it.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.it.2025.03.003","url":null,"abstract":"<p><p>The Molecular Mechanisms of Immune Cell Development and Function (MMICDF) meeting sponsored by the Federation of American Societies of Experimental Biology (FASEB) occupies a special niche because of its focus on the molecular mechanisms that underpin immunological processes. This biennial meeting with small groupings of participants and interactive nature has provided a forum for intense, informative, and influential scientific discussions. The meeting is unique for its focus on molecular mechanisms that control the exceptional processes of DNA recombination, somatic hypermutation (SHM), and gene expression during immune cell development, activation, and differentiation. The organizers of the foundational meeting reflect on the coalescence of scientific advances that catalyzed its origin, review meeting highlights to celebrate its 20th anniversary, and project into the future.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"46 5","pages":"364-371"},"PeriodicalIF":13.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What vaccines teach us about pathogen ecology. 疫苗教给我们的病原体生态学知识。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-05-01 Epub Date: 2025-04-10 DOI: 10.1016/j.it.2025.03.006
Alejandro Cabezas-Cruz, Ana L Cano-Argüelles, Pierre Tonnerre
{"title":"What vaccines teach us about pathogen ecology.","authors":"Alejandro Cabezas-Cruz, Ana L Cano-Argüelles, Pierre Tonnerre","doi":"10.1016/j.it.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.it.2025.03.006","url":null,"abstract":"<p><p>Vaccination campaigns have reshaped infectious disease dynamics, exerting selective pressures on pathogens. While some are controlled, others persist via antigenic variation or reservoirs. This Science & Society explores the evolutionary and ecological impacts of vaccination, highlighting its role in pathogen adaptation and implications for future disease control strategies.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"46 5","pages":"353-356"},"PeriodicalIF":13.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The five senses of immunity. 免疫系统的五种感觉。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-05-01 Epub Date: 2025-04-18 DOI: 10.1016/j.it.2025.03.005
Douglas F Nixon, Nathaniel D Bachtel, Nathaniel Hupert, Ioannis Eleftherianos
{"title":"The five senses of immunity.","authors":"Douglas F Nixon, Nathaniel D Bachtel, Nathaniel Hupert, Ioannis Eleftherianos","doi":"10.1016/j.it.2025.03.005","DOIUrl":"https://doi.org/10.1016/j.it.2025.03.005","url":null,"abstract":"<p><p>A genealogy of immunity reveals increasingly complex systems for pathogen response, organism homeostasis, and multispecies interaction. New studies show how the five senses can all contribute to behavioral, shared and population level immunity redefining our understanding of the ways organisms communicate among and defend themselves.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"46 5","pages":"361-363"},"PeriodicalIF":13.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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