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Trends in Immunology最新文献

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Immune evasion in ovarian cancer: implications for immunotherapy and emerging treatments.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-23 DOI: 10.1016/j.it.2024.12.006
Romi Gupta, Raj Kumar, Courtney A Penn, Narendra Wajapeyee
{"title":"Immune evasion in ovarian cancer: implications for immunotherapy and emerging treatments.","authors":"Romi Gupta, Raj Kumar, Courtney A Penn, Narendra Wajapeyee","doi":"10.1016/j.it.2024.12.006","DOIUrl":"https://doi.org/10.1016/j.it.2024.12.006","url":null,"abstract":"<p><p>Ovarian cancer (OC) is the most lethal gynecologic malignancy, characterized by multiple histological subtypes, each with distinct pathological and clinical features. Current treatment approaches include cytotoxic chemotherapies, poly(ADP-ribose) polymerase (PARP) inhibitors, bevacizumab, hormonal therapy, immunotherapy, and antibody-drug conjugates (ADCs). In this review we discuss immune evasion mechanisms in OC and the role of genetics, the tumor microenvironment, and tumor heterogeneity in influencing these processes. We also discuss the use of immunotherapies for OC treatment, either alone or in combination with other anticancer agents, with a focus on their clinical outcomes. Finally, we highlight emerging immunotherapies that have either succeeded or are on the verge of significantly impacting cancer treatment, and we discuss their potential utility in the effective treatment of OC.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-21 DOI: 10.1016/j.it.2024.12.005
Beatriz León
{"title":"Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?","authors":"Beatriz León","doi":"10.1016/j.it.2024.12.005","DOIUrl":"https://doi.org/10.1016/j.it.2024.12.005","url":null,"abstract":"<p><p>Conventional dendritic cells (cDCs) are sentinels of the mammalian immune system that sense a wide range of danger and homeostatic signals to induce appropriately targeted T cell immune responses. Traditionally classified into two main subsets, cDC1 and cDC2, recent research shows that cDC2s exhibit significant heterogeneity and can be further subdivided. Studies in mice and humans show that, beyond their ontogeny, cDC2s acquire dynamic and tissue-specific characteristics that are influenced by local environmental signals, which impact on their functions during homeostasis, inflammation, and infection. The novel concept is proposed that tissue-derived signals and tissue plasticity can override preestablished developmental programming, thereby redefining developmental trajectories and cDC2 functionality. Ultimately, understanding cDC2 heterogeneity and plasticity has important implications for modulating T cell immunity in health and disease.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging community engagement to shape biomedical research priorities.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-21 DOI: 10.1016/j.it.2024.12.004
Sara Suliman, Lillian Agyei, Shaista A Afzal, Shanell Williams
{"title":"Leveraging community engagement to shape biomedical research priorities.","authors":"Sara Suliman, Lillian Agyei, Shaista A Afzal, Shanell Williams","doi":"10.1016/j.it.2024.12.004","DOIUrl":"https://doi.org/10.1016/j.it.2024.12.004","url":null,"abstract":"<p><p>Community engagement is essential for shaping equitable biomedical research priorities, but it is often underutilized, especially for marginalized populations. To integrate community feedback from the public into research, herein we describe a collaborative pilot funded by the Chan Zuckerberg Initiative which pairs the University of California San Francisco (UCSF) with the Rafiki Coalition for Health and Wellness. Utilizing focus groups modeled on Research Prioritization by Affected Communities, participants identified themes that included mistrust in healthcare, representation gaps, and the need for culturally responsive research. Priorities such as mental health, chronic disease, and access to black providers were highlighted. The findings emphasize the need for sustained, grassroots partnerships to drive inclusive research agendas.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophages boosting human skin morphogenesis. 巨噬细胞促进人体皮肤形态发生。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.1016/j.it.2024.11.009
Martin E Baumdick, Madeleine J Bunders
{"title":"Macrophages boosting human skin morphogenesis.","authors":"Martin E Baumdick, Madeleine J Bunders","doi":"10.1016/j.it.2024.11.009","DOIUrl":"10.1016/j.it.2024.11.009","url":null,"abstract":"<p><p>Gopee and colleagues' recent analyses of diverse high-dimensional datasets of prenatal and adult skin, together with data from complex skin organoids, uncover the important contributions of macrophages in modulating prenatal skin development, scarless wound healing, and angiogenesis. These findings identify a role for skin immune cells in tissue development.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"1-3"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting molecular pathways to control immune checkpoint inhibitor toxicities. 靶向分子途径控制免疫检查点抑制剂毒性。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-27 DOI: 10.1016/j.it.2024.11.014
Robin Reschke, Ryan J Sullivan, Evan J Lipson, Alexander H Enk, Thomas F Gajewski, Jessica C Hassel
{"title":"Targeting molecular pathways to control immune checkpoint inhibitor toxicities.","authors":"Robin Reschke, Ryan J Sullivan, Evan J Lipson, Alexander H Enk, Thomas F Gajewski, Jessica C Hassel","doi":"10.1016/j.it.2024.11.014","DOIUrl":"10.1016/j.it.2024.11.014","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICIs) have transformed cancer treatment but are frequently associated with immune-related adverse events (irAEs). This article offers a novel synthesis of findings from both preclinical and clinical studies, focusing on the molecular mechanisms driving irAEs across diverse organ systems. It examines key immune cells, such as T cell subsets and myeloid cells, which are instrumental in irAE pathogenesis, alongside an in-depth analysis of cytokine signaling [interleukin (IL)-6, IL-17, IL-4), interferon γ (IFN-γ), IL-1β, tumor necrosis factor α (TNF-α)], integrin-mediated interactions [integrin subunits αITGA)4 and ITGB7], and microbiome-related factors that contribute to irAE pathology. This exploration of modifiable pathways uncovers new opportunities to mitigate irAEs by using available antibodies (Abs) that target key inflammatory molecules across tumor types, while ideally preserving the antitumor efficacy of ICIs.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"61-73"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Born to be wild: utilizing natural microbiota for reliable biomedical research. 天生野性：利用天然微生物群进行可靠的生物医学研究。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-16 DOI: 10.1016/j.it.2024.11.013
Philipp Bruno, Thomas Schüler, Stephan P Rosshart
{"title":"Born to be wild: utilizing natural microbiota for reliable biomedical research.","authors":"Philipp Bruno, Thomas Schüler, Stephan P Rosshart","doi":"10.1016/j.it.2024.11.013","DOIUrl":"10.1016/j.it.2024.11.013","url":null,"abstract":"<p><p>Laboratory mice housed under specific pathogen-free (SPF) conditions are the standard model in biomedical research. However, experiments with a particular inbred mouse strain performed in different laboratories often yield inconsistent or conflicting data due to housing-specific variations in the composition and diversity of SPF microbiota. These variations affect immune and nonimmune cell functions, leading to systemic physiological changes. Consequently, microbiota-dependent inconsistencies have raised general doubts regarding the suitability of mice as model organisms. Since stability positively correlates with biological diversity, we postulate that increasing species diversity can improve microbiota stability and mouse physiology, enhancing robustness, reproducibility, and experimental validity. Similar to the generation of inbred mouse strains in the last century, we suggest a worldwide initiative to define a transplantable 'wild' microbiota that stably colonizes mice irrespective of housing conditions.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"17-28"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain macrophages in vascular health and dysfunction. 巨噬细胞在脑血管健康和功能障碍中的作用。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-27 DOI: 10.1016/j.it.2024.11.012
Mitchell Bijnen, Sucheta Sridhar, Annika Keller, Melanie Greter
{"title":"Brain macrophages in vascular health and dysfunction.","authors":"Mitchell Bijnen, Sucheta Sridhar, Annika Keller, Melanie Greter","doi":"10.1016/j.it.2024.11.012","DOIUrl":"10.1016/j.it.2024.11.012","url":null,"abstract":"<p><p>Diverse macrophage populations inhabit the rodent and human central nervous system (CNS), including microglia in the parenchyma and border-associated macrophages (BAMs) in the meninges, choroid plexus, and perivascular spaces. These innate immune phagocytes are essential in brain development and maintaining homeostasis, but they also play diverse roles in neurological diseases. In this review, we highlight the emerging roles of CNS macrophages in regulating vascular function in health and disease. We discuss that, in addition to microglia, BAMs, including perivascular macrophages, play roles in supporting vascular integrity and maintaining blood flow. We highlight recent advancements in understanding how these macrophages are implicated in protecting against vascular dysfunction and modulating the progression of cerebrovascular diseases, as seen in vessel-associated neurodegeneration.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"46-60"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting immune evasion in hepatocellular carcinoma-initiating cells. 肝癌起始细胞的靶向免疫逃避。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-24 DOI: 10.1016/j.it.2024.12.002
Rafael Sirera, Manuel Beltrán-Visiedo, Lorenzo Galluzzi
{"title":"Targeting immune evasion in hepatocellular carcinoma-initiating cells.","authors":"Rafael Sirera, Manuel Beltrán-Visiedo, Lorenzo Galluzzi","doi":"10.1016/j.it.2024.12.002","DOIUrl":"10.1016/j.it.2024.12.002","url":null,"abstract":"<p><p>Tumor-initiating cells (TICs) are particularly efficient at evading detection and elimination by the human immune system. Recent data from Yang and collaborators demonstrate that - at least in preclinical hepatocellular carcinoma models - the immunological privilege of CD49f<sup>+</sup> TICs can be limited by targeting CD155, resulting in restored sensitivity to immune checkpoint inhibitors.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"4-6"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epstein-Barr virus hijacks B cell metabolism to establish persistent infection and drive pathogenesis. Epstein-Barr病毒劫持B细胞代谢，建立持续感染并驱动发病机制。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-20 DOI: 10.1016/j.it.2024.11.011
Bojana Müller-Durovic, Jessica Jäger, Glenn R Bantug, Christoph Hess
{"title":"Epstein-Barr virus hijacks B cell metabolism to establish persistent infection and drive pathogenesis.","authors":"Bojana Müller-Durovic, Jessica Jäger, Glenn R Bantug, Christoph Hess","doi":"10.1016/j.it.2024.11.011","DOIUrl":"10.1016/j.it.2024.11.011","url":null,"abstract":"<p><p>When B cells engage in an immune response, metabolic reprogramming is key to meeting cellular energetic and biosynthetic demands. Epstein-Barr virus (EBV) is a highly prevalent gamma-herpesvirus, latently infecting B cells for the human host's lifetime. By hijacking signaling pathways of T cell-dependent humoral immunity, EBV activates B cells in a T cell-independent manner, forcing lymphoblastoid transformation. Interlinked with this coercion of signaling pathways, EBV has also evolved strategies to manipulate B cell metabolism. In this opinion article we integrate recent findings from studies of B cell metabolic reprogramming after EBV infection and during antigen-specific activation, respectively. We hypothesize that defining EBV host-cell metabolic vulnerabilities that differ from pathways required for B cell immunity might uncover novel therapeutic targets against EBV-related diseases.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"7-16"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics. 全身性脓疱性牛皮癣：免疫机制，遗传学和新兴治疗方法。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-27 DOI: 10.1016/j.it.2024.12.001
Chih-Chun Lee, Yu-Huei Huang, Ching-Chi Chi, Wen-Hung Chung, Chun-Bing Chen
{"title":"Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics.","authors":"Chih-Chun Lee, Yu-Huei Huang, Ching-Chi Chi, Wen-Hung Chung, Chun-Bing Chen","doi":"10.1016/j.it.2024.12.001","DOIUrl":"10.1016/j.it.2024.12.001","url":null,"abstract":"<p><p>Generalized pustular psoriasis (GPP) is a rare human autoinflammatory disorder with life-threatening systemic effects. Keratinocyte-derived interleukin (IL)-36 signaling has been identified as a key mediator of immune response in the skin of affected individuals. Recognition of various mutations along the IL-36 axis and the downstream nuclear transcription factor κB (NF-κB) signaling have established GPP as genetically, immunologically, and histopathologically distinct and amenable to immunomodulation, which is epitomized by the recent success of IL-36 antagonism. This review covers recent discoveries of the genetic and immunological underpinnings of GPP, which have proved fertile ground for improving the quality of care of this clinically challenging and debilitating condition.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"74-89"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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