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The immune-endocrine interplay in sex differential responses to viral infection and COVID-19. 免疫-内分泌在对病毒感染和 COVID-19 的性别差异反应中的相互作用。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-11-18 DOI: 10.1016/j.it.2024.10.004
Valentino D'Onofrio, Rafick Pierre Sékaly
{"title":"The immune-endocrine interplay in sex differential responses to viral infection and COVID-19.","authors":"Valentino D'Onofrio, Rafick Pierre Sékaly","doi":"10.1016/j.it.2024.10.004","DOIUrl":"https://doi.org/10.1016/j.it.2024.10.004","url":null,"abstract":"<p><p>Men are at higher risk for developing severe COVID-19 than women, while women are at higher risk for developing post-acute sequelae of COVID-19 (PASC). This highlights the impact of sex differences on immune responses and clinical outcomes of acute COVID-19 or PASC. A dynamic immune-endocrine interface plays an important role in the development of effective immune responses impacting the control of viral infections. In this opinion article we discuss mechanisms underlying the transcriptional and epigenetic regulation of immune responses by sex hormones during viral infections. We propose that disruption of this delicate immune-endocrine interplay can result in worsened outcomes of viral disease. We also posit that insights into these immune mechanisms can propel the development of novel immunomodulatory interventions that leverage immune-endocrine pathways to treat viral infections.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unanticipated specificity in effector-triggered immunity. 效应器触发免疫中意想不到的特异性。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-11-15 DOI: 10.1016/j.it.2024.10.008
Alejandra Zárate-Potes, Hinrich Schulenburg, Katja Dierking
{"title":"Unanticipated specificity in effector-triggered immunity.","authors":"Alejandra Zárate-Potes, Hinrich Schulenburg, Katja Dierking","doi":"10.1016/j.it.2024.10.008","DOIUrl":"https://doi.org/10.1016/j.it.2024.10.008","url":null,"abstract":"<p><p>Effector-triggered immunity (ETI) enables hosts to react to pathogens by monitoring few key cellular processes. ETI responses are assumed to be similar toward related pathogen effectors. However, recent evidence from the invertebrate model Caenorhabditis elegans and pore-forming toxins indicates a much more complex and specific ETI than previously anticipated.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimmune interactions in the olfactory epithelium: maintaining a sensory organ at an immune barrier interface. 嗅觉上皮细胞的神经免疫相互作用：在免疫屏障界面上维持一个感觉器官。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-11-15 DOI: 10.1016/j.it.2024.10.005
Mohammed N Ullah, Nicholas R Rowan, Andrew P Lane
{"title":"Neuroimmune interactions in the olfactory epithelium: maintaining a sensory organ at an immune barrier interface.","authors":"Mohammed N Ullah, Nicholas R Rowan, Andrew P Lane","doi":"10.1016/j.it.2024.10.005","DOIUrl":"https://doi.org/10.1016/j.it.2024.10.005","url":null,"abstract":"<p><p>While primarily a sensory organ, the mammalian olfactory epithelium (OE) also plays a critical role as an immune barrier. Mechanisms governing interactions between the immune system and this specialized chemosensory tissue are gaining interest, in part sparked by the COVID-19 pandemic. Regulated inflammation is intrinsic to normal mucosal healing and homeostasis, but prolonged OE inflammation is associated with persistent loss of smell, belying the intertwining of local mucosal immunology and olfactory function. Evidence supports bidirectional communication between OE cells and the immune system in health and disease. Recent investigations suggest that neuro-immune cross-talk modulates olfactory stem cell behavior and neuronal regeneration dynamics, prioritizing the epithelial-like non-neuronal framework with immune barrier function at the expense of the neurosensory organ in chronic inflammation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approaches for studying neuroimmune interactions in Alzheimer's disease. 研究阿尔茨海默病神经免疫相互作用的方法。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-11-12 DOI: 10.1016/j.it.2024.10.002
Chih-Chung 'Jerry' Lin, Yuyao Tian, Rudolph E Tanzi, Mehdi Jorfi
{"title":"Approaches for studying neuroimmune interactions in Alzheimer's disease.","authors":"Chih-Chung 'Jerry' Lin, Yuyao Tian, Rudolph E Tanzi, Mehdi Jorfi","doi":"10.1016/j.it.2024.10.002","DOIUrl":"https://doi.org/10.1016/j.it.2024.10.002","url":null,"abstract":"<p><p>Peripheral immune cells play an important role in the pathology of Alzheimer's disease (AD), impacting processes such as amyloid and tau protein aggregation, glial activation, neuronal integrity, and cognitive decline. Here, we examine cutting-edge strategies - encompassing animal and cellular models - used to investigate the roles of peripheral immune cells in AD. Approaches such as antibody-mediated depletion, genetic ablation, and bone marrow chimeras in mouse models have been instrumental in uncovering T, B, and innate immune cell disease-modifying functions. However, challenges such as specificity, off-target effects, and differences between human and mouse immune systems underscore the need for more human-relevant models. Emerging multicellular models replicating critical aspects of human brain tissue and neuroimmune interactions increasingly offer fresh insights into the role of immune cells in AD pathogenesis. Refining these methodologies can deepen our understanding of immune cell contributions to AD and support the development of novel immune-related therapeutic interventions.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholesterol sensing and metabolic adaptation in tissue immunity. 组织免疫中的胆固醇感应和代谢适应。
IF 4.1 1区 医学
Trends in Immunology Pub Date : 2024-11-01 Epub Date: 2024-10-17 DOI: 10.1016/j.it.2024.09.013
Eric V Dang, Andrea Reboldi
{"title":"Cholesterol sensing and metabolic adaptation in tissue immunity.","authors":"Eric V Dang, Andrea Reboldi","doi":"10.1016/j.it.2024.09.013","DOIUrl":"10.1016/j.it.2024.09.013","url":null,"abstract":"<p><p>Cholesterol metabolites, particularly oxidized forms known as oxysterols, play crucial roles in modulating immune and metabolic processes across various tissues. Concentrations of local cholesterol and its metabolites influence tissue-specific immune responses by shaping the metabolic and spatial organization of immune cells in barrier organs like the small intestine (SI) and lungs. We explore recent molecular and cellular evidence supporting the metabolic adaptation of innate and adaptive immune cells in the SI and lung, driven by cholesterol and cholesterol metabolites. Further research should unravel the detailed molecular mechanisms and spatiotemporal adaptations involving cholesterol metabolites in distinct mucosal tissues in homeostasis or infection. We posit that pharmacological interventions targeting the generation or sensing of cholesterol metabolites might be leveraged to enhance long-term immune protection in mucosal tissues or prevent autoinflammatory states.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"861-870"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regional specialization within the mammalian respiratory immune system. 哺乳动物呼吸道免疫系统的区域特化。
IF 4.1 1区 医学
Trends in Immunology Pub Date : 2024-11-01 Epub Date: 2024-10-21 DOI: 10.1016/j.it.2024.09.011
David P Hoytema van Konijnenburg, Peter A Nigrovic, Ivan Zanoni
{"title":"Regional specialization within the mammalian respiratory immune system.","authors":"David P Hoytema van Konijnenburg, Peter A Nigrovic, Ivan Zanoni","doi":"10.1016/j.it.2024.09.011","DOIUrl":"10.1016/j.it.2024.09.011","url":null,"abstract":"<p><p>The respiratory tract is exposed to infection from inhaled pathogens, including viruses, bacteria, and fungi. So far, a comprehensive assessment that integrates common and distinct aspects of the immune response along different areas of the respiratory tract has been lacking. Here, we discuss key recent findings regarding anatomical, functional, and microbial factors driving regional immune adaptation in the mammalian respiratory system, how they differ between mice and humans, and the similarities and differences with the gastrointestinal tract. We demonstrate that, under evolutionary pressure, mammals evolved spatially organized immune defenses that vary between the upper and lower respiratory tract. Overall, we propose that the functional specialization of the immune response along the respiratory tract has fundamental implications for the management of infectious or inflammatory diseases.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"871-891"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systems immunology insights into brain metastasis. 系统免疫学洞察脑转移。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-11-01 Epub Date: 2024-10-22 DOI: 10.1016/j.it.2024.09.010
Wenjuan Dong, Jianting Sheng, Johnny Z M Cui, Hong Zhao, Stephen T C Wong
{"title":"Systems immunology insights into brain metastasis.","authors":"Wenjuan Dong, Jianting Sheng, Johnny Z M Cui, Hong Zhao, Stephen T C Wong","doi":"10.1016/j.it.2024.09.010","DOIUrl":"10.1016/j.it.2024.09.010","url":null,"abstract":"<p><p>Brain metastasis poses formidable clinical challenges due to its intricate interactions with the brain's unique immune environment, often resulting in poor prognoses. This review delves into systems immunology's role in uncovering the dynamic interplay between metastatic cancer cells and brain immunity. Leveraging spatial and single-cell technologies, along with advanced computational modeling, systems immunology offers unprecedented insights into mechanisms of immune evasion and tumor proliferation. Recent studies highlight potential immunotherapeutic targets, suggesting strategies to boost antitumor immunity and counteract cancer cell evasion in the brain. Despite substantial progress, challenges persist, particularly in accurately simulating human conditions. This review underscores the need for interdisciplinary collaboration to harness systems immunology's full potential, aiming to dramatically improve outcomes for patients with brain metastasis.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"903-916"},"PeriodicalIF":13.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spinal cord injury: T cells to the rescue? 脊髓损伤：T 细胞来救命？
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-11-01 Epub Date: 2024-10-11 DOI: 10.1016/j.it.2024.10.001
Richard M Ransohoff
{"title":"Spinal cord injury: T cells to the rescue?","authors":"Richard M Ransohoff","doi":"10.1016/j.it.2024.10.001","DOIUrl":"10.1016/j.it.2024.10.001","url":null,"abstract":"<p><p>Gao, Kim, and colleagues recently reported that clonal populations of CD4<sup>+</sup> T cells could be detected in mice that underwent spinal cord injury (SCI). A subset of clones mediated enhanced motor recovery and suppressed inflammation. Further studies may point towards novel cell therapies for SCI, for which care is presently supportive only.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"849-850"},"PeriodicalIF":13.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Channel plan: control of adaptive immune responses by pannexins. 通道计划：泛内联蛋白对适应性免疫反应的控制。
IF 4.1 1区 医学
Trends in Immunology Pub Date : 2024-11-01 Epub Date: 2024-10-10 DOI: 10.1016/j.it.2024.09.009
Igor Santiago-Carvalho, Masaki Ishikawa, Henrique Borges da Silva
{"title":"Channel plan: control of adaptive immune responses by pannexins.","authors":"Igor Santiago-Carvalho, Masaki Ishikawa, Henrique Borges da Silva","doi":"10.1016/j.it.2024.09.009","DOIUrl":"10.1016/j.it.2024.09.009","url":null,"abstract":"<p><p>The development of mammalian adaptive (i.e., B and T cell-mediated) immune responses is tightly controlled at transcriptional, epigenetic, and metabolic levels. Signals derived from the extracellular milieu are crucial regulators of adaptive immunity. Beyond the traditionally studied cytokines and chemokines, many other extracellular metabolites can bind to specialized receptors and regulate T and B cell immune responses. These molecules often accumulate extracellularly through active export by plasma membrane transporters. For example, mammalian immune and non-immune cells express pannexin (PANX)1-3 channels on the plasma membrane, which release many distinct small molecules, notably intracellular ATP. Here, we review novel findings defining PANXs as crucial regulators of T and B cell immune responses in disease contexts such as cancer or viral infections.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"892-902"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Constructing polymorphonuclear cells: chromatin folding shapes nuclear morphology. 构建多形核细胞：染色质折叠塑造核形态。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-11-01 Epub Date: 2024-10-21 DOI: 10.1016/j.it.2024.09.012
Cornelis Murre, Indumathi Patta, Shreya Mishra, Ming Hu
{"title":"Constructing polymorphonuclear cells: chromatin folding shapes nuclear morphology.","authors":"Cornelis Murre, Indumathi Patta, Shreya Mishra, Ming Hu","doi":"10.1016/j.it.2024.09.012","DOIUrl":"10.1016/j.it.2024.09.012","url":null,"abstract":"<p><p>Immune cell fate decisions are regulated, at least in part, by nuclear architecture. Here, we outline how nuclear architecture instructs mammalian polymorphonuclear cell differentiation. We discuss how in neutrophils loop extrusion mechanisms regulate the expression of genes involved in phagocytosis and shape nuclear morphology. We propose that diminished loop extrusion programs also orchestrate eosinophil and basophil differentiation. We portray a new model in which competitive physical forces, loop extrusion, and phase separation, instruct mononuclear versus polymorphonuclear cell fate decisions. We posit that loop extrusion programs instruct the spatial organization of cytoplasmic organelles, including neutrophil granules, mitochondria, and endoplasmic reticulum. Finally, we suggest that changing loop extrusion programs might allow the engineering of new nuclear shapes and artificial cytoplasmic architectures.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"851-860"},"PeriodicalIF":13.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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