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Trends in Immunology最新文献

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Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-26 DOI: 10.1016/j.it.2025.02.004
Bhesh Raj Sharma, Thirumala-Devi Kanneganti
{"title":"Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death.","authors":"Bhesh Raj Sharma, Thirumala-Devi Kanneganti","doi":"10.1016/j.it.2025.02.004","DOIUrl":"https://doi.org/10.1016/j.it.2025.02.004","url":null,"abstract":"<p><p>Lytic cell death is crucial for antimicrobial and antitumor immunity; however, unchecked pyroptosis drives pathology in sepsis. Wright et al. demonstrate that widespread cell death following pyroptosis is propagated by extracellular vesicles (EVs) carrying gasdermin D (GSDMD) pores that become integrated into the membrane of neighboring cells, driving inflammatory cell death.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel insights and recent progress in osteoimmunology.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-25 DOI: 10.1016/j.it.2025.02.003
Iannis E Adamopoulos, Yongwon Choi, Hiroshi Takayanagi
{"title":"Novel insights and recent progress in osteoimmunology.","authors":"Iannis E Adamopoulos, Yongwon Choi, Hiroshi Takayanagi","doi":"10.1016/j.it.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.it.2025.02.003","url":null,"abstract":"<p><p>Osteoimmunology is an interdisciplinary branch of immunology studying bidirectional interactions between the immune and skeletal systems. Bone marrow is vital for the production of immune cells and is implicated in multiple diseases across all immunology disciplines. Here, we briefly discuss recent progress from the past 5 years in the field and how it impacts our current understanding of health and disease.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helper ILCs in the human hematopoietic system.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-25 DOI: 10.1016/j.it.2025.01.009
Xiaoyu Su, Zhaoqun Deng, Yu Lan, Bing Liu, Chen Liu
{"title":"Helper ILCs in the human hematopoietic system.","authors":"Xiaoyu Su, Zhaoqun Deng, Yu Lan, Bing Liu, Chen Liu","doi":"10.1016/j.it.2025.01.009","DOIUrl":"https://doi.org/10.1016/j.it.2025.01.009","url":null,"abstract":"<p><p>Helper innate lymphoid cells (ILCs), comprising groups ILC1, ILC2, and ILC3, possess unique advantages in eliciting rapid immune responses and were recently found to exhibit direct tumor-killing capacities comparable with those of cytotoxic ILCs [natural killer (NK) cells] in humans and mice. Although ILCs are primarily tissue-resident cells, their role in the hematopoietic system is increasingly being recognized. This review provides an overview of ILC ontogeny, as well as the physiological and pathological roles of these cells within the human and murine hematopoietic systems. We recapitulate recent advancements regarding ILC embryonic hematopoietic origin and the dynamic interactions between ILCs and leukemic cells or other immune cell populations, highlighting the dual roles ILCs can play in carcinogenesis. Exploring the functional potential of ILCs can inform the design of rational immunotherapeutic strategies against hematological malignancies.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic and stress response adaptations in T cells to fever and physiological heat.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-20 DOI: 10.1016/j.it.2025.01.007
Benjamin A Wilander, Jeffrey C Rathmell
{"title":"Metabolic and stress response adaptations in T cells to fever and physiological heat.","authors":"Benjamin A Wilander, Jeffrey C Rathmell","doi":"10.1016/j.it.2025.01.007","DOIUrl":"https://doi.org/10.1016/j.it.2025.01.007","url":null,"abstract":"<p><p>Fevers are an ancient feature of the inflammatory microenvironment. While fevers may improve the immune response to pathogens, mechanisms are unclear. We explore recent studies of how fever-range temperatures inform mammalian T cell metabolism, differentiation, and stress responses. Recent evidence indicates that metabolic programs initiated by fever are maintained upon return to thermo-normality, potentially providing a lasting benefit. Despite its impact, temperature remains overlooked and warrants further study. This is especially apparent when considering the wide temperature differential between tissues within the body and during inflammatory disease progression. We propose that differences in the metabolic and stress responses between T cell subsets upon thermal stress contribute to determining immune cell makeup and fate during inflammation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complement: you gutsy thing!: (Trends in Immunology 45, 228-230; 2024).
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-15 DOI: 10.1016/j.it.2025.02.001
Claudia Kemper
{"title":"Complement: you gutsy thing!: (Trends in Immunology 45, 228-230; 2024).","authors":"Claudia Kemper","doi":"10.1016/j.it.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.it.2025.02.001","url":null,"abstract":"","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-01 Epub Date: 2025-01-21 DOI: 10.1016/j.it.2024.12.005
Beatriz León
{"title":"Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?","authors":"Beatriz León","doi":"10.1016/j.it.2024.12.005","DOIUrl":"10.1016/j.it.2024.12.005","url":null,"abstract":"<p><p>Conventional dendritic cells (cDCs) are sentinels of the mammalian immune system that sense a wide range of danger and homeostatic signals to induce appropriately targeted T cell immune responses. Traditionally classified into two main subsets, cDC1 and cDC2, recent research shows that cDC2s exhibit significant heterogeneity and can be further subdivided. Studies in mice and humans show that, beyond their ontogeny, cDC2s acquire dynamic and tissue-specific characteristics that are influenced by local environmental signals, which impact on their functions during homeostasis, inflammation, and infection. The novel concept is proposed that tissue-derived signals and tissue plasticity can override preestablished developmental programming, thereby redefining developmental trajectories and cDC2 functionality. Ultimately, understanding cDC2 heterogeneity and plasticity has important implications for modulating T cell immunity in health and disease.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"104-120"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mouse gut blueprint: regionality and resilience.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-01 Epub Date: 2025-01-28 DOI: 10.1016/j.it.2025.01.004
Qiwei Ge, Shujie Chen
{"title":"Mouse gut blueprint: regionality and resilience.","authors":"Qiwei Ge, Shujie Chen","doi":"10.1016/j.it.2025.01.004","DOIUrl":"10.1016/j.it.2025.01.004","url":null,"abstract":"<p><p>Mayassi and colleagues utilized spatial transcriptomics to create a comprehensive blueprint of the mouse gut, exploring its adaptability and resilience under perturbed conditions. Their work highlights the adaptive capabilities of the murine gut's regionalized structure, providing insights into how it functions in a coordinated manner and how it responds to external challenges.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"94-96"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CCR8: a promising therapeutic target against tumor-infiltrating regulatory T cells.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-01 Epub Date: 2025-01-30 DOI: 10.1016/j.it.2025.01.001
Yuanjia Wen, Yu Xia, Xiangping Yang, Huayi Li, Qinglei Gao
{"title":"CCR8: a promising therapeutic target against tumor-infiltrating regulatory T cells.","authors":"Yuanjia Wen, Yu Xia, Xiangping Yang, Huayi Li, Qinglei Gao","doi":"10.1016/j.it.2025.01.001","DOIUrl":"10.1016/j.it.2025.01.001","url":null,"abstract":"<p><p>Tumor-infiltrating regulatory T (TI-Treg) cells constitute key components within the tumor microenvironment (TME) to suppress antitumor immunity and facilitate tumor progression. Although multiple therapies have been developed to eliminate TI-Treg cells, most of them exhibit only modest efficacy and harbor risks of inducing immune-related adverse events (irAEs). Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in the treatment of various cancers. Here, we concentrate on the latest understanding of CCR8 regarding its expression, functions, and regulation, and summarize the current landscape of CCR8-targeted therapies. With favorable efficacy and safety, the latter represent an important class of next-generation putative cancer immunotherapies.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"153-165"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular RNA acts as an antiviral MAVS signalosome scaffold.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-01 Epub Date: 2025-01-30 DOI: 10.1016/j.it.2025.01.003
Yang Liu, Xuetao Cao
{"title":"Cellular RNA acts as an antiviral MAVS signalosome scaffold.","authors":"Yang Liu, Xuetao Cao","doi":"10.1016/j.it.2025.01.003","DOIUrl":"10.1016/j.it.2025.01.003","url":null,"abstract":"<p><p>The adaptor protein mitochondrial antiviral signaling protein (MAVS)-mediated innate immune response is essential for host defense against RNA viruses. Gokhale and colleagues report that cellular mRNAs assemble and activate the MAVS signalosome by directly binding to MAVS and regulating its interactors, consequently enhancing antiviral signaling and interferon expression to inhibit viral infection.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"97-99"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decidual stromal cells: fibroblasts specialized in immunoregulation during pregnancy.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-01 Epub Date: 2025-02-13 DOI: 10.1016/j.it.2024.12.007
Tatiana Llorca, María José Ruiz-Magaña, Ana C Abadía, Carmen Ruiz-Ruiz, Enrique G Olivares
{"title":"Decidual stromal cells: fibroblasts specialized in immunoregulation during pregnancy.","authors":"Tatiana Llorca, María José Ruiz-Magaña, Ana C Abadía, Carmen Ruiz-Ruiz, Enrique G Olivares","doi":"10.1016/j.it.2024.12.007","DOIUrl":"10.1016/j.it.2024.12.007","url":null,"abstract":"<p><p>Decidual stromal cells (DSCs) are involved in immunoregulatory mechanisms that prevent fetal rejection by the mammalian maternal immune system. Recent studies using single-cell RNA sequencing demonstrated the existence of different types of human and mouse DSCs, highlighting corresponding differentiation (decidualization) pathways, and suggesting their involvement in the immune response during normal and pathological pregnancy. DSCs may be considered tissue-specialized fibroblasts because both DSCs and fibroblasts share phenotypic and functional similarities in immunologically challenged tissues, especially in terms of their immune functions. Indeed, fibroblasts can setup, support, and suppress immune responses and these functions are also performed by DSCs. Moreover, fibroblasts and DSCs can induce ectopic foci as tertiary lymphoid structures (TLSs), and endometriosis, respectively. Thus, understanding DSC immunoregulatory functions is of timely relevance.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"138-152"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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